NF-κB activates prostate-specific antigen expression and is upregulated in androgen-independent prostate cancer

Molecular and Cellular Biology

Volumn 22, Issue 8, 2002, Pages 2862-2870

  Chen, Charlie D ^a   Sawyers, Charles L ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE KINASE KINASE; PROSTATE SPECIFIC ANTIGEN; TUMOR NECROSIS FACTOR ALPHA;

ANTIGEN EXPRESSION; ARTICLE; CANCER GROWTH; CARCINOGENESIS; CELL GROWTH; CELL SURVIVAL; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROSTATE CANCER; PROTEIN ANALYSIS; TRANSCRIPTION REGULATION;

ANDROGENS; ANIMALS; BINDING SITES; ENHANCER ELEMENTS (GENETICS); FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MALE; MICE; NF-KAPPA B; PROSTATE-SPECIFIC ANTIGEN; PROSTATIC NEOPLASMS; TETRADECANOYLPHORBOL ACETATE; TRANSPLANTATION, HETEROLOGOUS; TUMOR CELLS, CULTURED;

EID: 0036196320     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.22.8.2862-2870.2002     Document Type: Article

References (42)

1. Transcription activating and repressing functions of the androgen receptor are differentially influenced by mutations in the deoxyribonucleic acid binding domain
2. Mitogen-activated protein kinase kinase kinase 1 activates androgen receptor-dependent transcription and apoptosis in prostate cancer
3. Series introduction: The transcription factor NF-κB and human disease
4. Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-κB
5. TNF-α and 9-cis-retinoic acid synergistically induce ICAM-1 expression: Evidence for interaction of retinoid receptors with NF-κB
6. Donor site competition is involved in the regulation of alternative splicing of the rat β-tropomyosin pre-mRNA
7. A 6-kb promoter fragment mimics in transgenic mice the prostate-specific and androgen-regulated expression of the endogenous prostate-specific antigen gene in humans
8. Evidence for clonal outgrowth of androgen-independent prostate cancer cells from androgen-dependent tumors through a two-step process
9. A mechanism for hormone-independent prostate cancer through modulation of androgen receptor signaling by the HER-2/neu tyrosine kinase
10. Genistein inhibits NF-κB activation in prostate cancer cells
11. A cytoplasmic inhibitor of the JNK signal transduction pathway
12. NF-κB RelA-deficient lymphocytes: Normal development of T cells and B cells, impaired production of IgA and IgG1 and reduced proliferative responses
13. Multiple layers of cooperativity regulate enhanceosome-responsive RNA polymerase II transcription complex assembly
14. Phenylarsine oxide blocks interleukin-1 β-induced activation of the nuclear transcription factor NF-κB, inhibits proliferation, and induces apoptosis of acute myelogenous leukemia cells
15. Oncogenic Ha-Ras-induced signaling activates NF-κB transcriptional activity, which is required for cellular transformation
16. NF-κB and Rel proteins: Evolutionarily conserved mediators of immune responses
17. Androgen receptor stabilization in recurrent prostate cancer is associated with hypersensitivity to low androgen
18. NF-κB controls cell growth and differentiation through transcriptional regulation of cyclin D1
19. Cooperative assembly of androgen receptor into a nucleoprotein complex that regulates the prostate-specific antigen enhancer
20. Inhibition of NF-κB activity through maintenance of IκBα levels contributes to dihydrotestosterone-mediated repression of the interleukin-6 promoter
21. The RelA NF-κB subunit and the aryl hydrocarbon receptor (AhR) cooperate to transactivate the c-myc promoter in mammary cells
22. Activation of NF-κ/Rel occurs early during neoplastic transformation of mammary cells
23. Progression of metastatic human prostate cancer to androgen independence in immunodeficient SCID mice
24. Mice lacking the c-rel proto-oncogene exhibit defects in lymphocyte proliferation, humoral immunity, and interleukin-2 expression
25. Amplification and overexpression of androgen receptor gene in hormone-refractory prostate cancer
26. Rel/NF-κB/I κB story
27. Characterization of a neuronal κB binding factor distinct from NF-κB
28. Tumor necrosis factor-α-induced apoptosis in prostate cancer cells through inhibition of nuclear factor-κB by an IκBα "super-repressor"
29. Constitutive activation of NF-κB during progression of breast cancer to hormone-independent growth
30. Inhibition of nuclear factor-κB activation confers sensitivity to tumor necrosis factor-α by impairment of cell cycle progression in human glioma cells
31. Constitutive activation of IκB kinase α and NF-κB in prostate cancer cells is inhibited by ibuprofen
32. Mutual transcriptional interference between RelA and androgen receptor
33. Identification of a positive regulatory element responsible for tissue-specific expression of prostate-specific antigen
34. Aberrant rel/nfkb genes and activity in human cancer
35. Prostate-specific antigen expression is regulated by an upstream enhancer
36. Inducibility of κ immunoglobulin enhancer binding protein NF-κB by a posttranslational mechanism
37. Multiple nuclear factors interact with the immunoglobulin enhancer sequences
38. Targeted disruption of the p50 subunit of NF-κB leads to multifocal defects in immune responses
39. B cells from p50/NF-κB knockout mice have selective defects in proliferation, differentiation, germ-line CH transcription, and Ig class switching
40. Suppression of TNF-α-induced apoptosis by NF-κB
41. 2+ dependence, and differential half-site recognition