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Volumn 25, Issue 5, 2007, Pages 477-489

The NF-κB/IL-6 pathway in metastatic androgen-independent prostate cancer: New therapeutic approaches?

Author keywords

Androgen independence; IL 6; Metastasis; New therapies; NF B; Prostate cancer

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 6;

EID: 34648837499     PISSN: 07244983     EISSN: 14338726     Source Type: Journal    
DOI: 10.1007/s00345-007-0175-6     Document Type: Review
Times cited : (66)

References (114)
  • 1
    • 0035180451 scopus 로고    scopus 로고
    • Interleukin-6 is an autocrine growth factor in human prostate cancer
    • Giri D, Ozen M, Ittmann M (2001) Interleukin-6 is an autocrine growth factor in human prostate cancer. Am J Pathol 159:2159-2165
    • (2001) Am J Pathol , vol.159 , pp. 2159-2165
    • Giri, D.1    Ozen, M.2    Ittmann, M.3
  • 2
    • 1842668004 scopus 로고    scopus 로고
    • Interleukin-6 promotes androgen-independent growth in LNCaP human prostate cancer cells
    • Lee SO, Lou W, Hou M, de Miguel F, Gerber L, Gao AC (2003) Interleukin-6 promotes androgen-independent growth in LNCaP human prostate cancer cells. Clin Cancer Res 9:370-376
    • (2003) Clin Cancer Res , vol.9 , pp. 370-376
    • Lee, S.O.1    Lou, W.2    Hou, M.3    de Miguel, F.4    Gerber, L.5    Gao, A.C.6
  • 3
    • 0034651980 scopus 로고    scopus 로고
    • Interleukin-6 induces prostate cancer cell growth accompanied by activation of stat3 signaling pathway
    • Lou W, Ni Z, Dyer K, Tweardy DJ, Gao AC (2000) Interleukin-6 induces prostate cancer cell growth accompanied by activation of stat3 signaling pathway. Prostate 42:239-242
    • (2000) Prostate , vol.42 , pp. 239-242
    • Lou, W.1    Ni, Z.2    Dyer, K.3    Tweardy, D.J.4    Gao, A.C.5
  • 4
    • 0035667565 scopus 로고    scopus 로고
    • Plasma levels of interleukin-6 and its soluble receptor are associated with prostate cancer progression and metastasis
    • Shariat SF, Andrews B, Kattan MW, Kim J, Wheeler TM, Slawin KM (2001) Plasma levels of interleukin-6 and its soluble receptor are associated with prostate cancer progression and metastasis. Urology 58:1008-1015
    • (2001) Urology , vol.58 , pp. 1008-1015
    • Shariat, S.F.1    Andrews, B.2    Kattan, M.W.3    Kim, J.4    Wheeler, T.M.5    Slawin, K.M.6
  • 5
    • 0032830265 scopus 로고    scopus 로고
    • Elevated levels of circulating interleukin-6 and transforming growth factor-beta1 in patients with metastatic prostatic carcinoma
    • Adler HL, McCurdy MA, Kattan MW, Timme TL, Scardino PT, Thompson TC (1999) Elevated levels of circulating interleukin-6 and transforming growth factor-beta1 in patients with metastatic prostatic carcinoma. J Urol 161:182-187
    • (1999) J Urol , vol.161 , pp. 182-187
    • Adler, H.L.1    McCurdy, M.A.2    Kattan, M.W.3    Timme, T.L.4    Scardino, P.T.5    Thompson, T.C.6
  • 6
    • 0032880248 scopus 로고    scopus 로고
    • Circulating levels of interleukin-6 in patients with hormone refractory prostate cancer
    • Drachenberg DE, Elgamal AA, Rowbotham R, Peterson M, Murphy GP (1999) Circulating levels of interleukin-6 in patients with hormone refractory prostate cancer. Prostate 41:127-133
    • (1999) Prostate , vol.41 , pp. 127-133
    • Drachenberg, D.E.1    Elgamal, A.A.2    Rowbotham, R.3    Peterson, M.4    Murphy, G.P.5
  • 8
    • 0028880675 scopus 로고
    • Endogenous interleukin 6 is a resistance factor for cis-diamminedichloroplatinum and etoposide mediated cytotoxicity of human prostate carcinoma cell lines
    • Borsellino N, Belldegrun A, Bonavida B (1995) Endogenous interleukin 6 is a resistance factor for cis-diamminedichloroplatinum and etoposide mediated cytotoxicity of human prostate carcinoma cell lines. Cancer Res 55:4633-4639
    • (1995) Cancer Res , vol.55 , pp. 4633-4639
    • Borsellino, N.1    Belldegrun, A.2    Bonavida, B.3
  • 9
    • 0031897632 scopus 로고    scopus 로고
    • NF-kappaB and Rel proteins: Evolutionarily conserved mediators of immune responses
    • Ghosh S, May MJ, Kopp EB (1998) NF-kappaB and Rel proteins: evolutionarily conserved mediators of immune responses. Ann Rev Immunol 16:225-260
    • (1998) Ann Rev Immunol , vol.16 , pp. 225-260
    • Ghosh, S.1    May, M.J.2    Kopp, E.B.3
  • 10
    • 0033596127 scopus 로고    scopus 로고
    • Control of apoptosis by Rel/NF-kappaB transcription factors
    • Barkett M, Gilmore TD (1999) Control of apoptosis by Rel/NF-kappaB transcription factors. Oncogene 18:6910-6924
    • (1999) Oncogene , vol.18 , pp. 6910-6924
    • Barkett, M.1    Gilmore, T.D.2
  • 11
    • 0029976817 scopus 로고    scopus 로고
    • An essential role for NF-κB in preventing TNF-beta-induced cell death
    • Beg AA, Baltimore D (1996) An essential role for NF-κB in preventing TNF-beta-induced cell death. Science 274:782-784
    • (1996) Science , vol.274 , pp. 782-784
    • Beg, A.A.1    Baltimore, D.2
  • 12
    • 0033587084 scopus 로고    scopus 로고
    • Mutations in the IkBa gene in Hodgkin's disease suggest a tumour suppressor role for IkB
    • Cabannes E, Khan G, Aillet F, Jarrett RF, Hay RT (1999) Mutations in the IkBa gene in Hodgkin's disease suggest a tumour suppressor role for IkB. Oncogene 18:3063-3070
    • (1999) Oncogene , vol.18 , pp. 3063-3070
    • Cabannes, E.1    Khan, G.2    Aillet, F.3    Jarrett, R.F.4    Hay, R.T.5
  • 13
    • 0032943591 scopus 로고    scopus 로고
    • The nuclear factor-kappa B RelA transcription factor is constitutively activated in human pancreatic adenocarcinoma cells
    • Wang W, Abbruzzese JL, Evans DB, Larry L, Cleary KR, Chiao PJ. 1999. The nuclear factor-kappa B RelA transcription factor is constitutively activated in human pancreatic adenocarcinoma cells. Clin Cancer Res 5: 119-127
    • (1999) Clin Cancer Res , vol.5 , pp. 119-127
    • Wang, W.1    Abbruzzese, J.L.2    Evans, D.B.3    Larry, L.4    Cleary, K.R.5    Chiao, P.J.6
  • 15
    • 0030927167 scopus 로고    scopus 로고
    • Constitutive activation of NF-κB during progression of breast cancer to hormone-independent growth
    • Nakshatri HPB-N, Martin DA, Goulet RJ, Sledge GW (1997) Constitutive activation of NF-κB during progression of breast cancer to hormone-independent growth. Mol Cell Biol 17:3629-3639
    • (1997) Mol Cell Biol , vol.17 , pp. 3629-3639
    • Nakshatri, H.P.B.-N.1    Martin, D.A.2    Goulet, R.J.3    Sledge, G.W.4
  • 17
    • 0035354187 scopus 로고    scopus 로고
    • Nuclear factor kappa B is constitutively active in C-cell carcinoma and required for RET-induced transformation
    • Ludwig L, Kessler H, Wagner M, Hoang-Vu C, Dralle H, Adler G, Bohm BO, Schmid RM (2001) Nuclear factor kappa B is constitutively active in C-cell carcinoma and required for RET-induced transformation. Cancer Res 61: 4526-4535
    • (2001) Cancer Res , vol.61 , pp. 4526-4535
    • Ludwig, L.1    Kessler, H.2    Wagner, M.3    Hoang-Vu, C.4    Dralle, H.5    Adler, G.6    Bohm, B.O.7    Schmid, R.M.8
  • 18
    • 0034689773 scopus 로고    scopus 로고
    • Role of NF-κB in p53-mediated programmed cell death
    • Ryan KM, Ernst MK, Rice NR, Vousden KH (2004) Role of NF-κB in p53-mediated programmed cell death. Nature 404:892-897
    • (2004) Nature , vol.404 , pp. 892-897
    • Ryan, K.M.1    Ernst, M.K.2    Rice, N.R.3    Vousden, K.H.4
  • 19
    • 0033011889 scopus 로고    scopus 로고
    • Activation dependent transcriptional regulation of the human Fas promoter requires NF-B p50-p65 recruitment
    • Chan H, Bartos DP, Owen-Schaub LB (1999) Activation dependent transcriptional regulation of the human Fas promoter requires NF-B p50-p65 recruitment. Mol Cell Biol 19:2098-2108
    • (1999) Mol Cell Biol , vol.19 , pp. 2098-2108
    • Chan, H.1    Bartos, D.P.2    Owen-Schaub, L.B.3
  • 20
    • 0032588170 scopus 로고    scopus 로고
    • NF-kappaB function in growth control: Regulation of cyclin D1 expression and G0/G1-to-S-phase transition
    • Hinz M, Krappmann D, Eichten A, Heder A, Scheidereit C, Strauss M (1999) NF-kappaB function in growth control: Regulation of cyclin D1 expression and G0/G1-to-S-phase transition. Mol Cell Biol 19:2690-2698
    • (1999) Mol Cell Biol , vol.19 , pp. 2690-2698
    • Hinz, M.1    Krappmann, D.2    Eichten, A.3    Heder, A.4    Scheidereit, C.5    Strauss, M.6
  • 21
    • 0036546501 scopus 로고    scopus 로고
    • NF-kappa B in cancer: From innocent bystander to major culprit
    • Karin M, Cao Y, Greten FR, Li ZW (2002) NF-kappa B in cancer: From innocent bystander to major culprit. Nat Rev Cancer 2:301-310
    • (2002) Nat Rev Cancer , vol.2 , pp. 301-310
    • Karin, M.1    Cao, Y.2    Greten, F.R.3    Li, Z.W.4
  • 22
    • 0035137882 scopus 로고    scopus 로고
    • Control of oncogenesis and cancer therapy resistance by the transcription factor NF-kappaB
    • Baldwin AS (2001) Control of oncogenesis and cancer therapy resistance by the transcription factor NF-kappaB. J Clin Invest 107:241-246
    • (2001) J Clin Invest , vol.107 , pp. 241-246
    • Baldwin, A.S.1
  • 23
    • 1842479017 scopus 로고    scopus 로고
    • Expression of nuclear factor-kappa B and I kappa B alpha proteins in prostatic adenocarcinomas: Correlation of nuclear factor-kappa B immunoreactivity with disease recurrence
    • Ross JS, Kallakury BV, Sheehan CE, Fisher HA, Kaufman RP Jr, Kaur P, Gray K, Stringer B (2004) Expression of nuclear factor-kappa B and I kappa B alpha proteins in prostatic adenocarcinomas: Correlation of nuclear factor-kappa B immunoreactivity with disease recurrence. Clin Cancer Res. 10:2466-2472
    • (2004) Clin Cancer Res. , vol.10 , pp. 2466-2472
    • Ross, J.S.1    Kallakury, B.V.2    Sheehan, C.E.3    Fisher, H.A.4    Kaufman Jr., R.P.5    Kaur, P.6    Gray, K.7    Stringer, B.8
  • 24
    • 0036150911 scopus 로고    scopus 로고
    • The role of IKK in constitutive activation of NF-kappaB transcription factor in prostate carcinoma cells
    • Gasparian AV, Yao YJ, Kowalczyk D, Lyakh LA, Karseladze A, Slaga TJ, Budunova IV (2002) The role of IKK in constitutive activation of NF-kappaB transcription factor in prostate carcinoma cells. J Cell Sci 115(Pt 1):141-151
    • (2002) J Cell Sci , vol.115 , Issue.PART 1 , pp. 141-151
    • Gasparian, A.V.1    Yao, Y.J.2    Kowalczyk, D.3    Lyakh, L.A.4    Karseladze, A.5    Slaga, T.J.6    Budunova, I.V.7
  • 26
    • 0033605575 scopus 로고    scopus 로고
    • Mitogen-activated protein kinase/ERK kinase kinases 2 and 3 activate nuclear factorkappaB through I kappa B kinase-alpha and I kappa B kinase-beta
    • Zhao Q, Lee FS (1999) Mitogen-activated protein kinase/ERK kinase kinases 2 and 3 activate nuclear factorkappaB through I kappa B kinase-alpha and I kappa B kinase-beta. J Biol Chem 274:8355-8358
    • (1999) J Biol Chem , vol.274 , pp. 8355-8358
    • Zhao, Q.1    Lee, F.S.2
  • 27
    • 3242798367 scopus 로고    scopus 로고
    • NF-kB activation in human prostate cancer: Important mediator or epiphenomenon?
    • Suh J, Rabson A.B (2004) NF-kB activation in human prostate cancer: important mediator or epiphenomenon? J Cell Biochem 91:100-117
    • (2004) J Cell Biochem , vol.91 , pp. 100-117
    • Suh, J.1    Rabson, A.B.2
  • 28
    • 0036842110 scopus 로고    scopus 로고
    • Contributions of mitogen-activated protein kinase and nuclear factor kappa B to N-(4- hydroxyphenyl)retinamide-induced apoptosis in prostate cancer cells
    • Shimada K, Nakamura M, Ishida E, Kishi M, Yonehara S, Konishi N (2002) Contributions of mitogen-activated protein kinase and nuclear factor kappa B to N-(4- hydroxyphenyl)retinamide-induced apoptosis in prostate cancer cells. Mol Carcinog 35:127-137
    • (2002) Mol Carcinog , vol.35 , pp. 127-137
    • Shimada, K.1    Nakamura, M.2    Ishida, E.3    Kishi, M.4    Yonehara, S.5    Konishi, N.6
  • 29
    • 0036719081 scopus 로고    scopus 로고
    • Propapoptotic effects of NF-kappaB in LNCaP prostate cancer cells lead to serine protease activation
    • Kimura K, Gelmann EP (2002) Propapoptotic effects of NF-kappaB in LNCaP prostate cancer cells lead to serine protease activation. Cell Death Differ 9:972-980
    • (2002) Cell Death Differ , vol.9 , pp. 972-980
    • Kimura, K.1    Gelmann, E.P.2
  • 30
    • 0036196320 scopus 로고    scopus 로고
    • NF-KB activates prostate-specific antigen expression and is upregulated in androgen-independent prostate cancer
    • Charlie D, Sawyers CL (2002) NF-KB activates prostate-specific antigen expression and is upregulated in androgen-independent prostate cancer. Mol Cell Biol 22:2862-2870
    • (2002) Mol Cell Biol , vol.22 , pp. 2862-2870
    • Charlie, D.1    Sawyers, C.L.2
  • 31
    • 0033517999 scopus 로고    scopus 로고
    • Constitutive activation of IkappaB kinase alpha and NF-kappaB in prostate cancer cells is inhibited by ibuprofen
    • Palayoor ST, Youmell MY, Calderwood SK, Coleman CN, Price BD (1999) Constitutive activation of IkappaB kinase alpha and NF-kappaB in prostate cancer cells is inhibited by ibuprofen. Oncogene 18:7389-7394
    • (1999) Oncogene , vol.18 , pp. 7389-7394
    • Palayoor, S.T.1    Youmell, M.Y.2    Calderwood, S.K.3    Coleman, C.N.4    Price, B.D.5
  • 32
    • 0043170868 scopus 로고    scopus 로고
    • Id-1 expression promotes cell survival through activation of NF-kappaB signalling pathway in prostate cancer cells
    • Ling MT, Wang X, Ouyang XS, Xu K, Tsao SW, Wong YC (2003) Id-1 expression promotes cell survival through activation of NF-kappaB signalling pathway in prostate cancer cells. Oncogene 22:4498-4508
    • (2003) Oncogene , vol.22 , pp. 4498-4508
    • Ling, M.T.1    Wang, X.2    Ouyang, X.S.3    Xu, K.4    Tsao, S.W.5    Wong, Y.C.6
  • 33
    • 0035920131 scopus 로고    scopus 로고
    • The PTEN tumor suppressor protein inhibits tumor necrosis factor-induced nuclear factor kappa B activity
    • Gustin JA, Maehama T, Dixon JE, Donner DB (2001) The PTEN tumor suppressor protein inhibits tumor necrosis factor-induced nuclear factor kappa B activity. J Biol Chem 276:27740-27744
    • (2001) J Biol Chem , vol.276 , pp. 27740-27744
    • Gustin, J.A.1    Maehama, T.2    Dixon, J.E.3    Donner, D.B.4
  • 35
    • 2342510148 scopus 로고    scopus 로고
    • Secreted transforming growth factor beta2 activates NF-kappaB, blocks apoptosis, and is essential for the survival of some tumor cells
    • Lu T, Burdelya LG, Swiatkowski SM, Boiko AD, Howe PH, Stark GR, Gudkov AV (2004) Secreted transforming growth factor beta2 activates NF-kappaB, blocks apoptosis, and is essential for the survival of some tumor cells. Proc Natl Acad Sci USA 101:7112-7117
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 7112-7117
    • Lu, T.1    Burdelya, L.G.2    Swiatkowski, S.M.3    Boiko, A.D.4    Howe, P.H.5    Stark, G.R.6    Gudkov, A.V.7
  • 36
    • 0042303832 scopus 로고    scopus 로고
    • Transforming growth factor-beta1 activates interleukin-6 expression in prostate cancer cells through the synergistic collaboration of the Smad2, p38-NF-kappaB, JNK, and Ras signaling pathways
    • Park JI, Lee MG, Cho K, Park BJ, Chae KS, Byun DS, Ryu BK, Park YK, Chi SG (2003) Transforming growth factor-beta1 activates interleukin-6 expression in prostate cancer cells through the synergistic collaboration of the Smad2, p38-NF-kappaB, JNK, and Ras signaling pathways. Oncogene 22:4314-4332
    • (2003) Oncogene , vol.22 , pp. 4314-4332
    • Park, J.I.1    Lee, M.G.2    Cho, K.3    Park, B.J.4    Chae, K.S.5    Byun, D.S.6    Ryu, B.K.7    Park, Y.K.8    Chi, S.G.9
  • 37
    • 0038036872 scopus 로고    scopus 로고
    • Constitutive activation of nuclear factor KB p50/p65 and Fra-1 and JunD is essential for deregulated interleukin 6 expression in prostate cancer
    • Zerbini LF, Wang Y, Cho JY, Libermann TA. (2003) Constitutive activation of nuclear factor KB p50/p65 and Fra-1 and JunD is essential for deregulated interleukin 6 expression in prostate cancer. Cancer Res 63:2206-2215
    • (2003) Cancer Res , vol.63 , pp. 2206-2215
    • Zerbini, L.F.1    Wang, Y.2    Cho, J.Y.3    Libermann, T.A.4
  • 38
    • 0029662224 scopus 로고    scopus 로고
    • Inhibition of NF kappa B activity through maintenance of IkappaBalpha levels contributes to dihydrotestosterone-mediated repression of the interleukin-6 promoter
    • Keller ET, Chang C, Ershler WB (1996) Inhibition of NF kappa B activity through maintenance of IkappaBalpha levels contributes to dihydrotestosterone-mediated repression of the interleukin-6 promoter. J Biol Chem 271:26267-26275
    • (1996) J Biol Chem , vol.271 , pp. 26267-26275
    • Keller, E.T.1    Chang, C.2    Ershler, W.B.3
  • 39
    • 0038036872 scopus 로고    scopus 로고
    • Constitutive activation of nuclear factor kappaB p50/p65 and Fra-1 and JunD is essential for deregulated interleukin 6 expression in prostate cancer
    • Zerbini LF, Wang Y, Cho JY, Libermann TA (2003) Constitutive activation of nuclear factor kappaB p50/p65 and Fra-1 and JunD is essential for deregulated interleukin 6 expression in prostate cancer. Cancer Res 63:2206-2215
    • (2003) Cancer Res , vol.63 , pp. 2206-2215
    • Zerbini, L.F.1    Wang, Y.2    Cho, J.Y.3    Libermann, T.A.4
  • 40
    • 0033963825 scopus 로고    scopus 로고
    • Enhanced GBX2 expression stimulates growth of human prostate cancer cells via transcriptional up-regulation of the interleukin 6 gene
    • Gao AC, Lou W, Isaacs JT (2000) Enhanced GBX2 expression stimulates growth of human prostate cancer cells via transcriptional up-regulation of the interleukin 6 gene. Clin Cancer Res 6:493-497
    • (2000) Clin Cancer Res , vol.6 , pp. 493-497
    • Gao, A.C.1    Lou, W.2    Isaacs, J.T.3
  • 41
    • 0034730176 scopus 로고    scopus 로고
    • Stat3-interacting protein (StIP1) regulates cytokine signal transduction
    • Collum RG, Brutsaert S, Lee G, Schindler C.A (2000) Stat3-interacting protein (StIP1) regulates cytokine signal transduction. Proc Natl Acad Sci USA 97:10120-10125
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 10120-10125
    • Collum, R.G.1    Brutsaert, S.2    Lee, G.3    Schindler, C.A.4
  • 42
    • 0034658541 scopus 로고    scopus 로고
    • Roles of STAT3 in mediating the cell growth, differentiation and survival signals relayed through the IL-6 family of cytokine receptors
    • Hirano T, Ishihara K, Hibi M (2000) Roles of STAT3 in mediating the cell growth, differentiation and survival signals relayed through the IL-6 family of cytokine receptors. Oncogene 19:2548-2556
    • (2000) Oncogene , vol.19 , pp. 2548-2556
    • Hirano, T.1    Ishihara, K.2    Hibi, M.3
  • 43
    • 0025677214 scopus 로고
    • Expression of the interleukin 6 receptor and interleukin 6 in prostate carcinoma cells
    • Siegall CB, Schwab G, Nordan RP, FitzGerald DJ, Pastan I (1990) Expression of the interleukin 6 receptor and interleukin 6 in prostate carcinoma cells. Cancer Res 50:7786-7788
    • (1990) Cancer Res , vol.50 , pp. 7786-7788
    • Siegall, C.B.1    Schwab, G.2    Nordan, R.P.3    FitzGerald, D.J.4    Pastan, I.5
  • 44
    • 0028209796 scopus 로고
    • Interleukin 6 receptor mRNA in prostate carcinomas and benign prostate hyperplasia
    • Siegsmund MJ, Yamazaki H, Pastan I (1994) Interleukin 6 receptor mRNA in prostate carcinomas and benign prostate hyperplasia. J Urol 151:1396-1399
    • (1994) J Urol , vol.151 , pp. 1396-1399
    • Siegsmund, M.J.1    Yamazaki, H.2    Pastan, I.3
  • 45
    • 0031014669 scopus 로고    scopus 로고
    • Interleukin-6 as a paracrine and autocrine growth factor in human prostatic carcinoma cells in vitro
    • Okamoto M, Lee C, Oyasu R (1997) Interleukin-6 as a paracrine and autocrine growth factor in human prostatic carcinoma cells in vitro. Cancer Res 57:141-146
    • (1997) Cancer Res , vol.57 , pp. 141-146
    • Okamoto, M.1    Lee, C.2    Oyasu, R.3
  • 46
    • 0033988528 scopus 로고    scopus 로고
    • Interleukin-6 activates phosphatidylinositol-3 kinase, which inhibits apoptosis in human prostate cancer cell lines
    • Chung TD, Yu JJ, Kong TA, Spiotto MT, Lin JM (2000) Interleukin-6 activates phosphatidylinositol-3 kinase, which inhibits apoptosis in human prostate cancer cell lines. Prostate 42:1-7
    • (2000) Prostate , vol.42 , pp. 1-7
    • Chung, T.D.1    Yu, J.J.2    Kong, T.A.3    Spiotto, M.T.4    Lin, J.M.5
  • 49
    • 0033551110 scopus 로고    scopus 로고
    • Interleukin-6 induces G1 arrest through induction of p27 (Kip1), a cyclin-dependent kinase inhibitor, and neuron-like morphology in LNCaP prostate tumor cells
    • Mori S, Murakami-Mori K, Bonavida B (1999) Interleukin-6 induces G1 arrest through induction of p27 (Kip1), a cyclin-dependent kinase inhibitor, and neuron-like morphology in LNCaP prostate tumor cells. Biochem Biophys Res Commun 257:609-614
    • (1999) Biochem Biophys Res Commun , vol.257 , pp. 609-614
    • Mori, S.1    Murakami-Mori, K.2    Bonavida, B.3
  • 50
    • 0034651796 scopus 로고    scopus 로고
    • STAT3 mediates IL-6-induced neuroendocrine differentiation in prostate cancer cells
    • Spiotto MT, Chung TD (2000) STAT3 mediates IL-6-induced neuroendocrine differentiation in prostate cancer cells. Prostate 42:186-195
    • (2000) Prostate , vol.42 , pp. 186-195
    • Spiotto, M.T.1    Chung, T.D.2
  • 51
    • 17144411462 scopus 로고    scopus 로고
    • C/EBPdelta is a downstream mediator of IL-6 induced growth inhibition of prostate cancer cells
    • Sanford DC, Dewille JW (2005) C/EBPdelta is a downstream mediator of IL-6 induced growth inhibition of prostate cancer cells. Prostate 63:143-154
    • (2005) Prostate , vol.63 , pp. 143-154
    • Sanford, D.C.1    Dewille, J.W.2
  • 52
    • 0034817053 scopus 로고    scopus 로고
    • Prostate cancer cells (LNCaP) generated after long-term interleukin 6 (IL-6) treatment express IL-6 and acquire an IL-6 partially resistant phenotype
    • Hobisch A, Ramoner R, Fuchs D, Godoy-Tundidor S, Bartsch G, Klocker H, Culig Z (2001) Prostate cancer cells (LNCaP) generated after long-term interleukin 6 (IL-6) treatment express IL-6 and acquire an IL-6 partially resistant phenotype. Clin Cancer Res 7:2941-2948
    • (2001) Clin Cancer Res , vol.7 , pp. 2941-2948
    • Hobisch, A.1    Ramoner, R.2    Fuchs, D.3    Godoy-Tundidor, S.4    Bartsch, G.5    Klocker, H.6    Culig, Z.7
  • 53
    • 0037331278 scopus 로고    scopus 로고
    • Accelerated in vivo growth of prostate tumors that up-regulate interleukin-6 is associated with reduced retinoblastoma protein expression and activation of the mitogen-activated protein kinase pathway
    • Steiner H, Godoy-Tundidor S, Rogatsch H, Berger AP, Fuchs D, Comuzzi B, Bartsch G, Hobisch A, Culig Z (2003) Accelerated in vivo growth of prostate tumors that up-regulate interleukin-6 is associated with reduced retinoblastoma protein expression and activation of the mitogen-activated protein kinase pathway. Am J Pathol 162:655-663
    • (2003) Am J Pathol , vol.162 , pp. 655-663
    • Steiner, H.1    Godoy-Tundidor, S.2    Rogatsch, H.3    Berger, A.P.4    Fuchs, D.5    Comuzzi, B.6    Bartsch, G.7    Hobisch, A.8    Culig, Z.9
  • 54
    • 0033451992 scopus 로고    scopus 로고
    • Synergistic roles for Pim-1 and c-Myc in STAT3-mediated cell cycle progression and antiapoptosis
    • Shirogane T, Fukada T, Muller JM, Shima DT, Hibi M, Hirano T (1999) Synergistic roles for Pim-1 and c-Myc in STAT3-mediated cell cycle progression and antiapoptosis. Immunity 11:709-719
    • (1999) Immunity , vol.11 , pp. 709-719
    • Shirogane, T.1    Fukada, T.2    Muller, J.M.3    Shima, D.T.4    Hibi, M.5    Hirano, T.6
  • 55
    • 0035504081 scopus 로고    scopus 로고
    • Transcriptional regulation of bcl-2 by nuclear factor kappa B and its significance in prostate cancer
    • Catz SD, Johnson JL (2001) Transcriptional regulation of bcl-2 by nuclear factor kappa B and its significance in prostate cancer. Oncogene 20:7342-7351
    • (2001) Oncogene , vol.20 , pp. 7342-7351
    • Catz, S.D.1    Johnson, J.L.2
  • 56
    • 0032516898 scopus 로고    scopus 로고
    • Transcriptional activation of the p21(WAF1,CIP1,SDI1) gene by interleukin-6 type cytokines. A prerequisite for their pro-differentiating and anti-apoptotic effects on human osteoblastic cells
    • Bellido T, O'Brien CA, Roberson PK, Manolagas SC (1998) Transcriptional activation of the p21(WAF1,CIP1,SDI1) gene by interleukin-6 type cytokines. A prerequisite for their pro-differentiating and anti-apoptotic effects on human osteoblastic cells. J Biol Chem 273:21137-21144
    • (1998) J Biol Chem , vol.273 , pp. 21137-21144
    • Bellido, T.1    O'Brien, C.A.2    Roberson, P.K.3    Manolagas, S.C.4
  • 57
    • 0037108955 scopus 로고    scopus 로고
    • p300 mediates androgen-independent transactivation of the androgen receptor by interleukin 6
    • Debes JD, Schmidt LJ, Huang H, Tindall DJ (2002) p300 mediates androgen-independent transactivation of the androgen receptor by interleukin 6. Cancer Res 62:5632-5636
    • (2002) Cancer Res , vol.62 , pp. 5632-5636
    • Debes, J.D.1    Schmidt, L.J.2    Huang, H.3    Tindall, D.J.4
  • 58
    • 0034901655 scopus 로고    scopus 로고
    • Interleukin-6 induces androgen responsiveness in prostate cancer cells through up-regulation of androgen receptor expression
    • Lin DL, Whitney MC, Yao Z, Keller ET (2001) Interleukin-6 induces androgen responsiveness in prostate cancer cells through up-regulation of androgen receptor expression. Clin Cancer Res 7:1773-1781
    • (2001) Clin Cancer Res , vol.7 , pp. 1773-1781
    • Lin, D.L.1    Whitney, M.C.2    Yao, Z.3    Keller, E.T.4
  • 59
    • 0343238244 scopus 로고    scopus 로고
    • Interleukin 6 activates androgen receptor-mediated gene expression through a signal transducer and activator of transcription 3-dependent pathway in LNCaP prostate cancer cells
    • Chen T, Wang LH, Farrar WL (2000) Interleukin 6 activates androgen receptor-mediated gene expression through a signal transducer and activator of transcription 3-dependent pathway in LNCaP prostate cancer cells. Cancer Res. 60:2132-2135
    • (2000) Cancer Res. , vol.60 , pp. 2132-2135
    • Chen, T.1    Wang, L.H.2    Farrar, W.L.3
  • 60
    • 0032532688 scopus 로고    scopus 로고
    • Interleukin-6 regulates prostate-specific protein expression in prostate carcinoma cells by activation of the androgen receptor
    • Hobisch A, Eder IE, Putz T, Horninger W, Bartsch G, Klocker H, Culig Z (1998) Interleukin-6 regulates prostate-specific protein expression in prostate carcinoma cells by activation of the androgen receptor. Cancer Res 58:4640-4645
    • (1998) Cancer Res , vol.58 , pp. 4640-4645
    • Hobisch, A.1    Eder, I.E.2    Putz, T.3    Horninger, W.4    Bartsch, G.5    Klocker, H.6    Culig, Z.7
  • 61
    • 0037564511 scopus 로고    scopus 로고
    • Interleukin-6 differentially regulates androgen receptor transactivation via PI3K-Akt, STAT3, and MAPK, three distinct signal pathways in prostate cancer cells
    • Yang L, Wang L, Lin HK, Kan PY, Xie S, Tsai MY, Wang PH, Chen YT, Chang C (2003) Interleukin-6 differentially regulates androgen receptor transactivation via PI3K-Akt, STAT3, and MAPK, three distinct signal pathways in prostate cancer cells. Biochem Biophys Res Commun 305:462-469
    • (2003) Biochem Biophys Res Commun , vol.305 , pp. 462-469
    • Yang, L.1    Wang, L.2    Lin, H.K.3    Kan, P.Y.4    Xie, S.5    Tsai, M.Y.6    Wang, P.H.7    Chen, Y.T.8    Chang, C.9
  • 62
    • 0036510548 scopus 로고    scopus 로고
    • Activation of the androgen receptor N-terminal domain by interleukin-6 via MAPK and STAT3 signal transduction pathways
    • Ueda T, Bruchovsky N, Sadar MD (2002) Activation of the androgen receptor N-terminal domain by interleukin-6 via MAPK and STAT3 signal transduction pathways. J Biol Chem 277:7076-7085
    • (2002) J Biol Chem , vol.277 , pp. 7076-7085
    • Ueda, T.1    Bruchovsky, N.2    Sadar, M.D.3
  • 63
    • 0037447330 scopus 로고    scopus 로고
    • Constitutive activation of the Ras/mitogen-activated protein kinase signaling pathway promotes androgen hypersensitivity in LNCaP prostate cancer cells
    • Bakin RE, Gioeli D, Sikes SA, Bissonette EA, Weber MJ (2003) Constitutive activation of the Ras/mitogen-activated protein kinase signaling pathway promotes androgen hypersensitivity in LNCaP prostate cancer cells. Cancer Res. 63:1981-1989
    • (2003) Cancer Res. , vol.63 , pp. 1981-1989
    • Bakin, R.E.1    Gioeli, D.2    Sikes, S.A.3    Bissonette, E.A.4    Weber, M.J.5
  • 64
    • 0035912833 scopus 로고    scopus 로고
    • Akt suppresses androgen induced apoptosis by phosphorylating and inhibiting androgen receptor
    • Lin HK, Yeh S, Kang HY, Chang C (2001) Akt suppresses androgen induced apoptosis by phosphorylating and inhibiting androgen receptor. Proc Natl Acad Sci USA 98:7200-7205
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 7200-7205
    • Lin, H.K.1    Yeh, S.2    Kang, H.Y.3    Chang, C.4
  • 65
    • 0037930810 scopus 로고    scopus 로고
    • APPL suppresses androgen receptor transactivation via potentiating Akt activity
    • Yang L, Lin HK, Altuwaijri S, Xie S, Wang L, Chang C (2003) APPL suppresses androgen receptor transactivation via potentiating Akt activity. J Biol Chem 278:16820-16827
    • (2003) J Biol Chem , vol.278 , pp. 16820-16827
    • Yang, L.1    Lin, H.K.2    Altuwaijri, S.3    Xie, S.4    Wang, L.5    Chang, C.6
  • 67
    • 21344441226 scopus 로고    scopus 로고
    • p300 regulates androgen receptor-independent expression of prostate-specific antigen in prostate cancer cells treated chronically with interleukin-6
    • Debes JD, Comuzzi B, Schmidt LJ, Dehm SM, Culig Z, Tindall DJ (2005) p300 regulates androgen receptor-independent expression of prostate-specific antigen in prostate cancer cells treated chronically with interleukin-6. Cancer Res 65:5965-5973
    • (2005) Cancer Res , vol.65 , pp. 5965-5973
    • Debes, J.D.1    Comuzzi, B.2    Schmidt, L.J.3    Dehm, S.M.4    Culig, Z.5    Tindall, D.J.6
  • 69
    • 0347696003 scopus 로고    scopus 로고
    • Suppression versus induction of androgen receptor functions by the phosphatidylinositol 3-kinase/Akt pathway in prostate cancer LNCaP cells with different passage numbers
    • Lin HK, Hu YC, Yang L, Altuwaijri S, Chen YT, Kang HY, Chang C (2003) Suppression versus induction of androgen receptor functions by the phosphatidylinositol 3-kinase/Akt pathway in prostate cancer LNCaP cells with different passage numbers. J Biol Chem 278:50902-50907
    • (2003) J Biol Chem , vol.278 , pp. 50902-50907
    • Lin, H.K.1    Hu, Y.C.2    Yang, L.3    Altuwaijri, S.4    Chen, Y.T.5    Kang, H.Y.6    Chang, C.7
  • 71
    • 2442685366 scopus 로고    scopus 로고
    • Regulation of interleukin-6-mediated PI3K activation and neuroendocrine differentiation by androgen signaling in prostate cancer LNCaP cells
    • Xie S, Lin HK, Ni J, Yang L, Wang L, di Sant'Agnese PA, Chang C (2004) Regulation of interleukin-6-mediated PI3K activation and neuroendocrine differentiation by androgen signaling in prostate cancer LNCaP cells. Prostate 60:61-67
    • (2004) Prostate , vol.60 , pp. 61-67
    • Xie, S.1    Lin, H.K.2    Ni, J.3    Yang, L.4    Wang, L.5    di Sant'Agnese, P.A.6    Chang, C.7
  • 72
    • 12344314055 scopus 로고    scopus 로고
    • Constitutive activation of gp130 leads to neuroendocrine differentiation in vitro and in vivo
    • Palmer J, Ernst M, Hammacher A, Hertzog PJ (2005) Constitutive activation of gp130 leads to neuroendocrine differentiation in vitro and in vivo. Prostate 62:282-289
    • (2005) Prostate , vol.62 , pp. 282-289
    • Palmer, J.1    Ernst, M.2    Hammacher, A.3    Hertzog, P.J.4
  • 73
    • 0041833727 scopus 로고    scopus 로고
    • Androgen receptor represses the neuroendocrine transdifferentiation process in prostate cancer cells
    • Wright M, Tsai M, Aebersold R (2003) Androgen receptor represses the neuroendocrine transdifferentiation process in prostate cancer cells. Mol Endocrinol 17:1726-1737
    • (2003) Mol Endocrinol , vol.17 , pp. 1726-1737
    • Wright, M.1    Tsai, M.2    Aebersold, R.3
  • 74
    • 31944445413 scopus 로고    scopus 로고
    • Genetic analysis of neuroendocrine tumor cells in prostatic carcinoma
    • Sauer CG, Roemer A, Grobholz R (2006) Genetic analysis of neuroendocrine tumor cells in prostatic carcinoma. Prostate 66:227-234
    • (2006) Prostate , vol.66 , pp. 227-234
    • Sauer, C.G.1    Roemer, A.2    Grobholz, R.3
  • 76
    • 0038079838 scopus 로고    scopus 로고
    • Bombesin stimulates nuclear factor kappa B activation and expression of proangiogenic factors in prostate cancer cells
    • Levine L, Lucci JA 3rd, Pazdrak B, Cheng JZ, Guo YS, Townsend CM Jr, Hellmich MR (2003) Bombesin stimulates nuclear factor kappa B activation and expression of proangiogenic factors in prostate cancer cells. Cancer Res 63:3495-3502
    • (2003) Cancer Res , vol.63 , pp. 3495-3502
    • Levine, L.1    Lucci III, J.A.2    Pazdrak, B.3    Cheng, J.Z.4    Guo, Y.S.5    Townsend Jr., C.M.6    Hellmich, M.R.7
  • 77
    • 22144449607 scopus 로고    scopus 로고
    • Constitutive activation of P I3 K-Akt and NF-kappaB during prostate cancer progression in autochthonous transgenic mouse model
    • Shukla S, Maclennan GT, Marengo SR, Resnick MI, Gupta S (2005) Constitutive activation of P I3 K-Akt and NF-kappaB during prostate cancer progression in autochthonous transgenic mouse model. Prostate 64:224-239
    • (2005) Prostate , vol.64 , pp. 224-239
    • Shukla, S.1    Maclennan, G.T.2    Marengo, S.R.3    Resnick, M.I.4    Gupta, S.5
  • 79
    • 0033022342 scopus 로고    scopus 로고
    • A mechanism for hormone-independent prostate cancer through modulation of androgen receptor signaling by the HER-2/neu tyrosine kinase
    • Craft N, Shostak Y, Carey M, Sawyers CL (1999) A mechanism for hormone-independent prostate cancer through modulation of androgen receptor signaling by the HER-2/neu tyrosine kinase. Nat Med 5:280-285
    • (1999) Nat Med , vol.5 , pp. 280-285
    • Craft, N.1    Shostak, Y.2    Carey, M.3    Sawyers, C.L.4
  • 80
    • 0033545848 scopus 로고    scopus 로고
    • From HER2/Neu signal cascade to androgen receptor and its coactivators: A novel pathway by induction of androgen target genes through MAP kinase in prostate cancer cells
    • Yeh S, Lin HK, Kang HY, Thin TH, Lin MF, Chang C (1999) From HER2/Neu signal cascade to androgen receptor and its coactivators: A novel pathway by induction of androgen target genes through MAP kinase in prostate cancer cells. Proc Natl Acad Sci USA 96:5458-5463
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 5458-5463
    • Yeh, S.1    Lin, H.K.2    Kang, H.Y.3    Thin, T.H.4    Lin, M.F.5    Chang, C.6
  • 81
    • 0032492879 scopus 로고    scopus 로고
    • Requirement of ErbB2 for signalling by interleukin-6 in prostate carcinoma cells
    • Qiu Y, Ravi L, Kung HJ (1998) Requirement of ErbB2 for signalling by interleukin-6 in prostate carcinoma cells. Nature 393:83-85
    • (1998) Nature , vol.393 , pp. 83-85
    • Qiu, Y.1    Ravi, L.2    Kung, H.J.3
  • 82
    • 25444494484 scopus 로고    scopus 로고
    • EGFR and Her-2 regulate the constitutive activation of NF-kappaB in PC-3 prostate cancer cells
    • Le Page C, Koumakpayi IH, Lessard L, Mes-Masson AM, Saad F (2005) EGFR and Her-2 regulate the constitutive activation of NF-kappaB in PC-3 prostate cancer cells. Prostate 65:130-140
    • (2005) Prostate , vol.65 , pp. 130-140
    • Le Page, C.1    Koumakpayi, I.H.2    Lessard, L.3    Mes-Masson, A.M.4    Saad, F.5
  • 83
    • 0034660281 scopus 로고    scopus 로고
    • Bisphosphonates in the management of prostate carcinoma metastatic to the skeleton
    • Papapoulos SE, Hamdy NA, van der Pluijm G (2000) Bisphosphonates in the management of prostate carcinoma metastatic to the skeleton. Cancer 88(12 Suppl):3047-3053
    • (2000) Cancer , vol.88 , Issue.12 SUPPL. , pp. 3047-3053
    • Papapoulos, S.E.1    Hamdy, N.A.2    van der Pluijm, G.3
  • 85
    • 0034284970 scopus 로고    scopus 로고
    • Bone resorption by osteoclasts
    • Teitelbaum S (2000) Bone resorption by osteoclasts, Science 289:504-508
    • (2000) Science , vol.289 , pp. 504-508
    • Teitelbaum, S.1
  • 88
    • 0000057945 scopus 로고    scopus 로고
    • Alteration of the hormonal bioactivity of parathyroid hormone-related protein (PTHrP) as a result of limited proteolysis by prostate-specific antigen
    • Iwamura M, Hellman J, Cockett AT, Lilja H, Gershagen S. (1996) Alteration of the hormonal bioactivity of parathyroid hormone-related protein (PTHrP) as a result of limited proteolysis by prostate-specific antigen. Urology 48:317-325
    • (1996) Urology , vol.48 , pp. 317-325
    • Iwamura, M.1    Hellman, J.2    Cockett, A.T.3    Lilja, H.4    Gershagen, S.5
  • 89
    • 0142008439 scopus 로고    scopus 로고
    • The addition of interleukin-6 soluble receptor and transforming growth factor beta1 improves a preoperative nomogram for predicting biochemical progression in patients with clinically localized prostate cancer
    • Kattan MW, Shariat SF, Andrews B, Zhu K, Canto E, Matsumoto K, Muramoto M, Scardino PT, Ohori M, Wheeler TM, Slawin KM (2003) The addition of interleukin-6 soluble receptor and transforming growth factor beta1 improves a preoperative nomogram for predicting biochemical progression in patients with clinically localized prostate cancer. J Clin Oncol 21:3573-3579
    • (2003) J Clin Oncol , vol.21 , pp. 3573-3579
    • Kattan, M.W.1    Shariat, S.F.2    Andrews, B.3    Zhu, K.4    Canto, E.5    Matsumoto, K.6    Muramoto, M.7    Scardino, P.T.8    Ohori, M.9    Wheeler, T.M.10    Slawin, K.M.11
  • 90
    • 8544283079 scopus 로고    scopus 로고
    • Endogenous inhibitors of nuclear factor-kappaB, an opportunity for cancer control
    • Chen F (2004) Endogenous inhibitors of nuclear factor-kappaB, an opportunity for cancer control. Cancer Res 64:8135-81358
    • (2004) Cancer Res , vol.64 , pp. 8135-81358
    • Chen, F.1
  • 91
    • 0027980321 scopus 로고
    • The ubiquitin-proteasome pathway is required for processing the NF-κB precursor protein and the activation of NF-κB
    • Palombella VJ, Rando OJ, Goldberg AL, Maniatis T (1994) The ubiquitin-proteasome pathway is required for processing the NF-κB precursor protein and the activation of NF-κB. Cell 78:773-785
    • (1994) Cell , vol.78 , pp. 773-785
    • Palombella, V.J.1    Rando, O.J.2    Goldberg, A.L.3    Maniatis, T.4
  • 92
    • 0033920566 scopus 로고    scopus 로고
    • Protease inhibitor-induced apoptosis: Accumulation of wt 53, p21 WAF1/ CIP1, and induction of apoptosis are independent markers of proteasome inhibition
    • An WG, Hwang SG, Trepel JB, Blagosklonny MV (2000) Protease inhibitor-induced apoptosis: Accumulation of wt 53, p21 WAF1/CIP1, and induction of apoptosis are independent markers of proteasome inhibition. Leukemia 14:1276-1283
    • (2000) Leukemia , vol.14 , pp. 1276-1283
    • An, W.G.1    Hwang, S.G.2    Trepel, J.B.3    Blagosklonny, M.V.4
  • 93
    • 0035328584 scopus 로고    scopus 로고
    • Enhanced chemosensitivity to CPT-11 with proteasome inhibitor PS-341: Implications for systemic nuclear factor-kappaB inhibition
    • Cusack JC Jr, Liu R, Houston M, Abendroth K, Elliott PJ, Adams J, Baldwin AS Jr (2001) Enhanced chemosensitivity to CPT-11 with proteasome inhibitor PS-341: Implications for systemic nuclear factor-kappaB inhibition. Cancer Res 61:3535-3540
    • (2001) Cancer Res , vol.61 , pp. 3535-3540
    • Cusack Jr., J.C.1    Liu, R.2    Houston, M.3    Abendroth, K.4    Elliott, P.J.5    Adams, J.6    Baldwin Jr., A.S.7
  • 94
    • 0035849720 scopus 로고    scopus 로고
    • Blockade of NF-kappaB activity in human prostate cancer cells is associated with suppression of angiogenesis, invasion, and metastasis
    • Huang S, Pettaway CA, Uehara H (2001) Blockade of NF-kappaB activity in human prostate cancer cells is associated with suppression of angiogenesis, invasion, and metastasis. Oncogene 20:4188-4197
    • (2001) Oncogene , vol.20 , pp. 4188-4197
    • Huang, S.1    Pettaway, C.A.2    Uehara, H.3
  • 95
    • 0032481131 scopus 로고    scopus 로고
    • Prostate carcinoma cell death resulting from inhibition of proteasome activity is independent of functional Bcl-2 and p53
    • Herrmann JL, Briones F Jr, Brisbay S, Logothetis CJ, McDonnell TJ (1998) Prostate carcinoma cell death resulting from inhibition of proteasome activity is independent of functional Bcl-2 and p53. Oncogene 17:2889-2899
    • (1998) Oncogene , vol.17 , pp. 2889-2899
    • Herrmann, J.L.1    Briones Jr., F.2    Brisbay, S.3    Logothetis, C.J.4    McDonnell, T.J.5
  • 96
    • 0035300479 scopus 로고    scopus 로고
    • The proteasome inhibitor PS-341 inhibits growth, induces apoptosis, and overcomes drug resistance in human multiple myeloma cells
    • Hideshima T, Richardson P, Chauhan D, Palombella VJ, Elliott PJ, Adams J, Anderson KC (2001) The proteasome inhibitor PS-341 inhibits growth, induces apoptosis, and overcomes drug resistance in human multiple myeloma cells. Cancer Res 61:3071-3076
    • (2001) Cancer Res , vol.61 , pp. 3071-3076
    • Hideshima, T.1    Richardson, P.2    Chauhan, D.3    Palombella, V.J.4    Elliott, P.J.5    Adams, J.6    Anderson, K.C.7
  • 99
    • 19944428834 scopus 로고    scopus 로고
    • Small molecule inhibitors of IkappaB kinase are selectively toxic for subgroups of diffuse large B-cell lymphoma defined by gene expression profiling
    • Lam LT, Davis RE, Pierce J, Hepperle M, Xu Y, Hottelet M, Nong Y, Wen D, Adams J, Dang L, Staudt LM (2005) Small molecule inhibitors of IkappaB kinase are selectively toxic for subgroups of diffuse large B-cell lymphoma defined by gene expression profiling. Clin Cancer Res 11:28-40
    • (2005) Clin Cancer Res , vol.11 , pp. 28-40
    • Lam, L.T.1    Davis, R.E.2    Pierce, J.3    Hepperle, M.4    Xu, Y.5    Hottelet, M.6    Nong, Y.7    Wen, D.8    Adams, J.9    Dang, L.10    Staudt, L.M.11
  • 101
    • 0035933772 scopus 로고    scopus 로고
    • Inhibition of NF-kappa B activity by thalidomide through suppression of IkappaB kinase activity
    • Keifer JA, Guttridge DC, Ashburner BP, Baldwin AS Jr (2001) Inhibition of NF-kappa B activity by thalidomide through suppression of IkappaB kinase activity. J Biol Chem 276:22382-22387
    • (2001) J Biol Chem , vol.276 , pp. 22382-22387
    • Keifer, J.A.1    Guttridge, D.C.2    Ashburner, B.P.3    Baldwin Jr., A.S.4
  • 102
    • 34648878668 scopus 로고    scopus 로고
    • Thalidomide and its analogues as cyclooxygenase inhibitors
    • Noguchi T, Shimazawa R, Nagasawa K (2002) Thalidomide and its analogues as cyclooxygenase inhibitors. Bioorg Med Chem Lett 54:31-38
    • (2002) Bioorg Med Chem Lett , vol.54 , pp. 31-38
    • Noguchi, T.1    Shimazawa, R.2    Nagasawa, K.3
  • 104
    • 2942711726 scopus 로고    scopus 로고
    • Thalidomid: Current role in the treatment of non-plasma cell malignancies
    • Erratum in: J Clin Oncol 2004 22:2973
    • Kumar S, Witzig TE, Rajkumar SV (2004) Thalidomid: Current role in the treatment of non-plasma cell malignancies. J Clin Oncol 22:2477-2488. Erratum in: J Clin Oncol 2004 22:2973
    • (2004) J Clin Oncol , vol.22 , pp. 2477-2488
    • Kumar, S.1    Witzig, T.E.2    Rajkumar, S.V.3
  • 107
    • 0030615201 scopus 로고    scopus 로고
    • Nuclear factor-kappaB: A pivotal transcription factor in chronic inflammatory diseases
    • Barnes PJ, Karin M (1997) Nuclear factor-kappaB: A pivotal transcription factor in chronic inflammatory diseases. N Engl J Med 336:1066-1071
    • (1997) N Engl J Med , vol.336 , pp. 1066-1071
    • Barnes, P.J.1    Karin, M.2
  • 109
    • 0035992417 scopus 로고    scopus 로고
    • Inhibition of nuclear factor (B activation in PC3 cells by genistein is mediated via Akt signaling pathway
    • Li Y, Sarkar FH (2002) Inhibition of nuclear factor (B activation in PC3 cells by genistein is mediated via Akt signaling pathway. Clin Cancer Res 8:2369-2377
    • (2002) Clin Cancer Res , vol.8 , pp. 2369-2377
    • Li, Y.1    Sarkar, F.H.2
  • 110
    • 33646727546 scopus 로고    scopus 로고
    • Genistein inhibits radiation-induced activation of NF-kappaB in prostate cancer cells promoting apoptosis and G2/M cell cycle arrest
    • Raffoul JJ, Wang Y, Kucuk O, Forman JD, Sarkar FH, Hillman GG (2006) Genistein inhibits radiation-induced activation of NF-kappaB in prostate cancer cells promoting apoptosis and G2/M cell cycle arrest. BMC Cancer 6:107
    • (2006) BMC Cancer , vol.6 , pp. 107
    • Raffoul, J.J.1    Wang, Y.2    Kucuk, O.3    Forman, J.D.4    Sarkar, F.H.5    Hillman, G.G.6
  • 111
    • 33646397565 scopus 로고    scopus 로고
    • Antitumor, antimetastatic activities of docetaxel are enhanced by genistein through regulation of osteoprotegerin/receptor activator of nuclear factor-kappaB (RANK)/RANK ligand/MMP-9 signaling in prostate cancer
    • Li Y, Kucuk O, Hussain M, Abrams J, Cher ML, Sarkar FH (2006) Antitumor, antimetastatic activities of docetaxel are enhanced by genistein through regulation of osteoprotegerin/receptor activator of nuclear factor-kappaB (RANK)/RANK ligand/MMP-9 signaling in prostate cancer. Cancer Res 66:4816-4825
    • (2006) Cancer Res , vol.66 , pp. 4816-4825
    • Li, Y.1    Kucuk, O.2    Hussain, M.3    Abrams, J.4    Cher, M.L.5    Sarkar, F.H.6
  • 113
    • 0034163461 scopus 로고    scopus 로고
    • Inhibition of constitutively activated Stat3 signaling pathway suppresses growth of prostate cancer cells
    • Ni Z, Lou W, Leman ES, Gao AC (2000) Inhibition of constitutively activated Stat3 signaling pathway suppresses growth of prostate cancer cells. Cancer Res 60:1225-1228
    • (2000) Cancer Res , vol.60 , pp. 1225-1228
    • Ni, Z.1    Lou, W.2    Leman, E.S.3    Gao, A.C.4
  • 114
    • 13944250650 scopus 로고    scopus 로고
    • In vivo antitumor efficacy of STAT3 blockade using a transcription factor decoy approach: Implications for cancer therapy
    • Xi S, Gooding WE, Grandis JR (2005) In vivo antitumor efficacy of STAT3 blockade using a transcription factor decoy approach: Implications for cancer therapy. Oncogene 24:970-979
    • (2005) Oncogene , vol.24 , pp. 970-979
    • Xi, S.1    Gooding, W.E.2    Grandis, J.R.3


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