Imidazoline drugs stabilize lysosomes and inhibit oxidative cytotoxicity in astrocytes

Free Radical Biology and Medicine

Volumn 32, Issue 5, 2002, Pages 394-405

  Choi, Sang Hyun ^a   Choi, Dong Hee ^a   Lee, Jeong Jin ^a   Park, Moon Sung ^a   Chun, Boe Gwun ^a  

^a Korea University College of Medicine   (South Korea)

Author keywords

Astrocytes; BU224; Cathepsin D; Cytochrome c; Free radicals; Guanabenz; Guanfacine; Idazoxan; Lysosomal stability; Mitochondrial potential; Naphthazarin; RS 45041 190

Indexed keywords

2 (2 IMIDAZOLIN 2 YL)QUINOLINE; ACRIDINE ORANGE; CATHEPSIN D; CYTOCHROME C; GUANABENZ; GUANFACINE; HOE 33342; IDAZOXAN; IMIDAZOLINE DERIVATIVE; LACTATE DEHYDROGENASE; NAPHTHAZARIN; PROPIDIUM IODIDE; RS 45041 190; UNCLASSIFIED DRUG; 4 CHLORO 2 (IMIDAZOLIN 2 YL)ISOINDOLINE; 4-CHLORO-2-(IMIDAZOLIN-2-YL)ISOINDOLINE; ALPHA ADRENERGIC RECEPTOR BLOCKING AGENT; ANTINEOPLASTIC AGENT; DIAGNOSTIC AGENT; DRUG RECEPTOR; FISH VENOM; IMIDAZOLE DERIVATIVE; INDOLE DERIVATIVE; LIGAND; NAPHTHOQUINONE; PEPSTATIN; PROTEINASE INHIBITOR; REACTIVE OXYGEN METABOLITE;

ANIMAL CELL; ARTICLE; ASTROCYTE; BRAIN MITOCHONDRION; CELL DEATH; CONTROLLED STUDY; CYTOTOXICITY; DRUG EFFECT; ENZYME RELEASE; LYSOSOME; MEMBRANE POTENTIAL; NEUROPROTECTION; NEWBORN; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT; STAINING; ANIMAL; APOPTOSIS; BRAIN CORTEX; CELL DIVISION; CELL LINE; CELL MEMBRANE POTENTIAL; COMPARATIVE STUDY; ENZYMOLOGY; GLIA; METABOLISM; MITOCHONDRION; OXIDATION REDUCTION REACTION; PHYSIOLOGY; SPRAGUE DAWLEY RAT;

ACRIDINE ORANGE; ADRENERGIC ALPHA-ANTAGONISTS; ANIMAL; ANIMALS, NEWBORN; ANTINEOPLASTIC AGENTS; APOPTOSIS; ASTROCYTES; CATHEPSIN D; CELL DIVISION; CELL LINE; CEREBRAL CORTEX; COMPARATIVE STUDY; CYTOCHROME C; FISH VENOMS; GUANABENZ; GUANFACINE; HIV PROTEASE INHIBITORS; IDAZOXAN; IMIDAZOLES; INDOLES; LACTATE DEHYDROGENASE; LIGANDS; LYSOSOMES; MEMBRANE POTENTIALS; MITOCHONDRIA; NAPHTHOQUINONES; NEUROGLIA; OXIDATION-REDUCTION; PEPSTATINS; PROTEASE INHIBITORS; RATS; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES; RECEPTORS, DRUG; SUPPORT, NON-U.S. GOV'T; ANIMALS; CYTOCHROME C GROUP; L-LACTATE DEHYDROGENASE;

EID: 0036489196     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0891-5849(01)00819-X     Document Type: Article

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