메뉴 건너뛰기




Volumn 47, Issue 11, 1998, Pages 1735-1747

Normal glucose-induced suppression of glucose production but impaired stimulation of glucose disposal in type 2 diabetes: Evidence for a concentration-dependent defect in uptake

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; INSULIN;

EID: 0031719659     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.47.11.1735     Document Type: Article
Times cited : (72)

References (70)
  • 1
    • 0022467301 scopus 로고
    • Postprandial hyperglycemia in patients with non-insulin-dependent diabetes mellitus
    • Firth RG, Bell PM, Marsh HM, Hansen I, Rizza RA: Postprandial hyperglycemia in patients with non-insulin-dependent diabetes mellitus. J Clin Invest 77:1525-1532, 1986
    • (1986) J Clin Invest , vol.77 , pp. 1525-1532
    • Firth, R.G.1    Bell, P.M.2    Marsh, H.M.3    Hansen, I.4    Rizza, R.A.5
  • 2
    • 0025066579 scopus 로고
    • Contribution of abnormal muscle and liver glucose metabolism to postprandial hyperglycemia in NIDDM
    • Mitrakou A, Kelley D, Veneman T, Jenssen T, Pangburn T, Reilly J, Gerich J: Contribution of abnormal muscle and liver glucose metabolism to postprandial hyperglycemia in NIDDM. Diabetes 39:1381-1390, 1990
    • (1990) Diabetes , vol.39 , pp. 1381-1390
    • Mitrakou, A.1    Kelley, D.2    Veneman, T.3    Jenssen, T.4    Pangburn, T.5    Reilly, J.6    Gerich, J.7
  • 4
    • 0020684724 scopus 로고
    • Regulation of splanchnic and peripheral glucose uptake by insulin and hyperglycemia in man
    • DeFronzo RA, Ferrannini E, Hendler R, Felig P, Wahren J: Regulation of splanchnic and peripheral glucose uptake by insulin and hyperglycemia in man. Diabetes 32:35-45, 1983
    • (1983) Diabetes , vol.32 , pp. 35-45
    • DeFronzo, R.A.1    Ferrannini, E.2    Hendler, R.3    Felig, P.4    Wahren, J.5
  • 5
    • 0030901308 scopus 로고    scopus 로고
    • Glucose effectiveness assessed under dynamic and steady-state conditions
    • Ader M, Ni T, Bergman RN: Glucose effectiveness assessed under dynamic and steady-state conditions. J Clin Invest 99:1187-1199, 1997
    • (1997) J Clin Invest , vol.99 , pp. 1187-1199
    • Ader, M.1    Ni, T.2    Bergman, R.N.3
  • 6
    • 0023278013 scopus 로고
    • Kinetics of glucose disposal in whole body and across the forearm in man
    • Yki-Jarvinen H, Young AA, Lamkin C, Foley JE: Kinetics of glucose disposal in whole body and across the forearm in man. J Clin Invest 79:1713-1719, 1987
    • (1987) J Clin Invest , vol.79 , pp. 1713-1719
    • Yki-Jarvinen, H.1    Young, A.A.2    Lamkin, C.3    Foley, J.E.4
  • 7
    • 0027199061 scopus 로고
    • Mechanism by which hyperglycemia inhibits hepatic glucose production in conscious rats
    • Rossetti L, Giaccari A, Barzilai N, Howard K, Sebel G, Hu M: Mechanism by which hyperglycemia inhibits hepatic glucose production in conscious rats. J Clin Invest 92:1126-1134, 1993
    • (1993) J Clin Invest , vol.92 , pp. 1126-1134
    • Rossetti, L.1    Giaccari, A.2    Barzilai, N.3    Howard, K.4    Sebel, G.5    Hu, M.6
  • 8
    • 17744405359 scopus 로고
    • Dose-response characteristics for effects of insulin on production and utilization of glucose in man
    • Rizza RA, Mandarino LJ, Gerich JE: Dose-response characteristics for effects of insulin on production and utilization of glucose in man. Am J Physiol 240:E630-E639, 1981
    • (1981) Am J Physiol , vol.240
    • Rizza, R.A.1    Mandarino, L.J.2    Gerich, J.E.3
  • 9
  • 10
    • 0023595214 scopus 로고
    • Insulin action in non-insulin-dependent diabetes mellitus: The relationship between hepatic and extrahepatic insulin resistance and obesity
    • Firth R, Bell P, Rizza R: Insulin action in non-insulin-dependent diabetes mellitus: the relationship between hepatic and extrahepatic insulin resistance and obesity. Metabolism 36:1091-1095, 1987
    • (1987) Metabolism , vol.36 , pp. 1091-1095
    • Firth, R.1    Bell, P.2    Rizza, R.3
  • 11
    • 0021691098 scopus 로고
    • Relationships between insulin secretion, insulin action, and fasting plasma glucose concentration in nondiabetic and non-insulin-dependent diabetic subjects
    • Bogardus C, Lillioja S, Howard BV, Reaven G, Mott D: Relationships between insulin secretion, insulin action, and fasting plasma glucose concentration in nondiabetic and non-insulin-dependent diabetic subjects. J Clin Invest 74:1238-1246, 1984
    • (1984) J Clin Invest , vol.74 , pp. 1238-1246
    • Bogardus, C.1    Lillioja, S.2    Howard, B.V.3    Reaven, G.4    Mott, D.5
  • 12
    • 0022577797 scopus 로고
    • Effects of tolazamide and exogenous insulin on insulin action in patients with non-insulin-dependent diabetes mellitus
    • Firth RG, Bell PM, Rizza RA: Effects of tolazamide and exogenous insulin on insulin action in patients with non-insulin-dependent diabetes mellitus. N Engl J Med 314:1280-1286, 1986
    • (1986) N Engl J Med , vol.314 , pp. 1280-1286
    • Firth, R.G.1    Bell, P.M.2    Rizza, R.A.3
  • 15
    • 0027234332 scopus 로고
    • Effect of a sulfonylurea (gliclazide) treatment on insulin sensitivity and glucose-mediated glucose disposal in patients with non-insulin-dependent diabetes mellitus (NIDDM)
    • Wajchenberg BL, Santomauro ATMG, Porrelli RN: Effect of a sulfonylurea (gliclazide) treatment on insulin sensitivity and glucose-mediated glucose disposal in patients with non-insulin-dependent diabetes mellitus (NIDDM). Diabetes Res Clin Pract 20:147-154, 1993
    • (1993) Diabetes Res Clin Pract , vol.20 , pp. 147-154
    • Wajchenberg, B.L.1    Santomauro, A.T.M.G.2    Porrelli, R.N.3
  • 16
    • 0025605915 scopus 로고
    • Minimal model analysis of intravenous glucose tolerance test-derived insulin sensitivity in diabetic subjects
    • Welch S, Gebhart SSP, Bergman RN, Phillips LS: Minimal model analysis of intravenous glucose tolerance test-derived insulin sensitivity in diabetic subjects. J Clin Endocrinol Metab 71:1508-1518, 1990
    • (1990) J Clin Endocrinol Metab , vol.71 , pp. 1508-1518
    • Welch, S.1    Gebhart, S.S.P.2    Bergman, R.N.3    Phillips, L.S.4
  • 17
    • 0027829685 scopus 로고
    • Estimates of insulin action in normal, obese, and NIDDM man: Comparison of insulin and glucose infusion test, CIGMA, minimal model, and glucose clamp techniques
    • Davis SN, Monti L, Piatti PM, Moller N, Ng L, Coppack S, Brown MD, Orskov H, Alberti KG: Estimates of insulin action in normal, obese, and NIDDM man: comparison of insulin and glucose infusion test, CIGMA, minimal model, and glucose clamp techniques. Diabetes Res 23:1-18, 1993
    • (1993) Diabetes Res , vol.23 , pp. 1-18
    • Davis, S.N.1    Monti, L.2    Piatti, P.M.3    Moller, N.4    Ng, L.5    Coppack, S.6    Brown, M.D.7    Orskov, H.8    Alberti, K.G.9
  • 18
    • 0027470782 scopus 로고
    • Insulin sensitivity, insulin secretion, and glucose effectiveness in diabetic and nondiabetic cirrhotic patients
    • Kruszynska YT, Harry DS, Bergman RN, McIntyre N: Insulin sensitivity, insulin secretion, and glucose effectiveness in diabetic and nondiabetic cirrhotic patients. Diabetologia 36:121-128, 1993
    • (1993) Diabetologia , vol.36 , pp. 121-128
    • Kruszynska, Y.T.1    Harry, D.S.2    Bergman, R.N.3    McIntyre, N.4
  • 19
    • 0028304581 scopus 로고
    • Non-insulin-mediated glucose disappearance in subjects with IDDM
    • Quon MJ, Cochran C, Taylor SI, Eastman RC: Non-insulin-mediated glucose disappearance in subjects with IDDM. Diabetes 43:890-896, 1994
    • (1994) Diabetes , vol.43 , pp. 890-896
    • Quon, M.J.1    Cochran, C.2    Taylor, S.I.3    Eastman, R.C.4
  • 21
    • 0029823503 scopus 로고    scopus 로고
    • Reduced glucose effectiveness associated with reduced insulin release: An artifact of the minimal-model method
    • Finegood DT, Tzur D: Reduced glucose effectiveness associated with reduced insulin release: an artifact of the minimal-model method. Am J Physiol 271:E485-E495, 1996
    • (1996) Am J Physiol , vol.271
    • Finegood, D.T.1    Tzur, D.2
  • 22
    • 0027999957 scopus 로고
    • Assessment of insulin action and glucose effectiveness in diabetic and nondiabetic humans
    • Alzaid AA, Dinneen SF, Turk DJ, Caumo A, Cobelli C, Rizza RA: Assessment of insulin action and glucose effectiveness in diabetic and nondiabetic humans. J Clin Invest 94:2341-2348, 1994
    • (1994) J Clin Invest , vol.94 , pp. 2341-2348
    • Alzaid, A.A.1    Dinneen, S.F.2    Turk, D.J.3    Caumo, A.4    Cobelli, C.5    Rizza, R.A.6
  • 23
    • 0031054198 scopus 로고    scopus 로고
    • Unpaired basal glucose effectiveness in NIDDM: Contribution of defects in glucose disappearance and production, measured using an optimized minimal model independent protocol
    • Basu A, Caumo A, Bettini F, Gelisio A, Alzaid A, Cobelli C: unpaired basal glucose effectiveness in NIDDM: contribution of defects in glucose disappearance and production, measured using an optimized minimal model independent protocol. Diabetes 46:421-432, 1997
    • (1997) Diabetes , vol.46 , pp. 421-432
    • Basu, A.1    Caumo, A.2    Bettini, F.3    Gelisio, A.4    Alzaid, A.5    Cobelli, C.6
  • 25
    • 0029912588 scopus 로고    scopus 로고
    • The hot but not the cold minimal model allows precise assessment of insulin sensitivity in NIDDM subjects
    • Avogaro A, Vicini P, Valerio A, Caumo A, Cobelli C: The hot but not the cold minimal model allows precise assessment of insulin sensitivity in NIDDM subjects. Am J Physiol 270:E532-E540, 1996
    • (1996) Am J Physiol , vol.270
    • Avogaro, A.1    Vicini, P.2    Valerio, A.3    Caumo, A.4    Cobelli, C.5
  • 26
    • 0019950002 scopus 로고
    • Practical closed-loop insulin delivery: A system for the maintenance of overnight euglycemia and the calculation of basal insulin requirements in insulin-dependent diabetics
    • White NH, Skor D, Santiago JV: Practical closed-loop insulin delivery: a system for the maintenance of overnight euglycemia and the calculation of basal insulin requirements in insulin-dependent diabetics. Ann Intern Med 97:210-213, 1982
    • (1982) Ann Intern Med , vol.97 , pp. 210-213
    • White, N.H.1    Skor, D.2    Santiago, J.V.3
  • 27
    • 0024265025 scopus 로고
    • Modeling error and apparent isotope discrimination confound estimation of endogenous glucose production during euglycemic glucose clamps
    • Finegood DT, Bergman RN, Vranic M: Modeling error and apparent isotope discrimination confound estimation of endogenous glucose production during euglycemic glucose clamps. Diabetes 37:1025-1034, 1988
    • (1988) Diabetes , vol.37 , pp. 1025-1034
    • Finegood, D.T.1    Bergman, R.N.2    Vranic, M.3
  • 28
    • 0024539271 scopus 로고
    • Effects of basal insulin supplementation on disposition of mixed meal in obese patients with NIDDM
    • McMahon M, Marsh HM, Rizza RA: Effects of basal insulin supplementation on disposition of mixed meal in obese patients with NIDDM. Diabetes 38:291-303, 1989
    • (1989) Diabetes , vol.38 , pp. 291-303
    • McMahon, M.1    Marsh, H.M.2    Rizza, R.A.3
  • 30
    • 0028794829 scopus 로고
    • Measurement of abdominal and visceral fat with computed tomography and dual-energy X-ray absorptiometry
    • Jensen MD, Kanaley JA, Reed JE, Sheedy PF: Measurement of abdominal and visceral fat with computed tomography and dual-energy X-ray absorptiometry. Am J Clin Nutr 61:274-278, 1995
    • (1995) Am J Clin Nutr , vol.61 , pp. 274-278
    • Jensen, M.D.1    Kanaley, J.A.2    Reed, J.E.3    Sheedy, P.F.4
  • 31
    • 0027223164 scopus 로고
    • Quantitation of measurement error with optimal segments: Basis for adaptive time course smoothing
    • Bradley DC, Steil GM, Bergman RN: Quantitation of measurement error with optimal segments: basis for adaptive time course smoothing. Am J Physiol 264:E902-E911, 1993
    • (1993) Am J Physiol , vol.264
    • Bradley, D.C.1    Steil, G.M.2    Bergman, R.N.3
  • 32
  • 33
    • 0028816227 scopus 로고
    • Glucose turnover in presence of changing glucose concentrations: Error analysis for glucose disappearance
    • Caumo A, Homan M, Katz H, Cobelli C, Rizza R: Glucose turnover in presence of changing glucose concentrations: error analysis for glucose disappearance. Am J Physiol 269:E557-E567, 1995
    • (1995) Am J Physiol , vol.269
    • Caumo, A.1    Homan, M.2    Katz, H.3    Cobelli, C.4    Rizza, R.5
  • 34
    • 0027417084 scopus 로고
    • Methods for assessment of the rate of onset and offset of insulin action during nonsteady state in humans
    • Butler PC, Caumo A, Zerman A, O'Brien PC, Cobelli C, Rizza RA: Methods for assessment of the rate of onset and offset of insulin action during nonsteady state in humans. Am J Physiol 264:E548-E569, 1993
    • (1993) Am J Physiol , vol.264
    • Butler, P.C.1    Caumo, A.2    Zerman, A.3    O'Brien, P.C.4    Cobelli, C.5    Rizza, R.A.6
  • 35
    • 0016873527 scopus 로고
    • Futile cycles in the metabolism of glucose
    • Katz J, Rognstad R: Futile cycles in the metabolism of glucose. Curr Top Cell Regul 10:237-289, 1976
    • (1976) Curr Top Cell Regul , vol.10 , pp. 237-289
    • Katz, J.1    Rognstad, R.2
  • 36
    • 0006736211 scopus 로고
    • Increased activity of the glucose cycle in the liver: Early characteristic of type 2 diabetes
    • Efendic S, Wajngot A, Vranic M: Increased activity of the glucose cycle in the liver: early characteristic of type 2 diabetes. Proc Natl Acad Sci U S A 82:2965-2969, 1985
    • (1985) Proc Natl Acad Sci U S A , vol.82 , pp. 2965-2969
    • Efendic, S.1    Wajngot, A.2    Vranic, M.3
  • 37
    • 0025966024 scopus 로고
    • Contribution to postprandial hyperglycemia and effect on initial splanchnic glucose clearance of hepatic glucose cycling in glucose-intolerant or NIDDM patients
    • Butler RC, Rizza RA: Contribution to postprandial hyperglycemia and effect on initial splanchnic glucose clearance of hepatic glucose cycling in glucose-intolerant or NIDDM patients. Diabetes 40:73-81, 1991
    • (1991) Diabetes , vol.40 , pp. 73-81
    • Butler, R.C.1    Rizza, R.A.2
  • 38
    • 0018084372 scopus 로고
    • Hyperglycemia inhibits glucose production in man independent of changes in glucoregulatory hormones
    • Sacca L, Hendler R, Sherwin RS: Hyperglycemia inhibits glucose production in man independent of changes in glucoregulatory hormones. J Clin Endocrinol Metab 47:1160-1161, 1978
    • (1978) J Clin Endocrinol Metab , vol.47 , pp. 1160-1161
    • Sacca, L.1    Hendler, R.2    Sherwin, R.S.3
  • 40
    • 0019434155 scopus 로고
    • Autoregulation by glucose of hepatic balance: Permissive effect of insulin
    • Davidson MB: Autoregulation by glucose of hepatic balance: permissive effect of insulin. Metabolism 30:279-284, 1981
    • (1981) Metabolism , vol.30 , pp. 279-284
    • Davidson, M.B.1
  • 41
    • 0026602267 scopus 로고
    • Role of reduced suppression of glucose production and diminished early insulin release in impaired glucose tolerance
    • Mitrakou A, Kelley D, Mokan M, Veneman T, Pangburn T, Reilly J, Gerich J: Role of reduced suppression of glucose production and diminished early insulin release in impaired glucose tolerance. N Engl J Med 326:22-29, 1992
    • (1992) N Engl J Med , vol.326 , pp. 22-29
    • Mitrakou, A.1    Kelley, D.2    Mokan, M.3    Veneman, T.4    Pangburn, T.5    Reilly, J.6    Gerich, J.7
  • 46
    • 0029939780 scopus 로고    scopus 로고
    • Glucose regulates in vivo glucose-6-phosphatase gene expression in the liver of diabetic rats
    • Massillon D, Barzilai N, Chen W, Hu M, Rossetti L: Glucose regulates in vivo glucose-6-phosphatase gene expression in the liver of diabetic rats. J Biol Chem 271:9871-9874, 1996
    • (1996) J Biol Chem , vol.271 , pp. 9871-9874
    • Massillon, D.1    Barzilai, N.2    Chen, W.3    Hu, M.4    Rossetti, L.5
  • 47
    • 0024511329 scopus 로고
    • Predominant role of gluconeogenesis in increased hepatic glucose production in NIDDM
    • Consoli A, Nurjhan N, Capani F, Gerich J: Predominant role of gluconeogenesis in increased hepatic glucose production in NIDDM. Diabetes 38:550-557, 1989
    • (1989) Diabetes , vol.38 , pp. 550-557
    • Consoli, A.1    Nurjhan, N.2    Capani, F.3    Gerich, J.4
  • 48
    • 0344435498 scopus 로고
    • Insulin inhibition of overnight glucose production and gluconeogenesis from lactate in NIDDM
    • Yki-Järvinen H, Helve E, Sane T, Nurjhan N, Taskinen M: Insulin inhibition of overnight glucose production and gluconeogenesis from lactate in NIDDM. Am J Physiol 256:E732-E739, 1989
    • (1989) Am J Physiol , vol.256
    • Yki-Järvinen, H.1    Helve, E.2    Sane, T.3    Nurjhan, N.4    Taskinen, M.5
  • 49
    • 0020078617 scopus 로고
    • Pathways of carbon flux in gluconeogeneis
    • Brosnan JT: Pathways of carbon flux in gluconeogeneis. Fed Proc 41:91-94, 1982
    • (1982) Fed Proc , vol.41 , pp. 91-94
    • Brosnan, J.T.1
  • 50
    • 0021873259 scopus 로고
    • 14C-labeled substrates
    • 14C-labeled substrates. Am J Physiol 17:391-399, 1985
    • (1985) Am J Physiol , vol.17 , pp. 391-399
    • Katz, J.1
  • 52
    • 0028847791 scopus 로고
    • The effects of non-insulin-dependent diabetes mellitus on the kinetics of onset of insulin action in hepatic and extrahepatic tissues
    • Turk D, Alzaid A, Dinneen S, Nair KS, Rizza R: The effects of non-insulin-dependent diabetes mellitus on the kinetics of onset of insulin action in hepatic and extrahepatic tissues. J Clin Invest 95:755-762, 1995
    • (1995) J Clin Invest , vol.95 , pp. 755-762
    • Turk, D.1    Alzaid, A.2    Dinneen, S.3    Nair, K.S.4    Rizza, R.5
  • 53
    • 0029980383 scopus 로고    scopus 로고
    • Interaction of carbohydrate and fat fuels in human skeletal muscle: Impact of obesity and NIDDM
    • Mandarino LJ, Consoli A, Jain A, Kelley DE: Interaction of carbohydrate and fat fuels in human skeletal muscle: impact of obesity and NIDDM. Am J Physiol 270:E463-E470, 1996
    • (1996) Am J Physiol , vol.270
    • Mandarino, L.J.1    Consoli, A.2    Jain, A.3    Kelley, D.E.4
  • 54
    • 0022387842 scopus 로고
    • Rates of non-insulin-mediated glucose uptake are elevated in type II diabetic subjects
    • Baron AD, Kolterman OG, Bell J, Mandarino LJ, Olefsky JM: Rates of non-insulin-mediated glucose uptake are elevated in type II diabetic subjects. J Clin Invest 76:1782-1788, 1985
    • (1985) J Clin Invest , vol.76 , pp. 1782-1788
    • Baron, A.D.1    Kolterman, O.G.2    Bell, J.3    Mandarino, L.J.4    Olefsky, J.M.5
  • 55
    • 0022551871 scopus 로고
    • Direct evidence for a stimulatory effect of hyperglycemia per se on peripheral glucose disposal in type II diabetes
    • Capaldo B, Santoro D, Riccardi G, Perrotti N, Sacca L: Direct evidence for a stimulatory effect of hyperglycemia per se on peripheral glucose disposal in type II diabetes. J Clin Invest 77:1285-1290, 1986
    • (1986) J Clin Invest , vol.77 , pp. 1285-1290
    • Capaldo, B.1    Santoro, D.2    Riccardi, G.3    Perrotti, N.4    Sacca, L.5
  • 57
    • 0026611962 scopus 로고
    • 31P nuclear magnetic resonance measurements of muscle glucose-6-phosphate
    • 31P nuclear magnetic resonance measurements of muscle glucose-6-phosphate. J Clin Invest 89:1069-1075, 1992
    • (1992) J Clin Invest , vol.89 , pp. 1069-1075
    • Rothman, D.L.1    Shulman, R.G.2    Shulman, G.I.3
  • 58
    • 0027523284 scopus 로고
    • Hepatic and extrahepatic insulin action in humans: Measurement in the absence of non-steady-state error
    • Katz H, Butler P, Homan M, Zerman A, Caumo A, Cobelli C, Rizza R: Hepatic and extrahepatic insulin action in humans: measurement in the absence of non-steady-state error. Am J Physiol 264:E561-E566, 1993
    • (1993) Am J Physiol , vol.264
    • Katz, H.1    Butler, P.2    Homan, M.3    Zerman, A.4    Caumo, A.5    Cobelli, C.6    Rizza, R.7
  • 59
    • 0024592718 scopus 로고
    • Differential effects of insulin and hyperglycemia on intracellular glucose disposition in humans
    • Ferrannini E, Locatelli L, Jequier E, Felber JP: Differential effects of insulin and hyperglycemia on intracellular glucose disposition in humans. Metabolism 38:459-465, 1989
    • (1989) Metabolism , vol.38 , pp. 459-465
    • Ferrannini, E.1    Locatelli, L.2    Jequier, E.3    Felber, J.P.4
  • 60
    • 0029839993 scopus 로고    scopus 로고
    • In vivo NMR evidence for moderate glucose accumulation in human skeletal muscle during hyperglycemia
    • Ronan R, Velho G, Carlier PG, Jouvensal L, Bloch G: In vivo NMR evidence for moderate glucose accumulation in human skeletal muscle during hyperglycemia. Am J Physiol 271:E434-E438, 1996
    • (1996) Am J Physiol , vol.271
    • Ronan, R.1    Velho, G.2    Carlier, P.G.3    Jouvensal, L.4    Bloch, G.5
  • 62
    • 0025190082 scopus 로고
    • Metabolic effects of hyperglycemia and hyperinsulinemia on fat of intracellular glucose in NIDDM
    • Henry RR, Gumbiner B, Flynn T, Thorburn AW: Metabolic effects of hyperglycemia and hyperinsulinemia on fat of intracellular glucose in NIDDM. Diabetes 39:149-156, 1990
    • (1990) Diabetes , vol.39 , pp. 149-156
    • Henry, R.R.1    Gumbiner, B.2    Flynn, T.3    Thorburn, A.W.4
  • 63
    • 0026598750 scopus 로고
    • Hyperglycaemia compensates for the defects in insulin-mediated glucose metabolism and in the activation of glycogen synthase in the skeletal muscle of patients with type 2 (non-insulin-dependent) diabetes mellitus
    • Vaag A, Damsbo P, Hother-Nielsen O, Beck-Nielsen H: Hyperglycaemia compensates for the defects in insulin-mediated glucose metabolism and in the activation of glycogen synthase in the skeletal muscle of patients with type 2 (non-insulin-dependent) diabetes mellitus. Diabetologia 35:80-88, 1992
    • (1992) Diabetologia , vol.35 , pp. 80-88
    • Vaag, A.1    Damsbo, P.2    Hother-Nielsen, O.3    Beck-Nielsen, H.4
  • 64
    • 0025695163 scopus 로고
    • Hyperglycemia normalizes insulin-stimulated skeletal muscle glucose oxidation and storage in non-insulin-dependent diabetes mellitus
    • Kelley DE, Mandarino LJ: Hyperglycemia normalizes insulin-stimulated skeletal muscle glucose oxidation and storage in non-insulin-dependent diabetes mellitus. J Clin Invest 86:1999-2007, 1990
    • (1990) J Clin Invest , vol.86 , pp. 1999-2007
    • Kelley, D.E.1    Mandarino, L.J.2
  • 65
    • 0031728154 scopus 로고    scopus 로고
    • Overnight normalization of glucose concentrations improves hepatic but not extrahepatic insulin action in subjects with type 2 diabetes mellitus
    • Wise SD, Nielsen MF, Cryer PE, Rizza RA: Overnight normalization of glucose concentrations improves hepatic but not extrahepatic insulin action in subjects with type 2 diabetes mellitus. J Clin Endocrinol Metab 83:2461-2469, 1998
    • (1998) J Clin Endocrinol Metab , vol.83 , pp. 2461-2469
    • Wise, S.D.1    Nielsen, M.F.2    Cryer, P.E.3    Rizza, R.A.4
  • 66
    • 0025943822 scopus 로고
    • Effects of pancreas transplantation on postprandial glucose metabolism
    • Katz H, Homan M, Velosa J, Robertson P, Rizza R: Effects of pancreas transplantation on postprandial glucose metabolism. N Engl J Med 325:1278-1283, 1991
    • (1991) N Engl J Med , vol.325 , pp. 1278-1283
    • Katz, H.1    Homan, M.2    Velosa, J.3    Robertson, P.4    Rizza, R.5
  • 67
    • 0027526476 scopus 로고
    • Dynamics of hepatic and peripheral insulin effects suggest common rate-limiting step in vivo
    • Bradley DC, Poulin RA, Bergman RN: Dynamics of hepatic and peripheral insulin effects suggest common rate-limiting step in vivo. Diabetes 42:296-306, 1993
    • (1993) Diabetes , vol.42 , pp. 296-306
    • Bradley, D.C.1    Poulin, R.A.2    Bergman, R.N.3
  • 68
    • 0026443620 scopus 로고
    • Importance of peripheral insulin levels for insulin-induced suppression of glucose production in depancreatized dogs
    • Giacca A, Fisher SJ, Shi ZQ, Gupta R, Lickley HLA, Vranic M: Importance of peripheral insulin levels for insulin-induced suppression of glucose production in depancreatized dogs. J Clin Invest 90:1769-1777, 1992
    • (1992) J Clin Invest , vol.90 , pp. 1769-1777
    • Giacca, A.1    Fisher, S.J.2    Shi, Z.Q.3    Gupta, R.4    Lickley, H.L.A.5    Vranic, M.6
  • 69
    • 0028980981 scopus 로고
    • Gluconeogenesis and intrahepatic those phosphate flux in response to fasting or substrate loads
    • Neese RA, Schwarz J, Faix D, Turner S, Letscher A, Vu D, Hellerstein MK: Gluconeogenesis and intrahepatic those phosphate flux in response to fasting or substrate loads. J Biol Chem 270:14452-14463, 1995
    • (1995) J Biol Chem , vol.270 , pp. 14452-14463
    • Neese, R.A.1    Schwarz, J.2    Faix, D.3    Turner, S.4    Letscher, A.5    Vu, D.6    Hellerstein, M.K.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.