Predicting the mutagenicity of tobacco-related N-nitrosamines in humans using 11 strains of Salmonella typhimurium YG7108, each coexpressing a form of human cytochrome P450 along with NADPH-cytochrome P450 reductase

Environmental and Molecular Mutagenesis

Volumn 38, Issue 4, 2001, Pages 339-346

  Fujita, Ken Ichi ^a   Kamataki, Tetsuya ^a  

^a HOKKAIDO UNIVERSITY   (Japan)

Author keywords

Human genotoxicity; Mutagen producing capacity; Mutation assay

Indexed keywords

1 NITROSOPIPERIDINE; 4 (METHYLNITROSAMINO) 1 (3 PYRIDYL) 1 BUTANONE; CYTOCHROME P450 1A1; CYTOCHROME P450 1A2; CYTOCHROME P450 1B1; CYTOCHROME P450 2A6; CYTOCHROME P450 2C19; CYTOCHROME P450 2C8; CYTOCHROME P450 2C9; CYTOCHROME P450 2D6; CYTOCHROME P450 2E1; CYTOCHROME P450 3A4; CYTOCHROME P450 3A5; DIETHYLNITROSAMINE; N NITROSOANABASINE; NITROSAMINE; NITROSONORNICOTINE; UNCLASSIFIED DRUG;

ARTICLE; ENZYME ACTIVATION; GENOTOXICITY; HUMAN; MUTAGENICITY; NONHUMAN; PROTEIN EXPRESSION; SALMONELLA TYPHIMURIUM; STRAIN DIFFERENCE; TOBACCO;

CYTOCHROME P-450 ENZYME SYSTEM; HUMANS; MUTAGENICITY TESTS; MUTATION; NADPH-FERRIHEMOPROTEIN REDUCTASE; NITROSAMINES; RECOMBINANT PROTEINS; SALMONELLA TYPHIMURIUM; TOBACCO;

NICOTIANA TABACUM; SALMONELLA TYPHIMURIUM;

EID: 0035684794     PISSN: 08936692     EISSN: None     Source Type: Journal    
DOI: 10.1002/em.10036     Document Type: Article

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