Immunomodulation after allogeneic bone marrow transplantation by CD4 +CD25+ regulatory T cells

Microbes and Infection

Volumn 7, Issue 7-8, 2005, Pages 1066-1072

  Hoffmann, Petra ^a   Boeld, Tina J ^a   Piseshka, Biserka ^a   Edinger, Matthias ^a  

^a UNIVERSITY HOSPITAL REGENSBURG   (Germany)

Author keywords

Graft versus host disease; Leukemia; Tolerance

Indexed keywords

CD4 ANTIGEN; INTERLEUKIN 2 RECEPTOR ALPHA;

ALLOGENIC BONE MARROW TRANSPLANTATION; CELL PROTECTION; CLINICAL STUDY; DISEASE MODEL; DONOR; GRAFT VERSUS HOST REACTION; HISTOCOMPATIBILITY; HUMAN; IMMUNE RESPONSE; IMMUNOLOGICAL TOLERANCE; IMMUNOMODULATION; IMMUNOSUPPRESSIVE TREATMENT; LYMPHOCYTE FUNCTION; PATHOGENESIS; PRIORITY JOURNAL; REGULATORY MECHANISM; REVIEW; T LYMPHOCYTE;

ANIMALIA;

EID: 22144482051     PISSN: 12864579     EISSN: 1769714X     Source Type: Journal    
DOI: 10.1016/j.micinf.2005.03.035     Document Type: Short Survey

References (45)

1. P. Reddy Pathophysiology of acute graft-vs.-host disease Hematol. Oncol. 21 2003 149 161
2. Z. Wu, S.J. Bensinger, J. Zhang, C. Chen, X. Yuan, X. Huang, J.F. Markmann, A. Kassaee, B.R. Rosengard, W.W. Hancock, M.H. Sayegh, and L.A. Turka Homeostatic proliferation is a barrier to transplantation tolerance Nat. Med. 10 2004 87 92
3. E.J. Suchin, P.B. Langmuir, E. Palmer, M.H. Sayegh, A.D. Wells, and L.A. Turka Quantifying the frequency of alloreactive T cells in vivo: new answers to an old question J. Immunol. 166 2001 973 981
4. W.D. Shlomchik, M.S. Couzens, C.B. Tang, J. McNiff, M.E. Robert, J. Liu, M.J. Shlomchik, and S.G. Emerson Prevention of graft vs. host disease by inactivation of host antigen-presenting cells Science 285 1999 412 415
5. C.C. Matte, J. Liu, J. Cormier, B.E. Anderson, I. Athanasiadis, D. Jain, J. McNiff, and W.D. Shlomchik Donor APCs are required for maximal GVHD but not for GVL Nat. Med. 10 2004 987 992
6. T. Teshima, R. Ordemann, P. Reddy, S. Gagin, C. Liu, K.R. Cooke, and J.L. Ferrara Acute graft-vs.-host disease does not require alloantigen expression on host epithelium Nat. Med. 8 2002 575 581
7. 25+ regulatory T cells down-regulate co-stimulatory molecules on antigen-presenting cells Eur. J. Immunol. 30 2000 1538 1543
8. R.S. Bystry, V. Aluvihare, K.A. Welch, M. Kallikourdis, and A.G. Betz B cells and professional APCs recruit regulatory T cells via CCL4 Nat. Immunol. 2 2001 1126 1132
9. M.G. Roncarolo, R. Bacchetta, C. Bordignon, S. Narula, and M.K. Levings Type 1 T regulatory cells Immunol. Rev. 182 2001 68 79
10. S. Sakaguchi Naturally arising CD4+ regulatory t cells for immunologic self-tolerance and negative control of immune responses Annu. Rev. Immunol. 22 2004 531 562
11. P. Hoffmann, J. Ermann, M. Edinger, C.G. Fathman, and S. Strober Donor-type CD4(+)CD25(+) regulatory T cells suppress lethal acute graft-vs.-host disease after allogeneic bone marrow transplantation J. Exp. Med. 196 2002 389 399
12. J.L. Cohen, A. Trenado, D. Vasey, D. Klatzmann, and B.L. Salomon CD4(+)CD25(+) immunoregulatory T Cells: new therapeutics for graft-vs.-host disease J. Exp. Med. 196 2002 401 406
13. P.A. Taylor, C.J. Lees, and B.R. Blazar The infusion of ex vivo activated and expanded CD4(+)CD25(+) immune regulatory cells inhibits graft-vs.-host disease lethality Blood 99 2002 3493 3499
14. S.C. Jones, G.F. Murphy, and R. Korngold Post-hematopoietic cell transplantation control of graft-vs.-host disease by donor CD4(+)25(+) T cells to allow an effective graft-vs.-leukemia response Biol. Blood Marrow Transplant. 9 2003 243 256
15. + regulatory T cells J. Immunol. 170 2003 3939 3943
16. + regulatory T cells suppress acute GVHD lethality without loss of GVL activity Blood 100 2002 142a
17. + regulatory T cells protects from lethal acute GVHD Blood 105 2005 2220 2226
18. + T-regulatory cells are potent inhibitors of GVHD and BM graft rejection Blood 104 2004 3804 3812
19. + regulatory T cells favor immune reconstitution and control graft-vs.-host disease while maintaining graft-vs.-leukemia J. Clin. Invest. 112 2003 1688 1696
20. + T lymphocytes Blood 103 2004 4216 4221
21. + T cells facilitate hematopoietic engraftment independent of host resistance and alloantigen recognition Blood 102 2003 38a [abstract]
22. M. Edinger, P. Hoffmann, J. Ermann, K. Drago, C.G. Fathman, S. Strober, and R.S. Negrin CD4(+)CD25(+) regulatory T cells preserve graft-vs.-tumor activity while inhibiting graft-vs.-host disease after bone marrow transplantation Nat. Med. 9 2003 1144 1150
23. X.C. Li, T.B. Strom, L.A. Turka, and A.D. Wells T cell death and transplantation tolerance Immunity 14 2001 407 416
24. L. Van Parijs, and A.K. Abbas Homeostasis and self-tolerance in the immune system: turning lymphocytes off Science 280 1998 243 248
25. R.I. Lechler, O.A. Garden, and L.A. Turka The complementary roles of deletion and regulation in transplantation tolerance Nat. Rev. Immunol. 3 2003 147 158
26. + immunoregulatory T-cells of donor origin suppress alloreactivity after BMT Biol. Blood Marrow Transplant. 8 2002 525 535
27. + regulatory T cells Eur. J. Immunol. 32 2002 1621 1630
28. P. Hoffmann, R. Eder, L.A. Kunz-Schughart, R. Andreesen, and M. Edinger Large-scale in vitro expansion of polyclonal human CD4(+)CD25 high regulatory T cells Blood 104 2004 895 903
29. Y. Li, X.C. Li, X.X. Zheng, A.D. Wells, L.A. Turka, and T.B. Strom Blocking both signal 1 and signal 2 of T-cell activation prevents apoptosis of alloreactive T cells and induction of peripheral allograft tolerance Nat. Med. 5 1999 1298 1302
30. H. Jonuleit, E. Schmitt, H. Kakirman, M. Stassen, J. Knop, and A.H. Enk Infectious tolerance: human CD25(+) regulatory T cells convey suppressor activity to conventional CD4(+) T helper cells J. Exp. Med. 196 2002 255 260
31. F. Annunziato, L. Cosmi, F. Liotta, E. Lazzeri, R. Manetti, V. Vanini, P. Romagnani, E. Maggi, and S. Romagnani Phenotype, localization, and mechanism of suppression of CD4(+)CD25(+) human thymocytes J. Exp. Med. 196 2002 379 387
32. + regulatory T cells Semin. Immunol. 16 2004 89 98
33. +CD25 high regulatory cells in human peripheral blood J. Immunol. 167 2001 1245 1253
34. + T regulatory cells Nat. Immunol. 4 2003 337 342
35. S. Hori, T. Nomura, and S. Sakaguchi Control of regulatory T cell development by the transcription factor Foxp3 Sciencce 299 2003 1057 1061
36. + regulatory T cells Nat. Immunol. 4 2003 330 336
37. - T cells J. Clin. Invest. 112 2003 1437 1443
38. + regulatory T cells by TGF-beta induction of transcription factor Foxp3 J. Exp. Med. 198 2003 1875 1886
39. H. Jonuleit, E. Schmitt, M. Stassen, A. Tuettenberg, J. Knop, and A.H. Enk Identification and functional characterization of human CD4(+)CD25(+) T cells with regulatory properties isolated from peripheral blood J. Exp. Med. 193 2001 1285 1294
40. Y. Miura, C.J. Thoburn, E.C. Bright, M.L. Phelps, T. Shin, E.C. Matsui, W.H. Matsui, S. Arai, E.J. Fuchs, G.B. Vogelsang, R.J. Jones, and A.D. Hess Association of Foxp3 regulatory gene expression with graft-vs.-host disease Blood 104 2004 2187 2193
41. J. Sanchez, J. Casano, M.A. Alvarez, J. Roman-Gomez, C. Martin, F. Martinez, P. Gomez, J. Serrano, C. Herrera, and A. Torres Kinetic of regulatory CD25high and activated CD134+ (OX40) T lymphocytes during acute and chronic graft-vs.-host disease after allogeneic bone marrow transplantation Br. J. Haematol. 126 2004 697 703
42. +CD25 high regulatory T cells Blood 103 2004 2410 2416
43. M. Stanzani, S.L. Martins, R.M. Saliba, L.S. St John, S. Bryan, D. Couriel, J. McMannis, R.E. Champlin, J.J. Molldrem, and K.V. Komanduri CD25 expression on donor CD4+ or CD8+ T cells is associated with an increased risk for graft-vs.-host disease after HLA-identical stem cell transplantation in humans Blood 103 2004 1140 1146
44. W.R. Godfrey, Y.G. Ge, D.J. Spoden, B.L. Levine, C.H. June, B.R. Blazar, and S.B. Porter In vitro-expanded human CD4(+)CD25(+) T-regulatory cells can markedly inhibit allogeneic dendritic cell-stimulated MLR cultures Blood 104 2004 453 461
45. + regulatory T cells ex vivo Blood 102 2003 2180 2186