Mn(III) pyrophosphate as an efficient tool for studying the mode of action of isoniazid on the InhA protein of Mycobacterium tuberculosis

Antimicrobial Agents and Chemotherapy

Volumn 46, Issue 7, 2002, Pages 2137-2144

  Nguyen, Michel ^a   Quémard, Annaïk ^a   Broussy, Sylvain ^a   Bernadou, Jean ^a   Meunier, Bernard ^a  

^a LCC LABORATOIRE DE CHIMIE DE COORDINATION   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ALDEHYDE DERIVATIVE; BACTERIAL PROTEIN; CARRIER PROTEIN; COENZYME A; ISONIAZID; ISONICOTINALDEHYDE; ISONICOTINAMIDE; ISONICOTINIC ACID; MANGANESE DERIVATIVE; MANGANESE PYROPHOSPHATE; NICOTINAMIDE ADENINE DINUCLEOTIDE; NICOTINAMIDE NUCLEOTIDE; NICOTINIC ACID ADENINE DINUCLEOTIDE PHOSPHATE; PROTEIN INHA; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE; UNCLASSIFIED DRUG; INHA PROTEIN, MYCOBACTERIUM; MANGANESE; OXIDOREDUCTASE; PYROPHOSPHATE; TUBERCULOSTATIC AGENT;

ANTIMICROBIAL ACTIVITY; AQUEOUS SOLUTION; ARTICLE; DRUG ACTIVATION; DRUG OXIDATION; ENZYME ACTIVE SITE; ENZYME ACTIVITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VITRO STUDY; INCUBATION TIME; INHIBITION KINETICS; ISOMERISM; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PRIORITY JOURNAL; STOICHIOMETRY; X RAY CRYSTALLOGRAPHY; BIOTRANSFORMATION; DRUG ANTAGONISM; DRUG EFFECT; METABOLISM; OXIDATION REDUCTION REACTION;

ANTITUBERCULAR AGENTS; BIOTRANSFORMATION; DIPHOSPHATES; ISONIAZID; MANGANESE; MYCOBACTERIUM TUBERCULOSIS; NAD; OXIDATION-REDUCTION; OXIDOREDUCTASES; BACTERIAL PROTEINS;

EID: 0035984784     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.46.7.2137-2144.2002     Document Type: Article

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