Substrate diversity of herpes simplex virus thymidine kinase. Impact of the kinematics of the enzyme

Journal of Biological Chemistry

Volumn 274, Issue 45, 1999, Pages 31967-31973

  Pilger, Beatrice D ^a   Perozzo, Remo ^a   Alber, Frank ^b,c   Wurth, Christine ^a   Folkers, Gerd ^a   Scapozza, Leonardo ^a  

^a ETH ZURICH   (Switzerland)

^b INFM   (Italy)

^c SISSA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

NUCLEIC ACID BASE; THYMIDINE KINASE; VIRUS ENZYME;

ARTICLE; BINDING AFFINITY; CALORIMETRY; CATALYSIS; ENZYME ANALYSIS; ENZYME KINETICS; ENZYME SUBSTRATE COMPLEX; GENE THERAPY; HERPES SIMPLEX VIRUS 1; MOLECULAR DYNAMICS; NONHUMAN; PRIORITY JOURNAL; SITE DIRECTED MUTAGENESIS;

AMINO ACID SEQUENCE; CATALYTIC DOMAIN; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; HERPESVIRUS 1, HUMAN; KINETICS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MOLECULAR WEIGHT; MUTAGENESIS, SITE-DIRECTED; SEQUENCE ALIGNMENT; SUBSTRATE SPECIFICITY; THYMIDINE KINASE;

EID: 0033527750     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.274.45.31967     Document Type: Article

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