Role of IL-6 in directing the initial immune response to schistosome eggs

Journal of Immunology

Volumn 164, Issue 5, 2000, Pages 2419-2426

  La Flamme, Anne Camille ^a   MacDonald, Andrew S ^a   Pearce, Edward J ^a,b  

^a Department of Population Medicine and Diagnostic Sciences   (United States)

^b NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 6;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; EGG; FEMALE; MOUSE; NEGATIVE FEEDBACK; NONHUMAN; PATHOPHYSIOLOGY; PRIMARY IMMUNE RESPONSE; PRIORITY JOURNAL; REGULATORY MECHANISM; SCHISTOSOMA MANSONI; SCHISTOSOMIASIS; TH2 CELL;

EID: 0034161672     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.164.5.2419     Document Type: Article

References (43)

1. Akira, S., T. Taga, and T. Kishimoto. 1993. Interleukin-6 in biology and medicine. Adv. Immunol. 54:1.
2. Silvennoinen, O., and J. N. Ihne. 1996. Biology and characterization of hematopoietic cytokines. In Signaling by the Hematopoietic Cytokine Receptors. Chapman & Hall, New York.
3. Hirano, T., T. Taga, N. Nakano, K. Yasukawa, S. Kashiwamura, K. Shimizu, K. Nakajima, K. H. Pyum, and T. Kishimoto. 1985. Purification to homogeneity and characterization of human B cell differentiation factor. Proc. Natl. Acad. Sci. USA 85:5490.
4. Uyttenhove, C., P. G. Coulie, and J. Van Snick. 1988. T cell growth factor and differentiation induced by interleukin-HPI/IL-6, the murine hybridoma/plastocytoma growth factor. J. Exp. Med. 167:1417.
5. La Flamme, A. C., and E. J. Pearce. 1999. The absence of IL-6 does not affect Th2 cell development in vivo, but does lead to impaired proliferation, IL-2 receptor expression, and B cell responses. J. Immunol. 162:5829.
6. Giraudo, E., M. Arese, C. Toniatti, M. Strasly, L. Primo, A. Mantovani, G. Ciliberto, and F. Bussolino. 1996. IL-6 is an in vitro and in vivo autocrine growth factor for middle T antigen-transformed endothelial cells. J. Immunol. 157:2618.
7. Noma, T., T. Mizuta, A. Rosen, T. Hirano, T. Kishimoto, and T. Honjo. 1987. Enhancement of interleukin-2 receptor expression on T cells by multiple B-lymphotropic lymphokines. Immunol. Lett. 15:249.
8. Loire, K., J. Van Damme, J. Verwilghen, M. L. Baroja, and J. L. Ceuppens. 1990. IL-6 is an accessory signal in the alternative CD2-mediated pathway of T cell activation. J. Immunol. 144:4681.
9. Takai, Y., G. G. Wong, S. C. Clark, S. J. Burakoff, and S. H. Hermann. 1988. B cell stimulatory factor-2 is involved in the differentiation of cytotoxic T lymphocytes. J. Immunol. 140:508.
10. Steel, D. M., and A. S. Whitehead. 1994. The major acute phase reactants. Immunol. Today 15:81.
11. Rincon, M., J. Anguila, T. Nakamura, E. Fikrig, and R. A. Flavell. 1997. Interleukin-6 directs the differentiation of IL-4-producing CD4 T cells. J. Exp. Med. 185:461.
12. Grzych, J. M., E. J. Pearce, A. Cheever, A. Caulada, P. Caspar. S. Hieny, F. A. Lewis, and A. Sher. 1991. Egg deposition is the major stimulus for the production of Th2 cytokines in murine Schistosoma mansoni. J. Immunol. 146:1322.
13. Sabin, E. A., and E. J. Pearce. 1995. Early IL-4 production by non-CD4 cells at the site of antigen deposition predicts the development of a T helper 2 cell response to Schistosoma mansoni eggs. J. Immunol. 155:4844.
14. Wynn, T. A., I. Eltoum, A. W. Cheever, F. A. Lewis, W. C. Gause, and A. Sher. 1993. Analysis of cytokine mRNA expression during primary granuloma formation induced by eggs of Schistosoma mansoni. J. Immunol. 151:1430.
15. + Th2 response induced by Schistosoma mansoni eggs develops rapidly, through an early, transient, ThO-like stage. J. Immunol. 148:2283.
16. Pearce, E. J., P. Caspar, J. M. Grzych, F. A. Lewis, and A. Sher. 1991. Down-regulation of Th1 cytokine production accompanies the induction of Th2 responses by a parasitic helminth, Schistosoma mansoni. J. Exp. Med. 173:159.
17. Trinchieri, G. 1998. Interleukin-12: a cytokine at the interface of inflammation and immunity. Adv. Immunol. 70:83.
18. Takenaka, H., S. Marou, N. Yamamoto, M. Wysocka, S. Ono, M. Kobayashi, H. Yagita, K. Okumura, T. Hamaoka, G. Trinchieri, and H. Fujiwara. 1997. Regulation of T cell-dependent and -independent IL-12 production by the three Th2-type cytokines IL-10, IL-6, and IL-4. J. Leukocyte Biol. 61:80.
19. Mizuhara, H., M. Uno, N. Seki, M. Yamashita, M. Yamaoka, T. Ogawa, K. Kaneda, T. Fujii, H. Senoh, and H. Fujiwara. 1996. Critical involvement of interferon γ in the pathogenesis of T-cell activation-associated hepatitis and regulatory mechanisms of interieukin-6 for the manifestations of hepatitis. Hepatology 23:1608.
20. Yamamoto, N., J. P. Zou, X. F. Li, H. Takenaka, S. Noda, T. Fujii, S. Ono, Y. Kobayashi, N. Mukaida, K. Matsushima, H. Fujiwara, and T. Hamaoka. 1995. Regulalory mechanisms for the production of IFN-γ and TNF by antitumor T cells or macrophages in the tumor-bearing state. J. Immunol. 154:2281.
21. Xing, Z., J. Gauldie, G. Cox, H. Baumann, M. Jordana, X. Lei, and M. K. Achong. 1998. IL-6 is an anti-inflammatory cytokine required for controlling local and systemic acute inflammatory responses. J. Clin. Invest. 101:311.
22. Wynn, T. A., I. Eltoum, I. P. Oswald, A. W. Cheever, and A. Sher. 1994. Endogenous interleukin 12 (IL-12) regulates granuloma formation induced by eggs of Schistosoma mansoni and exogenous IL-12 both inhibits and prophylactically immunizes against egg pathology. J. Exp. Med. 179:1551.
23. Boros, D. L., and K. S. Warren. 1970. Delayed hypersensitivity-type granuloma formation and dermal reaction induced and elicited by a soluble factor isolated from Schistosoma mansoni eggs. J. Exp. Med. 132:488.
24. Boctor, F. N., T. E. Nash, and A. W. Cheever. 1979. Isolation of a polysaccharide antigen from Schistosoma mansoni eggs. J. Immunol. 122:39.
25. Vella A. T., and E. J. Pearce. 1994. Schistosoma mansoni egg-primed Th0 and Th2 cells: failure to downregulate IFN-γ production following in vitro culture. Scand. J. Immunol. 39:12.
26. Rosa-Brunet, L., F. D. Finkelman, A. W. Cheever, M. A. Kopf, and E. J. Pearce. 1997. IL-4 protects against TNF-α-mediated cachexia and death during acute schistosomiasis. J. Immunol. 159:777.
27. Mosmann, T. R., and T. A. T. Fong. 1989. Specific assays for cytokine production by T cells. J. Immunol. Methods 116:151.
28. McDyer, J. F., C. Wu, and R. A. Seder. 1998. The regulation of IL-12: its role in infectious, autoimmune, and allergic diseases. J. Allergy Clin. Immunol. 102:11.
29. Fiorentino, D. F., M. W. Bond, and T. R. Mosmann. 1989. Two types of mouse T helper cell. IV. Th2 clones secrete a factor that inhibits cytokine production by Th1 clones. J. Exp. Med. 170:2081.
30. Hsu, D. H., K. W. Moore, and H. Spits. 1992. Differential effects of IL-4 and IL-10 on interleukin-2-induced interferon-γ synthesis and lymphokine-activated killer activity. Int. Immunol. 4:563.
31. Nishimura, N., C. Tohyama, M. Satoh, H. Nishimura, and V. E. Reeve. 1999. Defective immune response and severe skin damage following UVB irradiation in interleukin-6-deficient mice. Immunology 97:77.
32. Wynn, T. A., R. Morawetz, T. Scharton-Kersten, S. Hieny, H. C. Morse, R. Kuhn, W. Muller, A. W. Cheever, and A. Sher. 1997. Analysis of granuloma formation in double cytokine-deficient mice reveals a central role for IL-10 in polarizing both T helper cell 1- and T helper cell 2-type cytokine responses in vivo. J. Immunol. 159:5023.
33. Fiorentino, D. F., A. Zlotnik, T. R. Mosmann, M. Howard, and A. O'Garra. 1991. IL-10 inhibits cytokine production by activated macrophages. J. Immunol. 147:3815.
34. Sabin, E. A., M. A. Kopf, and E. J. Pearce. 1996. Schistosoma mansoni eggs-induced early IL-4 production is dependent upon IL-5 and eosinophils. J. Exp. Med. 184:1871.
35. + T cells. FASEB J. 8:A471.
36. Blum, A. M., A. Metwali, D. Elliott, J. Li, M. Sandor, and J. V. Weinstock. 1998. IL-6-deficient mice form granulomas in murine schistosomiasis that exhibit an altered B cell response. Cell. Immunol. 188:64.
37. - B cells: possible involvement in age-associated cytokine dysregulation. Int. Immunol. 9:745.
38. Grewal, I. S., and R. A. Flavell. 1998. CD40 and CD154 in cell-mediated immunity. Annu. Rev. Immunol. 16:111.
39. Finkelman, F. D., K. D. Madden, A. W. Cheever, I. M. Katona, S. C. Morris, M. K. Gately, B. R. Hubbard, W. C. Gause, and J. F. Urban. 1994. Effects of interleukin 12 on immune responses and host protection in mice infected with intestinal nematode parasites. J. Exp. Med. 179:1563.
40. Wynn, T. A., D. Jankovic, S. Hieny, K. Zioncheck, P. Jardieu, A. W. Cheever, and A. Sher. 1995. IL-12 exacerbates rather than suppresses T helper 2-dependent pathology in the absence of endogenous IFN-γ. J. Immunol. 154:3999.
41. Gerosa, F., C. Paganin, D. Peritt, F. Paiola, M. T. Scupoli, M. Aste-Amezaga, I. Frank, and G. Trinchieri. 1996. Interleukin-12 primes human CD4 and CD8 T cell clones for high production of both interferon-γ and interleukin-10. J. Exp. Med. 183:2559.
42. Windhagen, A., D. E. Anderson, A. Carrizosa R. E. Williams, and D. A. Hafler. 1996. IL-12 induces human T cells secreting IL-10 with IFN-γ. J. Immunol. 157:1127.
43. Oswald, I. P., P. Caspar, D. Jankovic, T. A. Wynn, E. J. Pearce, and A. Sher. 1994. IL-12 inhibits Th2 cytokine responses induced by eggs of Schistosoma mansoni. J. Immunol. 153:1707.