The cadA gene of Vibrio cholerae is induced during infection and plays a role in acid tolerance

Molecular Microbiology

Volumn 34, Issue 4, 1999, Pages 836-849

  Merrell, D Scott ^a   Camilli, Andrew ^a  

^a TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARBOXYLIC ACID; INORGANIC ACID; LYSINE DECARBOXYLASE; ORNITHINE DECARBOXYLASE;

ANIMAL EXPERIMENT; ARTICLE; BACTERIAL COLONIZATION; DNA SEQUENCE; GENE MUTATION; GENETIC TRANSCRIPTION; INTESTINE INFECTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; STOMACH ACID; VIBRIO CHOLERAE;

ANIMALIA; BACTERIA (MICROORGANISMS); NEGIBACTERIA; ORYCTOLAGUS CUNICULUS; PROKARYOTA; VIBRIO CHOLERAE;

EID: 0032704187     PISSN: 0950382X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2958.1999.01650.x     Document Type: Article

References (52)

1. Altschul, S.F. Madden, T.L., Schaffer, A.A., Zhang, J., Zhang, Z., Miller W., et al. (1997) Gapped BLAST and PSI-BLAST: A new generation of protein database search programs. Nucleic Acids Res 25: 3389-3402.
2. Auger, E.A., and Bennett, G.N. (1989) Regulation of lysine decarboxylase activity in Escherichia coli K-12. Arch Microbiol 151: 466-468.
3. Baik, H.S., Bearson, S., Dunbar, S., and Foster, J.W. (1996) The acid tolerance response of Salmonella typhimurium provides protection against organic acids. Microbiology 142: 3195-3200.
4. Bearson, S., Bearson, B., and Foster, J.W. (1997) Acid stress responses in enterobacteria. FEMS Microbiol Lett 147: 173-180.
5. Bearson, B.L., Wilson, L., and Foster, J.W. (1998) A low pH-inducible, PhoPQ-dependent acid tolerance response protects Salmonella typhimurium against inorganic acid stress. J Bacteriol 180: 2409-2417.
6. Buchanan, R.E., Gibbons, N.E., Cowan, S.T., Holt, J.G., Liston, J., Murray, R.G.E., et al. (1974) Bergey's Manual of Determinative Bacteriology. Baltimore: Williams and Wilkins.
7. Camilli, A., and Mekalanos, J.J. (1995) Use of recombinase gene fusions to identify Vibrio cholerae genes induced during infection. Mol Microbiol 18: 671-683.
8. Camilli, A., Beattie, D., and Mekalanos, J. (1994) Use of genetic recombination as a reporter of gene expression. Proc Natl Acad Sci USA 91: 2634-2638.
9. Carroll, P.A., Tashima, K.T., Rogers, M.B., DiRita, V.J., and Calderwood, S.B. (1997) Phase variation in tcpH modulates expression of the ToxR regulon in Vibrio cholerae. Mol Microbiol 25: 1099-1111.
10. Cash, R.A., Music, S.I., Libonati, J.P., Snyder, M.J.J., Wenzel, R.P., and Hornick, R.B. (1974) Response of man to infection with Vibrio cholerae. I. Clinical, serologic, and bacteriologic responses to a known inoculum. J Infect Dis 129: 45-52.
11. Champion, G.A., Neely, M.N., Brennan, M.A., and DiRita, V.J. (1997) A branch in the ToxR regulatory cascade of Vibrio cholerae revealed by characterization of toxT mutant strains. Mol Microbiol 23: 323-331.
12. Chiang, S.L., and Mekalanos, J.J. (1998) Use of signaturetagged transposon mutagenesis to identify Vibrio cholerae genes critical for colonization. Mol Microbiol 27: 797-805.
13. Cummings, J.H. (1981) Short chain fatty acids in the human colon. Gut 22: 763-779.
14. DiRita, V.J., Parsot, C., Jander, G., and Mekalanos, J.J. (1991) Regulatory cascade controls virulence in Vibrio cholerae. Proc Natl Acad Sci USA 88: 5403-5407.
15. Donnenberg, M.S., and Kaper, J.B. (1991) Construction of an eae deletion mutant of enteropathogenic Escherichia coli by using a positive-selection suicide vector. Infect Immun 59: 4310-4317.
16. Formal, S.B., Kundel, D., Schneider, H., Kunev, N., and Sprinz, H. (1961) Studies with Vibrio cholerae in the ligated loop of the rabbit intestine. Br J Exp Pathol 42: 504-510.
17. Foster, J.W. (1991) Salmonella acid shock proteins are required for the adaptive acid tolerance response. J Bacteriol 173: 6896-6902.
18. Foster, J.W. (1999) When protons attack: Microbial strategies of acid adaptation. Curr Opin Microbiol 2: 170-174.
19. Foster, J.W., and Hall, H.K. (1991) Inducible pH homeostasis and the acid tolerance response of Salmonella typhimurium. J Bacteriol 173: 5129-5135.
20. Gale, E.F., and Epps, H.M.R. (1942) The effect of the pH of the medium during growth on the enzymic activities of bacteria (E. coli and M. lysodiekticus) and the biological significance of the changes produced. Biochemistry 36: 600-619.
21. Goldberg, M.C., Boyko, S.A., Butterton, J.R., Stoebner, J.A., Payne, S.M., and Calderwood, S.B. (1992) Characterization of a Vibrio cholerae virulence factor homologous to the family of TonB-dependent proteins. Mol Microbiol 6: 2407-2418.
22. Hanahan, D. (1983) Studies on transformation of Escherichia coli with plasmids. J Mol Biol 166: 557-580.
23. Hase, C.C., and Mekalanos, J.J. (1998) TcpP protein is a positive regulator of virulence gene expression in Vibrio cholerae. Proc Natl Acad Sci USA 95: 730-734.
24. Henderson, D.P., and Payne, S.M. (1994) Vibrio cholerae iron transport systems: roles of heme and siderophore iron transport in virulence and identification of a gene associated with multiple iron transport systems. Infect Immun 62: 5120-5125.
25. Hersh, B.M., Farooq, F.T., Barstad, D.N., Blankenhorn, D.L., and Slonczewski, J.L. (1996) A glutamate-dependent acid resistance gene in Escherichia coli. J Bacteriol 178: 3978-3981.
26. Kaper, J.B., Fasano, A., and Trucksis, M. (1994) Toxins of Vibrio cholerae. In Vibrio Cholerae and Cholera: Molecular to Global Perspectives. Wachsmuth, I.K., Blake, P.A., and Olsvik, O. (eds). Washington, DC: American Society for Microbiology Press, pp. 145-176.
27. Kolter, R., Inuzuka, M., and Helinski, D.R. (1978) Trans-complementation-dependent replication of a low molecular weight origin fragment from plasmid R6K. Cell 15: 1199-1208.
28. Lee, I.S., Sloncewski, J.L., and Foster, J.W. (1994) A low-pH inducible stationary phase acid tolerance response in Salmonella typhimurium. J Bacteriol 176: 1422-1426.
29. Lee, S.H., Angelichio, M.J., Mekalanos, J.J., and Camilli, A. (1998) Nucleotide sequence and spatiotemporal expression of the Vibrio cholerae vieSAB genes during infection. J Bacteriol 180: 2298-2305.
30. Lin, J., Lee, I.S., Frej, J., Slonczewski, J.L., and Foster, J.W. (1995) Comparative analysis of extreme acid survival in Salmonella typhimurium, Shigella flexneri and Escherichia coli. J Bacteriol 177 (4097-4104).
31. Mahan, M.J., Slauch, J.M., Hanna, P.C., Camilli, A., Tobias, J.W., Waldor, M.K., et al. (1993) Selection for bacterial genes that are specifically induced in host tissues: The hunt for virulence factors (review). Infect Agents Dis 2: 263-268.
32. Marron, L., Emerson, N., Gahan, C.G., and Hill, C. (1997) A mutant of Listeria monocytogenes LO28 unable to induce an acid tolerance response displays diminished virulence in a murine model. Appl Environ Microbiol 63: 4945-4947.
33. Meng, S.Y., and Bennett, G.N. (1992a) Nucleotide sequence of the Escherichia coli cad operon: A system for neutralization of low extracellular pH. J Bacteriol 174: 2659-2669.
34. Meng, S.Y., and Bennett, G.N. (1992b) Regulation of the Escherichia coli cad operon: Location of a site required for acid induction. J Bacteriol 174: 2670-2678.
35. Miller, V.L., and Mekalanos, J.J. (1988) A novel suicide vector and its use in construction of insertion mutations: Osmoregulation of outer membrane proteins and virulence determinants in Vibrio cholerae requires toxR. J Bacteriol 170: 2575-2583.
36. Neely, M.N., and Olson, E.R. (1996) Kinetics of expression of the Escherichia coli cad operon as a function of pH and lysine. J Bacteriol 178: 5522-5528.
37. Neely, M.N., Dell, C.L., and Olson, E.R. (1994) Roles of LysP and CadC in mediating the lysine requirement for acid induction of the Escherichia coli cad operon. J Bacteriol 176: 3278-3285.
38. Park, Y.K., Bearson, B., Bang, S.H., Bang, I.S., and Foster, J.W. (1996) Internal pH crisis, lysine decarboxylase and the acid tolerance response of Salmonella typhimurium. Mol Microbiol 20: 605-611.
39. Peterson, K.M., and Mekalanos, J.J. (1988) Characterization of the Vibrio cholerae ToxR regulon: Identification of novel genes involved in intestinal colonization [published erratum appears in Infect Immun 1989 57 (2): 660]. Infect Immun 56: 2822-2829.
40. Ramesh, M.V., and Kolattukudy, P.E. (1996) Disruption of the serine proteinase gene (sep) in Aspergillus flavus leads to a compensatory increase in the expression of a metalloproteinase gene (mep20). J Bacteriol 178: 3899-3907.
41. Roberts, A., Pearson, G.D., and Mekalanos, J.J. (1992) Cholera vaccine strains derived from a 1991 Peruvian isolate of Vibrio cholerae and other El Tor strains. In Proceedings of the 28th Joint Conference, U.S.-Japan Cooperative Medical Science Program on Cholera and Related Diarrheal Diseases.
42. Samartzidou, H., and Delcour, A.H. (1999) Excretion of endogenous cadaverine leads to a decrease in porinmediated outer membrane permeability. J Bacteriol 181: 791-798.
43. Scott, D.R., Weeks, D., Hong, C., Postius, S., Melchers, K., and Sachs, G. (1998) The role of internal urease in acid resistance of Helicobacter pylori. Gastroenterology 114: 58-70.
44. Skorupski, K., and Taylor, R.K. (1997) Control of the ToxR virulence ragulon in Vibrio cholerae by environmental stimuli. Mol Microbiol 25: 1003-1009.
45. Skorupski, K., and Taylor, R.K. (1999) A new level in the Vibrio cholerae ToxR virulence cascade: aphA is required for transcriptional activation of the tcpPH operon. Mol Microbiol 31: 763-771.
46. Takayama, M., Ohyama, T., Igarashi, K., and Kobayashi, H. (1994) Escherichia coli cad operon functions as a supplier of carbon dioxide. Mol Microbiol 11: 913-918.
47. Taylor, R.K., Miller, V.L., Furlong, D.B., and Mekalanos, J.J. (1987) Use of phoA gene fusions to identify a pilus colonization factor coordinately regulated with cholera toxin. Proc Natl Acad Sci USA 84: 2833-2837.
48. Wachsmuth, I.K., Blake P.A., and Olsvik, O. (1994) Vibrio Cholerae and Cholera: Molecular to Global Perspectives. Washington, DC: American Society for Microbiology Press.
49. Waldor, M.K., and Mekalanos, J.J. (1996) Lysogenic conversion by a filamentous phage encoding cholera toxin [see comments]. Science 272: 1910-1914.
50. Watson, N., Dunyak, D.S., Rosey, E.L., Slonczewski, J.L., and Olson, E.R. (1992) Identification of elements involved in transcriptional regulation of the Escherichia coli cad operon by external pH. J Bacteriol 174: 530-540.
51. Wong, S.M., Carroll, P.A., Rahme, L.G., Ausubel, F.M., and Calderwood, S.B. (1998) Modulation of expression of the ToxR regulon in Vibrio cholerae by a member of the two-component family of response regulators. Infect Immun 66: 5854-5861.
52. Yildiz, F.H., and Schoolnik, G.K. (1998) Role of rpoS in stress survival and virulence of Vibrio cholerae. J Bacteriol 180: 773-784.