Induction of FoxP3+CD4+25+ regulatory T cells following hemopoietic stem cell transplantation: Role of bone marrow-derived facilitating cells

Journal of Immunology

Volumn 179, Issue 4, 2007, Pages 2153-2162

  Taylor, Kendra N ^a   Shinde Patil, Vivek R ^a   Cohick, Evan ^a   Colson, Yolonda L ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD86 ANTIGEN; CPG OLIGODEOXYNUCLEOTIDE; TRANSCRIPTION FACTOR FOXP3; CYTOKINE; FORKHEAD TRANSCRIPTION FACTOR; FOXP3 PROTEIN, MOUSE; OLIGONUCLEOTIDE; UNCLASSIFIED DRUG;

ALLOGENEIC STEM CELL TRANSPLANTATION; ANIMAL CELL; ANTIGEN EXPRESSION; ARTICLE; BONE MARROW CELL; CD4 LYMPHOCYTE COUNT; CELL ACTIVATION; CELL ACTIVITY; CELL INTERACTION; CONTROLLED STUDY; FEMALE; HEMATOPOIETIC STEM CELL TRANSPLANTATION; LYMPHOCYTE DIFFERENTIATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY T LYMPHOCYTE; ALLOTRANSPLANTATION; ANIMAL; BIOSYNTHESIS; CD8+ T LYMPHOCYTE; CELL DIFFERENTIATION; DRUG EFFECT; GENE EXPRESSION REGULATION; GRAFT SURVIVAL; GRAFT VERSUS HOST REACTION; IMMUNOLOGY; METABOLISM; TRANSPLANTATION TOLERANCE;

ANIMALS; ANTIGENS, CD86; BONE MARROW CELLS; CD8-POSITIVE T-LYMPHOCYTES; CELL DIFFERENTIATION; CYTOKINES; FEMALE; FORKHEAD TRANSCRIPTION FACTORS; GENE EXPRESSION REGULATION; GRAFT SURVIVAL; GRAFT VS HOST DISEASE; HEMATOPOIETIC STEM CELL TRANSPLANTATION; MICE; OLIGONUCLEOTIDES; T-LYMPHOCYTES, REGULATORY; TRANSPLANTATION TOLERANCE; TRANSPLANTATION, HOMOLOGOUS;

EID: 34848863355     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.179.4.2153     Document Type: Article

References (53)

1. Slavin, S., A. Nagler, E. Naparstek, Y. Kapelushnik, M. Aker, G. Cividalli, G. Varadi, M. Kirschbaum, A. Ackerstein, S. Samuel, et al. 1998. Nonmyeloablative stem cell transplantation and cell therapy as an alternative to conventional bone marrow transplantation with lethal cytoreduction for the treatment of malignant and nonmalignant hematologic diseases. Blood 91: 756-763.
2. Hentschke, P., L. Barkholt, M. Uzunel, J. Mattsson, P. Wersall, P. Pisa, J. Martola, N. Albiin, A. Wernerson, M. Soderberg, et al. 2003. Low-intensity conditioning and hematopoietic stem cell transplantation in patients with renal and colon carcinoma. Bone Marrow Transplant. 31: 253-261.
3. Kaufman, C., Y. Colson, S. Wren, S. Watkins, R. Simmons, and S. Ildstad. 1994. Phenotypic characterization of a novel bone-marrow derived cell that facilitates engraftment of allogeneic bone marrow stem cells. Blood 84: 2436-2466.
4. Colson, Y. L., K. Christopher, J. Glickman, K. N. Taylor, R. Wright, and D. L. Perkins. 2004. Absence of clinical GVHD and the in vivo induction of regulatory T cells after transplantation of facilitating cells. Blood 104: 3829-3835.
5. Fugier-Vivier, I. J., F. Rezzoug, Y. Huang, A. J. Graul-Layman, C. L. Schanie, H. Xu, P. M. Chilton, and S. T. Ildstad. 2005. Plasmacytoid precursor dendritic cells facilitate allogeneic hematopoietic stem cell engraftment. J. Exp. Med. 201: 373-383.
6. - cells in whole bone marrow facilitate the engraftment of hematopoietic stem cells across allogeneic barriers. Immunity 11: 579-590.
7. Colonna, M., G. Trinchieri, and Y. J. Liu. 2004. Plasmacytoid dendritic cells in immunity. Nat. Immunol. 5: 1219-1226.
8. Sparwasser, T., R. M. Vabulas, B. Villmow, G. B. Lipford, and H. Wagner. 2000. Bacterial CpG-DNA activates dendritic cells in vivo: T helper cell-independent cytotoxic T cell responses to soluble proteins. Eur. J. Immunol. 30: 3591-3597.
9. + dendritic cells. J. Immunol. 166: 5000-5007.
10. Kadowaki, N., S. Ho, S. Antonenko, R. W. Malefyt, R. A. Kastelein, F. Bazan, and Y. J. Liu. 2001. Subsets of human dendritic cell precursors express different toll-like receptors and respond to different microbial antigens. J. Exp. Med. 194: 863-869.
11. Krug, A., S. Rothenfusser, V. Hornung, B. Jahrsdorfer, S. Blackwell, Z. K. Ballas, S. Endres, A. M. Krieg, and G. Hartmann. 2001. Identification of CpG oligonucleotide sequences with high induction of IFN-α/β in plasmacytoid dendritic cells. Eur. J. Immunol. 31: 2154-2163.
12. Krieg, A. M. 2003. CpG motifs: the active ingredient in bacterial extracts? Nat. Med. 9: 831-835.
13. Verthelyi, D., and R. A. Zeuner. 2003. Differential signaling by CpG DNA in DCs and B cells: not just TLR9. Trends Immunol. 24: 519-522.
14. Lutz, M. B., and G. Schuler. 2002. Immature, semi-mature and fully mature dendritic cells: which signals induce tolerance or immunity? Trends Immunol. 23: 445-449.
15. + T cells with regulatory properties by repetitive stimulation with allogeneic immature human dendritic cells. J. Exp. Med. 192: 1213-1222.
16. Roncarolo, M. G., M. K. Levings, and C. Traversari. 2001. Differentiation of T regulatory cells by immature dendritic cells. J. Exp. Med. 193: F5-F9.
17. Wakkach, A., N. Fournier, V. Brun, J. P. Breittmayer, F. Cottrez, and H. Groux. 2003. Characterization of dendritic cells that induce tolerance and T regulatory 1 cell differentiation in vivo. Immunity 18: 605-617.
18. + regulatory T cells. J. Immunol. 173: 4433-4442.
19. + bone marrow subpopulation that promotes allogeneic stem cell engraftment. Nat. Med. 6: 904-909.
20. Taylor, K. N., V. R. Shinde Patil, and Y. L. Colson. 2006. Reconstitution of allogeneic hemopoietic stem cells: the essential role of FcRγ and the TCR β-chain-FCp33 complex. J. Immunol. 177: 1444-1450.
21. + T cells promote engraftment and tolerance following MHC-mismatched hematopoietic cell transplantation. Blood 105: 1828-1836.
22. + regulatory T cells suppress lethal acute graft-versus-host disease after allogeneic bone marrow transplantation. J. Exp. Med. 196: 389-399.
23. + immunoregulatory T Cells: new therapeutics for graft-versus-host disease. J. Exp. Med. 196: 401-406.
24. + immune regulatory cells inhibits graft-versus-host disease lethality. Blood 99: 3493-3499.
25. + immunoregulatory T cells that control autoimmune diabetes. Immunity 12: 431-440.
26. Sakaguchi, S., N. Sakaguchi, M. Asano, M. Itoh, and M. Toda. 1995. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor α-chains (CD25): breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J. Immunol. 155: 1151-1164.
27. + immunoregulatory T cells is antigen nonspecific. J. Immunol. 164: 183-190.
28. + immunoregulatory cells. J. Immunol. 167: 1137-1140.
29. + immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production. J. Exp. Med. 188: 287-296.
30. Gursel, M., D. Verthelyi, I. Gursel, K. J. Ishii, and D. M. Klinman. 2002. Differential and competitive activation of human immune cells by distinct classes of CpG oligodeoxynucleotide. J. Leukocyte Biol. 71: 813-820.
31. Hara, M., C. I. Kingsley, M. Niimi, S. Read, S. E. Turvey, A. R. Bushell, P. J. Morris, F. Powrie, and K. J. Wood. 2001. IL-10 is required for regulatory T cells to mediate tolerance to alloantigens in vivo. J. Immunol. 166: 3789-3796.
32. + regulatory T cells prevent graft rejection: CTLA-4- and IL-10-dependent immunoregulation of alloresponses. J. Immunol. 168: 1080-1086.
33. Sawitzki, B., C. I. Kingsley, V. Oliveira, M. Karim, M. Herber, and K. J. Wood. 2005. IFN-γ production by alloantigen-reactive regulatory T cells is important for their regulatory function in vivo. J. Exp. Med. 201: 1925-1935.
34. Ziegler, S. F. 2006. FOXP3: of mice and men. Annu. Rev. Immunol. 24: 209-226.
35. Li-Weber, M., M. Giasi, and P. H. Krammer. 1998. Involvement of Jun and Rel proteins in up-regulation of interleukin-4 gene activity by the T cell accessory molecule CD28. J. Biol. Chem. 273: 32460-32466.
36. Siefken, R., S. Klein-Hessling, E. Serfling, R. Kurrle, and R. Schwinzer. 1998. A CD28-associated signaling pathway leading to cytokine gene transcription and T cell proliferation without TCR engagement. J. Immunol. 161: 1645-1651.
37. + regulatory T cells preserve graft-versus-tumor activity while inhibiting graft-versus-host disease after bone marrow transplantation. Nat. Med. 9: 1144-1150.
38. + regulatory T cells. Microbes Infect. 7: 1066-1072.
39. + T cells for IL-2 and exploit it for the induction of IL-10 production. Int. Immunol. 17: 279-288.
40. von Boehmer, H. 2005. Mechanisms of suppression by suppressor T cells. Nat. Immunol. 6: 338-344.
41. Waldmann, H., T. C. Chen, L. Graca, E. Adams, S. Daley, S. Cobbold, and P. J. Fairchild. 2006. Regulatory T cells in transplantation. Semin. Immunol. 18: 111-119.
42. + regulatory T cells by TGF-β induction of transcription factor Foxp3. J. Exp. Med. 198: 1875-1886.
43. + regulatory T cells by antigen-processing dendritic cells. J. Exp. Med. 198: 235-247.
44. Takenaka, H., S. Maruo, N. Yamamoto, M. Wysocka, S. Ono, M. Kobayashi, H. Yagita, K. Okumura, T. Hamaoka, G. Trinchieri, and H. Fujiwara. 1997. Regulation of T cell-dependent and -independent IL-12 production by the three Th2-type cytokines IL-10, IL-6, and IL-4. J. Leukocyte Biol. 61: 80-87.
45. La Flamme, A. C., A. S. MacDonald, and E. J. Pearce. 2000. Role of IL-6 in directing the initial immune response to schistosome eggs. J. Immunol. 164: 2419-2426.
46. Dodge, I. L., M. W. Carr, M. Cernadas, and M. B. Brenner. 2003. IL-6 production by pulmonary dendritic cells impedes Th1 immune responses. J. Immunol. 170: 4457-4464.
47. Okada, T., Z. X. Lian, M. Naiki, A. A. Ansari, S. Ikehara, and M. E. Gershwin. 2003. Murine thymic plasmacytoid dendritic cells. Eur. J. Immunol. 33: 1012-1019.
48. Gangopadhyay, N. N., H. Shen, R. Landreneau, J. D. Luketich, and M. J. Schuchert. 2004. Isolation and tracking of a rare lymphoid progenitor cell which facilitates bone marrow transplantation in mice. J. Immunol. Methods 292: 73-81.
49. Steinbrink, K., M. Wolfl, H. Jonuleit, J. Knop, and A. H. Enk. 1997. Induction of tolerance by IL-10-treated dendritic cells. J. Immunol. 159: 4772-4780.
50. Caux, C., C. Massacrier, B. Vanbervliet, C. Barthelemy, Y. J. Liu, and J. Banchereau. 1994. Interleukin 10 inhibits T cell alloreaction induced by human dendritic cells. Int. Immunol. 6: 1177-1185.
51. + T-cell proliferation: modulation by autocrine IL-10, enhanced T-cell apoptosis and T regulatory type 1 cells. Int. Immunol. 16: 1037-1052.
52. Lohr, J., B. Knoechel, S. Jiang, A. H. Sharpe, and A. K. Abbas. 2003. The inhibitory function of B7 costimulators in T cell responses to foreign and self-antigens. Nat. Immunol. 4: 664-669.
53. + immune regulatory cells are required for induction of tolerance to alloantigen via costimulatory blockade. J. Exp. Med. 193: 1311-1318.