Interleukin 6 activates androgen receptor-mediated gene expression through a signal transducer and activator of transcription 3-dependent pathway in LNCaP prostate cancer cells

Cancer Research

Volumn 60, Issue 8, 2000, Pages 2132-2135

  Chen, Taosheng ^a,b   Wang, Li Hua ^b   Farrar, William L ^b  

^a SAIC FREDERICK INC   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; ANDROGEN RECEPTOR; INTERLEUKIN 6; MITOGEN ACTIVATED PROTEIN KINASE; TRANSCRIPTION FACTOR;

ANIMAL CELL; ARTICLE; CANCER GROWTH; CELL LYSATE; ENZYME ACTIVITY; ENZYME INHIBITION; GENE EXPRESSION; GENE MUTATION; GENETIC TRANSCRIPTION; GENETIC TRANSFECTION; IMMUNE RESPONSE; IMMUNOPRECIPITATION; NONHUMAN; PRIORITY JOURNAL; PROSTATE CANCER; REPORTER GENE; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

CARRIER PROTEINS; DISEASE PROGRESSION; DNA-BINDING PROTEINS; ENZYME ACTIVATION; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, REPORTER; HUMANS; INTERLEUKIN-6; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; JANUS KINASE 2; MALE; METRIBOLONE; MITOGEN-ACTIVATED PROTEIN KINASES; MUTATION; PROSTATIC NEOPLASMS; PROTEIN BINDING; PROTEIN-TYROSINE KINASES; PROTEINS; PROTO-ONCOGENE PROTEINS; RECEPTORS, ANDROGEN; REPRESSOR PROTEINS; RESPONSE ELEMENTS; SIGNAL TRANSDUCTION; STAT3 TRANSCRIPTION FACTOR; SUPPRESSOR OF CYTOKINE SIGNALING PROTEINS; TESTOSTERONE CONGENERS; TRANS-ACTIVATORS; TRANSFECTION; TUMOR CELLS, CULTURED;

EID: 0343238244     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (30)

1. Gaddipati, J. P., McLeod, D. G., Heidenberg, H. B., Sesterhenn, I. A., Finger, M. J., Moul, J. W., and Srivastava, S. Frequent detection of codon 877 mutation in the androgen receptor gene in advanced prostate cancers. Cancer Res., 54: 2861-2864, 1994.
2. Visakorpi, T., Hyytinen, E., Koivisto, P., Tanner, M., Keinanen, R., Palmberg, C., Palotie, A., Tammela, T., Isola, J., and Kallionierni, O. P. In vivo amplification of the androgen receptor gene and progression of human prostate cancer. Nat. Genet., 9: 401-406, 1995.
3. Craft, N., Shostak, Y., Carey, M., and Sawyers, C. L. A mechanism for hormone-independent prostate cancer through modulation of androgen receptor signaling by the HER-2/neu tyrosine kinase. Nat. Med., 5: 280-285, 1999.
4. Culig, Z., Hobisch, A., Cronauer, M. V., Radmayr, C., Trapman, J., Hittmair, A., Bartsch, G., and Klocker, H. Androgen receptor activation in prostatic tumor cell lines by insulin-like growth factor-1, keratinocyte growth factor, and epidermal growth factor. Cancer Res., 54: 5474-5478, 1994.
5. Kishimoto, T., Akira, S., and Taga, T. Interleukin-6 and its receptor: a paradigm for cytokines. Science (Washington DC), 258: 593-597, 1992.
6. Siegsmund, M. J., Yamazaki, H., and Pastan, I. Interleukin 6 receptor mRNA in prostate carcinomas and benign prostate hyperplasia. J. Urol., 151: 1396-1399, 1994.
7. Hutchins, D., and Steel, C. M. Regulation of ICAM-1 (CD54) expression in human breast cancer cell lines by interleukin 6 and fibroblast-derived factors. Int. J. Cancer, 58: 80-84, 1994.
8. Okamoto, M., Lee, C., and Oyasu, R. Interleukin-6 as a paracrine and autocrine growth factor in human prostatic carcinoma cells in vitro. Cancer Res., 57: 141-146, 1997.
9. Hobisch, A., Eder, I. E., Putz, T., Horninger, W., Bartsch, G., Klocker, H., and Culig, Z. Interleukin-6 regulates prostate-specific protein expression in prostate carcinoma cells by activation of the androgen receptor. Cancer Res., 58: 4640-4645, 1998.
10. Twillie, D. A., Eisenberger, M. A., Carducci, M. A., Hseih, W. S., Kim, W. Y., and Simons, J. W. Interleukin-6: a candidate mediator of human prostate cancer morbidity. Urology, 45: 542-549, 1995.
11. Hoosein, N., Abdul, M., McCabe, R., Gero, E., Deftos, L., Banks, M., Hodges, S., Finn, L., and Logothetis, C. Clinical significance of elevation in neuroendocrine factors and interleukin-6 in metasiatic prostate cancer. Uoul. Oncol., 1: 246-251, 1995.
12. Drachenberg, D. E., Elgamal, A. A., Rowbotham, R., Peterson, M., and Murphy, G. P. Circulating levels of interleukin-6 in patients with hormone refractory prostate cancer. Prostate, 41: 127-133, 1999.
13. Siegall, C. B., Schwab, G., Nordan, R. P., FitzGerald, D. J., and Pastan, I. Expression of the interleukin 6 receptor and interleukin 6 in prostate carcinoma cells. Cancer Res., 50: 7786-7788, 1990.
14. Qiu, Y., Ravi, L., and Kung, H. J. Requirement of ErhB2 for signalling by interleukin-6 in prostate carcinoma cells. Nature (Lond.), 393: 83-85, 1998.
15. Chen, T., Cho, R. W., Stork, P. J., and Weber, M. J. Elevation of cyclic adenosine 3′,5′-monophosphate potentiates activation of mitogen-activated protein kinase by growth factors in LNCaP prostate cancer cells. Cancer Res., 59: 213-218, 1999.
16. Kato, S., Endoh, H., Masuhiro, Y., Kitamoto, T., Uchiyama, S., Sasaki, H., Masushige, S., Gotoh, Y., Nishida, E., and Kawashima, H. Activation of the estrogen receptor through phosphorylation by mitogen-activated protein kinase. Science (Washington DC), 270: 1491-1494, 1995.
17. Zhang, Z., Jones, S., Hagood, J. S., Fuentes, N. L., and Fuller, G. M. STAT3 acts as a co-activator of glucocorticoid receptor signaling. J. Biol. Chem., 272: 30607-30610, 1997.
18. Thalmann, G. N., Anezinis, P. E., Chang, S. M., Zhau, H. E., Kim, E. E., Hopwood, V. L., Pathak, S., von Eschenbach, A. C., and Chung, L. W. Androgen-independent cancer progression and bone metastasis in the LNCaP model of human prostate cancer. Cancer Res., 54: 2577-2581, 1994.
19. Minami, M., Inoue, M., Wei, S., Takeda, K., Matsumoto, M., Kishimoto, T., and Akira, S. STAT3 activation is a critical step in gp 130-mediated terminal differentiation and growth arrest of a myeloid cell line. Proc. Natl. Acad. Sci. USA, 93: 3963-3966, 1996.
20. Endo, T. A., Masuhara, M., Yokouchi, M., Suzuki, R., Sakamoto, H., Mitsui, K., Matsumoto, A., Tanimura, S., Ohtsubo, M., Misawa, H., Miyazaki, T., Leonor, N., Taniguchi, T., Fujita, T., Kanakura, Y., Komiya, S., and Yoshimura, A. A new protein containing an SH2 domain that inhibits JAK kinases. Nature (Lond), 387: 921-924, 1997.
21. Masuhara, M., Sakamoto, H., Matsumoto, A., Suzuki, R., Yasukawa, H., Mitsui, K., Wakioka, T., Tanimura, S., Sasaki, A., Misawa, H., Yokouchi, M., Ohtsubo, M., and Yoshimura, A. Cloning and characterization of novel CIS family genes. Biochem. Biophys. Res. Commun., 239: 439-446, 1997.
22. Zhang, Z., Fuentes, N. L., and Fuller, G. M. Characterization of the IL-6 responsive elements in the gamma fibrinogen gene promoter. J. Biol. Chem., 270: 24287-24291, 1995.
23. Wang, L. H., Kirken, R. A., Erwin, R. A., Yu, C. R., and Farrar, W. L. JAK3, STAT, and MAPK signaling pathways as novel molecular targets for the tyrphostin AG-490 regulation of IL-2-mediated T cell response. J. Immunol., 162: 3897-3904, 1999.
24. Froesch, B. A., Takayama, S., and Reed, J. C. BAG-IL protein enhances androgen receptor function. J. Biol. Chem., 273: 11660-11666, 1998.
25. Nakashima, K., Yanagisawa, M., Arakawa, H., Kimura, N., Hisatsune, T., Kawabata, M., Miyazono, K., and Taga, T. Synergistic signaling in fetal brain by STAT3-Smadl complex bridged hy p300. Science (Washington DC), 284: 479-482, 1999.
26. Lou, W., Ni, Z., Dyer, K., Tweardy, D. J., and Gao, A. C. Interleukin-6 induces prostate cancer cell growth accompanied by activation of STAT3 signaling pathway. Prostate, 42: 239-242, 2000.
27. Spiotto, M. T., and Chung, T. D. STAT3 mediates IL-6-induced growth inhibition in the human prostate cancer cell line LNCaP. Prostate, 42: 88-98, 2000.
28. Garcia, R., and Jove, R. Activation of STAT transcription factors in oncogenic tyrosine kinase signaling. J. Biomed. Sci., 5: 79-85, 1998.
29. Catlett-Faclone, R., Landowski, T. H., Oshiro, M. M., Turkson, J., Levitzki, A., Savino, R., Ciliberto, G., Moscinski, L., Fernandez-Luna, J. L., Nunez, G., Dalton, W. S., and Jove, R. Constitutive activation of Stat3 signaling confers resistance to apoptosis in human U266 myeloma cells. Immunity, 10: 105-115, 1999.
30. Bromberg, J. F., Wrzeszczynska, M. H., Devgan, G., Zhao, Y., Pestell, R. G., Albanese, C., and Darnell, J. E. J. Stat3 as an oncogene. Cell, 98: 295-303, 1999.