Elevated N1-acetylspermidine levels in gerbil and rat brains after CNS injury

Journal of Neurochemistry

Volumn 74, Issue 3, 2000, Pages 1106-1111

  Rao, A Muralikrishna ^a   Hatcher, James F ^a   Doǧan, Aclan ^a   Dempsey, Robert J ^a,b  

^a UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

^b University of Wisconsin Health   (United States)

Author keywords

Cerebral ischemia; MDL 72527; Omithine decarboxylase; Polyamine interconversion pathway; Polyamine oxidase; Polyamines; Putrescine; Spermidine spermine N1 acetyltransferase; Traumatic brain injury

Indexed keywords

MESSENGER RNA; N,N' BIS(2,3 BUTADIENYL)PUTRESCINE; N1 ACETYLSPERMIDINE; ORNITHINE DECARBOXYLASE; POLYAMINE OXIDASE; PUTRESCINE; DRUG DERIVATIVE; N(1) ACETYLSPERMIDINE; N(1)-ACETYLSPERMIDINE; SPERMIDINE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN EDEMA; BRAIN INFARCTION; BRAIN INJURY; BRAIN ISCHEMIA; CENTRAL NERVOUS SYSTEM DISEASE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; ESSENTIAL HYPERTENSION; GERBIL; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; ANIMAL; BLOOD BRAIN BARRIER; BRAIN; BRAIN ARTERY; DRUG ANTAGONISM; FOREBRAIN; METABOLISM; PERIPHERAL OCCLUSIVE ARTERY DISEASE; REPERFUSION INJURY; SPONTANEOUSLY HYPERTENSIVE RAT; SPRAGUE DAWLEY RAT; TRANSIENT ISCHEMIC ATTACK; VASCULARIZATION;

ANIMALIA; GERBILLINAE;

ANIMALS; ARTERIAL OCCLUSIVE DISEASES; BLOOD-BRAIN BARRIER; BRAIN; BRAIN INJURIES; CEREBRAL ARTERIES; GERBILLINAE; ISCHEMIC ATTACK, TRANSIENT; MALE; PROSENCEPHALON; PUTRESCINE; RATS; RATS, INBRED SHR; RATS, SPRAGUE-DAWLEY; REPERFUSION INJURY; SPERMIDINE;

EID: 0033621944     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.2000.741106.x     Document Type: Article

References (44)

1. Başkaya M. K., Rao A. M., Prasad M. R., and Dempsey R. J. (1996a) Regional activity of ornithine decarboxylase and edema formation after traumatic brain injury. Neurosurgery 38, 140-145.
2. Başkaya M. K., Rao A. M., Puckett L., Prasad M. R., and Dempsey R. J. (1996A) Effect of difluoromethylornithine treatment on regional ornithine decarboxylase activity and edema formation after experimental brain injury. J. Neurotrauma 13, 85-92.
3. Başkaya M. K., Rao A. M., Doǧan A., Donaldson D., and Dempsey R. J. (1997a) The biphasic opening of the blood-brain barrier in the cortex and hippocampus after traumatic brain injury in rats. Neurosci. Lett. 226, 33-36.
4. Başkaya M. K., Rao A. M., Doǧan A., Donaldson D., Gellin G., and Dempsey R. J. (1997b) Regional brain polyamine levels in permanent focal cerebral ischemia. Brain Res. 744, 302-308.
5. Başkaya M. K., Rao A. M., Donaldson D., Prasad M. R., and Dempsey R. J. (1997c) Protective effects of ifenprodil on ischemic injury size, blood-brain barrier breakdown, and edema formaion in focal cerebral ischemia. Neurosurgery 40, 364-370.
6. Baudry M. and Najm I. (1994) Kainate-induced seizure activity stimulates the polyamine inter-conversion pathway in rat brain. Neurosci. Lett. 171, 151-154.
7. 1-acetyltransferase - the turning point in polyamine metabolism. FASEB J. 7, 653-661.
8. de Vera N., Camon L., and Martinez E. (1997) Polyamines and brain injury. Amino Acids 12, 1-7.
9. Dempsey R. J., Carney J. M., and Kindy M. S. (1991) Modulation of ornithine decarboxylase mRNA following transient ischemia in the gerbil brain. J. Cereb. Blood Flow Metab. 11, 979-985.
10. Doǧan A., Başkaya M. K., Rao V. L. R., Rao A. M., and Dempsey R. J. (1998) Intraluminal suture occlusion of the middle cerebral artery in spontaneously hypertensive rats. Neurol Res. 20, 265-270.
11. Doǧan A., Rao A. M., Baskaya M. K., Hatcher J., Temiz C., Rao V. L. R., and Dempsey R. J. (1999a) Contribution of polyamine oxidase to brain injury after trauma. J. Neurosurg. 90, 1078-1082.
12. Doǧan A., Rao A. M., Hatcher J., Rao V. L. R., Baskaya M. K., and Dempsey R. J. (19996) Effects of MDL 72527, a specific inhibitor of polyamine oxidase, on brain edema, ischemic injury volume, and tissue polyamine levels in rats after temporary middle cerebral artery occlusion. J. Neurochem. 72, 765-770.
13. 1-acetyltransferase by a post-transcriptional mechanism in mammalian cells. Biochem. J. 294, 491-495.
14. Hayashi Y. and Baudry M. (1995) Effect of kainate-induced seizure activity on the polyamine interconversion pathway in juvenile rat brain. Dev. Brain Res. 87, 96-99.
15. Henley C. M., Muszynski C., Cherian L., and Robertson C. S. (1996) Activation of ornithine decarboxylase and accumulation of putrescine after traumatic brain injury. J. Neurotrauma 13, 487-496.
16. Henley C. M., Wey K., Takashima A., Mills C., Granmayeh E., Krishnappa I., and Robertson C. S. (1997) S-Adenosylmethionine decarboxylase activity is decreased in the rat cortex after traumatic brain injury. J. Neurochem. 69, 259-265.
17. Ivanova S., Botchkina G. I., Alabed Y., Meistrell M., Batliwalla F., Dubinsky J. M., Iadecola C., Wang H. C., Gregersen P. K., Eaton J. W., and Tracey K. J. (1998) Cerebral ischemia enhances polyamine oxidation - Identification of enzymatically formed 3-aminopropanal as an endogenous mediator of neuronal and glial cell death. J. Exp. Med. 188, 327-340.
18. Johnson T. D. (1998) Polyamines and cerebral ischemia. Prog. Drug Res. 50, 193-258.
19. Kabra P. M., Lee H. K., Lubich W. P., and Marton L. J. (1986) Solid-phase extraction and determination of dansyl derivatives of unconjugated and acetylated polyamines by reversed-phase liquid chromatography: improved separation systems for polyamines in cerebrospinal fluid, urine and tissue. J. Chromatogr. 380, 19-32.
20. Keinanen R., Miettinen S., Yrjanheikki J., and Koistinaho J. (1997) Induction of ornithine decarboxylase mRNA in transient focal cerebral ischemia in the rat. Neurosci. Lett. 239, 69-72.
21. Kindy M. S., Hu Y., and Dempsey R. J. (1994) Blockade of ornithine decarboxylase enzyme protects against ischemic brain damage. J. Cereb. Blood Flow Metab. 14, 1040-1045.
22. Koenig H., Goldstone A. D., and Lu C. Y. (1983) Blood brain barrier breakdown in brain edema following cold injury is mediated by microvascular polyamines. Biochem. Biophys. Res. Commun. 116, 1039-1048.
23. Lukkarinen J., Grohn O. H. J., Sinervirta R., Jarvinen A., Kauppinen R. A., Janne J., and Alhonen L. I. (1997) Transgenic rats as models for studying the role of ornithine decarboxylase expression in permanent middle cerebral artery occlusion. Stroke 28, 639-645.
24. Lukkarinen J. A., Kauppinen R. A., Grohn O. H., Oja J. M., Sinervirta R., Jarvinen A., Alhonen L. I., and Janne J. (1998) Neuroprotective role of ornithine decarboxylase activation in transient focal cerebral ischaemia: a study using ornithine decarboxylase-overexpressing transgenic rats. Eur. J. Neurosci. 10, 2046-2055.
25. Marton L. J. and Pegg A. E. (1995) Polyamines as targets for therapeutic intervention. Annu. Rev. Pharmacol. Toxicol. 35, 55-91.
26. Morgan D. M. (1987) Polyamines. Essays Biochem. 23, 82-115.
27. Morgan D. M. L. (1998) Polyamine oxidases - enzymes of unknown function? Biochem. Soc. Trans. 26, 586-591.
28. Paschen W. (1992a) Polyamine metabolism in different pathological states of the brain. Mol. Chem. Neuropathol. 16, 241-271.
29. Paschen W. (1992A) Polyamine metabolism in reversible cerebral ischemia. Cerebrovasc. Brain Metab. Rev. 4, 59-88.
30. Paschen W., Rohn G., Meese C. O., Djuricic B., and Schmidt-Kastner R. (1988) Polyamine metabolism in reversible cerebral ischemia: effect of alpha-difluoromethylornithine. Brain Res. 453, 9-16.
31. Paschen W., Cleef M., Rohn G., Muller M., and Pajunen A. E. (1993) Ischemia-induced disturbances of polyamine synthesis. Prog. Brain Res. 96, 147-160.
32. Pegg A. E. and McCann P. P. (1982) Polyamine metabolism and function. Am. J. Physiol. 243, C212-C221.
33. Persson L. and Pegg A. E. (1984) Studies of the induction of spermidine/spermine N1-acetyltransferase using a specific antiserum. J. Biol. Chem. 259, 12364-12367.
34. Rao A. M., Baskaya M. K., Maley M. E., Prasad M. R., and Dempsey R. J. (1995) Ornithine decarboxylase activity and edema formation in cerebral ischemia of conscious gerbils. J. Neurochem. 65, 2639-2643.
35. Rao A. M., Baskaya M. K., Maley M. E., Kindy M. S., and Dempsey R. J. (1997) Beneficial effects of S-adenosyl-L-methionine on blood-brain barrier breakdown and neuronal survival after transient cerebral ischemia in gerbils. Mol. Brain Res. 44, 134-138.
36. Rao A. M., Hatcher J. F., Baskaya M. K., and Dempsey R. J. (1998) Simultaneous assay of ornithine decarboxylase and polyamines after central nervous system injury in gerbils and rats. Neurosci. Lett. 256, 65-68.
37. Rao A. M., Hatcher J. F., and Dempsey R. J. (1999a) CDP-choline: neuroprotection in transient forebrain ischemia of gerbils. J. Neurosci. Res. 58, 697-705.
38. Rao A. M., Hatcher J. F., Kindy M. S., and Dempsey R. J. (1999b) Arachidonic acid and leukotriene C4: role in transient cerebral ischemia of gerbils. Neurochem. Res. 24, 1225-1232.
39. Schmitz M. P., Combs D. J., and Dempsey R. J. (1993) Difluoromethylornithine decreases postischemic brain edema and blood-brain barrier breakdown. Neurosurgery 33, 882-887.
40. Seiler N. (1995) Polyamine oxidase, properties and functions. Prog. Brain Res. 106, 333-344.
41. Seiler N, and Bolkenius F. N. (1985) Polyamine reutilization and turnover in brain. Neurochem. Res. 10, 529-544.
42. 1-acetyltransferase under the control of mouse metallothionein I promoter in transgenic mice: evidence for a striking post-transcriptional regulation of transgene expression by a polyamine analogue. Biochem. J. 338, 311-316.
43. 1-acetyltransferase - emerging targets for rational inhibitor design, in Polyamines: Regulation and Molecular Interaction (Casero R., ed), pp. 171-204. R. G. Landes Co., Austin, Texas.
44. 1-acetyltransferase mRNA levels show marked and region-specific changes in the early phase after transient forebrain ischemia. Mol. Brain Res. 38, 122-134.