메뉴 건너뛰기




Volumn 77, Issue 3 SUPPL., 2007, Pages

Impaired metabolism-secretion coupling in pancreatic β-cells: Role of determinants of mitochondrial ATP production

Author keywords

ATP; Glucose metabolism; Impaired insulin secretion; Mitochondria; Pancreatic cell

Indexed keywords

6 PHOSPHOFRUCTOKINASE; ADENOSINE TRIPHOSPHATASE (CALCIUM); ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); ADENOSINE TRIPHOSPHATE; CALCINEURIN; FATTY ACID; GLUCOKINASE; GLUCOSE; INSULIN; ISOCITRATE DEHYDROGENASE; KETONE BODY; MALATE DEHYDROGENASE; NITRIC OXIDE; OUABAIN; PHENYTOIN; POTASSIUM CHANNEL; PYRUVATE DEHYDROGENASE; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; TACROLIMUS; TRANSCRIPTION FACTOR NFAT; UNCOUPLING PROTEIN 2; VOLTAGE GATED CALCIUM CHANNEL;

EID: 34547699225     PISSN: 01688227     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.diabres.2007.01.026     Document Type: Article
Times cited : (30)

References (80)
  • 1
    • 0033760442 scopus 로고    scopus 로고
    • Triggering and amplifying pathways of regulation of insulin secretion by glucose
    • Henquin J.C. Triggering and amplifying pathways of regulation of insulin secretion by glucose. Diabetes 49 (2000) 1751-1760
    • (2000) Diabetes , vol.49 , pp. 1751-1760
    • Henquin, J.C.1
  • 2
    • 0030748260 scopus 로고    scopus 로고
    • Signal transduction mechanisms in nutrient-induced insulin secretion
    • Prentki M., Tornheim K., and Corkey B.E. Signal transduction mechanisms in nutrient-induced insulin secretion. Diabetologia 40 (1997) S32-S41
    • (1997) Diabetologia , vol.40
    • Prentki, M.1    Tornheim, K.2    Corkey, B.E.3
  • 3
    • 0033540037 scopus 로고    scopus 로고
    • Mitochondrial glutamate acts as a messenger in glucose-induced insulin exocytosis
    • Maechler P., and Wollheim C.B. Mitochondrial glutamate acts as a messenger in glucose-induced insulin exocytosis. Nature 402 (1999) 685-989
    • (1999) Nature , vol.402 , pp. 685-989
    • Maechler, P.1    Wollheim, C.B.2
  • 4
    • 0030894850 scopus 로고    scopus 로고
    • The pancreatic beta-cell as a fuel sensor: an electrophysiologist's viewpoint
    • Rorsman P. The pancreatic beta-cell as a fuel sensor: an electrophysiologist's viewpoint. Diabetologia 40 (1997) 487-495
    • (1997) Diabetologia , vol.40 , pp. 487-495
    • Rorsman, P.1
  • 6
    • 0036142664 scopus 로고    scopus 로고
    • Prior exposure to high glucose augments depolarization-induced insulin release by mitigating the decline of ATP level in rat islets
    • Fujimoto S., Mukai E., Hamamoto Y., Takeda T., Takehiro M., Yamada Y., et al. Prior exposure to high glucose augments depolarization-induced insulin release by mitigating the decline of ATP level in rat islets. Endocrinology 143 (2002) 213-221
    • (2002) Endocrinology , vol.143 , pp. 213-221
    • Fujimoto, S.1    Mukai, E.2    Hamamoto, Y.3    Takeda, T.4    Takehiro, M.5    Yamada, Y.6
  • 7
    • 0031892856 scopus 로고    scopus 로고
    • Effects of depletion of mitochondrial DNA in metabolism secretion coupling in INS-1 cells
    • Kennedy E.D., Maechler P., and Wollheim C.B. Effects of depletion of mitochondrial DNA in metabolism secretion coupling in INS-1 cells. Diabetes 47 (1998) 374-380
    • (1998) Diabetes , vol.47 , pp. 374-380
    • Kennedy, E.D.1    Maechler, P.2    Wollheim, C.B.3
  • 8
    • 17444440352 scopus 로고    scopus 로고
    • Creation and characterization of a mitochondrial DNA-depleted pancreatic β-cell line: impaired insulin secretion induced by glucose, leucine, and sulfonylureas
    • Tsuruzoe K., Araki E., Furukawa N., Shirotani T., Matsumoto K., Kaneko K., et al. Creation and characterization of a mitochondrial DNA-depleted pancreatic β-cell line: impaired insulin secretion induced by glucose, leucine, and sulfonylureas. Diabetes 47 (1998) 621-631
    • (1998) Diabetes , vol.47 , pp. 621-631
    • Tsuruzoe, K.1    Araki, E.2    Furukawa, N.3    Shirotani, T.4    Matsumoto, K.5    Kaneko, K.6
  • 9
    • 0022467904 scopus 로고
    • Pancreatic islet glucose metabolism and regulation of insulin secretion
    • Meglasson M.D., and Matschinsky F.M. Pancreatic islet glucose metabolism and regulation of insulin secretion. Diab. Metab. Rev. 2 (1986) 163-214
    • (1986) Diab. Metab. Rev. , vol.2 , pp. 163-214
    • Meglasson, M.D.1    Matschinsky, F.M.2
  • 10
    • 0026608764 scopus 로고
    • Close linkage of glucokinase locus on chromosome 7p to early-onset non-insulin-dependent diabetes mellitus
    • Froguel P., Vaxillaire M., Sun F., Velho G., Zouali H., Butel M.O., et al. Close linkage of glucokinase locus on chromosome 7p to early-onset non-insulin-dependent diabetes mellitus. Nature 356 (1992) 162-164
    • (1992) Nature , vol.356 , pp. 162-164
    • Froguel, P.1    Vaxillaire, M.2    Sun, F.3    Velho, G.4    Zouali, H.5    Butel, M.O.6
  • 11
    • 0025753951 scopus 로고
    • Activated macrophages kill pancreatic syngeneic islet cells via arginine-dependent nitric oxide generation
    • Kroncke K.D., Kolb-Bachofen V., Berschick B., Burkart V., and Kolb H. Activated macrophages kill pancreatic syngeneic islet cells via arginine-dependent nitric oxide generation. Biochem. Biophys. Res. Commun. 175 (1991) 752-758
    • (1991) Biochem. Biophys. Res. Commun. , vol.175 , pp. 752-758
    • Kroncke, K.D.1    Kolb-Bachofen, V.2    Berschick, B.3    Burkart, V.4    Kolb, H.5
  • 13
    • 0028179849 scopus 로고
    • Interleukin-1β-induced nitric oxide production activates apoptosis in pancreatic RINm5F cells
    • Ankarcrona M., Dypbukt J.M., Brune B., and Nicotera P. Interleukin-1β-induced nitric oxide production activates apoptosis in pancreatic RINm5F cells. Exp. Cell Res. 213 (1994) 172-177
    • (1994) Exp. Cell Res. , vol.213 , pp. 172-177
    • Ankarcrona, M.1    Dypbukt, J.M.2    Brune, B.3    Nicotera, P.4
  • 14
    • 0025288305 scopus 로고
    • Interleukin-1β inhibits glucokinase activity in clonal HIT-T15 beta-cells
    • Beggs M., Beresford G., Clarke J., Mertz R., Espinal J., and Hammonds P. Interleukin-1β inhibits glucokinase activity in clonal HIT-T15 beta-cells. FEBS Lett. 267 (1990) 217-220
    • (1990) FEBS Lett. , vol.267 , pp. 217-220
    • Beggs, M.1    Beresford, G.2    Clarke, J.3    Mertz, R.4    Espinal, J.5    Hammonds, P.6
  • 15
    • 0028670668 scopus 로고
    • + channels through suppression of phosphofructokinase activity and inhibits glucose-induced insulin release in pancreatic beta cells
    • + channels through suppression of phosphofructokinase activity and inhibits glucose-induced insulin release in pancreatic beta cells. J. Gen. Physiol. 104 (1994) 1079-1098
    • (1994) J. Gen. Physiol. , vol.104 , pp. 1079-1098
    • Tsuura, Y.1    Ishida, H.2    Hayashi, S.3    Sakamoto, K.4    Horie, M.5    Seino, Y.6
  • 16
    • 0025833992 scopus 로고
    • Interleukin-1β-induced nitric oxide production in isolated rat pancreatic islets requires gene transcription and may lead to inhibition of the Krebs cycle enzyme aconitase
    • Welsh N., Eizirik D.L., Bendtzen K., and Sandler S. Interleukin-1β-induced nitric oxide production in isolated rat pancreatic islets requires gene transcription and may lead to inhibition of the Krebs cycle enzyme aconitase. Endocrinology 129 (1991) 3167-3173
    • (1991) Endocrinology , vol.129 , pp. 3167-3173
    • Welsh, N.1    Eizirik, D.L.2    Bendtzen, K.3    Sandler, S.4
  • 17
    • 0034805145 scopus 로고    scopus 로고
    • Heat shock restores insulin secretion after injury by nitric oxide by maintaining glucokinase activity in rat islets
    • Takeda T., Tsuura Y., Fujita J., Fujimoto S., Mukai E., Kajikawa M., et al. Heat shock restores insulin secretion after injury by nitric oxide by maintaining glucokinase activity in rat islets. Biochem. Biophys. Res. Commun. 284 (2001) 20-25
    • (2001) Biochem. Biophys. Res. Commun. , vol.284 , pp. 20-25
    • Takeda, T.1    Tsuura, Y.2    Fujita, J.3    Fujimoto, S.4    Mukai, E.5    Kajikawa, M.6
  • 18
    • 0026632736 scopus 로고
    • Morphological and functional changes of islets of Langerhans in FK506-treated rats
    • Hirano Y., Fujihira S., Ohara K., Katsuki S., and Noguchi H. Morphological and functional changes of islets of Langerhans in FK506-treated rats. Transplantation 53 (1992) 889-894
    • (1992) Transplantation , vol.53 , pp. 889-894
    • Hirano, Y.1    Fujihira, S.2    Ohara, K.3    Katsuki, S.4    Noguchi, H.5
  • 19
    • 0030469605 scopus 로고    scopus 로고
    • Effects of tacrolimus (FK506) on human insulin gene expression, insulin mRNA levels, and insulin secretion in HIT-T15 cells
    • Redmon J.B., Olson L.K., Armstrong M.B., Greene M.J., and Robertson P.R. Effects of tacrolimus (FK506) on human insulin gene expression, insulin mRNA levels, and insulin secretion in HIT-T15 cells. J. Clin. Invest. 98 (1996) 2786-2793
    • (1996) J. Clin. Invest. , vol.98 , pp. 2786-2793
    • Redmon, J.B.1    Olson, L.K.2    Armstrong, M.B.3    Greene, M.J.4    Robertson, P.R.5
  • 21
    • 19944427094 scopus 로고    scopus 로고
    • Tacrolimus suppresses glucose-induced insulin release from pancreatic islets by reducing glucokinase activity
    • Radu R.G., Fujimoto S., Mukai E., Takehiro M., Shimono D., Nabe K., et al. Tacrolimus suppresses glucose-induced insulin release from pancreatic islets by reducing glucokinase activity. Am. J. Physiol. 288 (2005) E372-E380
    • (2005) Am. J. Physiol. , vol.288
    • Radu, R.G.1    Fujimoto, S.2    Mukai, E.3    Takehiro, M.4    Shimono, D.5    Nabe, K.6
  • 22
    • 0019888328 scopus 로고
    • High content of mitochondrial glycerol-3-phosphate dehydrogenase in pancreatic islets and its inhibition by diazoxide
    • MacDonald M.J. High content of mitochondrial glycerol-3-phosphate dehydrogenase in pancreatic islets and its inhibition by diazoxide. J. Biol. Chem. 256 (1981) 8287-8290
    • (1981) J. Biol. Chem. , vol.256 , pp. 8287-8290
    • MacDonald, M.J.1
  • 23
    • 0020093110 scopus 로고
    • Evidence for the malate aspartate shuttle in pancreatic islets
    • MacDonald M.J. Evidence for the malate aspartate shuttle in pancreatic islets. Arch. Biochem. Biophys. 213 (1982) 643-649
    • (1982) Arch. Biochem. Biophys. , vol.213 , pp. 643-649
    • MacDonald, M.J.1
  • 24
    • 0030055324 scopus 로고    scopus 로고
    • Metabolic signaling of insulin secretion
    • Malaisse W.J. Metabolic signaling of insulin secretion. Diab. Rev. 4 (1996) 145-159
    • (1996) Diab. Rev. , vol.4 , pp. 145-159
    • Malaisse, W.J.1
  • 25
    • 0014299016 scopus 로고
    • Effect of starvation on plasma immunoreactive insulin and non-suppressible insulin-like activity in normal and obese humans
    • Solomon S.S., Ensinck J.W., and Williams R.H. Effect of starvation on plasma immunoreactive insulin and non-suppressible insulin-like activity in normal and obese humans. Metabolism 17 (1968) 528-534
    • (1968) Metabolism , vol.17 , pp. 528-534
    • Solomon, S.S.1    Ensinck, J.W.2    Williams, R.H.3
  • 26
    • 0032878701 scopus 로고    scopus 로고
    • Analysis and a long-term follow up of ketosis-onset Japanese NIDDM patients
    • Tanaka K., Moriya T., Kanamori A., and Yajima Y. Analysis and a long-term follow up of ketosis-onset Japanese NIDDM patients. Diab. Res. Clin. Pract. 44 (1999) 137-146
    • (1999) Diab. Res. Clin. Pract. , vol.44 , pp. 137-146
    • Tanaka, K.1    Moriya, T.2    Kanamori, A.3    Yajima, Y.4
  • 27
    • 0016230591 scopus 로고
    • Action of B-hydroxy butyrate, acetoacetate and palmitate on the insulin release in the perfused isolated rat pancreas
    • Goberna R., Tamarit Jr. J., Osorio J., Fussganger R., Tamarit J., and Pfeiffer E.F. Action of B-hydroxy butyrate, acetoacetate and palmitate on the insulin release in the perfused isolated rat pancreas. Horm. Metab. Res. 6 (1974) 256-260
    • (1974) Horm. Metab. Res. , vol.6 , pp. 256-260
    • Goberna, R.1    Tamarit Jr., J.2    Osorio, J.3    Fussganger, R.4    Tamarit, J.5    Pfeiffer, E.F.6
  • 29
    • 0029036835 scopus 로고
    • Long term exposure to fatty acids and ketones inhibits B-cell functions in human pancreatic islets of Langerhans
    • Zhou Y.P., and Grill V. Long term exposure to fatty acids and ketones inhibits B-cell functions in human pancreatic islets of Langerhans. J. Clin. Endocrinol. Metab. 80 (1995) 1584-1590
    • (1995) J. Clin. Endocrinol. Metab. , vol.80 , pp. 1584-1590
    • Zhou, Y.P.1    Grill, V.2
  • 30
    • 19944428662 scopus 로고    scopus 로고
    • Chronic exposure to β-hydroxybutyrate inhibits glucose-induced insulin release from pancreatic islets by decreasing NADH contents
    • Takehiro M., Fujimoto S., Shimodahira M., Shimono D., Mukai E., Nabe K., et al. Chronic exposure to β-hydroxybutyrate inhibits glucose-induced insulin release from pancreatic islets by decreasing NADH contents. Am. J. Physiol. 288 (2005) E365-E371
    • (2005) Am. J. Physiol. , vol.288
    • Takehiro, M.1    Fujimoto, S.2    Shimodahira, M.3    Shimono, D.4    Mukai, E.5    Nabe, K.6
  • 31
    • 0020170460 scopus 로고
    • The stimulus-secretion coupling of glucose-induced insulin release: effect of aminooxyacetate upon nutrient-stimulated insulin secretion
    • Malaisse W.J., Malaisse-Lagae F., and Sener A. The stimulus-secretion coupling of glucose-induced insulin release: effect of aminooxyacetate upon nutrient-stimulated insulin secretion. Endocrinology 111 (1982) 392-397
    • (1982) Endocrinology , vol.111 , pp. 392-397
    • Malaisse, W.J.1    Malaisse-Lagae, F.2    Sener, A.3
  • 32
    • 0033548138 scopus 로고    scopus 로고
    • Role of NADH shuttle system in glucose-induced activation of mitochondrial metabolism and insulin secretion
    • Eto K., Tsubamoto Y., Terauchi Y., Sugiyama T., Kishimoto T., Takahashi N., et al. Role of NADH shuttle system in glucose-induced activation of mitochondrial metabolism and insulin secretion. Science 283 (1999) 981-985
    • (1999) Science , vol.283 , pp. 981-985
    • Eto, K.1    Tsubamoto, Y.2    Terauchi, Y.3    Sugiyama, T.4    Kishimoto, T.5    Takahashi, N.6
  • 33
    • 0026511753 scopus 로고
    • Beta-cell dysfunction induced by chronic hyperglycemia. Current ideas on mechanism of impaired glucose-induced insulin secretion
    • Leahy J.L., Bonner-Weir S., and Weir G.C. Beta-cell dysfunction induced by chronic hyperglycemia. Current ideas on mechanism of impaired glucose-induced insulin secretion. Diab. Care 15 (1992) 442-455
    • (1992) Diab. Care , vol.15 , pp. 442-455
    • Leahy, J.L.1    Bonner-Weir, S.2    Weir, G.C.3
  • 35
    • 0025877358 scopus 로고
    • β-Cell insensitivity to glucose in the GK rat, a spontaneous nonobese model for type II diabetes
    • Portha B., Serradas P., Bailbe D., Suzuki K., Goto Y., and Giroix M.H. β-Cell insensitivity to glucose in the GK rat, a spontaneous nonobese model for type II diabetes. Diabetes 40 (1991) 486-491
    • (1991) Diabetes , vol.40 , pp. 486-491
    • Portha, B.1    Serradas, P.2    Bailbe, D.3    Suzuki, K.4    Goto, Y.5    Giroix, M.H.6
  • 37
    • 0031964342 scopus 로고    scopus 로고
    • Electrophysiological and metabolic characterization of single β-cells and islets from diabetic GK rats
    • Hughes S.J., Faehling M., Thorneley C.W., Proks P., Ashcroft F.M., and Smith P.A. Electrophysiological and metabolic characterization of single β-cells and islets from diabetic GK rats. Diabetes 47 (1998) 73-81
    • (1998) Diabetes , vol.47 , pp. 73-81
    • Hughes, S.J.1    Faehling, M.2    Thorneley, C.W.3    Proks, P.4    Ashcroft, F.M.5    Smith, P.A.6
  • 38
    • 20244376316 scopus 로고    scopus 로고
    • Functional and morphological alterations of mitochondria in pancreatic beta cells from type 2 diabetic patients
    • Anello M., Lupi R., Spampinato D., Piro S., Masini M., Boggi U., et al. Functional and morphological alterations of mitochondria in pancreatic beta cells from type 2 diabetic patients. Diabetologia 48 (2005) 282-289
    • (2005) Diabetologia , vol.48 , pp. 282-289
    • Anello, M.1    Lupi, R.2    Spampinato, D.3    Piro, S.4    Masini, M.5    Boggi, U.6
  • 41
    • 0028057533 scopus 로고
    • Enzymatic, metabolic and secretory patterns in human islets of type 2 (non-insulin-dependent) diabetic patients
    • Fernandez-Alvarez J., Conget I., Rasschaert J., Sener A., Gomis R., and Malaisse W.J. Enzymatic, metabolic and secretory patterns in human islets of type 2 (non-insulin-dependent) diabetic patients. Diabetologia 37 (1994) 177-181
    • (1994) Diabetologia , vol.37 , pp. 177-181
    • Fernandez-Alvarez, J.1    Conget, I.2    Rasschaert, J.3    Sener, A.4    Gomis, R.5    Malaisse, W.J.6
  • 42
    • 0029978571 scopus 로고    scopus 로고
    • Normalization by insulin treatment of low mitochondrial glycerol phosphate dehydrogenase and pyruvate carboxylase in pancreatic islets of the GK rat
    • MacDonald M.J., Efendic S., and Östenson C.G. Normalization by insulin treatment of low mitochondrial glycerol phosphate dehydrogenase and pyruvate carboxylase in pancreatic islets of the GK rat. Diabetes 45 (1996) 886-890
    • (1996) Diabetes , vol.45 , pp. 886-890
    • MacDonald, M.J.1    Efendic, S.2    Östenson, C.G.3
  • 43
    • 0031865596 scopus 로고    scopus 로고
    • Overexpression of mitochondrial FAD-linked glycerol-3-phosphate dehydrogenase does not correct glucose-stimulated insulin secretion from diabetic GK rat pancreatic islets
    • Ueda K., Tanizawa Y., Ishihara H., Kizuki N., Ohta Y., Matsutani A., et al. Overexpression of mitochondrial FAD-linked glycerol-3-phosphate dehydrogenase does not correct glucose-stimulated insulin secretion from diabetic GK rat pancreatic islets. Diabetologia 41 (1998) 649-653
    • (1998) Diabetologia , vol.41 , pp. 649-653
    • Ueda, K.1    Tanizawa, Y.2    Ishihara, H.3    Kizuki, N.4    Ohta, Y.5    Matsutani, A.6
  • 45
    • 0027339801 scopus 로고
    • Abnormal insulin secretion and glucose metabolism in pancreatic islets from the spontaneously diabetic GK rat
    • Östenson C.G., Khan A., Abdel-Halim S.M., Guenifi A., Suzuki K., Goto Y., et al. Abnormal insulin secretion and glucose metabolism in pancreatic islets from the spontaneously diabetic GK rat. Diabetologia 36 (1993) 3-8
    • (1993) Diabetologia , vol.36 , pp. 3-8
    • Östenson, C.G.1    Khan, A.2    Abdel-Halim, S.M.3    Guenifi, A.4    Suzuki, K.5    Goto, Y.6
  • 46
    • 0027392911 scopus 로고
    • Functional and metabolic perturbations in isolated pancreatic islets from the GK rat, a genetic model of noninsulin-dependent diabetes
    • Giroix M.H., Vesco L., and Portha B. Functional and metabolic perturbations in isolated pancreatic islets from the GK rat, a genetic model of noninsulin-dependent diabetes. Endocrinology 132 (1993) 815-822
    • (1993) Endocrinology , vol.132 , pp. 815-822
    • Giroix, M.H.1    Vesco, L.2    Portha, B.3
  • 48
    • 0014470975 scopus 로고
    • Hyperglycemic, nonketotic coma following administration of Dilantin (Diphenylhydantoin)
    • Goldberg E.M., and Sanbar S.S. Hyperglycemic, nonketotic coma following administration of Dilantin (Diphenylhydantoin). Diabetes 18 (1969) 101-106
    • (1969) Diabetes , vol.18 , pp. 101-106
    • Goldberg, E.M.1    Sanbar, S.S.2
  • 49
    • 0016162026 scopus 로고
    • Effects of diphenylhydantoin upon glucose-induced insulin secretion in three patients with insulinoma
    • Hofeldt F.D., Dippe S.E., Levin S.R., Karam J.H., Blum M.R., and Forsham P.H. Effects of diphenylhydantoin upon glucose-induced insulin secretion in three patients with insulinoma. Diabetes 23 (1974) 192-198
    • (1974) Diabetes , vol.23 , pp. 192-198
    • Hofeldt, F.D.1    Dippe, S.E.2    Levin, S.R.3    Karam, J.H.4    Blum, M.R.5    Forsham, P.H.6
  • 50
    • 0015928172 scopus 로고
    • Effect of diphenylhydantoin on plasma-insulin in insulinoma
    • Pelkonen R., and Taskinen M.R. Effect of diphenylhydantoin on plasma-insulin in insulinoma. Lancet 1 7803 (1973) 604-605
    • (1973) Lancet , vol.1 , Issue.7803 , pp. 604-605
    • Pelkonen, R.1    Taskinen, M.R.2
  • 51
    • 0014867061 scopus 로고
    • The in vitro inhibition of insulin secretion by diphenylhydantoin
    • Kizer J.S., Vargas-Gordon M., Brendel K., and Bressler R. The in vitro inhibition of insulin secretion by diphenylhydantoin. J. Clin. Invest. 49 (1970) 1942-1948
    • (1970) J. Clin. Invest. , vol.49 , pp. 1942-1948
    • Kizer, J.S.1    Vargas-Gordon, M.2    Brendel, K.3    Bressler, R.4
  • 53
    • 0036095159 scopus 로고    scopus 로고
    • Intracellular pH plays a critical role in glucose-induced time-dependent potentiation of insulin release in rat islets
    • Gunawardana S.C., and Sharp G.W. Intracellular pH plays a critical role in glucose-induced time-dependent potentiation of insulin release in rat islets. Diabetes 51 (2002) 105-113
    • (2002) Diabetes , vol.51 , pp. 105-113
    • Gunawardana, S.C.1    Sharp, G.W.2
  • 54
    • 0024267356 scopus 로고
    • Modulation by cytosolic pH of calcium and rubidium fluxes in rat pancreatic islets
    • Best L., Yates A.P., Gordon C., and Tomlinson S. Modulation by cytosolic pH of calcium and rubidium fluxes in rat pancreatic islets. Biochem. Pharmacol. 37 (1988) 4611-4615
    • (1988) Biochem. Pharmacol. , vol.37 , pp. 4611-4615
    • Best, L.1    Yates, A.P.2    Gordon, C.3    Tomlinson, S.4
  • 56
    • 0026661115 scopus 로고
    • Electrophysiology of stimulus-secretion coupling in human β-cells
    • Misler S., Barnett D.W., Gillis K.D., and Pressel D.M. Electrophysiology of stimulus-secretion coupling in human β-cells. Diabetes 41 (1992) 1221-1228
    • (1992) Diabetes , vol.41 , pp. 1221-1228
    • Misler, S.1    Barnett, D.W.2    Gillis, K.D.3    Pressel, D.M.4
  • 57
    • 0026799234 scopus 로고
    • Intracellular pH and the stimulus-secretion coupling in insulin-producing RINm5F cells
    • Juntti-Berggren L., Rorsman P., Siffert W., and Berggren P.O. Intracellular pH and the stimulus-secretion coupling in insulin-producing RINm5F cells. Biochem. J. 287 (1992) 59-66
    • (1992) Biochem. J. , vol.287 , pp. 59-66
    • Juntti-Berggren, L.1    Rorsman, P.2    Siffert, W.3    Berggren, P.O.4
  • 58
    • 0023005757 scopus 로고
    • Effect of substitution of a permeable weak acid for the permissive role of glucose in amino acid-induced electrical activity in B-cells
    • Pace C.S., and Goldsmith K.T. Effect of substitution of a permeable weak acid for the permissive role of glucose in amino acid-induced electrical activity in B-cells. Endocrinology 119 (1986) 2433-2438
    • (1986) Endocrinology , vol.119 , pp. 2433-2438
    • Pace, C.S.1    Goldsmith, K.T.2
  • 59
    • 0024391443 scopus 로고
    • + channel by intracellular pH in B cells of the pancreatic islet
    • + channel by intracellular pH in B cells of the pancreatic islet. J. Membr. Biol. 109 (1989) 135-143
    • (1989) J. Membr. Biol. , vol.109 , pp. 135-143
    • Misler, S.1    Gillis, K.2    Tabcharani, J.3
  • 63
    • 0033517058 scopus 로고    scopus 로고
    • Regulation of intracellular ATP concentration under conditions of reduced ATP consumption in pancreatic islets
    • Tsuura Y., Fujimoto S., Kajikawa M., Ishida H., and Seino Y. Regulation of intracellular ATP concentration under conditions of reduced ATP consumption in pancreatic islets. Biochem. Biophys. Res. Commun. 261 (1999) 439-444
    • (1999) Biochem. Biophys. Res. Commun. , vol.261 , pp. 439-444
    • Tsuura, Y.1    Fujimoto, S.2    Kajikawa, M.3    Ishida, H.4    Seino, Y.5
  • 64
    • 0036326796 scopus 로고    scopus 로고
    • Ouabain suppresses glucose-induced mitochondrial ATP production and insulin release by generating reactive oxygen species in pancreatic islets
    • Kajikawa M., Fujimoto S., Tsuura Y., Mukai E., Takeda T., Hamamoto Y., et al. Ouabain suppresses glucose-induced mitochondrial ATP production and insulin release by generating reactive oxygen species in pancreatic islets. Diabetes 51 (2002) 2522-2529
    • (2002) Diabetes , vol.51 , pp. 2522-2529
    • Kajikawa, M.1    Fujimoto, S.2    Tsuura, Y.3    Mukai, E.4    Takeda, T.5    Hamamoto, Y.6
  • 65
    • 0033600762 scopus 로고    scopus 로고
    • Hydrogen peroxide alters mitochondrial activation and insulin secretion in pancreatic beta cells
    • Meachler P., Jornot L., and Wollheim C.B. Hydrogen peroxide alters mitochondrial activation and insulin secretion in pancreatic beta cells. J. Biol. Chem. 274 (1999) 27905-27913
    • (1999) J. Biol. Chem. , vol.274 , pp. 27905-27913
    • Meachler, P.1    Jornot, L.2    Wollheim, C.B.3
  • 71
    • 3242789423 scopus 로고    scopus 로고
    • Does the glucose-dependent insulin secretion mechanism itself cause oxidative stress in pancreatic β-cells?
    • Fridlyand L.E., and Philipson L.H. Does the glucose-dependent insulin secretion mechanism itself cause oxidative stress in pancreatic β-cells?. Diabetes 53 (2004) 1942-1948
    • (2004) Diabetes , vol.53 , pp. 1942-1948
    • Fridlyand, L.E.1    Philipson, L.H.2
  • 72
    • 0033305516 scopus 로고    scopus 로고
    • Sodium palmitate induces partial mitochondrial uncoupling and reactive oxygen species in rat pancreatic islets in vitro
    • Carlsson C., Borg L.A., and Welsh N. Sodium palmitate induces partial mitochondrial uncoupling and reactive oxygen species in rat pancreatic islets in vitro. Endocrinology 140 (1999) 3422-3428
    • (1999) Endocrinology , vol.140 , pp. 3422-3428
    • Carlsson, C.1    Borg, L.A.2    Welsh, N.3
  • 73
    • 0038165514 scopus 로고    scopus 로고
    • Mitochondrial functional state in clonal pancreatic beta-cells exposed to free fatty acids
    • Koshkin V., Wang X., Scherer P.E., Chan C.B., and Wheeler M.B. Mitochondrial functional state in clonal pancreatic beta-cells exposed to free fatty acids. J. Biol. Chem. 278 (2003) 19709-19715
    • (2003) J. Biol. Chem. , vol.278 , pp. 19709-19715
    • Koshkin, V.1    Wang, X.2    Scherer, P.E.3    Chan, C.B.4    Wheeler, M.B.5
  • 74
    • 0346340042 scopus 로고    scopus 로고
    • Superoxide-mediated activation of uncoupling protein 2 causes pancreatic β cell dysfunction
    • Krauss S., Zhang C.Y., Scorrano L., Dalgaard L.T., St-Pierre J., Grey S.T., et al. Superoxide-mediated activation of uncoupling protein 2 causes pancreatic β cell dysfunction. J. Clin. Invest. 112 (2003) 1831-1842
    • (2003) J. Clin. Invest. , vol.112 , pp. 1831-1842
    • Krauss, S.1    Zhang, C.Y.2    Scorrano, L.3    Dalgaard, L.T.4    St-Pierre, J.5    Grey, S.T.6
  • 75
    • 4644287377 scopus 로고    scopus 로고
    • Evidence against the involvement of oxidative stress in fatty acid inhibition of insulin secretion
    • Moore P.C., Ugas M.A., Hagman D.K., Parazzoli S.D., and Poitout V. Evidence against the involvement of oxidative stress in fatty acid inhibition of insulin secretion. Diabetes 53 (2004) 2610-2616
    • (2004) Diabetes , vol.53 , pp. 2610-2616
    • Moore, P.C.1    Ugas, M.A.2    Hagman, D.K.3    Parazzoli, S.D.4    Poitout, V.5
  • 76
    • 0035078830 scopus 로고    scopus 로고
    • Uncoupling protein 2: a possible link between fatty acid excess and impaired glucose-induced insulin secretion?
    • Lameloise N., Muzzin P., Prentki M., and Assimacopoulos-Jeannet F. Uncoupling protein 2: a possible link between fatty acid excess and impaired glucose-induced insulin secretion?. Diabetes 50 (2001) 803-809
    • (2001) Diabetes , vol.50 , pp. 803-809
    • Lameloise, N.1    Muzzin, P.2    Prentki, M.3    Assimacopoulos-Jeannet, F.4
  • 77
    • 0036724133 scopus 로고    scopus 로고
    • Role of ATP production and uncoupling protein-2 in the insulin secretory defect induced by chronic exposure to high glucose or free fatty acids and effects of peroxisome proliferator-activated receptor-γ inhibition
    • Patane G., Anello M., Piro S., Vigneri R., Purrello F., and Rabuazzo A.M. Role of ATP production and uncoupling protein-2 in the insulin secretory defect induced by chronic exposure to high glucose or free fatty acids and effects of peroxisome proliferator-activated receptor-γ inhibition. Diabetes 51 (2002) 2749-2756
    • (2002) Diabetes , vol.51 , pp. 2749-2756
    • Patane, G.1    Anello, M.2    Piro, S.3    Vigneri, R.4    Purrello, F.5    Rabuazzo, A.M.6
  • 78
    • 10944265062 scopus 로고    scopus 로고
    • Free fatty acid-induced β-cell defects are dependent on uncoupling protein 2 expression
    • Joseph J.W., Koshkin V., Saleh M.C., Sivitz W.I., Zhang C.Y., Lowell B.B., et al. Free fatty acid-induced β-cell defects are dependent on uncoupling protein 2 expression. J. Biol. Chem. 279 (2004) 51049-51056
    • (2004) J. Biol. Chem. , vol.279 , pp. 51049-51056
    • Joseph, J.W.1    Koshkin, V.2    Saleh, M.C.3    Sivitz, W.I.4    Zhang, C.Y.5    Lowell, B.B.6
  • 79
    • 0032861252 scopus 로고    scopus 로고
    • Lipid rather than glucose metabolism is implicated in altered insulin secretion caused by oleate in INS-1 cells
    • Segall L., Lameloise N., Assimacopoulos-Jeannet F., Roche E., Corkey P., Thumelin S., et al. Lipid rather than glucose metabolism is implicated in altered insulin secretion caused by oleate in INS-1 cells. Am. J. Physiol. 277 (1999) E521-E528
    • (1999) Am. J. Physiol. , vol.277
    • Segall, L.1    Lameloise, N.2    Assimacopoulos-Jeannet, F.3    Roche, E.4    Corkey, P.5    Thumelin, S.6
  • 80
    • 3843090515 scopus 로고    scopus 로고
    • β-cell lipotoxicity: burning fat into heat?
    • Poitout V. β-cell lipotoxicity: burning fat into heat?. Endocrinology 145 (2004) 3563-3565
    • (2004) Endocrinology , vol.145 , pp. 3563-3565
    • Poitout, V.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.