메뉴 건너뛰기




Volumn 62, Issue 3, 2002, Pages 747-755

Generation and analysis of constitutively active and physically destabilized mutants of the human β1-adrenoceptor

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE; ARGININE; BETA 1 ADRENERGIC RECEPTOR; BETA 1 ADRENERGIC RECEPTOR BLOCKING AGENT; BETA 2 ADRENERGIC RECEPTOR; BETAXOLOL; GUANOSINE 5' O (3 THIOTRIPHOSPHATE); ISOPRENALINE; LEUCINE; LIGAND; LYSINE;

EID: 0036765799     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.62.3.747     Document Type: Article
Times cited : (19)

References (31)
  • 1
    • 0034750053 scopus 로고    scopus 로고
    • Drag target discovery by pharmacogenetics: Mutations in the melanocortin system and eating disorders
    • Adan RAH and Vink T (2001) Drag target discovery by pharmacogenetics: mutations in the melanocortin system and eating disorders. Eur Neuropsychopharmacol 11:483-490.
    • (2001) Eur Neuropsychopharmacol , vol.11 , pp. 483-490
    • Adan, R.A.H.1    Vink, T.2
  • 3
    • 0026318020 scopus 로고
    • G-protein-coupled receptor genes as protooncogenes: Constitutively activating mutation of the alpha 1B-adrenergic receptor enhances mitogenesis and tumorigenicity
    • Allen LF, Lefkowitz RJ, Caren MG, and Cotecchia S (1991) G-protein-coupled receptor genes as protooncogenes: constitutively activating mutation of the alpha 1B-adrenergic receptor enhances mitogenesis and tumorigenicity. Proc Natl Acad Sci USA 88:11354-11358.
    • (1991) Proc Natl Acad Sci USA , vol.88 , pp. 11354-11358
    • Allen, L.F.1    Lefkowitz, R.J.2    Caren, M.G.3    Cotecchia, S.4
  • 5
    • 0037081221 scopus 로고    scopus 로고
    • 2 vasopressin receptor agonist and regulator of G-protein-signaling-sensitive G protein
    • 2 vasopressin receptor agonist and regulator of G-protein-signaling-sensitive G protein. Anal Biochem 300:212-220.
    • (2002) Anal Biochem , vol.300 , pp. 212-220
    • Feng, G.J.1    Cavalli, A.2    Milligan, G.3
  • 6
    • 0034464742 scopus 로고    scopus 로고
    • Uncovering molecular mechanisms involved in activation of G protein-coupled receptors
    • Gether U (2000) Uncovering molecular mechanisms involved in activation of G protein-coupled receptors. Endocr Rev 21:90-113.
    • (2000) Endocr Rev , vol.21 , pp. 90-113
    • Gether, U.1
  • 7
    • 0031018485 scopus 로고    scopus 로고
    • Structural instability of a constitutively active G protein-coupled receptor. Agonist-independent activation due to conformational flexibility
    • Gether U, Ballesteros JA, Seifert R, Sanders Bush E, Weinstein H, and Kobilka BK (1997) Structural instability of a constitutively active G protein-coupled receptor. Agonist-independent activation due to conformational flexibility. J Biol Chem 272:2587-2590.
    • (1997) J Biol Chem , vol.272 , pp. 2587-2590
    • Gether, U.1    Ballesteros, J.A.2    Seifert, R.3    Sanders Bush, E.4    Weinstein, H.5    Kobilka, B.K.6
  • 8
    • 0032808481 scopus 로고    scopus 로고
    • Coupling efficiencies of beta 1- and beta 2-adrenergic receptors expressed alone or together in translated GH3 pituitary cells
    • Guerrero SW and Minneman KP (1999) Coupling efficiencies of beta 1- and beta 2-adrenergic receptors expressed alone or together in translated GH3 pituitary cells. J Pharmacol Exp Ther 290:980-988.
    • (1999) J Pharmacol Exp Ther , vol.290 , pp. 980-988
    • Guerrero, S.W.1    Minneman, K.P.2
  • 9
    • 0032879444 scopus 로고    scopus 로고
    • Constitutively active mutants of the β-1-adrenergic receptor
    • Lattion AL, Abuin L, Neninger Tosato M, and Cotecchia S (1999) Constitutively active mutants of the β-1-adrenergic receptor. FEBS Lett 457:302-306.
    • (1999) FEBS Lett , vol.457 , pp. 302-306
    • Lattion, A.L.1    Abuin, L.2    Neninger Tosato, M.3    Cotecchia, S.4
  • 10
    • 0031794526 scopus 로고    scopus 로고
    • Agonist-independent regulation of constitutively active G protein-coupled receptors
    • Leurs R, Smit MJ, Alewijnse AE, and Timmerman H (1996) Agonist-independent regulation of constitutively active G protein-coupled receptors. Trends Biochem Sci 23:418-422.
    • (1996) Trends Biochem Sci , vol.23 , pp. 418-422
    • Leurs, R.1    Smit, M.J.2    Alewijnse, A.E.3    Timmerman, H.4
  • 11
    • 0027332078 scopus 로고
    • Efficacy of beta 1-adrenergic receptors is lower than that of beta 2-adrenergic receptors
    • Levy FO, Zhu X, Kaumann AJ, and Birnbaumer L (1993) Efficacy of beta 1-adrenergic receptors is lower than that of beta 2-adrenergic receptors. Proc Natl Acad Sci USA 90:10798-10802.
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 10798-10802
    • Levy, F.O.1    Zhu, X.2    Kaumann, A.J.3    Birnbaumer, L.4
  • 12
    • 0034763966 scopus 로고    scopus 로고
    • Inverse agonist up-regulates the constitutively active D3.49(164)Q mutant of the rat μ-opioid receptor by stabilizing the structure and blocking constitutive internalization and down-rcgulation
    • Li J, Chen C, Huang P, and Lin-Chen LY (2001a) Inverse agonist up-regulates the constitutively active D3.49(164)Q mutant of the rat μ-opioid receptor by stabilizing the structure and blocking constitutive internalization and down-rcgulation. Mol Pharmacol 60:1064-1075.
    • (2001) Mol Pharmacol , vol.60 , pp. 1064-1075
    • Li, J.1    Chen, C.2    Huang, P.3    Lin-Chen, L.Y.4
  • 13
    • 0035834092 scopus 로고    scopus 로고
    • Constitutive activation of the mu opioid receptor by mutation of D3.49(164), but not D3.32(147): D3.49(164) is critical for stabilization of the inactive form of the receptor and for its expression
    • Li J, Huang P, Chen C, de Riel JK, Weinstein H, and Liu-Chen LY (2001b) Constitutive activation of the mu opioid receptor by mutation of D3.49(164), but not D3.32(147): D3.49(164) is critical for stabilization of the inactive form of the receptor and for its expression. Biochemistry 40:12039-12050
    • (2001) Biochemistry , vol.40 , pp. 12039-12050
    • Li, J.1    Huang, P.2    Chen, C.3    De Riel, J.K.4    Weinstein, H.5    Liu-Chen, L.Y.6
  • 14
    • 0030473469 scopus 로고    scopus 로고
    • Inverse agonist-induced up-regulation of the human beta2-adrenoceptor in transfected neuroblastoma X glioma hybrid cells
    • MacEwan DJ and Milligan G (1996) Inverse agonist-induced up-regulation of the human beta2-adrenoceptor in transfected neuroblastoma X glioma hybrid cells. Mol Pharmacol 50:1479-1486.
    • (1996) Mol Pharmacol , vol.50 , pp. 1479-1486
    • MacEwan, D.J.1    Milligan, G.2
  • 16
    • 0034798763 scopus 로고    scopus 로고
    • Construction and analysis of function of GPCR-G protein fusion proteins
    • Milligan G (2002) Construction and analysis of function of GPCR-G protein fusion proteins. Methods Enzymol 343:260-273.
    • (2002) Methods Enzymol , vol.343 , pp. 260-273
    • Milligan, G.1
  • 18
    • 0024373087 scopus 로고
    • a promotes its removal from the plasma membrane
    • a promotes its removal from the plasma membrane. Biochem J 260:837-841.
    • (1989) Biochem J , vol.260 , pp. 837-841
    • Milligan, G.1    Unson, C.G.2
  • 19
    • 0032239841 scopus 로고    scopus 로고
    • Amino acids domains involved in constitutive activation of G protein coupled receptors
    • Pauwels PJ and Wurch T (1998) Amino acids domains involved in constitutive activation of G protein coupled receptors. Mol Neurobiol 17:109-135.
    • (1998) Mol Neurobiol , vol.17 , pp. 109-135
    • Pauwels, P.J.1    Wurch, T.2
  • 20
    • 0028331771 scopus 로고
    • A constitutively active mutant beta 2-adrenergic receptor is constitutively desensitized and phosphorylated
    • Pei G, Samama P, Lohse M, Wang M, Codina J, and Lefkowitz RJ (1994) A constitutively active mutant beta 2-adrenergic receptor is constitutively desensitized and phosphorylated. Proc Natl Acad Sci USA 91:2699-2702.
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 2699-2702
    • Pei, G.1    Samama, P.2    Lohse, M.3    Wang, M.4    Codina, J.5    Lefkowitz, R.J.6
  • 21
    • 0034986205 scopus 로고    scopus 로고
    • Detection of receptor ligands by monitoring selective stabilization of a Renilla luciferase-tagged, constitutively active mutant, G-protein-coupled receptor
    • Ramsay D, Bevan N, Bees S, and Milligan G (2001) Detection of receptor ligands by monitoring selective stabilization of a Renilla luciferase-tagged, constitutively active mutant, G-protein-coupled receptor. Br J Pharmacol 133:319-823.
    • (2001) Br J Pharmacol , vol.133 , pp. 319-823
    • Ramsay, D.1    Bevan, N.2    Bees, S.3    Milligan, G.4
  • 22
    • 0034731376 scopus 로고    scopus 로고
    • Differential targeting of beta-adrenergic receptor subtypes and adenylyl cyclase to cardiomyocyte cavealae. A mechanism to functionally regulate the cAMP signaling pathway
    • Rybin VO, Xu X, Lisanti MP, and Steinberg SF (2000) Differential targeting of beta-adrenergic receptor subtypes and adenylyl cyclase to cardiomyocyte cavealae. A mechanism to functionally regulate the cAMP signaling pathway. J Biol Chem 275:41447-41457.
    • (2000) J Biol Chem , vol.275 , pp. 41447-41457
    • Rybin, V.O.1    Xu, X.2    Lisanti, M.P.3    Steinberg, S.F.4
  • 23
    • 0027513982 scopus 로고
    • A mutation-induced activated state of the beta 2-adrenergic receptor. Extending the ternary complex model
    • Samama P, Cotecchia S, Costa T, and Lefkowitz RJ (1993) A mutation-induced activated state of the beta 2-adrenergic receptor. Extending the ternary complex model. J Biol Chem 268:4625-4686.
    • (1993) J Biol Chem , vol.268 , pp. 4625-4686
    • Samama, P.1    Cotecchia, S.2    Costa, T.3    Lefkowitz, R.J.4
  • 24
    • 0031029841 scopus 로고    scopus 로고
    • Constitutively active G protein-coupled receptors: Potential mechanisms of receptor activation
    • Scheer A and Cotecchia S (1997) Constitutively active G protein-coupled receptors: potential mechanisms of receptor activation. J Recept Signal Transduct Res 17:57-73.
    • (1997) J Recept Signal Transduct Res , vol.17 , pp. 57-73
    • Scheer, A.1    Cotecchia, S.2
  • 25
    • 0033181342 scopus 로고    scopus 로고
    • GPCR-G alpha fusion proteins: Molecular analysis of receptor-G-protein coupling
    • Seifert R, Wenzel-Seifert K, and Kobilka BK (1999) GPCR-G alpha fusion proteins: molecular analysis of receptor-G-protein coupling. Trends Pharmacol Sci 20:383-389.
    • (1999) Trends Pharmacol Sci , vol.20 , pp. 383-389
    • Seifert, R.1    Wenzel-Seifert, K.2    Kobilka, B.K.3
  • 26
    • 0035029169 scopus 로고    scopus 로고
    • Compartmentation of G protein-coupled signaling pathways in cardiac myocytes
    • Steinberg SF and Brunton LL (2001) Compartmentation of G protein-coupled signaling pathways in cardiac myocytes. Annu Rev Pharmacol Toxicol 41:751-773.
    • (2001) Annu Rev Pharmacol Toxicol , vol.41 , pp. 751-773
    • Steinberg, S.F.1    Brunton, L.L.2
  • 29
    • 0028314995 scopus 로고
    • Measurement of receptor-stimulated guanosine 5′-O-(γ-Thio)triphosphate binding by G proteins
    • Wieland T and Jakobs KH (1994) Measurement of receptor-stimulated guanosine 5′-O-(γ-Thio)triphosphate binding by G proteins. Methods Enzymol 237:1-13.
    • (1994) Methods Enzymol , vol.237 , pp. 1-13
    • Wieland, T.1    Jakobs, K.H.2
  • 30
    • 0034647762 scopus 로고    scopus 로고
    • Inhibition of spontaneous beta 2-adrenergic activation rescues beta 1-adrenergic contractile response in cardiomyocytes overexpressing beta 2-adrenoceptor
    • Zhang SJ, Cheng H, Zhou YY, Wang DJ, Zhu W, Ziman B, Spurgoen H, Lefkowitz RJ, Lakatta EG, Koch WJ, et al. (2000) Inhibition of spontaneous beta 2-adrenergic activation rescues beta 1-adrenergic contractile response in cardiomyocytes overexpressing beta 2-adrenoceptor. J Biol Chem 275:21773-21779.
    • (2000) J Biol Chem , vol.275 , pp. 21773-21779
    • Zhang, S.J.1    Cheng, H.2    Zhou, Y.Y.3    Wang, D.J.4    Zhu, W.5    Ziman, B.6    Spurgoen, H.7    Lefkowitz, R.J.8    Lakatta, E.G.9    Koch, W.J.10


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.