Physiological polyamines: Simple primordial stress molecules

Journal of Cellular and Molecular Medicine

Volumn 11, Issue 4, 2007, Pages 685-703

  Rhee, H J ^a   Kim, Eui Jin ^a   Lee, J K ^a  

^a Sogang University   (South Korea)

Author keywords

Pathogen host interaction; Physiological polyamines; Stress molecule; Tolerance

Indexed keywords

POLYAMINE;

ADAPTATION; ANIMAL; HUMAN; METABOLISM; OSMOTIC PRESSURE; OXIDATIVE STRESS; REVIEW; TRANSPORT AT THE CELLULAR LEVEL;

ADAPTATION, PHYSIOLOGICAL; ANIMALS; BIOLOGICAL TRANSPORT; HUMANS; OSMOTIC PRESSURE; OXIDATIVE STRESS; POLYAMINES;

BACTERIA (MICROORGANISMS); MAMMALIA;

EID: 34548150619     PISSN: 15821838     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1582-4934.2007.00077.x     Document Type: Review

References (171)

1. Henderson CM, Anderson CB, Howard MT. Antisense-induced ribosomal frameshifting. Nucleic Acids Res. 2006 34 : 4302 10.
2. Umekage S, Ueda T. Spermidine inhibits transient and stable ribosome subunit dissociation. FEBS Lett. 2006 580 : 1222 6.
3. Stephenson AH, Christian JF, Seidel ER. Polyamines regulate eukaryotic initiation factor 4Ebinding protein 1 gene transcription. Biochem Biophys Res Commun. 2004 323 : 204 12.
4. Childs AC, Mehta DJ, Gerner EW. Polyaminedependent gene expression. Cell Mol Life Sci. 2003 60 : 1394 406.
5. Kim SW, Mangold U, Waghorne C, Mobascher A, Shantz L, Banyard J, Zetter BR. Regulation of cell proliferation by the antizyme inhibitor: evidence for an antizyme-independent mechanism. J Cell Sci. 2006 119 : 2583 91.
6. Dayoub R, Thasler WE, Bosserhoff AK, Singer T, Jauch KW, Schlitt HJ, Weiss TS. Regulation of polyamine synthesis in human hepatocytes by hepatotrophic factor augmenter of liver regeneration. Biochem Biophys Res Commun. 2006 345 : 181 7.
7. Thomas T, Thomas TJ. Polyamine metabolism and cancer. J Cell Mol Med. 2003 7 : 113 26.
8. Nisenberg O, Pegg AE, Welsh PA, Keefer K, Shantz LM. Overproduction of cardiac S-adenosylmethionine decarboxylase in transgenic mice. Biochem J. 2006 393 : 295 302.
9. Cervelli M, Polticelli F, Federico R, Mariottini P. Heterologous expression and characterization of mouse spermine oxidase. J Biol Chem. 2003 278 : 5271 6.
10. Vujcic S, Diegelman P, Bacchi CJ, Kramer DL, Porter CW. Identification and characterization of a novel flavin-containing spermine oxidase of mammalian cell origin. Biochem J. 2002 367 : 665 75.
11. Igarashi K, Kashiwagi K. Polyamine transport in bacteria and yeast. Biochem J. 1999 344 : 633 42.
12. Garcia-Fernandez AJ, Rodriguez RA, Perez- Pertejo Y, Balana-Fouce R. Characterization of putrescine uptake in hamster amelanocytic melanoma AMEL-3 cells. Mol Cells. 2005 20 : 127 35.
13. O'Sullivan MC, Golding BT, Smith LL, Wyatt I. Molecular features necessary for the uptake of diamines and related compounds by the polyamine receptor of rat lung slices. Biochem Pharmacol. 1991 41 : 1839 48.
14. Magnusson LU, Farewell A, Nystrom T. ppGpp: a global regulator in Escherichia coli. Trends Microbiol. 2005 13 : 236 42.
15. Artsimovitch I, Patlan V, Sekine S, Vassylyeva MN, Hosaka T, Ochi K, Yokoyama S, Vassylyev, DG. Structural basis for transcription regulation by alarmone ppGpp. Cell. 2004 117 : 299 310.
16. Moris M, Braeken K, Schoeters E, Verreth C, Beullens S, Vanderleyden J, Michiels J. Effective symbiosis between Rhizobium etli and Phaseolus vulgaris requires the alarmone ppGpp. J Bacteriol. 2005 187 : 5460 9.
17. Harding HP, Zhang Y, Zeng H, Novoa I, Lu PD, Calfon M, Sadri N, Yun C, Popko B, Paules R, Stojdl DF, Bell JC, Hettmann T, Leiden JM, Ron D. An integrated stress response regulates amino acid metabolism and resistance to oxidative stress. Mol Cell. 2003 11 : 619 33.
18. Dever TE. Gene-specific regulation by general translation factors. Cell. 2002 108 : 545 56.
19. Jung IL, Kim IG. Polyamines and glutamate decarboxylase- based acid resistance in Escherichia coli. J Biol Chem. 2003 278 : 22846 52.
20. Bryans M, Harley E, Gilmour SK. Elevated cellular polyamine levels enhance promoter activity in vivo. Biochem Biophys Res Commun. 1996 226 : 618 25.
21. Panagiotidis CA, Huang SC, Canellakis ES. Posttranslational and transcriptional regulation of polyamine biosynthesis in Escherichia coli. Int J Biochem. 1994 26 : 991 1001.
22. Huang SC, Panagiotidis CA, Canellakis ES. Transcriptional effects of polyamines on ribosomal proteins and on polyamine-synthesizing enzymes in Escherichia coli. Proc Natl Acad Sci USA. 1990 87 : 3464 8.
23. Hobbs CA, Paul BA, Gilmour SK. Deregulation of polyamine biosynthesis alters intrinsic histone acetyltransferase and deacetylase activities in murine skin and tumors. Cancer Res. 2002 62 : 67 74.
24. Stjernborg L, Heby O, Mamont P, Persson L. Polyamine-mediated regulation of S-adenosylmethionine decarboxylase expression in mammalian cells. Studies using 5′-([(Z)-4-amino-2-butenyl]methylamino)- 5′-deoxyadenosine, a suicide inhibitor of the enzyme. Eur J Biochem. 1993 214 : 671 6.
25. Igarashi K, Saisho T, Yuguchi M, Kashiwagi K. Molecular mechanism of polyamine stimulation of the synthesis of oligopeptide-binding protein. J Biol Chem. 1997 272 : 4058 64.
26. Yoshida M, Meksuriyen D, Kashiwagi K, Kawai G, Igarashi K. Polyamine stimulation of the synthesis of oligopeptide-binding protein (OppA). Involvement of a structural change of the Shine-Dalgarno sequence and the initiation codon aug in oppa mRNA. J Biol Chem. 1999 274 : 22723 8.
27. Medina MA, Correa-Fiz F, Rodriguez-Caso C, Sanchez-Jimenez F. A comprehensive view of polyamine and histamine metabolism to the light of new technologies. J Cell Mol Med. 2005 9 : 854 64.
28. Panagiotidis CA, Artandi S, Calame K, Silverstein SJ. Polyamines alter sequence-specific DNA-protein interactions. Nucleic Acids Res. 1995 23 : 1800 9.
29. Gundogus-Ozcanli N, Sayilir C, Criss WE. Effects of polyamines, polyamine synthesis inhibitors, and polyamine analogs on casein kinase II using Myc oncoprotein as substrate. Biochem Pharmacol. 1999 58 : 251 4.
30. Lu B, Liang X, Scott GK, Chang CH, Baldwin MA, Thomas T, Benz CC. Polyamine inhibition of estrogen receptor (ER) DNA-binding and ligand-binding functions. Breast Cancer Res Treat. 1998 48 : 243 57.
31. Thomas T, Kulkarni GD, Gallo MA, Greenfield N, Lewis JS, Shirahata A, Thomas TJ. Effects of natural and synthetic polyamines on the conformation of an oligodeoxyRibonucleotide with the estrogen response element. Nucleic Acids Res. 1997 25 : 2396 402.
32. Thomas T, Kiang DT. Modulation of the binding of progesterone receptor to DNA by polyamines. Cancer Res. 1988 48 : 1217 22.
33. Giannakouros T, Nikolakaki H, Georgatsos JG. Concentration-dependent effects of natural polyamines on peptide chain initiation and elongation in a cell-free system of protein synthesis. Mol Cell Biochem. 1990 99 : 9 19.
34. Miyamoto S, Kashiwagi K, Ito K, Watanabe S, Igarashi K. Estimation of polyamine distribution and polyamine stimulation of protein synthesis in Escherichia coli. Arch Biochem Biophys. 1993 300 : 63 8.
35. Watanabe S, Kusama-Eguchi K, Kobayashi H, Igarashi K. Estimation of polyamine binding to macromolecules and ATP in bovine lymphocytes and rat liver. J Biol Chem. 1991 266 : 20803 9.
36. Tome ME, Fiser SM, Payne CM, Gerner EW. Excess putrescine accumulation inhibits the formation of modified eukaryotic initiation factor 5A (eIF-5A) and induces apoptosis. Biochem J. 1997 328 : 847 54.
37. Xie X, Tome ME, Gerner EW. Loss of intracellular putrescine pool-size regulation induces apoptosis. Exp Cell Res. 1997 230 : 386 92.
38. Brunton VG, Grant MH, Wallace HM. Mechanisms of spermine toxicity in baby-hamster kidney (BHK) cells. The role of amine oxidases and oxidative stress. Biochem J. 1991 280 : 193 8.
39. Seiler N, Raul F. Polyamines and apoptosis. J Cell Mol Med. 2005 9 : 623 42.
40. Miret JJ, Nainudel S, Goldemberg SH. Altered heat-shock response in polyamine-depleted bacteria. FEBS Lett. 1986 200 : 117 22.
41. Desiderio MA, Tacchini L, Anzon E, Pogliaghi G, Radice L, Bernelli-Zazzera A. Effects of polyamine imbalance on the induction of stress genes in hepatocarcinoma cells exposed to heat shock. Hepatology. 1996 24 : 150 6.
42. Desiderio MA, Dansi P, Tacchini L, Bernelli-Zazzera A. Influence of polyamines on DNA binding of heat shock and activator protein 1 transcription factors induced by heat shock. FEBS Lett. 1999 455 : 149 53.
43. Tkachenko AG, Shumkov MS. Role of putrescine in regulation of the sigmaS subunit of RNA polymerase in Escherichia coli cells on transition to stationary phase. Biochemistry. 2004 69 : 876 82.
44. 2-induced oxidative damage. Biochem Biophys Res Commun. 2003 301 : 915 22.
45. Oh TJ, Kim IG. The SOS induction of umu'-'lacZ fusion gene by oxidative damage is influenced by polyamines in Escherichia coli. Cell Biol Toxicol. 1999 15 : 291 7.
46. Oh TJ, Kim IG. The expression of Escherichia coli SOS genes recA and uvrA is inducible by polyamines. Biochem Biophys Res Commun. 1999 264 : 584 9.
47. Pan YH, Liao CC, Kuo CC, Duan KJ, Liang PH, Yuan HS, Hu ST, Chak KF. The critical roles of polyamines in regulating ColE7 production and restricting ColE7 uptake of the colicin-producing Escherichia coli. J Biol Chem. 2006 281 : 13083 91.
48. Kim IG, Oh TJ. SOS induction of the recA gene by UV-, gamma-irradiation and mitomycin C is mediated by polyamines in Escherichia coli K-12. Toxicol Lett. 2000 116 : 143 9.
49. Ha HC, Yager JD, Woster PA, Casero RA Jr. Structural specificity of polyamines and polyamine analogues in the protection of DNA from strand breaks induced by reactive oxygen species. Biochem Biophys Res Commun. 1998 244 : 298 303.
50. Muscari C, Guarnieri C, Stefanelli C, Giaccari A, Caldarera CM. Protective effect of spermine on DNA exposed to oxidative stress. Mol Cell Biochem. 1995 144 : 125 9.
51. Khan AU, Mei YH, Wilson T. A proposed function for spermine and spermidine: protection of replicating DNA against damage by singlet oxygen. Proc Natl Acad Sci USA 1992 89 : 11426 7.
52. Khan NA, Havouis R, Quemener V, Moulinoux JP. Protein kinase C inhibitor (H-7) potentiates antiproliferative effects of a polyamine biosynthesis inhibitor. Anticancer Res. 1992 12 : 1223 6.
53. Tofilon PJ, Deen DF, Marton LJ. Polyamine depletion and drug-induced chromosomal damage: new results. Science. 1992 258 : 1378.
54. Ha HC, Sirisoma NS, Kuppusamy P, Zweier JL, Woster PM, Casero RA Jr. The natural polyamine spermine functions directly as a free radical scavenger. Proc Natl Acad Sci USA. 1998 95 : 11140 5.
55. Amendola R, Bellini A, Cervelli M, Degan P, Marcocci L, Martini F, Mariottini P. Direct oxidative DNA damage, apoptosis and radio sensitivity by spermine oxidase activities in mouse neuroblastoma cells. Biochim Biophys Acta. 2005 1755 : 15 24.
56. Tkachenko A, Nesterova L, Pshenichnov M. The role of the natural polyamine putrescine in defense against oxidative stress in Escherichia coli. Arch Microbiol. 2001 176 : 155 7.
57. Ye B, Muller HH, Zhang J, Gressel J. Constitutively elevated levels of putrescine and putrescine-generating enzymes correlated with oxidant stress resistance in Conyza Bonariensis and Wheat. Plant Physiol. 1997 115 : 1443 51.
58. Bower JM, Mulvey MA. Polyamine-mediated resistance of uropathogenic Escherichia coli to nitrosative stress. J Bacteriol. 2006 188 : 928 33.
59. Takano K, Ogura M, Yoneda Y, Nakamura Y. Oxidative metabolites are involved in polyamineinduced microglial cell death. Neuroscience. 2005 134 : 1123 31.
60. Hernandez SM, Sanchez MS, de Tarlovsky MN. Polyamines as a defense mechanism against lipoperoxidation in Trypanosoma cruzi. Acta Trop. 2006 98 : 94 102.
61. Gerard F, Dri AM, Moreau PL. Role of Escherichia coli RpoS, LexA and H-NS global regulators in metabolism and survival under aerobic, phosphatestarvation conditions. Microbiology. 1999 145 : 1547 62.
62. Hodges GR, Marwaha J, Paul T, Ingold KU. A novel procedure for generating both nitric oxide and superoxide in situ from chemical sources at any chosen mole ratio. First application: tyrosine oxidation and a comparison with preformed peroxynitrite. Chem Res Toxicol. 2000 13 : 1287 93.
63. Kim JS, Choi SH, Lee JK. Lysine decarboxylase expression of Vibrio vulnificus is induced by SoxR in response to superoxide stress. J Bacteriol. 2006 188 : 8586 92.
64. Norikura T, Kojima-Yuasa A, Opare Kennedy D, Matsui-Yuasa I. Protective effect of gammaaminobutyric acid (GABA) against cytotoxicity of ethanol in isolated rat hepatocytes involves modulations in cellular polyamine levels. Amino Acids. 2007 32 : 419 23.
65. Kaplan F, Kopka J, Haskell DW, Zhao W, Schiller KC, Gatzke N, Sung DY, Guy CL. Exploring the temperature- stress metabolome of Arabidopsis. Plant Physiol. 2004 136 : 4159 68.
66. Shen W, Nada K, Tachibana S. Involvement of polyamines in the chilling tolerance of cucumber cultivars. Plant Physiol. 2000 124 : 431 9.
67. Park YK, Bearson B, Bang SH, Bang IS, Foster JW. Internal pH crisis, lysine decarboxylase and the acid tolerance response of Salmonella typhimurium. Mol Microbiol. 1996 20 : 605 11.
68. Griswold AR, Jameson-Lee M, Burne RA. Regulation and physiologic significance of the agmatine deiminase system of Streptococcus mutans UA159. J Bacteriol. 2006 188 : 834 41.
69. Wang X, Shi G, Xu Q, Hu J. Exogenous polyamines enhance copper tolerance of Nymphoides peltatum. J Plant Physiol. 2006 164 : 1062 70.
70. Maiale S, Sanchez DH, Guirado A, Vidal A, Ruiz OA. Spermine accumulation under salt stress. J Plant Physiol. 2004 161 : 35 42.
71. Kasinathan V, Wingler A. Effect of reduced arginine decarboxylase activity on salt tolerance and on polyamine formation during salt stress in Arabidopsis thaliana. Physiol Plant. 2004 121 : 101 7.
72. Chattopadhayay MK, Tiwari BS, Chattopadhyay G, Bose A, Sengupta DN, Ghosh B. Protective role of exogenous polyamines on salinity-stressed rice (Oryza sativa) plants. Physiol Plant. 2002 116 : 192 9.
73. Capell T, Bassie L, Christou P. Modulation of the polyamine biosynthetic pathway in transgenic rice confers tolerance to drought stress. Proc Natl Acad Sci USA. 2004 101 : 9909 14.
74. Chattopadhyay MK, Tabor CW, Tabor H. Polyamine deficiency leads to accumulation of reactive oxygen species in a spe2Delta mutant of Saccharomyces cerevisiae. Yeast. 2006 23 : 751 61.
75. Zhu MY, Wang WP, Bissette G. Neuroprotective effects of agmatine against cell damage caused by glucocorticoids in cultured rat hippocampal neurons. Neuroscience. 2006 141 : 2019 27.
76. Kasukabe Y, He L, Nada K, Misawa S, Ihara I, Tachibana S. Overexpression of spermidine synthase enhances tolerance to multiple environmental stresses and up-regulates the expression of various stress-regulated genes in transgenic Arabidopsis thaliana. Plant Cell Physiol. 2004 45 : 712 22.
77. Chattopadhyay MK, Tabor CW, Tabor H. Polyamines protect Escherichia coli cells from the toxic effect of oxygen. Proc Natl Acad Sci USA. 2003 100 : 2261 5.
78. Pedreno E, Lopez-Contreras AJ, Cremades A, Penafiel R. Protecting or promoting effects of spermine on DNA strand breakage induced by iron or copper ions as a function of metal concentration. J Inorg Biochem. 2005 99 : 2074 80.
79. Tkachenko AG, Pshenichnov MR, Nesterova, L. Putrescine as a oxidative stress protecting factor in Escherichia coli. Mikrobiologiia. 2001 70 : 487 94.
80. Warters RL, Newton GL, Olive PL, Fahey RC. Radioprotection of human cell nuclear DNA by polyamines: radiosensitivity of chromatin is influenced by tightly bound spermine. Radiat Res. 1999 151 : 354 62.
81. Khan AU, Di Mascio P, Medeiros MH, Wilson T. Spermine and spermidine protection of plasmid DNA against single-strand breaks induced by singlet oxygen. Proc Natl Acad Sci USA. 1992 89 : 11428 30.
82. Snyder RD, Sunkara PS. Effect of polyamine depletion on DNA damage and repair following UV irradiation of HeLa cells. Photochem Photobiol. 1990 52 : 525 32.
83. Hosford ME, Muller JG, Burrows CJ. Spermine participates in oxidative damage of guanosine and 8- oxoguanosine leading to deoxyribosylurea formation. J Am Chem Soc. 2004 126 : 9540 1.
84. Longo, LD, Packianathan, S, McQueary JA, Stagg RB, Byus CV, Cain CD. Acute hypoxia increases ornithine decarboxylase activity and polyamine concentrations in fetal rat brain. Proc Natl Acad Sci USA. 1993 90 : 692 6.
85. Packianathan S, Cain CD, Longo LD. Ornithine decarboxylase activity and polyamine concentrations in fetal rat brain: response to chronic hypoxic-hypoxia and/or carbon monoxide-hypoxia. Brain Res Dev Brain Res. 1994 83 : 138 41.
86. Sava IG, Battaglia V, Rossi CA, Salvi M, Toninello A. Free radical scavenging action of the natural polyamine spermine in rat liver mitochondria. Free Radic Biol Med. 2006 41 : 1272 81.
87. Rigobello MP, Toninello A, Siliprandi D, Bindoli A. Effect of spermine on mitochondrial glutathione release. Biochem Biophys Res Commun. 1993 194 : 1276 81.
88. Foster JW, Hall HK. Inducible pH homeostasis and the acid tolerance response of Salmonella typhimurium. J Bacteriol. 1991 173 : 5129 35.
89. Merrell DS, Camilli A. The cadA gene of Vibrio choleraeis induced during infection and plays a role in acid tolerance. Mol Microbiol. 1999 34 : 836 49.
90. Rhee JE, Kim KS, Choi SH. CadC activates pHdependent expression of the Vibrio vulnificus cadBA operon at a distance through direct binding to an upstream region. J Bacteriol. 2005 187 : 7870 5.
91. Castanie-Cornet MP, Penfound TA, Smith D, Elliott JF, Foster JW. Control of acid resistance in Escherichia coli. J Bacteriol. 1999 181 : 3525 35.
92. De Biase D, Tramonti A, Bossa F, Visca P. The response to stationary-phase stress conditions in Escherichia coli: role and regulation of the glutamic acid decarboxylase system. Mol Microbiol. 1999 32 : 1198 211.
93. Waterman SR, Small PL. Identification of sigma Sdependent genes associated with the stationaryphase acid-resistance phenotype of Shigella flexneri. Mol Microbiol. 1996 21 : 925 40.
94. Cotter PD, Gahan CG, Hill C. A glutamate decarboxylase system protects Listeria monocytogenesin gastric fluid. Mol Microbiol. 2001 40 : 465 75.
95. Iyer R, Williams C, Miller C. Arginine-agmatine antiporter in extreme acid resistance in Escherichia coli. J Bacteriol. 2003 185 : 6556 61.
96. Gong S, Richard H, Foster JW. YjdE (AdiC) is the arginine: agmatine antiporter essential for argininedependent acid resistance in Escherichia coli. J Bacteriol. 2003 185 : 4402 9.
97. Hersh BM, Farooq FT, Barstad DN, Blankenhorn DL, Slonczewski JL. A glutamate-dependent acid resistance gene in Escherichia coli. J Bacteriol. 1996 178 : 3978 81.
98. Kieboom J, Abee T. Arginine-dependent acid resistance in Salmonella enterica serovar Typhimurium. J Bacteriol. 2006 188 : 5650 3.
99. Richard H, Foster JW. Escherichia coli glutamateand arginine-dependent acid resistance systems increase internal pH and reverse transmembrane potential. J Bacteriol. 2004 186 : 6032 41.
100. Soksawatmaekhin W, Kuraishi A, Sakata K, Kashiwagi K, Igarashi K. Excretion and uptake of cadaverine by cadB and its physiological functions in Escherichia coli. Mol Microbiol. 2004 51 : 1401 12.
101. Aziz SM, Worthen DR, Yatin M, Ain KB, Crooks PA. A unique interaction between polyamine and multidrug resistance (P-glycoprotein) transporters in cultured Chinese hamster ovary cells transfected with mouse mdr-1 gene. Biochem Pharmacol. 1998 56 : 181 7.
102. Basle A, Delcour AH. Effect of two polyamine toxins on the bacterial porin OmpF. Biochem Biophys Res Commun. 2001 285 : 550 4.
103. Bredin J, Simonet V, Iyer R, Delcour AH, Pages JM. Colicins, spermine and cephalosporins: a competitive interaction with the OmpF eyelet. Biochem J. 2003 376 : 245 52.
104. delaVega AL, Delcour AH. Cadaverine induces closing of E. coli porins. EMBO J. 1995 14 : 6058 65.
105. Dela Vega AL, Delcour AH. Polyamines decrease Escherichia coli outer membrane permeability. J Bacteriol. 1996 178 : 3715 21.
106. Iyer R, Delcour AH. Complex inhibition of OmpF and OmpC bacterial porins by polyamines. J Biol Chem. 1997 272 : 18595 601.
107. Samartzidou H, Mehrazin M, Xu Z, Benedik MJ, Delcour AH. Cadaverine inhibition of porin plays a role in cell survival at acidic pH. J Bacteriol. 2003 185 : 13 9.
108. Samartzidou H, Delcour AH. Distinct sensitivities of OmpF and PhoE porins to charged modulators. FEBS Lett. 1999 444 : 65 70.
109. Tkachenko AG, Pozhidaeva ON, Shumkov MS. Role of polyamines in formation of multiple antibiotic resistance of Escherichia coli under stress conditions. Biochemistry. 2006 71 : 1042 9.
110. Iyer R, Wu Z, Woster PM, Delcour AH. Molecular basis for the polyamine-ompF porin interactions: inhibitor and mutant studies. J Mol Biol. 2000 297 : 933 45.
111. Schiller D, Kruse D, Kneifel H, Kramer R, Burkovski A. Polyamine transport and role of potE in response to osmotic stress in Escherichia coli. J Bacteriol. 2000 182 : 6247 9.
112. Jantaro S, Maenpaa P, Mulo P, Incharoensakdi A. Content and biosynthesis of polyamines in salt and osmotically stressed cells of Synechocystis sp. PCC 6803. FEMS Microbiol Lett. 2003 228 : 129 35.
113. Shapiguzov A, Lyukevich AA, Allakhverdiev SI, Sergeyenko TV, Suzuki I, Murata N, Los DA. Osmotic shrinkage of cells of Synechocystis sp. PCC 6803 by water efflux via aquaporins regulates osmostress-inducible gene expression. Microbiology. 2005 151 : 447 55.
114. Poulin R, Wechter RS, Pegg AE. An early enlargement of the putrescine pool is required for growth in L1210 mouse leukemia cells under hypoosmotic stress. J Biol Chem. 1991 266 : 6142 51.
115. Poulin R, Coward JK, Lakanen JR, Pegg AE. Enhancement of the spermidine uptake system and lethal effects of spermidine overaccumulation in ornithine decarboxylase-overproducing L1210 cells under hyposmotic stress. J Biol Chem. 1993 268 : 4690 8.
116. Lovkvist-Wallstrom E, Stjernborg-Ulvsback L, Scheffler IE, Persson L. Regulation of mammalian ornithine decarboxylase. Studies on the induction of the enzyme by hypotonic stress. Eur J Biochem. 1995 231 : 40 4.
117. Mitchell JL, Judd GG, Leyser A, Choe C. Osmotic stress induces variation in cellular levels of ornithine decarboxylase-antizyme. Biochem J. 1998 329 : 453 9.
118. Williams K. Modulation and block of ion channels: a new biology of polyamines. Cell Signal. 1997 9 : 1 13.
119. Hedfalk K, Tornroth-Horsefield S, Nyblom M, Johanson U, Kjellbom P, Neutze R. Aquaporin gating. Curr Opin Struct Biol. 2006 16 : 447 56.
120. Alcazar R, Marco F, Cuevas JC, Patron M, Ferrando A, Carrasco P, Tiburcio AF, Altabella T. Involvement of polyamines in plant response to abiotic stress. Biotechnol Lett. 2006 28 : 1867 76.
121. Urano K, Yoshiba Y, Nanjo T, Ito T, Yamaguchi- Shinozaki K, Shinozaki K. Arabidopsis stressinducible gene for arginine decarboxylase AtADC2 is required for accumulation of putrescine in salt tolerance. Biochem Biophys Res Commun. 2004 313 : 369 75.
122. Soyka S, Heyer AG. Arabidopsis knockout mutation of ADC2 gene reveals inducibility by osmotic stress. FEBS Lett. 1999 458 : 219 23.
123. Hummel I, Gouesbet G, El Amrani A, Ainouche A, Couee I. Characterization of the two arginine decarboxylase (polyamine biosynthesis) paralogues of the endemic subantarctic cruciferous species Pringlea antiscorbutica and analysis of their differential expression during development and response to environmental stress. Gene. 2004 342 : 199 209.
124. Gilad GM, Gilad VH. Overview of the brain polyamine-stress-response: regulation, development, and modulation by lithium and role in cell survival. Cell Mol Neurobiol. 2003 23 : 637 49.
125. Hayashi Y, Tanaka J, Morizumi Y, Kitamura Y, Hattori Y. Polyamine levels in brain and plasma after acute restraint or water-immersion restraint stress in mice. Neurosci Lett. 2004 355 : 57 60.
126. Gilad GM, Gilad VH. Polyamines in neurotrauma. Ubiquitous molecules in search of a function. Biochem Pharmacol. 1992 44 : 401 7.
127. Halonen T, Sivenius J, Miettinen R, Halmekyto M, Kauppinen R, Sinervirta R, Alakuijala L, Alhonen L, MacDonald E, Janne J, et al. Elevated seizure threshold and impaired spatial learning in transgenic mice with putrescine overproduction in the brain. Eur J Neurosci. 1993 5 : 1233 9.
128. Lukkarainen J, Kauppinen RA, Koistinaho J, Halmekyto, Alhonen LM, Janne J. Cerebral energy metabolism and immediate early gene induction following severe incomplete ischaemia in transgenic mice overexpressing the human ornithine decarboxylase gene: evidence that putrescine is not neurotoxic in vivo. Eur J Neurosci. 1995 7 : 1840 9.
129. 2+ concentration in the brain of transgenic mice overexpressing human ornithine decarboxylase gene. J Neurochem. 1992 58 : 831 6.
130. Kaasinen K, Koistinaho J, Alhonen L, Janne J. Overexpression of spermidine/spermine N-acetyltransferase in transgenic mice protects the animals from kainate-induced toxicity. Eur J Neurosci. 2000 12 : 540 8.
131. Kaasinen SK, Grohn OH, Keinanen TA, Alhonen L, Janne J. Overexpression of spermidine/spermine N1-acetyltransferase elevates the threshold to pentylenetetrazol-induced seizure activity in transgenic mice. Exp Neurol. 2003 183 : 645 52.
132. Williams K. Mechanisms influencing stimulatory effects of spermine at recombinant N-methyl-Daspartate receptors. Mol Pharmacol. 1994 46 : 161 8.
133. Williams K, Dawson VL, Romano C, Dichter MA, Molinoff PB. Characterization of polyamines having agonist, antagonist, and inverse agonist effects at the polyamine recognition site of the NMDA receptor. Neuron. 1990 5 : 199 208.
134. Yatin SM, Yatin M, Aulick T, Ain KB, Butterfield DA. Alzheimer's amyloid beta-peptide associated free radicals increase rat embryonic neuronal polyamine uptake and ornithine decarboxylase activity: protective effect of vitamin E. Neurosci Lett. 1999 263 : 17 20.
135. Yatin SM, Yatin M, Varadarajan S, Ain KB, Butterfield DA. Role of spermine in amyloid betapeptide- associated free radical-induced neurotoxicity. J Neurosci Res. 2001 63 : 395 401.
136. McClellan AJ, Tam S, Kaganovich D, Frydman J. Protein quality control: chaperones culling corrupt conformations. Nat Cell Biol. 2005 7 : 736 41.
137. Hara T, Nakamura K, Matsui M, Yamamoto A, Nakahara Y, Suzuki-Migishima R, Yokoyama M, Mishima K, Saito I, Okano H, Mizushima N. Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice. Nature. 2006 441 : 885 9.
138. Komatsu M, Kominami E, Tanaka K. Autophagy and neurodegeneration. Autophagy. 2006 2 : 315 7.
139. Okanojo M, Shiraki K, Kudou M, Nishikori S, Takagi M. Diamines prevent thermal aggregation and inactivation of lysozyme. J Biosci Bioeng. 2005 100 : 556 61.
140. Kim JH, Yenari MA, Giffard RG, Cho SW, Park KA, Lee JE. Agmatine reduces infarct area in a mouse model of transient focal cerebral ischemia and protects cultured neurons from ischemia-like injury. Exp Neurol. 2004 189 : 122 30.
141. Gilad GM, Salame K, Rabey JM, Gilad VH. Agmatine treatment is neuroprotective in rodent brain injury models. Life Sci. 1996 58 : PL 41 6.
142. Clarkson AN, Liu H, Pearson L, Kapoor M, Harrison JC, Sammut IA, Jackson DM, Appleton I. Neuroprotective effects of spermine following hypoxic- ischemic-induced brain damage: a mechanistic study. FASEB J. 2004 18 : 1114 6.
143. Fairbanks CA, Schreiber KL, Brewer KL, Yu CG, Stone LS, Kitto KF, Nguyen HO, Grocholski BM, Shoeman DW, Kehl LJ, Regunathan S, Reis DJ, Yezierski RP, Wilcox GL. Agmatine reverses pain induced by inflammation, neuropathy, and spinal cord injury. Proc Natl Acad Sci USA. 2000 97 : 10584 9.
144. Zhu MY, Piletz JE, Halaris A, Regunathan S. Effect of agmatine against cell death induced by NMDA and glutamate in neurons and PC12 cells. Cell Mol Neurobiol. 2003 23 : 865 72.
145. Wang WP, Iyo AH, Miguel-Hidalgo J, Regunathan S, Zhu MY. Agmatine protects against cell damage induced by NMDA and glutamate in cultured hippocampal neurons. Brain Res. 2006 1084 : 210 6.
146. Gilad GM, Gilad VH, Finberg JP, Rabey JM. Neurochemical evidence for agmatine modulation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) neurotoxicity. Neurochem Res. 2005 30 : 713 9.
147. Satriano J, Schwartz D, Ishizuka S, Lortie MJ, Thomson SC, Gabbai F, Kelly CJ, Blantz RC. Suppression of inducible nitric oxide generation by agmatine aldehyde: beneficial effects in sepsis. J Cell Physiol. 2001 188 : 313 20.
148. Takano K, Ogura M, Nakamura Y, Yoneda Y. Neuronal and glial responses to polyamines in the ischemic brain. Curr Neurovasc Res. 2005 2 : 213 23.
149. Rao AM, Hatcher JF, Dogan A, Dempsey RJ. Elevated N1-acetylspermidine levels in gerbil and rat brains after CNS injury. J Neurochem. 2000 74 : 1106 11.
150. Dogan A, Rao AM, Hatcher J, Rao VL, Baskaya MK, Dempsey RJ. Effects of MDL 72527, a specific inhibitor of polyamine oxidase, on brain edema, ischemic injury volume, and tissue polyamine levels in rats after temporary middle cerebral artery occlusion. J Neurochem. 1999 72 : 765 70.
151. +/- mice. J Clin Invest. 2004 113 : 867 75.
152. Lutz C, Navakoudis E, Seidlitz HK, Kotzabasis K. Simulated solar irradiation with enhanced UV-B adjust plastid- and thylakoid-associated polyamine changes for UV-B protection. Biochim Biophys Acta. 2005 1710 : 24 33.
153. Sharma SS, Dietz KJ. The significance of amino acids and amino acid-derived molecules in plant responses and adaptation to heavy metal stress. J Exp Bot. 2006 57 : 711 26.
154. Henderson B, Allan E, Coates AR. Stress wars: the direct role of host and bacterial molecular chaperones in bacterial infection. Infect Immun. 2006 74 : 3693 706.
155. Durand JM, Bjork GR. Putrescine or a combination of methionine and arginine restores virulence gene expression in a tRNA modification-deficient mutant of Shigella flexneri: a possible role in adaptation of virulence. Mol Microbiol. 2003 47 : 519 27.
156. Ware D, Jiang Y, Lin W, Swiatlo E. Involvement of potD in Streptococcus pneumoniae polyamine transport and pathogenesis. Infect Immun. 2006 74 : 352 61.
157. Shah P, Swiatlo E. Immunization with polyamine transport protein PotD protects mice against systemic infection with Streptococcus pneumoniae. Infect Immun. 2006 74 : 5888 92.
158. Torres AG, Vazquez-Juarez RC, Tutt CB, Garcia- Gallegos JG. Pathoadaptive mutation that mediates adherence of shiga toxin-producing Escherichia coli O111. Infect Immun. 2005 73 : 4766 76.
159. 2+-RhoA signaling pathway required for polyamine-dependent intestinal epithelial cell migration. Am J Physiol Cell Physiol. 2001 280 : C993 1007.
160. Chen C, Young BA, Coleman CS, Pegg AE, Sheppard D. Spermidine/spermine N1-acetyltransferase specifically binds to the integrin alpha9 subunit cytoplasmic domain and enhances cell migration. J Cell Biol. 2004 167 : 161 70.
161. Gobert AP, Cheng Y, Wang JY, Boucher JL, Iyer RK, Cederbaum SD, Casero RA Jr., Newton JC, Wilson KT. Helicobacter pyloriinduces macrophage apoptosis by activation of arginase II. J Immunol. 2002 168 : 4692 700.
162. Chaturvedi R, Cheng Y, Asim M, Bussiere FI, Xu H, Gobert AP, Hacker A, Casero RA Jr., Wilson KT. Induction of polyamine oxidase 1 by Helicobacter pylori causes macrophage apoptosis by hydrogen peroxide release and mitochondrial membrane depolarization. J Biol Chem. 2004 279 : 40161 73.
163. Xu H, Chaturvedi R, Cheng Y, Bussiere FI, Asim M, Yao MD, Potosky D, Meltzer SJ, Rhee JG, Kim SS, Moss SF, Hacker A, Wang Y, Casero RA Jr., Wilson KT. Spermine oxidation induced by Helicobacter pylori results in apoptosis and DNA damage: implications for gastric carcinogenesis. Cancer Res. 2004 64 : 8521 5.
164. Day WA Jr., Fernandez RE, Maurelli AT. Pathoadaptive mutations that enhance virulence: genetic organization of the cadA regions of Shigella spp. Infect Immun. 2001 69 : 7471 80.
165. McCormick BA, Fernandez MI, Siber AM, Maurelli AT. Inhibition of Shigella flexneri-induced transepithelial migration of polymorphonuclear leucocytes by cadaverine. Cell Microbiol. 1999 1 : 143 55.
166. Kierszenbaum F, Wirth JJ, McCann PP, Sjoerdsma A. Arginine decarboxylase inhibitors reduce the capacity of Trypanosoma cruzi to infect and multiply in mammalian host cells. Proc Natl Acad Sci USA. 1987 84 : 4278 82.
167. Bauer PM, Buga GM, Fukuto JM, Pegg AE, Ignarro LJ. Nitric oxide inhibits ornithine decarboxylase via S-nitrosylation of cysteine 360 in the active site of the enzyme. J Biol Chem. 2001 276 : 34458 64.
168. Cona A, Rea G, Angelini R, Federico R, Tavladoraki P. Functions of amine oxidases in plant development and defence. Trends Plant Sci. 2006 11 : 80 8.
169. Rea G, Metoui O, Infantino A, Federico R, Angelini R. Copper amine oxidase expression in defense responses to wounding and Ascochyta rabiei invasion. Plant Physiol. 2002 128 : 865 75.
170. Wisniewski JP, Rathbun EA, Knox JP, Brewin NJ. Involvement of diamine oxidase and peroxidase in insolubilization of the extracellular matrix: implications for pea nodule initiation by Rhizobium leguminosarum. Mol Plant Microbe Interact. 2000 13 : 413 20.
171. Perez-Amador MA, Leon J, Green PJ, Carbonell J. Induction of the arginine decarboxylase ADC2 gene provides evidence for the involvement of polyamines in the wound response in Arabidopsis. Plant Physiol. 2002 130 : 1454 63.