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Volumn 5, Issue 2, 2004, Pages 89-97

Alterations of glucose metabolism in type 2 diabetes mellitus. An overview

Author keywords

Glucose transport; Glucotoxicity; Glycogenesis; Glycolysis; Insulin resistance; Lipotoxicity

Indexed keywords

GLUCOSE;

EID: 3543031027     PISSN: 13899155     EISSN: None     Source Type: Journal    
DOI: 10.1023/B:REMD.0000021429.89218.c6     Document Type: Review
Times cited : (27)

References (89)
  • 1
    • 0012431804 scopus 로고    scopus 로고
    • Report of the expert committee on the diagnosis and classification of diabetes mellitus
    • Report of the expert committee on the diagnosis and classification of diabetes mellitus. Diabetes Care 2003;26(Suppl 1):S5-S20.
    • (2003) Diabetes Care , vol.26 , Issue.1 SUPPL.
  • 2
    • 0024244339 scopus 로고
    • Measurement of plasma glucose, free fatty acid, lactate, and insulin for 24 h in patients with NIDDM
    • Reaven GM, Hollenbeck C, Jeng CY, Wu MS, Chen YD. Measurement of plasma glucose, free fatty acid, lactate, and insulin for 24 h in patients with NIDDM. Diabetes 1988;37:1020-1024.
    • (1988) Diabetes , vol.37 , pp. 1020-1024
    • Reaven, G.M.1    Hollenbeck, C.2    Jeng, C.Y.3    Wu, M.S.4    Chen, Y.D.5
  • 3
    • 0024392514 scopus 로고
    • Glucose and free fatty acid metabolism in non-insulin-dependent diabetes mellitus. Evidence for multiple sites of insulin resistance
    • Groop LC, Bonadonna RC, DelPrato S, Ratheiser K, Zyck K, Ferrannini E, DeFronzo RA. Glucose and free fatty acid metabolism in non-insulin-dependent diabetes mellitus. Evidence for multiple sites of insulin resistance. J Clin Invest 1989;84:205-213.
    • (1989) J Clin Invest , vol.84 , pp. 205-213
    • Groop, L.C.1    Bonadonna, R.C.2    DelPrato, S.3    Ratheiser, K.4    Zyck, K.5    Ferrannini, E.6    DeFronzo, R.A.7
  • 4
  • 5
    • 0024026298 scopus 로고
    • Lilly lecture 1987. The triumvirate: Beta-cell, muscle, liver. A collusion responsible for NIDDM
    • DeFronzo RA. Lilly lecture 1987. The triumvirate: Beta-cell, muscle, liver. A collusion responsible for NIDDM. Diabetes 1988;37:667-687.
    • (1988) Diabetes , vol.37 , pp. 667-687
    • DeFronzo, R.A.1
  • 6
    • 0023589251 scopus 로고
    • Role of hyperglucagonemia in maintenance of increased rates of hepatic glucose output in type II diabetics
    • Baron AD, Schaeffer L, Shragg P, Kolterman OG. Role of hyperglucagonemia in maintenance of increased rates of hepatic glucose output in type II diabetics. Diabetes 1987;36:274-283.
    • (1987) Diabetes , vol.36 , pp. 274-283
    • Baron, A.D.1    Schaeffer, L.2    Shragg, P.3    Kolterman, O.G.4
  • 7
    • 0032988976 scopus 로고    scopus 로고
    • Role of glutamine in human carbohydrate metabolism in kidney and other tissues
    • Stumvoll M, Perriello G, Meyer C, Gerich J. Role of glutamine in human carbohydrate metabolism in kidney and other tissues. Kidney Int 1999;55:778-792.
    • (1999) Kidney Int , vol.55 , pp. 778-792
    • Stumvoll, M.1    Perriello, G.2    Meyer, C.3    Gerich, J.4
  • 8
    • 0024511329 scopus 로고
    • Predominant role of gluconeogenesis in increased hepatic glucose production in NIDDM
    • Consoli A, Nurjhan N, Capani F, Gerich J. Predominant role of gluconeogenesis in increased hepatic glucose production in NIDDM. Diabetes 1989;38:550-557.
    • (1989) Diabetes , vol.38 , pp. 550-557
    • Consoli, A.1    Nurjhan, N.2    Capani, F.3    Gerich, J.4
  • 9
    • 0026488079 scopus 로고
    • Increased rate of gluconeogenesis in type II diabetes mellitus. A 13C nuclear magnetic resonance study
    • Magnusson I, Rothman DL, Katz LD, Shulman RG, Shulman GI. Increased rate of gluconeogenesis in type II diabetes mellitus. A 13C nuclear magnetic resonance study. J Clin Invest 1992;90:1323-1327.
    • (1992) J Clin Invest , vol.90 , pp. 1323-1327
    • Magnusson, I.1    Rothman, D.L.2    Katz, L.D.3    Shulman, R.G.4    Shulman, G.I.5
  • 15
    • 0028955559 scopus 로고
    • Role of basal insulin in maintenance of intracellular glucose metabolic pathways in non-insulin-dependent diabetes mellitus
    • Suh KI, Song YM, Murata C, Joyce M, Ditzler TM, Henry RR. Role of basal insulin in maintenance of intracellular glucose metabolic pathways in non-insulin-dependent diabetes mellitus. Metabolism 1995;44:41-46.
    • (1995) Metabolism , vol.44 , pp. 41-46
    • Suh, K.I.1    Song, Y.M.2    Murata, C.3    Joyce, M.4    Ditzler, T.M.5    Henry, R.R.6
  • 16
    • 0030035651 scopus 로고    scopus 로고
    • Intracellular lactate- and pyruvate-interconversion rates are increased in muscle tissue of non-insulin-dependent diabetic individuals
    • Avogaro A, Toffolo G, Miola M, Valerio A, Tiengo A, Cobelli C, Del Prato S. Intracellular lactate- and pyruvate-interconversion rates are increased in muscle tissue of non-insulin-dependent diabetic individuals. J Clin Invest 1996;98:108-115.
    • (1996) J Clin Invest , vol.98 , pp. 108-115
    • Avogaro, A.1    Toffolo, G.2    Miola, M.3    Valerio, A.4    Tiengo, A.5    Cobelli, C.6    Del Prato, S.7
  • 17
    • 0025630056 scopus 로고
    • Mechanism of increased gluconeogenesis in noninsulin-dependent diabetes mellitus. Role of alterations in systemic, hepatic, and muscle lactate and alanine metabolism
    • Consoli A, Nurjhan N, Reilly JJ, Jr., Bier DM, Gerich JE. Mechanism of increased gluconeogenesis in noninsulin-dependent diabetes mellitus. Role of alterations in systemic, hepatic, and muscle lactate and alanine metabolism. J Clin Invest 1990;86:2038-2045.
    • (1990) J Clin Invest , vol.86 , pp. 2038-2045
    • Consoli, A.1    Nurjhan, N.2    Reilly Jr., J.J.3    Bier, D.M.4    Gerich, J.E.5
  • 18
    • 0019987653 scopus 로고
    • Insulin production rate, hepatic insulin retention and splanchnic carbohydrate metabolism after oral glucose ingestion in hyperinsulinaemic Type 2 (non-insulin-dependent) diabetes mellitus
    • Waldhausl W, Bratusch-Marrain P, Gasic S, Korn A, Nowotny P. Insulin production rate, hepatic insulin retention and splanchnic carbohydrate metabolism after oral glucose ingestion in hyperinsulinaemic Type 2 (non-insulin-dependent) diabetes mellitus. Diabetologia 1982;23:6-15.
    • (1982) Diabetologia , vol.23 , pp. 6-15
    • Waldhausl, W.1    Bratusch-Marrain, P.2    Gasic, S.3    Korn, A.4    Nowotny, P.5
  • 20
    • 0034034229 scopus 로고    scopus 로고
    • Glucose-6-phosphatase flux in vitro is increased in type 2 diabetes
    • Clore JN, Stillman J, Sugerman H. Glucose-6-phosphatase flux in vitro is increased in type 2 diabetes. Diabetes 2000;49:969-974.
    • (2000) Diabetes , vol.49 , pp. 969-974
    • Clore, J.N.1    Stillman, J.2    Sugerman, H.3
  • 22
    • 0025963777 scopus 로고
    • The role of free fatty acid metabolism in the pathogenesis of insulin resistance in obesity and noninsulin-dependent diabetes mellitus
    • Groop LC, Saloranta C, Shank M, Bonadonna RC, Ferrannini E, DeFronzo RA. The role of free fatty acid metabolism in the pathogenesis of insulin resistance in obesity and noninsulin-dependent diabetes mellitus. J Clin Endocrinol Metab 1991;72:96-107.
    • (1991) J Clin Endocrinol Metab , vol.72 , pp. 96-107
    • Groop, L.C.1    Saloranta, C.2    Shank, M.3    Bonadonna, R.C.4    Ferrannini, E.5    DeFronzo, R.A.6
  • 27
    • 0032104120 scopus 로고    scopus 로고
    • Evidence for defects in the trafficking and translocation of GLUT4 glucose transporters in skeletal muscle as a cause of human insulin resistance
    • Garvey WT, Maianu L, Zhu JH, Brechtel-Hook G, Wallace P, Baron AD. Evidence for defects in the trafficking and translocation of GLUT4 glucose transporters in skeletal muscle as a cause of human insulin resistance. J Clin Invest 1998;101:2377-2386.
    • (1998) J Clin Invest , vol.101 , pp. 2377-2386
    • Garvey, W.T.1    Maianu, L.2    Zhu, J.H.3    Brechtel-Hook, G.4    Wallace, P.5    Baron, A.D.6
  • 29
    • 0032192401 scopus 로고    scopus 로고
    • Insulin downregulates pyruvate dehydrogenase kinase (PDK) mRNA: Potential mechanism contributing to increased lipid oxidation in insulin-resistant subjects
    • Majer M, Popov KM, Harris RA, Bogardus C, Prochazka M. Insulin downregulates pyruvate dehydrogenase kinase (PDK) mRNA: Potential mechanism contributing to increased lipid oxidation in insulin-resistant subjects. Mol Genet Metab 1998;65:181-186.
    • (1998) Mol Genet Metab , vol.65 , pp. 181-186
    • Majer, M.1    Popov, K.M.2    Harris, R.A.3    Bogardus, C.4    Prochazka, M.5
  • 30
    • 0036558024 scopus 로고    scopus 로고
    • Starvation amidst plenty: PDKs and diabetes mellitus
    • Okar DA. Starvation amidst plenty: PDKs and diabetes mellitus. Trends Biochem Sci 2002;27:227-228.
    • (2002) Trends Biochem Sci , vol.27 , pp. 227-228
    • Okar, D.A.1
  • 31
    • 0025098765 scopus 로고
    • Quantitation of muscle glycogen synthesis in normal subjects and subjects with non-insulin-dependent diabetes by 13C nuclear magnetic resonance spectroscopy
    • Shulman GI, Rothman DL, Jue T, Stein P, DeFronzo RA, Shulman RG. Quantitation of muscle glycogen synthesis in normal subjects and subjects with non-insulin-dependent diabetes by 13C nuclear magnetic resonance spectroscopy. N Engl J Med 1990;322:223-228.
    • (1990) N Engl J Med , vol.322 , pp. 223-228
    • Shulman, G.I.1    Rothman, D.L.2    Jue, T.3    Stein, P.4    DeFronzo, R.A.5    Shulman, R.G.6
  • 32
    • 0021258643 scopus 로고
    • Correlation between muscle glycogen synthase activity and in vivo insulin action in man
    • Bogardus C, Lillioja S, Stone K, Mott D. Correlation between muscle glycogen synthase activity and in vivo insulin action in man. J Clin Invest 1984;73:1185-1190.
    • (1984) J Clin Invest , vol.73 , pp. 1185-1190
    • Bogardus, C.1    Lillioja, S.2    Stone, K.3    Mott, D.4
  • 33
    • 0023864887 scopus 로고
    • Muscle glycogen synthesis and disposition of infused glucose in humans with reduced rates of insulin-mediated carbohydrate storage
    • Young AA, Bogardus C, Wolfe-Lopez D, Mott DM. Muscle glycogen synthesis and disposition of infused glucose in humans with reduced rates of insulin-mediated carbohydrate storage. Diabetes 1988;37:303-308.
    • (1988) Diabetes , vol.37 , pp. 303-308
    • Young, A.A.1    Bogardus, C.2    Wolfe-Lopez, D.3    Mott, D.M.4
  • 34
    • 0025083772 scopus 로고
    • Skeletal muscle glycogen synthase activity in subjects with non-insulin-dependent diabetes mellitus after glyburide therapy
    • Nyomba BL, Freymond D, Raz I, Stone K, Mott DM, Bogardus C. Skeletal muscle glycogen synthase activity in subjects with non-insulin-dependent diabetes mellitus after glyburide therapy. Metabolism 1990;39:1204-1210.
    • (1990) Metabolism , vol.39 , pp. 1204-1210
    • Nyomba, B.L.1    Freymond, D.2    Raz, I.3    Stone, K.4    Mott, D.M.5    Bogardus, C.6
  • 35
    • 0034841515 scopus 로고    scopus 로고
    • Impaired muscle glycogen synthase in type 2 diabetes is associated with diminished phosphatidylinositol 3-kinase activation
    • Nikoulina SE, Ciaraldi TP, Carter L, Mudaliar S, Park KS, Henry RR. Impaired muscle glycogen synthase in type 2 diabetes is associated with diminished phosphatidylinositol 3-kinase activation. J Clin Endocrinol Metab 2001;86:4307-4314.
    • (2001) J Clin Endocrinol Metab , vol.86 , pp. 4307-4314
    • Nikoulina, S.E.1    Ciaraldi, T.P.2    Carter, L.3    Mudaliar, S.4    Park, K.S.5    Henry, R.R.6
  • 36
    • 0029142508 scopus 로고
    • Unchanged gene expression of glycogen synthase in muscle from patients with NIDDM following sulphonylurea-induced improvement of glycaemic control
    • Vestergaard H, Lund S, Bjorbaek C, Pedersen O. Unchanged gene expression of glycogen synthase in muscle from patients with NIDDM following sulphonylurea-induced improvement of glycaemic control. Diabetologia 1995;38:1230-1238.
    • (1995) Diabetologia , vol.38 , pp. 1230-1238
    • Vestergaard, H.1    Lund, S.2    Bjorbaek, C.3    Pedersen, O.4
  • 37
    • 0025860114 scopus 로고
    • Reduced glycogen synthase activity in skeletal muscle from obese patients with and without type 2 (non-insulin-dependent) diabetes mellitus
    • Damsbo P, Vaag A, Hother-Nielsen O, Beck-Nielsen H. Reduced glycogen synthase activity in skeletal muscle from obese patients with and without type 2 (non-insulin-dependent) diabetes mellitus. Diabetologia 1991;34:239-245.
    • (1991) Diabetologia , vol.34 , pp. 239-245
    • Damsbo, P.1    Vaag, A.2    Hother-Nielsen, O.3    Beck-Nielsen, H.4
  • 38
    • 0025014823 scopus 로고
    • Intracellular glucose oxidation and glycogen synthase activity are reduced in non-insulin-dependent (type II) diabetes independent of impaired glucose uptake
    • Thorburn AW, Gumbiner B, Bulacan F, Wallace P, Henry RR. Intracellular glucose oxidation and glycogen synthase activity are reduced in non-insulin-dependent (type II) diabetes independent of impaired glucose uptake. J Clin Invest 1990;85:522-529.
    • (1990) J Clin Invest , vol.85 , pp. 522-529
    • Thorburn, A.W.1    Gumbiner, B.2    Bulacan, F.3    Wallace, P.4    Henry, R.R.5
  • 39
    • 0026080841 scopus 로고
    • Impaired activation of skeletal muscle glycogen synthase in non-insulin-dependent diabetes mellitus is unrelated to the degree of obesity
    • Johnson AB, Argyraki M, Thow JC, Jones IR, Broughton D, Miller M, Taylor R. Impaired activation of skeletal muscle glycogen synthase in non-insulin-dependent diabetes mellitus is unrelated to the degree of obesity. Metabolism 1991;40:252-260.
    • (1991) Metabolism , vol.40 , pp. 252-260
    • Johnson, A.B.1    Argyraki, M.2    Thow, J.C.3    Jones, I.R.4    Broughton, D.5    Miller, M.6    Taylor, R.7
  • 40
    • 0027457357 scopus 로고
    • Abnormal activation of glycogen synthesis in fibroblasts from NIDDM subjects. Evidence for an abnormality specific to glucose metabolism
    • Wells AM, Sutcliffe IC, Johnson AB, Taylor R. Abnormal activation of glycogen synthesis in fibroblasts from NIDDM subjects. Evidence for an abnormality specific to glucose metabolism. Diabetes 1993;42:583-589.
    • (1993) Diabetes , vol.42 , pp. 583-589
    • Wells, A.M.1    Sutcliffe, I.C.2    Johnson, A.B.3    Taylor, R.4
  • 41
    • 0024210487 scopus 로고
    • Impaired insulin-stimulated muscle glycogen synthase activation in vivo in man is related to low fasting glycogen synthase phosphatase activity
    • Freymond D, Bogardus C, Okubo M, Stone K, Mott D. Impaired insulin-stimulated muscle glycogen synthase activation in vivo in man is related to low fasting glycogen synthase phosphatase activity. J Clin Invest 1988;82:1503-1509.
    • (1988) J Clin Invest , vol.82 , pp. 1503-1509
    • Freymond, D.1    Bogardus, C.2    Okubo, M.3    Stone, K.4    Mott, D.5
  • 42
    • 0025117502 scopus 로고
    • Insulin resistance is associated with reduced fasting and insulin-stimulated glycogen synthase phosphatase activity in human skeletal muscle
    • Kida Y, Esposito-Del Puente A, Bogardus C, Mott DM. Insulin resistance is associated with reduced fasting and insulin-stimulated glycogen synthase phosphatase activity in human skeletal muscle. J Clin Invest 1990;85:476-181.
    • (1990) J Clin Invest , vol.85 , pp. 476-1181
    • Kida, Y.1    Esposito-Del Puente, A.2    Bogardus, C.3    Mott, D.M.4
  • 43
    • 0036273020 scopus 로고    scopus 로고
    • Glycogen synthase kinase 3 (GSK-3) inhibitors as new promising drugs for diabetes, neurodegeneration, cancer, and inflammation
    • Martinez A, Castro A, Dorronsoro I, Alonso M. Glycogen synthase kinase 3 (GSK-3) inhibitors as new promising drugs for diabetes, neurodegeneration, cancer, and inflammation. Med Res Rev 2002;22:373-384.
    • (2002) Med Res Rev , vol.22 , pp. 373-384
    • Martinez, A.1    Castro, A.2    Dorronsoro, I.3    Alonso, M.4
  • 44
    • 0037383322 scopus 로고    scopus 로고
    • GSK-3: Tricks of the trade for a multi-tasking kinase
    • Doble BW, Woodgett JR. GSK-3: Tricks of the trade for a multi-tasking kinase. J Cell Sci 2003;116:1175-1186.
    • (2003) J Cell Sci , vol.116 , pp. 1175-1186
    • Doble, B.W.1    Woodgett, J.R.2
  • 45
    • 0035856949 scopus 로고    scopus 로고
    • Insulin signalling and the regulation of glucose and lipid metabolism
    • Saltiel AR, Kahn CR. Insulin signalling and the regulation of glucose and lipid metabolism. Nature 2001;414:799-806.
    • (2001) Nature , vol.414 , pp. 799-806
    • Saltiel, A.R.1    Kahn, C.R.2
  • 46
    • 0025311912 scopus 로고
    • Reduced postprandial skeletal muscle blood flow contributes to glucose intolerance in human obesity
    • Baron AD, Laakso M, Brechtel G, Hoit B, Watt C, Edelman SV. Reduced postprandial skeletal muscle blood flow contributes to glucose intolerance in human obesity. J Clin Endocrinol Metab 1990;70:1525-1533.
    • (1990) J Clin Endocrinol Metab , vol.70 , pp. 1525-1533
    • Baron, A.D.1    Laakso, M.2    Brechtel, G.3    Hoit, B.4    Watt, C.5    Edelman, S.V.6
  • 47
    • 0025292440 scopus 로고
    • Decreased effect of insulin to stimulate skeletal muscle blood flow in obese man. A novel mechanism for insulin resistance
    • Laakso M, Edelman SV, Brechtel G, Baron AD. Decreased effect of insulin to stimulate skeletal muscle blood flow in obese man. A novel mechanism for insulin resistance. J Clin Invest 1990;85:1844-1852.
    • (1990) J Clin Invest , vol.85 , pp. 1844-1852
    • Laakso, M.1    Edelman, S.V.2    Brechtel, G.3    Baron, A.D.4
  • 48
    • 0026801899 scopus 로고
    • Impaired insulin-mediated skeletal muscle blood flow in patients with NIDDM
    • Laakso M, Edelman SV, Brechtel G, Baron AD. Impaired insulin-mediated skeletal muscle blood flow in patients with NIDDM. Diabetes 1992;41:1076-1083.
    • (1992) Diabetes , vol.41 , pp. 1076-1083
    • Laakso, M.1    Edelman, S.V.2    Brechtel, G.3    Baron, A.D.4
  • 49
    • 0032555102 scopus 로고    scopus 로고
    • Role of tissue-specific blood flow and tissue recruitment in insulin-mediated glucose uptake of human skeletal muscle
    • Bonadonna RC, Saccomani MP, Del Prato S, Bonora E, DeFronzo RA, Cobelli C. Role of tissue-specific blood flow and tissue recruitment in insulin-mediated glucose uptake of human skeletal muscle. Circulation 1998;98:234-241.
    • (1998) Circulation , vol.98 , pp. 234-241
    • Bonadonna, R.C.1    Saccomani, M.P.2    Del Prato, S.3    Bonora, E.4    DeFronzo, R.A.5    Cobelli, C.6
  • 50
    • 0034037949 scopus 로고    scopus 로고
    • Interaction between insulin sensitivity and muscle perfusion on glucose uptake in human skeletal muscle: Evidence for capillary recruitment
    • Baron AD, Tarshoby M, Hook G, Lazaridis EN, Cronin J, Johnson A, Steinberg HO. Interaction between insulin sensitivity and muscle perfusion on glucose uptake in human skeletal muscle: Evidence for capillary recruitment. Diabetes 2000;49:768-774.
    • (2000) Diabetes , vol.49 , pp. 768-774
    • Baron, A.D.1    Tarshoby, M.2    Hook, G.3    Lazaridis, E.N.4    Cronin, J.5    Johnson, A.6    Steinberg, H.O.7
  • 51
    • 0033637747 scopus 로고    scopus 로고
    • Evidence for physiological coupling of insulin-mediated glucose metabolism and limb blood flow
    • Mather K, Laakso M, Edelman S, Hook G, Baron A. Evidence for physiological coupling of insulin-mediated glucose metabolism and limb blood flow. Am J Physiol Endocrinol Metab 2000;279:E1264-E1270.
    • (2000) Am J Physiol Endocrinol Metab , vol.279
    • Mather, K.1    Laakso, M.2    Edelman, S.3    Hook, G.4    Baron, A.5
  • 53
    • 50549202600 scopus 로고
    • The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus
    • Randle PJ, Garland PB, Hales CN, Newsholme EA. The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus. Lancet 1963;1:785-789.
    • (1963) Lancet , vol.1 , pp. 785-789
    • Randle, P.J.1    Garland, P.B.2    Hales, C.N.3    Newsholme, E.A.4
  • 55
    • 0028209552 scopus 로고
    • Free fatty acid and glucose metabolism in human aging: Evidence for operation of the Randle cycle
    • Bonadonna RC, Groop LC, Simonson DC, DeFronzo RA. Free fatty acid and glucose metabolism in human aging: Evidence for operation of the Randle cycle. Am J Physiol 1994;266:E501-E509.
    • (1994) Am J Physiol , vol.266
    • Bonadonna, R.C.1    Groop, L.C.2    Simonson, D.C.3    DeFronzo, R.A.4
  • 56
    • 0029151863 scopus 로고
    • Lipotoxicity in the pathogenesis of obesity-dependent NIDDM. Genetic and clinical implications
    • Unger RH. Lipotoxicity in the pathogenesis of obesity-dependent NIDDM. Genetic and clinical implications. Diabetes 1995;44:863-870.
    • (1995) Diabetes , vol.44 , pp. 863-870
    • Unger, R.H.1
  • 57
    • 0036092239 scopus 로고    scopus 로고
    • Banting lecture 2001: Dysregulation of fatty acid metabolism in the etiology of type 2 diabetes
    • McGarry JD. Banting lecture 2001: Dysregulation of fatty acid metabolism in the etiology of type 2 diabetes. Diabetes 2002;51:7-18.
    • (2002) Diabetes , vol.51 , pp. 7-18
    • McGarry, J.D.1
  • 59
    • 0242329843 scopus 로고    scopus 로고
    • Adiponectin: Linking the fat cell to insulin sensitivity
    • Goldfine AB, Kahn CR. Adiponectin: Linking the fat cell to insulin sensitivity. Lancet 2003;362:1431-1432.
    • (2003) Lancet , vol.362 , pp. 1431-1432
    • Goldfine, A.B.1    Kahn, C.R.2
  • 60
    • 0035403205 scopus 로고    scopus 로고
    • Circulating interleukin-6 in relation to adiposity, insulin action, and insulin secretion
    • Vozarova B, Weyer C, Hanson K, Tataranni PA, Bogardus C, Pratley RE. Circulating interleukin-6 in relation to adiposity, insulin action, and insulin secretion. Obes Res 2001;9:414-417.
    • (2001) Obes Res , vol.9 , pp. 414-417
    • Vozarova, B.1    Weyer, C.2    Hanson, K.3    Tataranni, P.A.4    Bogardus, C.5    Pratley, R.E.6
  • 61
    • 0030765908 scopus 로고    scopus 로고
    • Subcutaneous abdominal fat and thigh muscle composition predict insulin sensitivity independently of visceral fat
    • Goodpaster BH, Thaete FL, Simoneau JA, Kelley DE. Subcutaneous abdominal fat and thigh muscle composition predict insulin sensitivity independently of visceral fat. Diabetes 1997;46:1579-1585.
    • (1997) Diabetes , vol.46 , pp. 1579-1585
    • Goodpaster, B.H.1    Thaete, F.L.2    Simoneau, J.A.3    Kelley, D.E.4
  • 62
    • 0033927667 scopus 로고    scopus 로고
    • Cellular mechanisms of insulin resistance
    • Shulman GI. Cellular mechanisms of insulin resistance. J Clin Invest 2000;106:171-176.
    • (2000) J Clin Invest , vol.106 , pp. 171-176
    • Shulman, G.I.1
  • 63
    • 0030987889 scopus 로고    scopus 로고
    • High-fat feeding impairs insulin-stimulated GLUT4 recruitment via an early insulin-signaling defect
    • Zierath JR, Houseknecht KL, Gnudi L, Kahn BB. High-fat feeding impairs insulin-stimulated GLUT4 recruitment via an early insulin-signaling defect. Diabetes 1997;46:215-223.
    • (1997) Diabetes , vol.46 , pp. 215-223
    • Zierath, J.R.1    Houseknecht, K.L.2    Gnudi, L.3    Kahn, B.B.4
  • 64
    • 0030026355 scopus 로고    scopus 로고
    • Regulation of GLUT4 gene expression by arachidonic acid. Evidence for multiple pathways, one of which requires oxidation to prostaglandin E2
    • Long SD, Pekala PH. Regulation of GLUT4 gene expression by arachidonic acid. Evidence for multiple pathways, one of which requires oxidation to prostaglandin E2. J Biol Chem 1996;271:1138-1144.
    • (1996) J Biol Chem , vol.271 , pp. 1138-1144
    • Long, S.D.1    Pekala, P.H.2
  • 65
    • 0029853098 scopus 로고    scopus 로고
    • Lipid mediators of insulin resistance: Ceramide signalling down-regulates GLUT4 gene transcription in 3T3-L1 adipocytes
    • Long SD, Pekala PH. Lipid mediators of insulin resistance: Ceramide signalling down-regulates GLUT4 gene transcription in 3T3-L1 adipocytes. Biochem J 1996;319 (Pt 1):179-184.
    • (1996) Biochem J , vol.319 , Issue.1 PART , pp. 179-184
    • Long, S.D.1    Pekala, P.H.2
  • 66
    • 0030630131 scopus 로고    scopus 로고
    • New concepts in extracellular signaling for insulin action: The single gateway hypothesis
    • Bergman RN. New concepts in extracellular signaling for insulin action: The single gateway hypothesis. Recent Prog Horm Res discussion 385-357 1997;52:359-385.
    • (1997) Recent Prog Horm Res , vol.52 , pp. 359-385
    • Bergman, R.N.1
  • 67
    • 0033826669 scopus 로고    scopus 로고
    • Inhibition of lipolysis causes suppression of endogenous glucose production independent of changes in insulin
    • Mittelman SD, Bergman RN. Inhibition of lipolysis causes suppression of endogenous glucose production independent of changes in insulin. Am J Physiol Endocrinol Metab 2000;279:E630-E637.
    • (2000) Am J Physiol Endocrinol Metab , vol.279
    • Mittelman, S.D.1    Bergman, R.N.2
  • 68
    • 0036772294 scopus 로고    scopus 로고
    • Pathogenesis and prediction of diabetes mellitus: Lessons from integrative physiology
    • Bergman RN. Pathogenesis and prediction of diabetes mellitus: Lessons from integrative physiology. Mt Sinai J Med 2002;69:280-290.
    • (2002) Mt Sinai J Med , vol.69 , pp. 280-290
    • Bergman, R.N.1
  • 69
    • 0037324626 scopus 로고    scopus 로고
    • Insulin's effect on glucose production: Direct or indirect?
    • Barrett EJ. Insulin's effect on glucose production: Direct or indirect? J Clin Invest 2003;111:434-435.
    • (2003) J Clin Invest , vol.111 , pp. 434-435
    • Barrett, E.J.1
  • 71
    • 0022577797 scopus 로고
    • Effects of tolazamide and exogenous insulin on insulin action in patients with non-insulin-dependent diabetes mellitus
    • Firth RG, Bell PM, Rizza RA. Effects of tolazamide and exogenous insulin on insulin action in patients with non-insulin-dependent diabetes mellitus. N Engl J Med 1986;314:1280-1286.
    • (1986) N Engl J Med , vol.314 , pp. 1280-1286
    • Firth, R.G.1    Bell, P.M.2    Rizza, R.A.3
  • 72
    • 0022467301 scopus 로고
    • Postprandial hyperglycemia in patients with noninsulin-dependent diabetes mellitus. Role of hepatic and extrahepatic tissues
    • Firth RG, Bell PM, Marsh HM, Hansen I, Rizza RA. Postprandial hyperglycemia in patients with noninsulin-dependent diabetes mellitus. Role of hepatic and extrahepatic tissues. J Clin Invest 1986;77:1525-1532.
    • (1986) J Clin Invest , vol.77 , pp. 1525-1532
    • Firth, R.G.1    Bell, P.M.2    Marsh, H.M.3    Hansen, I.4    Rizza, R.A.5
  • 73
    • 0025066579 scopus 로고
    • Contribution of abnormal muscle and liver glucose metabolism to postprandial hyperglycemia in NIDDM
    • Mitrakou A, Kelley D, Veneman T, Jenssen T, Pangburn T, Reilly J, Gerich J. Contribution of abnormal muscle and liver glucose metabolism to postprandial hyperglycemia in NIDDM. In Diabetes, 1990; p. 1381-1390.
    • (1990) Diabetes , pp. 1381-1390
    • Mitrakou, A.1    Kelley, D.2    Veneman, T.3    Jenssen, T.4    Pangburn, T.5    Reilly, J.6    Gerich, J.7
  • 74
    • 0025066579 scopus 로고
    • Contribution of abnormal muscle and liver glucose metabolism to postprandial hyperglycemia in NIDDM
    • Mitrakou A, Kelley D, Veneman T, Jenssen T, Pangburn T, Reilly J, Gerich J. Contribution of abnormal muscle and liver glucose metabolism to postprandial hyperglycemia in NIDDM. Diabetes 1990;39:1381-1390.
    • (1990) Diabetes , vol.39 , pp. 1381-1390
    • Mitrakou, A.1    Kelley, D.2    Veneman, T.3    Jenssen, T.4    Pangburn, T.5    Reilly, J.6    Gerich, J.7
  • 75
    • 0029935830 scopus 로고    scopus 로고
    • Effects of a change in the pattern of insulin delivery on carbohydrate tolerance in diabetic and nondiabetic humans in the presence of differing degrees of insulin resistance
    • Basu A, Alzaid A, Dinneen S, Caumo A, Cobelli C, Rizza RA. Effects of a change in the pattern of insulin delivery on carbohydrate tolerance in diabetic and nondiabetic humans in the presence of differing degrees of insulin resistance. J Clin Invest 1996;97:2351-2361.
    • (1996) J Clin Invest , vol.97 , pp. 2351-2361
    • Basu, A.1    Alzaid, A.2    Dinneen, S.3    Caumo, A.4    Cobelli, C.5    Rizza, R.A.6
  • 76
    • 0034524938 scopus 로고    scopus 로고
    • Lack of suppression of glucagon contributes to postprandial hyperglycemia in subjects with type 2 diabetes mellitus
    • Shah P, Vella A, Basu A, Basu R, Schwenk WF, Rizza RA. Lack of suppression of glucagon contributes to postprandial hyperglycemia in subjects with type 2 diabetes mellitus. J Clin Endocrinol Metab 2000;85:4053-1059.
    • (2000) J Clin Endocrinol Metab , vol.85 , pp. 4053-11059
    • Shah, P.1    Vella, A.2    Basu, A.3    Basu, R.4    Schwenk, W.F.5    Rizza, R.A.6
  • 77
    • 0033985724 scopus 로고    scopus 로고
    • Effects of type 2 diabetes on the ability of insulin and glucose to regulate splanchnic and muscle glucose metabolism: Evidence for a defect in hepatic glucokinase activity
    • Basu A, Basu R, Shah P, Vella A, Johnson CM, Nair KS, Jensen MD, Schwenk WF, Rizza RA. Effects of type 2 diabetes on the ability of insulin and glucose to regulate splanchnic and muscle glucose metabolism: Evidence for a defect in hepatic glucokinase activity. Diabetes 2000;49:272-283.
    • (2000) Diabetes , vol.49 , pp. 272-283
    • Basu, A.1    Basu, R.2    Shah, P.3    Vella, A.4    Johnson, C.M.5    Nair, K.S.6    Jensen, M.D.7    Schwenk, W.F.8    Rizza, R.A.9
  • 78
    • 0034992273 scopus 로고    scopus 로고
    • Type 2 diabetes impairs splanchnic uptake of glucose but does not alter intestinal glucose absorption during enteral glucose feeding: Additional evidence for a defect in hepatic glucokinase activity
    • Basu A, Basu R, Shah P, Vella A, Johnson CM, Jensen M, Nair KS, Schwenk WF, Rizza RA. Type 2 diabetes impairs splanchnic uptake of glucose but does not alter intestinal glucose absorption during enteral glucose feeding: Additional evidence for a defect in hepatic glucokinase activity. Diabetes 2001;50:1351-1362.
    • (2001) Diabetes , vol.50 , pp. 1351-1362
    • Basu, A.1    Basu, R.2    Shah, P.3    Vella, A.4    Johnson, C.M.5    Jensen, M.6    Nair, K.S.7    Schwenk, W.F.8    Rizza, R.A.9
  • 80
    • 0031719659 scopus 로고    scopus 로고
    • Normal glucose-induced suppression of glucose production but impaired stimulation of glucose disposal in type 2 diabetes: Evidence for a concentration-dependent defect in uptake
    • Nielsen MF, Basu R, Wise S, Caumo A, Cobelli C, Rizza RA. Normal glucose-induced suppression of glucose production but impaired stimulation of glucose disposal in type 2 diabetes: Evidence for a concentration-dependent defect in uptake. Diabetes 1998;47:1735-1747.
    • (1998) Diabetes , vol.47 , pp. 1735-1747
    • Nielsen, M.F.1    Basu, R.2    Wise, S.3    Caumo, A.4    Cobelli, C.5    Rizza, R.A.6
  • 81
    • 0031054198 scopus 로고    scopus 로고
    • Impaired basal glucose effectiveness in NIDDM: Contribution of defects in glucose disappearance and production, measured using an optimized minimal model independent protocol
    • Basu A, Caumo A, Bettini F, Gelisio A, Alzaid A, Cobelli C, Rizza RA. Impaired basal glucose effectiveness in NIDDM: Contribution of defects in glucose disappearance and production, measured using an optimized minimal model independent protocol. Diabetes 1997;46:421-432.
    • (1997) Diabetes , vol.46 , pp. 421-432
    • Basu, A.1    Caumo, A.2    Bettini, F.3    Gelisio, A.4    Alzaid, A.5    Cobelli, C.6    Rizza, R.A.7
  • 82
    • 0032529147 scopus 로고    scopus 로고
    • Regulation of endogenous glucose production by glucose per se is impaired in type 2 diabetes mellitus
    • Mevorach M, Giacca A, Aharon Y, Hawkins M, Shamoon H, Rossetti L. Regulation of endogenous glucose production by glucose per se is impaired in type 2 diabetes mellitus. J Clin Invest 1998;102:744-753.
    • (1998) J Clin Invest , vol.102 , pp. 744-753
    • Mevorach, M.1    Giacca, A.2    Aharon, Y.3    Hawkins, M.4    Shamoon, H.5    Rossetti, L.6
  • 83
    • 0036307329 scopus 로고    scopus 로고
    • Glycemic control determines hepatic and peripheral glucose effectiveness in type 2 diabetic subjects
    • Hawkins M, Gabriely I, Wozniak R, Reddy K, Rossetti L, Shamoon H. Glycemic control determines hepatic and peripheral glucose effectiveness in type 2 diabetic subjects. Diabetes 2002;51:2179-2189.
    • (2002) Diabetes , vol.51 , pp. 2179-2189
    • Hawkins, M.1    Gabriely, I.2    Wozniak, R.3    Reddy, K.4    Rossetti, L.5    Shamoon, H.6
  • 84
    • 0242300566 scopus 로고    scopus 로고
    • Contribution of elevated free fatty acid levels to the lack of glucose effectiveness in type 2 diabetes
    • Hawkins M, Tonelli J, Kishore P, Stein D, Ragucci E, Gitig A, Reddy K. Contribution of elevated free fatty acid levels to the lack of glucose effectiveness in type 2 diabetes. Diabetes 2003;52:2748-2758.
    • (2003) Diabetes , vol.52 , pp. 2748-2758
    • Hawkins, M.1    Tonelli, J.2    Kishore, P.3    Stein, D.4    Ragucci, E.5    Gitig, A.6    Reddy, K.7
  • 85
    • 0029785315 scopus 로고    scopus 로고
    • Glucosamine-induced inhibition of liver glucokinase impairs the ability of hyperglycemia to suppress endogenous glucose production
    • Barzilai N, Hawkins M, Angelov I, Hu M, Rossetti L. Glucosamine-induced inhibition of liver glucokinase impairs the ability of hyperglycemia to suppress endogenous glucose production. Diabetes 1996;45:1329-1335.
    • (1996) Diabetes , vol.45 , pp. 1329-1335
    • Barzilai, N.1    Hawkins, M.2    Angelov, I.3    Hu, M.4    Rossetti, L.5
  • 86
    • 0029939780 scopus 로고    scopus 로고
    • Glucose regulates in vivo glucose-6-phosphatase gene expression in the liver of diabetic rats
    • Massillon D, Barzilai N, Chen W, Hu M, Rossetti L. Glucose regulates in vivo glucose-6-phosphatase gene expression in the liver of diabetic rats. J Biol Chem 1996;271:9871-9874.
    • (1996) J Biol Chem , vol.271 , pp. 9871-9874
    • Massillon, D.1    Barzilai, N.2    Chen, W.3    Hu, M.4    Rossetti, L.5
  • 88
    • 0033215244 scopus 로고    scopus 로고
    • In L6 skeletal muscle cells, glucose induces cytosolic translocation of protein kinase C-alpha and trans-activates the insulin receptor kinase
    • Caruso M, Miele C, Oriente F, Maitan A, Bifulco G, Andreozzi F, Condorelli G, Formisano P, Beguinot F. In L6 skeletal muscle cells, glucose induces cytosolic translocation of protein kinase C-alpha and trans-activates the insulin receptor kinase. J Biol Chem 1999;274:28637-28644.
    • (1999) J Biol Chem , vol.274 , pp. 28637-28644
    • Caruso, M.1    Miele, C.2    Oriente, F.3    Maitan, A.4    Bifulco, G.5    Andreozzi, F.6    Condorelli, G.7    Formisano, P.8    Beguinot, F.9


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