Deregulation of polyamine biosynthesis alters intrinsic histone acetyltransferase and deacetylase activities in murine skin and tumors

Cancer Research

Volumn 62, Issue 1, 2002, Pages 67-74

  Hobbs, Cheryl A ^a   Paul, Barry A ^a   Gilmour, Susan K ^a  

^a LANKENAU INSTITUTE FOR MEDICAL RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN BINDING PROTEIN; EFLORNITHINE; HISTONE ACETYLTRANSFERASE; HISTONE DEACETYLASE; HISTONE H4; LYSINE; POLYAMINE; PROTEIN P300;

ACETYLATION; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIOSYNTHESIS; CELL CULTURE; CHROMATIN STRUCTURE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; EPITHELIUM CELL; GENETIC TRANSCRIPTION; KERATINOCYTE; MOUSE; NONHUMAN; ONCOGENE RAS; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; SKIN TUMOR; SOLID TUMOR; TRANSGENIC MOUSE; TUMOR REGRESSION;

ACETYLATION; ACETYLTRANSFERASES; ANIMALS; BIOGENIC POLYAMINES; CELL TRANSFORMATION, NEOPLASTIC; FEMALE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HISTONE ACETYLTRANSFERASES; HISTONE DEACETYLASES; HISTONES; KERATINOCYTES; MALE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; ORNITHINE DECARBOXYLASE; SACCHAROMYCES CEREVISIAE PROTEINS; SKIN; SKIN NEOPLASMS;

EID: 0036142967     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (65)

1. Histone acetyltransferase activity and interaction with ADA2 are critical for GCN5 function in vivo
2. Histone acetyltransferase activity of yeast Gen5p is required for the activation of target genes in vivo
3. The acetyltransferase activity of CBP stimulates transcription
4. Histone acetyltransferase activity is conserved between yeast and human GCN5 and is required for complementation of growth and transcriptional activation
5. Transcriptional repression by UME6 involves deacetylation of lysine 5 of histone H4 by RPD3
6. A positive role for histone acetylation in transcription factor access to nucleosomal DNA
7. Histone acetyltransferase complexes
8. Histone deacetylases: Transcriptional repression with SINers and NuRDs
9. Transcription factor-specific requirements for coactivators and their acetyltransferase functions
10. Retinoid receptors in health and disease: Co-regulators and the chromatin connection
11. Co-activators and co-repressors in the integration of transcriptional responses
12. Coactivator and corepressor complexes in nuclear receptor function
13. Histone acetyltransferase activity of CBP is controlled by cycledependent kinases and oncoprotein E1A
14. Phosphorylation by p44 MAP Kinase/ERK1 stimulates CBP histone acetyl transferase activity in vitro
15. Regulation of hormoneinduced histone hyperacetylation and gene activation via acetylation of an acetylase
16. ATF-2 has intrinsic histone acetyltransferase activity which is modulated by phosphorylation
17. Mutations truncating the EP300 acetylase in human cancers
18. When the band begins to play: Histone acetylation caught in the crossfire of gene control
19. Something about silencing
20. Rubinstein Taybi syndrome caused by mutations in the transcriptional co-activator CBP
21. p 300 gene alterations in colorectal and gastric carcinomas
22. Histone deacetylases, transcriptional control, and cancer
23. Effect of spermine on acetylation of histones in rabbit heart
24. Decreased expression of protooncogenes c-fos, c-myc, and c-jun following polyamine depletion in IEC-6 cells
25. Polyamines differentially modulate the transcription of growth-associated genes in human colon carcinoma cells
26. Elevated cellular polyamine levels enhance promoter activity in vivo
27. Role of ornithine decarboxylase in epidermal tumorigenesis
28. Ornithine decarboxylase overexpression leads to increased epithelial tumor invasiveness
29. Increased frequency of spontaneous skin tumors in transgenic mice which overexpress ornithine decarboxylase
30. Co-operation between follicular ornithine decarboxylase and v-Ha-ras induces spontaneous papillomas and malignant conversion in transgenic skin
31. Biphasic effect of polyamines on chromatin-bound histone deacetylase
32. Activation by polyamines of the acetylation of endogenous histones in isolated chromatin and nuclei from Artemia
33. Polyamines inhibit the yeast histone deacetylase
34. Ornithine decarboxylase transformation of N1H/3T3 cells is mediated by altered epidermal growth factor receptor activity
35. High levels of intracellular polyamines promote histone acetyltransferase activity resulting in chromatin hyperacetylation
36. Acetylation and deacetylation of histone H4 continue through metaphase with depletion of more-acetylated isoforms and altered site usage
37. Histone H4 isoforms acetylated at specific lysine residues define individual chromosomes and chromatin domains in Drosophila polytene nuclei
38. Yeast heterochromatin: Regulation of its assembly and inheritance by histones
39. Type B histone acetyltransferase Hatlp participates in telomeric silencing
40. Altered differentiation of mouse epidermal cells treated with retinyl acetate in vitro
41. Calcium regulation of growth and differentiation of mouse epidermal cells in culture
42. Inhibition of ornithine decarboxylase (ODC) decreases tumor vascularization and reverses spontaneous tumors in ODC/Ras transgenic mice
43. Role of CBP/P300 in nuclear receptor signalling
44. p300 and CBP: Partners for lifedeath
45. A p300/CBP-associated factor that competes with the adenoviral oncoprotein EIA
46. Overlapping but distinct patterns of histone acetylation by the human coactivators p300 and PCAF within nucleosomal substrates
47. Mammalian GCN5 and P/CAF acetyl transferases have homologous amino-terminal domains important for recognition of nucleosomal substrates
48. Histone deacetylases: Silencers for hire
49. Sin meets NuRD and other tails of repression
50. 1 and S phase of the cell cycle is regulated by repressor complexes containing HDAC-Rb-hSWI/SNF and Rb-hSWI/SNF
51. DNA methyltransferase Dnmt 1 associates with histone deacetylase activity
52. Functional interaction between GCN5 and polyamines: A new role for core histone acetylation
53. Tumor progression is accompanied by significant changes in the levels of expression of polyamine metabolism regulatory genes and clusterin (sulfated glycoprotein 2) in human prostate cancer specimens
54. Development of difluoromethylomithine (DFMO) as a chemoprevention agent
55. Polyamines and acetytpolyamines increase the stability and alter the conformation of nucleosome core particles
56. Implications and concepts of polyamine-nucleic acid interactions
57. Acetylation: A regulatory modification to rival phosphorylation?
58. A CBP integrator complex mediates transcriptional activation and AP-1 inhibition by nuclear receptors
59. Nuclear integration of JAK/STAT and Ras/AP-1 signaling by CBP and p300
60. Non-random acetylation of histone H4 by a cytoplasmic histone acetyltransferase as determined by novel methodology
61. Nucleosomal DNA regulates the core-histone-binding subunit of the human Hat 1 acetyltransferase
62. HAT1 and HAT2 proteins are components of a yeast nuclear histone acetyltransferase enzyme specific for free histone H4
63. Nuclear compartmentalization and gene activity
64. Positions of potential: Nuclear organization and gene expression