Effects of a change in the pattern of insulin delivery on carbohydrate tolerance in diabetic and nondiabetic humans in the presence of differing degrees of insulin resistance

Journal of Clinical Investigation

Volumn 97, Issue 10, 1996, Pages 2351-2361

  Basu, Ananda ^a   Alzaid, Aus ^b   Dinneen, Sean ^a   Caumo, Andrea ^c   Cobelli, Claudio ^d   Rizza, Robert A ^a  

^a MAYO CLINIC   (United States)

^b Riyadh Armed Forces Hospital ^*  (Saudi Arabia)

^c SAN RAFFAELE HOSPITAL   (Italy)

^d UNIVERSITY OF PADOVA   (Italy)

Author keywords

endogenous glucose release; glucose utilization; non insulin dependent diabetes mellitus; obesity; postprandial

Indexed keywords

C PEPTIDE; GLUCAGON; GLUCOSE; GROWTH HORMONE; INSULIN;

ADULT; ARTICLE; BODY MASS; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; GLUCOSE BLOOD LEVEL; GLUCOSE TOLERANCE; GLUCOSE UTILIZATION; HUMAN; HYPERGLYCEMIA; INSULIN RELEASE; INSULIN RESISTANCE; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; OBESITY; POSTPRANDIAL STATE; PRIORITY JOURNAL;

EID: 0029935830     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI118678     Document Type: Article

References (47)

1. Bantle, J.P., D.C. Laine, G.W. Castle, J.W. Thomas, B.J. Hoogwerf, and F.C. Goetz. 1983. Postprandial glucose and insulin responses to meals containing different carbohydrates in normal and diabetic subjects. N. Engl. J. Med. 309:7-12.
2. Reaven, G.M., C.B. Hollenbeck, and Y.-D.I. Chen. 1993. Relationship between glucose tolerance, insulin secretion, and insulin action in non-obese individuals with varying degrees of glucose tolerance. Diabetologia. 32:52-55.
3. Osei, K., J.M. Falko, T.M. O'Dorisio, P.G. Fields, and B. Bossetti. 1986. Gastric inhibitory polypeptide responses and glucose turnover rates after natural meals in type II diabetic patients. J. Clin. Endocrinol. & Metab. 62:325-330.
4. Firth, R.G., P.M. Bell, H.M. Marsh, I. Hansen, and R.A. Rizza. 1986. Postprandial hyperglycemia in patients with noninsulin-dependent diabetes mellitus: role of hepatic and extrahepatic tissues. J. Clin. Invest. 77:1525-1532.
5. Ferrannini, E., D.C. Simonson, L.D. Katz, G. Reichard, Jr., S. Bevilacqua, E.J. Barrett, M. Olsson, and R.A. DeFronzo. 1988. The disposal of an oral glucose load in patients with non-insulin-dependent diabetes. Metabolism. 37: 79-85.
6. McMahon, M., H.M. Marsh, and R.A. Rizza. 1989. Effects of basal insulin supplementation on disposition of mixed meal in obese patients with NIDDM. Diabetes. 38:291-303.
7. Mitrakou, A., D. Kelley, T. Veneman, T. Jenssen, T. Pangburn, J. Reilly, and J. Gerich. 1990. Contribution of abnormal muscle and liver glucose metabolism to postprandial hyperglycemia in NIDDM. Diabetes. 39:1381-1390.
8. Butler, R.C., and R.A. Rizza. 1991. Contribution to postprandial hyperglycemia and effect on initial splanchnic glucose clearance of hepatic glucose cycling in glucose-intolerant or NIDDM patients. Diabetes. 40:73-81.
9. Kelley, D., M. Mokan, and T. Veneman. 1994. Impaired postprandial glucose utilization in non-insulin-dependent diabetes mellitus. Metabolism. 43: 1549-1557.
10. Shen, S.W., G.M. Reaven, and J.W. Farquhar. 1970. Comparison of impedance to insulin-mediated glucose uptake in normal subjects and in subjects with latent diabetes. J. Clin. Invest. 49:2151-2160.
11. Harano, Y., S. Ohgaku, H. Hidaka, K. Haneda, R. Kikkawa, Y. Shigeta, and H. Abe. 1977. Glucose, insulin and somatostatin infusion for the determination of insulin sensitivity. J. Clin. Endocrinol. & Metab. 45:1124-1127.
12. DeFronzo, R., D. Deibert, R. Hendler, P. Felig, and V. Soman. 1979. Insulin sensitivity and insulin binding to monocytes in maturity-onset diabetes. J. Clin. Invest. 63:939-946.
13. Kolterman, O.G., R.S. Gray, J. Griffin, P. Burstein, J. Insel, J.A. Scarlett, and J.M. Olefsky. 1981. Receptor and postreceptor defects contribute to the insulin resistance in noninsulin-dependent diabetes mellitus. J. Clin. Invest. 68:957-969.
14. Rizza, R.A., L.J. Mandarino, and J.E. Gerich. 1981. Mechanism and significance of insulin resistance in non-insulin-dependent diabetes mellitus. Diabetes. 30:990-995.
15. Cherrington, A.D., P.E. Williams, and M.S. Harris. 1978. Relationship between the plasma glucose level and glucose uptake in the conscious dog. Metabolism. 27:787-791.
16. Sacca, L., R. Hendler, and R.S. Sherwin. 1978. Hyperglycemia inhibits glucose production in man independent of changes in glucoregulatory hormones. J. Clin. Endocrinol. & Metab. 47:1160-1161.
17. Best, J.D., G.J. Taborsky, Jr., J.B. Halter, and D. Porte, Jr. 1981. Glucose disposal is not proportional to plasma glucose level in man. Diabetes. 30: 847-850.
18. Hansen, I.L., P.E. Cryer, and R.A. Rizza. 1985. Comparison of insulin-mediated and glucose-mediated glucose disposal in patients with insulin-dependent diabetes mellitus and in nondiabetic subjects. Diabetes. 34:751-755.
19. Capaldo, B., D. Santoro, G. Riccardi, N. Perrotti, and L. Saccà. 1986. Direct evidence for a stimulatory effect of hyperglycemia per se on peripheral glucose disposal in type II diabetes. J. Clin. Invest. 77:1285-1290.
20. Alzaid, A.A., S.F. Dinneen, D.J. Turk, A. Caumo, C. Cobelli, and R.A. Rizza. 1994. Assessment of insulin action and glucose effectiveness in diabetic and nondiabetic humans. J. Clin. Invest. 94:2341-2348.
21. Nolan, J.J., B. Ludvik, P. Beerdsen, M. Joyce, and J. Olefsky. 1994. Improvement in glucose tolerance and insulin resistance in obese subjects treated with troglitazone. N. Engl. J. Med. 331:1188-1193.
22. Gutniak, M., C. Orskov, J.J. Holst, B. Ahren, and S. Efendic. 1992. Antidiabetogenic effect of glucagon-like peptide-1 (7-36)amide in normal subjects and patients with diabetes mellitus. N. Engl. J. Med. 326:1316-1322.
23. Howey, D.C., R.R. Bowsher, R.L. Brunelle, and J.R. Woodworth. 1994. [Lys(B28), Pro(B29)]-human insulin. A rapidly absorbed analogue of human insulin. Diabetes. 43:396-402.
24. Shuster, L.T., V.L.W. Go, R.A. Rizza, P.C. O'Brien, and F.J. Service. 1988. Incretin effect due to increased secretion and decreased clearance of insulin in normal humans. Diabetes. 37:200-203.
25. White, N.H., D. Skor, and J.V. Santiago. 1982. Practical closed-loop insulin delivery. A system for the maintenance of overnight euglycemia and the calculation of basal insulin requirements in insulin-dependent diabetics. Ann. Intern. Med. 97:210-213.
26. Katz, H., M. Homan, M. Jensen, A. Caumo, C. Cobelli, and R. Rizza. 1994. Assessment of insulin action in NIDDM in the presence of dynamic changes in insulin and glucose concentration. Diabetes. 43:289-296.
27. Bradley, D.C., G.M. Steil, and R.N. Bergman. 1993. Quantitation of measurement error with optimal segments: basis for adaptive time course smoothing. Am. J. Physiol. 264:E902-911.
28. Steele, R., J.S. Wall, R.C. De Bodo, N. Altszuler, S.P. Kiang, and C. Bjerknes. 1956. Measurement of size and turnover rate of body glucose pool by the isotope dilution method. Am. J. Physiol. 187:15-24.
29. Tiku, M.L. 1982. Robust statistics for testing equality of means or variances. Communications in Statistics-Theory and Methods. 11:2543-2558.
30. Kraegen, E.W., D.J. Chisholm, and M.E. McNamara. 1981. Timing of insulin delivery with meals. Horm. Metab. Res. 13:365-367.
31. Bratusch-Marrain, P.R., and W.K. Waldhäusl. 1985. Impact of the "early peak" of insulin secretion on glucose utilization in man. Horm. Metabol. Res. 17:163-164.
32. Bruce, D.G., D.J. Chisholm, L.H. Storlien, and E.W. Kraegen. 1988. Physiological importance of deficiency in early prandial insulin secretion in non-insulin-dependent diabetes. Diabetes. 37:736-744.
33. Luzi, L., and R.A. DeFronzo. 1989. Effect of loss of first-phase insulin secretion on hepatic glucose production and tissue glucose disposal in humans. Am. J. Physiol. 257:E241-E246.
34. Calles-Escandon, J., and D.C. Robbins. 1987. Loss of early phase of insulin release in humans impairs glucose tolerance and blunts thermic effect of glucose. Diabetes. 36:1167-1172.
35. National Diabetes Data Group. 1979. Classification and diagnosis of diabetes mellitus and other categories of glucose intolerance. Diabetes. 28:1039-1057.
36. Katz, H., M. Homan, J. Velosa, P. Robertson, and R. Rizza. 1991. Effects of pancreas transplantation on postprandial glucose metabolism. N. Engl. J. Med. 325:1278-1283.
37. Giacca, A., S.J. Fisher, Z.Q. Shi, R. Gupta, H.L.A. Lickley, and M. Vranic. 1992. Importance of peripheral insulin levels for insulin-induced suppression of glucose production in depancreatized dogs. J. Clin. Invest. 90:1769-1777.
38. Bradley, D.C., R.A. Poulin, and R.N. Bergman. 1993. Dynamics of hepatic and peripheral insulin effects suggest common rate-limiting step in vivo. Diabetes. 42:296-306.
39. Jaspan, J.B., J. Ruddick, and E. Rayfield. 1984. Transhepatic glucagon gradients in man: evidence for glucagon extraction by human liver. J. Clin. Endocrinol. & Metab. 58:287-292.
40. Blackard, W.G., N.C. Nelson, and S.S. Andrews. 1974. Portal and peripheral vein immunoreactive glucagon concentrations after arginine or glucose infusions. Diabetes. 23:199-202.
41. Jaspan, J.B., A.H. Huen, C.G. Morley, A.R. Moossa, and A.H. Rubenstein. 1977. The role of the liver in glucagon metabolism. J. Clin. Invest. 60:421-428.
42. Jaspan, J.B., K.S. Polonsky, M. Lewis, J. Pensler, W. Pugh, A.R. Moossa, and A.H. Rubenstein. 1981. Hepatic metabolism of glucagon in the dog: contribution of the liver to overall metabolic disposal of glucagon. Am. J. Physiol. 240:E233-E244.
43. Dinneen, S., A. Alzaid, D. Turk, and R. Rizza. 1995. Failure of glucagon suppression contributes to postprandial hyperglycemia in IDDM. Diabetologia. 38:337-343.
44. Johansson, C., O. Wisen, S. Efendic, and K. Uvnuäs-Wallensten. 1981. Effects of somatostatin on gastrointestinal propagation and absorption of oral glucose in man. Digestion. 22:126-137.
45. 14C labeled substrates. Am. J. Physiol. 17:391-399.
46. Brosnan, J.T. 1982. Pathways of carbon flux in gluconeogenesis. Fed. Proc. 41:91-94.
47. Doeden, B., and R. Rizza. 1987. Use of variable insulin infusion to assess insulin action in obesity: defects in both the kinetics and amplitude of response. J. Clin. Endocrinol. & Metab. 64:902-908.