Computational design of receptor and sensor proteins with novel functions

Nature

Volumn 423, Issue 6936, 2003, Pages 185-190

  Looger, Loren L ^a   Dwyer, Mary A ^a   Smith, James J ^a   Hellinga, Homme W ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOSENSORS; BIOTECHNOLOGY; COMPUTATIONAL METHODS; ENZYMES;

BIOLOGICAL PROCESSES;

PROTEINS;

RECEPTOR PROTEIN; TRINITROTOLUENE;

LIGAND; PROTEIN;

ANALYTIC METHOD; ARTICLE; BINDING AFFINITY; CALCULATION; CHIRALITY; COMPLEX FORMATION; CONTROL SYSTEM; GENE EXPRESSION REGULATION; LIGAND BINDING; MOLECULAR MODEL; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FUNCTION; SENSOR; SIGNAL TRANSDUCTION; STRUCTURE ANALYSIS;

AMINO ACID SEQUENCE; BACTERIA; BINDING SITES; BIOSENSING TECHNIQUES; COMPUTER SIMULATION; DRUG DESIGN; ELECTROSTATICS; HYDROGEN BONDING; HYDROPHOBICITY; LACTIC ACID; LIGANDS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PERIPLASMIC BINDING PROTEINS; PROTEIN CONFORMATION; SEROTONIN; SIGNAL TRANSDUCTION; SUBSTRATE SPECIFICITY; THERMODYNAMICS; TRINITROTOLUENE;

BACTERIA (MICROORGANISMS);

EID: 0038752617     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/nature01556     Document Type: Article

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