Zaprinast inhibits hydrogen peroxide-induced lysosomal destabilization and cell death in astrocytes

European Journal of Pharmacology

Volumn 571, Issue 2-3, 2007, Pages 106-115

  Choi, Jae Hyuck ^a   Kim, Dong Hoon ^a   Yun, In Jin ^a   Chang, Jun Hee ^a   Chun, Boe Gwun ^a   Choi, Sang Hyun ^a  

^a Korea University College of Medicine   (South Korea)

Author keywords

Astrocyte; Desferrioxamine; Hydrogen peroxide; Lysosomal stability; Mitochondrial potential; Oxidative stress; Rotenone; Sphingosine; Zaprinast

Indexed keywords

ACRIDINE; CATHEPSIN D; CYCLIC GMP DEPENDENT PROTEIN KINASE INHIBITOR; HYDROGEN PEROXIDE; LACTATE DEHYDROGENASE; PHOSPHODIESTERASE INHIBITOR; REACTIVE OXYGEN METABOLITE; ROTENONE; SPHINGOSINE; ZAPRINAST;

ANIMAL CELL; APOPTOSIS; ARTICLE; ASTROCYTE; CELL CULTURE; CELL DEATH; CONTROLLED STUDY; CYTOSOL; CYTOTOXICITY; LYSOSOME; MITOCHONDRION; NONHUMAN; OXIDATION; PRIORITY JOURNAL; RAT;

ANIMALS; ANIMALS, NEWBORN; ASTROCYTES; CATHEPSIN D; CELL DEATH; CELLS, CULTURED; CEREBRAL CORTEX; CYCLIC GMP; CYCLIC GMP-DEPENDENT PROTEIN KINASES; CYTOPROTECTION; CYTOSOL; DEFEROXAMINE; DOSE-RESPONSE RELATIONSHIP, DRUG; HYDROGEN PEROXIDE; INTRACELLULAR MEMBRANES; L-LACTATE DEHYDROGENASE; LYSOSOMES; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA; OXIDATIVE STRESS; PHOSPHODIESTERASE INHIBITORS; PROTECTIVE AGENTS; PURINONES; RATS; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES; ROTENONE; SPHINGOSINE; THIONUCLEOTIDES; UNCOUPLING AGENTS;

EID: 34548598647     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2007.06.042     Document Type: Article

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