Computational design of a biologically active enzyme

Science

Volumn 304, Issue 5679, 2004, Pages 1967-1971

  Dwyer, Mary A ^a   Looger, Loren L ^a,b   Hellinga, Homme W ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

^b GEOPHYSICAL LABORATORY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING ENERGY; ESCHERICHIA COLI; GLUCOSE; MUTAGENESIS; PROTEINS;

BIOLOGICALLY ACTIVE ENZYMES; COMPUTATIONAL DESIGN; PROTEIN CHEMISTRY;

BIOCATALYSTS;

RIBOSE; TRIOSEPHOSPHATE ISOMERASE;

ENZYME;

ARTICLE; BACTERIAL GROWTH; COMPETITIVE INHIBITION; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME STRUCTURE; ESCHERICHIA COLI; GENE MUTATION; GLUCONEOGENESIS; MATHEMATICAL MODEL; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FOLDING; SEQUENCE ANALYSIS; STEREOCHEMISTRY; THERMOSTABILITY; VALIDATION PROCESS;

ALGORITHMS; BINDING SITES; CATALYSIS; CATALYTIC DOMAIN; COMPUTATIONAL BIOLOGY; COMPUTER SIMULATION; DIHYDROXYACETONE PHOSPHATE; DIMERIZATION; DIRECTED MOLECULAR EVOLUTION; ENZYME STABILITY; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; GLYCERALDEHYDE 3-PHOSPHATE; GLYCEROL; HYDROGEN BONDING; KINETICS; LACTATES; LIGANDS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; MUTATION; PERIPLASMIC BINDING PROTEINS; PROTEIN CONFORMATION; PROTEIN ENGINEERING; PROTONS; TRIOSE-PHOSPHATE ISOMERASE;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI;

EID: 3042655537     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1098432     Document Type: Article

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