The rational of catalytic activity of herpes simplex virus thymidine kinase. A combined biochemical and quantum chemical study

Journal of Biological Chemistry

Volumn 276, Issue 24, 2001, Pages 21692-21697

  Sulpizi, Marialore ^a,b   Schelling, Pierre ^c   Folkers, Gerd ^c   Carloni, Paolo ^a,b,d   Scapozza, Leonardo ^c  

^a SISSA   (Italy)

^b INFM   (Italy)

^c ETH ZURICH   (Switzerland)

^d INTERNATIONAL CENTRE FOR GENETIC ENGINEERING AND BIOTECHNOLOGY   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

BIOASSAY; DNA; ENZYMES; GENES; TOXICITY; VIRUSES;

LIGANDS; QUANTUM CHEMISTRY;

BIOCHEMISTRY;

ANTIVIRUS AGENT; GLUTAMIC ACID; LIGAND; NUCLEOSIDE ANALOG; PRODRUG; THYMIDINE KINASE; VIRUS ENZYME; ENZYME INHIBITOR; HYBRID PROTEIN; ISOENZYME;

AB INITIO CALCULATION; ARTICLE; BIOCHEMISTRY; BIODIVERSITY; CATALYSIS; CHEMICAL STRUCTURE; DENSITY FUNCTIONAL THEORY; DIPOLE; DRUG DESIGN; ENERGY TRANSFER; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME INHIBITION; ENZYME KINETICS; ENZYME METABOLISM; ENZYME SUBSTRATE; ESCHERICHIA COLI; GENE THERAPY; HERPES SIMPLEX VIRUS 1; MOLECULAR INTERACTION; NONHUMAN; PHOSPHORYLATION; PRIORITY JOURNAL; QUANTUM CHEMISTRY; SUICIDE GENE; ULTRAVIOLET SPECTROPHOTOMETRY; BINDING SITE; CHEMISTRY; COMPARATIVE STUDY; COMPUTER PROGRAM; ENZYME SPECIFICITY; ENZYMOLOGY; HUMAN; KINETICS; METABOLISM; PROTEIN CONFORMATION; QUANTUM THEORY; X RAY CRYSTALLOGRAPHY;

ESCHERICHIA COLI; HUMAN HERPESVIRUS 1; SIMPLEXVIRUS;

ANTIVIRAL AGENTS; BINDING SITES; CATALYSIS; CRYSTALLOGRAPHY, X-RAY; ENZYME INHIBITORS; HERPESVIRUS 1, HUMAN; HUMANS; ISOENZYMES; KINETICS; LIGANDS; MODELS, MOLECULAR; PROTEIN CONFORMATION; QUANTUM THEORY; RECOMBINANT FUSION PROTEINS; SOFTWARE; SUBSTRATE SPECIFICITY; THYMIDINE KINASE;

EID: 0035877661     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M010223200     Document Type: Article

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