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Volumn 2, Issue 4, 2007, Pages 389-396

Towards individualized medicine: Flies lead the way

Author keywords

Disease modeling; Drosophila melanogaster; Drug development; Endophenotypes; Forward screens; Neurological disease

Indexed keywords

2 METHYL 6 (PHENYLETHYNYL)PYRIDINE; AMYLOID PRECURSOR PROTEIN; FENOBAM; FRAGILE X MENTAL RETARDATION PROTEIN; GAMMA SECRETASE; METABOTROPIC RECEPTOR; METABOTROPIC RECEPTOR ANTAGONIST; PRESENILIN 1; PRESENILIN 2; UNCLASSIFIED DRUG;

EID: 34447306864     PISSN: 14796708     EISSN: None     Source Type: Journal    
DOI: 10.2217/14796708.2.4.389     Document Type: Review
Times cited : (1)

References (53)
  • 1
    • 0034837386 scopus 로고    scopus 로고
    • A systematic analysis of human disease-associated gene sequences in Drosophila melanogaster
    • Reiter LT, Potocki L, Chien S, Gribskov M, Bier E: A systematic analysis of human disease-associated gene sequences in Drosophila melanogaster. Genome Res. 11 (6), 1114-1125 (2001).
    • (2001) Genome Res , vol.11 , Issue.6 , pp. 1114-1125
    • Reiter, L.T.1    Potocki, L.2    Chien, S.3    Gribskov, M.4    Bier, E.5
  • 2
    • 0038439322 scopus 로고    scopus 로고
    • Mushroom body memoir: From maps to models
    • Heisenberg M: Mushroom body memoir: from maps to models. Nat. Rev. Neurosci. 4(4), 266-275 (2003).
    • (2003) Nat. Rev. Neurosci , vol.4 , Issue.4 , pp. 266-275
    • Heisenberg, M.1
  • 3
    • 0033694834 scopus 로고    scopus 로고
    • Ion channels and synaptic organization: Analysis of the Drosophila genome
    • Littleton JT, Ganetzky B: Ion channels and synaptic organization: analysis of the Drosophila genome. Neuron 26(1), 35-43 (2000).
    • (2000) Neuron , vol.26 , Issue.1 , pp. 35-43
    • Littleton, J.T.1    Ganetzky, B.2
  • 4
    • 2542560342 scopus 로고    scopus 로고
    • Drosophila parkin mutants have decreased mass and cell size and increased sensitivity to oxygen radical stress
    • Pesah Y, Pham T, Burgess H et al.: Drosophila parkin mutants have decreased mass and cell size and increased sensitivity to oxygen radical stress. Development 131 (9), 2183-2194 (2004).
    • (2004) Development , vol.131 , Issue.9 , pp. 2183-2194
    • Pesah, Y.1    Pham, T.2    Burgess, H.3
  • 5
    • 33745602748 scopus 로고    scopus 로고
    • Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin
    • Park J, Lee SB, Lee S et al.: Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin. Nature 441(7097), 1157-1161 (2006).
    • (2006) Nature , vol.441 , Issue.7097 , pp. 1157-1161
    • Park, J.1    Lee, S.B.2    Lee, S.3
  • 6
    • 33745589773 scopus 로고    scopus 로고
    • Drosophila PINK1 is required for mitochondrial function and interacts genetically with parkin
    • Clark IE, Dodson MW, Jiang C et al.: Drosophila PINK1 is required for mitochondrial function and interacts genetically with parkin. Nature 441(7097), 1162-1166 (2006).
    • (2006) Nature , vol.441 , Issue.7097 , pp. 1162-1166
    • Clark, I.E.1    Dodson, M.W.2    Jiang, C.3
  • 7
    • 24044472010 scopus 로고    scopus 로고
    • Drosophila DJ-1 mutants are selectively sensitive to environmental toxins associated with Parkinson's disease
    • Meulener M, Whitworth AJ, Armstrong-Gold CE et al.: Drosophila DJ-1 mutants are selectively sensitive to environmental toxins associated with Parkinson's disease. Curr. Biol. 15(17), 1572-1577 (2005).
    • (2005) Curr. Biol , vol.15 , Issue.17 , pp. 1572-1577
    • Meulener, M.1    Whitworth, A.J.2    Armstrong-Gold, C.E.3
  • 8
    • 0036962392 scopus 로고    scopus 로고
    • A Drosophila homolog of the polyglutamine disease gene SCA2 is a dosage-sensitive regulator of actin filament formation
    • Satterfield TF, Jackson SM, Pallanck LJ: A Drosophila homolog of the polyglutamine disease gene SCA2 is a dosage-sensitive regulator of actin filament formation. Genetics 162(4), 1687-1702 (2002).
    • (2002) Genetics , vol.162 , Issue.4 , pp. 1687-1702
    • Satterfield, T.F.1    Jackson, S.M.2    Pallanck, L.J.3
  • 9
    • 23844543718 scopus 로고    scopus 로고
    • Suppression of Huntington's disease pathology in Drosophila by human single-chain Fv antibodies
    • Wolfgang WJ, Miller TW, Webster JM et al.: Suppression of Huntington's disease pathology in Drosophila by human single-chain Fv antibodies. Proc. Natl Acad. Sci. USA 102(32), 11563-11568 (2005).
    • (2005) Proc. Natl Acad. Sci. USA , vol.102 , Issue.32 , pp. 11563-11568
    • Wolfgang, W.J.1    Miller, T.W.2    Webster, J.M.3
  • 10
    • 8144229817 scopus 로고    scopus 로고
    • Interference of human and Drosophila APP and APP-like proteins with PNS development in Drosophila
    • Merdes G, Soba P, Loewer A, Bilic MV, Beyreuther K, Paro R: Interference of human and Drosophila APP and APP-like proteins with PNS development in Drosophila. EMBO J. 23(20), 4082-4095 (2004).
    • (2004) EMBO J , vol.23 , Issue.20 , pp. 4082-4095
    • Merdes, G.1    Soba, P.2    Loewer, A.3    Bilic, M.V.4    Beyreuther, K.5    Paro, R.6
  • 11
    • 2142645114 scopus 로고    scopus 로고
    • Age-dependent neurodegeneration and Alzheimer-amyloid plaque formation in transgenic Drosophila
    • Greeve I, Kretzschmar D, Tschape JA et al.: Age-dependent neurodegeneration and Alzheimer-amyloid plaque formation in transgenic Drosophila. J. Neurosci. 24(16), 3899-3906 (2004).
    • (2004) J. Neurosci , vol.24 , Issue.16 , pp. 3899-3906
    • Greeve, I.1    Kretzschmar, D.2    Tschape, J.A.3
  • 12
    • 34047106848 scopus 로고    scopus 로고
    • Cytoskeleton proteins are modulators of mutant tau-induced neurodegeneration in Drosophila
    • Blard O, Feuillette S, Bou J et al.: Cytoskeleton proteins are modulators of mutant tau-induced neurodegeneration in Drosophila. Hum. Mol. Genet. 16(5), 555-566 (2007).
    • (2007) Hum. Mol. Genet , vol.16 , Issue.5 , pp. 555-566
    • Blard, O.1    Feuillette, S.2    Bou, J.3
  • 13
    • 29444455075 scopus 로고    scopus 로고
    • Drosophila as a model for human neurodegenerative disease
    • Bilen J, Bonini NM: Drosophila as a model for human neurodegenerative disease. Annu. Rev. Genet. 39, 153-171 (2005).
    • (2005) Annu. Rev. Genet , vol.39 , pp. 153-171
    • Bilen, J.1    Bonini, N.M.2
  • 14
    • 18344385161 scopus 로고    scopus 로고
    • Demented flies? Using Drosophila to model human neurodegenerative diseases
    • Michno K, van de Hoef D, Wu H, Boulianne GL: Demented flies? Using Drosophila to model human neurodegenerative diseases. Clin. Genet. 67(6), 468-475 (2005).
    • (2005) Clin. Genet , vol.67 , Issue.6 , pp. 468-475
    • Michno, K.1    van de Hoef, D.2    Wu, H.3    Boulianne, G.L.4
  • 15
    • 33947605931 scopus 로고    scopus 로고
    • Childhood autism and associated comorbidities
    • Zafeiriou DI, Ververi A, Vargiami E: Childhood autism and associated comorbidities. Brain Dev. 29(5), 257-272 (2006).
    • (2006) Brain Dev , vol.29 , Issue.5 , pp. 257-272
    • Zafeiriou, D.I.1    Ververi, A.2    Vargiami, E.3
  • 16
    • 0036827976 scopus 로고    scopus 로고
    • Epilepsy in Fragile X syndrome
    • Berry-Kravis E: Epilepsy in Fragile X syndrome. Dev. Med. Child Neurol. 44(11), 724-728 (2002).
    • (2002) Dev. Med. Child Neurol , vol.44 , Issue.11 , pp. 724-728
    • Berry-Kravis, E.1
  • 17
    • 20044388322 scopus 로고    scopus 로고
    • Pharmacological rescue of synaptic plasticity, courtship behavior, and mushroom body defects in a Drosophila model of Fragile X syndrome
    • McBride SM, Choi CH, Wang Y et al.: Pharmacological rescue of synaptic plasticity, courtship behavior, and mushroom body defects in a Drosophila model of Fragile X syndrome. Neuron 45(5), 753-764 (2005).
    • (2005) Neuron , vol.45 , Issue.5 , pp. 753-764
    • McBride, S.M.1    Choi, C.H.2    Wang, Y.3
  • 19
    • 24344457816 scopus 로고    scopus 로고
    • Suppression of two major Fragile X Syndrome mouse model phenotypes by the mGluR5 antagonist MPEP
    • Yan QJ, Rammal M, Tranfaglia M, Bauchwitz RP: Suppression of two major Fragile X Syndrome mouse model phenotypes by the mGluR5 antagonist MPEP. Neuropharmacology 49(7), 1053-1066 (2005).
    • (2005) Neuropharmacology , vol.49 , Issue.7 , pp. 1053-1066
    • Yan, Q.J.1    Rammal, M.2    Tranfaglia, M.3    Bauchwitz, R.P.4
  • 20
    • 34249095727 scopus 로고    scopus 로고
    • Fragile X-associated tremor/ataxia syndrome: Intrafamilial variability and the size of the FMR1 premutation CGG repeat
    • Capelli LP, Goncalves MR, Kok F et al.: Fragile X-associated tremor/ataxia syndrome: intrafamilial variability and the size of the FMR1 premutation CGG repeat. Mov. Disord. 22(6), 866-870 (2007).
    • (2007) Mov. Disord , vol.22 , Issue.6 , pp. 866-870
    • Capelli, L.P.1    Goncalves, M.R.2    Kok, F.3
  • 21
    • 0041880131 scopus 로고    scopus 로고
    • RNA-mediated neurodegeneration caused by the Fragile X premutation rCGG repeats in Drosophila
    • Jin P, Zarnescue DC, Zhang F et al.: RNA-mediated neurodegeneration caused by the Fragile X premutation rCGG repeats in Drosophila. Neuron 39(5), 739-747 (2003).
    • (2003) Neuron , vol.39 , Issue.5 , pp. 739-747
    • Jin, P.1    Zarnescue, D.C.2    Zhang, F.3
  • 22
    • 27644483475 scopus 로고    scopus 로고
    • Abnormal elevation of FMR1 mRNA is associated with psychological symptoms in individuals with the Fragile X premutation
    • Hessl D, Tassone F, Loesch DZ et al.: Abnormal elevation of FMR1 mRNA is associated with psychological symptoms in individuals with the Fragile X premutation. Am. J. Med. Genet. B. Neuropsychiatr. Genet. 139(1), 115-121 (2005).
    • (2005) Am. J. Med. Genet. B. Neuropsychiatr. Genet , vol.139 , Issue.1 , pp. 115-121
    • Hessl, D.1    Tassone, F.2    Loesch, D.Z.3
  • 24
    • 14644412883 scopus 로고    scopus 로고
    • The Drosophila Fragile X protein functions as a negative regulator in the orb autoregulatory pathway
    • Costa A, Wang Y, Dockendorff TC et al.: The Drosophila Fragile X protein functions as a negative regulator in the orb autoregulatory pathway. Dev. Cell 8(3), 331-342 (2005).
    • (2005) Dev. Cell , vol.8 , Issue.3 , pp. 331-342
    • Costa, A.1    Wang, Y.2    Dockendorff, T.C.3
  • 25
    • 33746822949 scopus 로고    scopus 로고
    • Investigating the relationship between FMR1 allele length and cognitive ability in children: A subtle effect of the normal allele range on the normal ability range?
    • Loat CS, Craig G, Plomin R, Craig IW: Investigating the relationship between FMR1 allele length and cognitive ability in children: a subtle effect of the normal allele range on the normal ability range? Ann. Hum. Genet. 70(Pt 5), 555-565 (2006).
    • (2006) Ann. Hum. Genet , vol.70 , Issue.PART 5 , pp. 555-565
    • Loat, C.S.1    Craig, G.2    Plomin, R.3    Craig, I.W.4
  • 26
    • 13844275951 scopus 로고    scopus 로고
    • Mean age of onset in familial Alzheimer's disease is determined by amyloid β42
    • Duering M, Grimm MO, Grimm HS, Schroder J, Hartmann T: Mean age of onset in familial Alzheimer's disease is determined by amyloid β42. Neurobiol. Aging 26(6), 785-788 (2005).
    • (2005) Neurobiol. Aging , vol.26 , Issue.6 , pp. 785-788
    • Duering, M.1    Grimm, M.O.2    Grimm, H.S.3    Schroder, J.4    Hartmann, T.5
  • 27
    • 0031594142 scopus 로고    scopus 로고
    • Increased Aβ42(43) from cell lines expressing presenilin 1 mutations
    • Mehta ND, Refolo LM, Eckman C et al.: Increased Aβ42(43) from cell lines expressing presenilin 1 mutations. Ann. Neurol. 43(2), 256-258 (1998).
    • (1998) Ann. Neurol , vol.43 , Issue.2 , pp. 256-258
    • Mehta, N.D.1    Refolo, L.M.2    Eckman, C.3
  • 28
    • 0033537921 scopus 로고    scopus 로고
    • Enhancement of amyloid β42 secretion by 28 different presenilin 1 mutations of familial Alzheimer's disease
    • Murayama O, Tomita T, Nihonmatsu N et al.: Enhancement of amyloid β42 secretion by 28 different presenilin 1 mutations of familial Alzheimer's disease. Neurosci. Lett. 265(1), 61-63 (1999).
    • (1999) Neurosci. Lett , vol.265 , Issue.1 , pp. 61-63
    • Murayama, O.1    Tomita, T.2    Nihonmatsu, N.3
  • 29
    • 33646715856 scopus 로고    scopus 로고
    • Modeling clinically heterogeneous presenilin mutations with transgenic Drosophila
    • Seidner GA, Ye Y, Faraday MM, Alvord WG, Fortini ME: Modeling clinically heterogeneous presenilin mutations with transgenic Drosophila. Curr. Biol. 16(10), 1026-1033 (2006).
    • (2006) Curr. Biol , vol.16 , Issue.10 , pp. 1026-1033
    • Seidner, G.A.1    Ye, Y.2    Faraday, M.M.3    Alvord, W.G.4    Fortini, M.E.5
  • 30
    • 33745700370 scopus 로고    scopus 로고
    • Mean age-of-onset of familial Alzheimer disease caused by presenilin mutations correlates with both increased Aβ42 and decreased Aβ40
    • Kumar-Singh S, Theuns J, Van Broeck B et al.: Mean age-of-onset of familial Alzheimer disease caused by presenilin mutations correlates with both increased Aβ42 and decreased Aβ40. Hum. Mutat. 27(7), 686-695 (2006).
    • (2006) Hum. Mutat , vol.27 , Issue.7 , pp. 686-695
    • Kumar-Singh, S.1    Theuns, J.2    Van Broeck, B.3
  • 31
    • 33947288917 scopus 로고    scopus 로고
    • Regulation of γ-secretase activity in Alzheimer's disease
    • Zhou S, Zhou H, Walian PJ, Jap BK: Regulation of γ-secretase activity in Alzheimer's disease. Biochemistry 46(10), 2553-2563 (2007).
    • (2007) Biochemistry , vol.46 , Issue.10 , pp. 2553-2563
    • Zhou, S.1    Zhou, H.2    Walian, P.J.3    Jap, B.K.4
  • 34
    • 0036021395 scopus 로고    scopus 로고
    • Temperature-sensitive paralytic mutants are enriched for those causing neurodegeneration in Drosophila
    • Palladino MJ, Hadley TJ, Ganetzky B: Temperature-sensitive paralytic mutants are enriched for those causing neurodegeneration in Drosophila. Genetics 161(3), 1197-1208 (2002).
    • (2002) Genetics , vol.161 , Issue.3 , pp. 1197-1208
    • Palladino, M.J.1    Hadley, T.J.2    Ganetzky, B.3
  • 35
    • 33750052263 scopus 로고    scopus 로고
    • Wasted away, a Drosophila mutation in triosephosphate isomerase, causes paralysis, neurodegeneration, and early death
    • Gnerer JP, Kreber RA, Ganetzky B: Wasted away, a Drosophila mutation in triosephosphate isomerase, causes paralysis, neurodegeneration, and early death. Proc. Natl Acad. Sci. USA 103(41), 14987-14993 (2006).
    • (2006) Proc. Natl Acad. Sci. USA , vol.103 , Issue.41 , pp. 14987-14993
    • Gnerer, J.P.1    Kreber, R.A.2    Ganetzky, B.3
  • 36
    • 0031282443 scopus 로고    scopus 로고
    • Spongecake and eggroll: Two hereditary diseases in Drosophila resemble patterns of human brain degeneration
    • Min KT, Benzer S: Spongecake and eggroll: two hereditary diseases in Drosophila resemble patterns of human brain degeneration. Curr. Biol. 7(11), 885-888 (1997).
    • (1997) Curr. Biol , vol.7 , Issue.11 , pp. 885-888
    • Min, K.T.1    Benzer, S.2
  • 37
    • 0037011118 scopus 로고    scopus 로고
    • The neurodegeneration mutant lochrig interferes with cholesterol homeostasis and APPl processing
    • Tschape JA, Hammerschmied C, Muhlig-Versen M, Athenstaedt K, Daum G, Kretzschmar D: The neurodegeneration mutant lochrig interferes with cholesterol homeostasis and APPl processing. EMBO J. 21(23), 6367-6376 (2002).
    • (2002) EMBO J , vol.21 , Issue.23 , pp. 6367-6376
    • Tschape, J.A.1    Hammerschmied, C.2    Muhlig-Versen, M.3    Athenstaedt, K.4    Daum, G.5    Kretzschmar, D.6
  • 38
    • 2342472071 scopus 로고    scopus 로고
    • The Drosophila carbonyl reductase sniffer prevents oxidative stress-induced neurodegeneration
    • Botella JA, Ulschmid JK, Gruenewald C et al.: The Drosophila carbonyl reductase sniffer prevents oxidative stress-induced neurodegeneration. Curr. Biol. 14(19), 782-786 (2004).
    • (2004) Curr. Biol , vol.14 , Issue.19 , pp. 782-786
    • Botella, J.A.1    Ulschmid, J.K.2    Gruenewald, C.3
  • 39
    • 34447294969 scopus 로고    scopus 로고
    • Autism and epilepsy: A retrospective follow-up study
    • doi: 10.1016/j.braindev.2006.12.012 , Epub ahead of print
    • Hara H: Autism and epilepsy: a retrospective follow-up study. Brain Dev. doi: 10.1016/j.braindev.2006.12.012 (2007) (Epub ahead of print).
    • (2007) Brain Dev
    • Hara, H.1
  • 40
    • 15944421252 scopus 로고    scopus 로고
    • Social experience and pheromonal perception can change male-male interactions in Drosophila melanogaster
    • Svetec N, Ferveur JF: Social experience and pheromonal perception can change male-male interactions in Drosophila melanogaster. J. Exp. Biol. 208(Pt 5), 891-898 (2005).
    • (2005) J. Exp. Biol , vol.208 , Issue.PART 5 , pp. 891-898
    • Svetec, N.1    Ferveur, J.F.2
  • 41
    • 33846510504 scopus 로고    scopus 로고
    • Robin? C, Daborn PJ, Hoffmann AA: Fighting fly genes. Trends Genet. 23(2), 51-54 (2007).
    • Robin? C, Daborn PJ, Hoffmann AA: Fighting fly genes. Trends Genet. 23(2), 51-54 (2007).
  • 42
    • 33748417696 scopus 로고    scopus 로고
    • Hollingworth P, Hamshere ML, Moskvina V et al.: Four components describe behavioral symptoms in 1120 individuals with late-onset Alzheimer's disease. J. Am. Geriatr. Soc. 54(9), 1348-1354 (2006).
    • Hollingworth P, Hamshere ML, Moskvina V et al.: Four components describe behavioral symptoms in 1120 individuals with late-onset Alzheimer's disease. J. Am. Geriatr. Soc. 54(9), 1348-1354 (2006).
  • 43
    • 17744362737 scopus 로고    scopus 로고
    • Working memory and learning in early Alzheimer's disease
    • Germano C, Kinsella GJ: Working memory and learning in early Alzheimer's disease. Neuropsychol. Rev. 15(1), 1-10 (2005).
    • (2005) Neuropsychol. Rev , vol.15 , Issue.1 , pp. 1-10
    • Germano, C.1    Kinsella, G.J.2
  • 44
    • 0036206165 scopus 로고    scopus 로고
    • Memory enhancement and formation by atypical PKM activity in Drosophila melanogaster
    • Drier EA, Tello MK, Cowan M et al.: Memory enhancement and formation by atypical PKM activity in Drosophila melanogaster. Nat. Neurosci. 5(4), 316-324 (2002).
    • (2002) Nat. Neurosci , vol.5 , Issue.4 , pp. 316-324
    • Drier, E.A.1    Tello, M.K.2    Cowan, M.3
  • 45
    • 33747479175 scopus 로고    scopus 로고
    • Genetically increased risk of sleep disruption in Alzheimer's disease
    • Craig D, Hart DJ, Passmore AP: Genetically increased risk of sleep disruption in Alzheimer's disease. Sleep 29(8), 1003-1007 (2006).
    • (2006) Sleep , vol.29 , Issue.8 , pp. 1003-1007
    • Craig, D.1    Hart, D.J.2    Passmore, A.P.3
  • 46
    • 33748802246 scopus 로고    scopus 로고
    • A Drosophila model for age-associated changes in sleep-wake cycles
    • Koh K, Evans JM, Hendricks JC, Sehgal A: A Drosophila model for age-associated changes in sleep-wake cycles. Proc. Natl Acad. Sci. USA 103(37), 13843-13847 (2006).
    • (2006) Proc. Natl Acad. Sci. USA , vol.103 , Issue.37 , pp. 13843-13847
    • Koh, K.1    Evans, J.M.2    Hendricks, J.C.3    Sehgal, A.4
  • 47
    • 33746191376 scopus 로고    scopus 로고
    • Functional screening of traditional antidepressants with primary cortical neuronal networks grown on multielectrode neurochips
    • Gramowski A, Jugelt K, Stuwe S et al.: Functional screening of traditional antidepressants with primary cortical neuronal networks grown on multielectrode neurochips. Eur. J. Neurosci. 24(2), 455-465 (2006).
    • (2006) Eur. J. Neurosci , vol.24 , Issue.2 , pp. 455-465
    • Gramowski, A.1    Jugelt, K.2    Stuwe, S.3
  • 48
    • 0242657586 scopus 로고    scopus 로고
    • A rapid cellular FRET assay of polyglutamine aggregation identifies a novel inhibitor
    • Pollitt SK, Pallos J, Shau J et al.: A rapid cellular FRET assay of polyglutamine aggregation identifies a novel inhibitor. Neuron 40(4), 685-694 (2003).
    • (2003) Neuron , vol.40 , Issue.4 , pp. 685-694
    • Pollitt, S.K.1    Pallos, J.2    Shau, J.3
  • 49
    • 33750374340 scopus 로고    scopus 로고
    • Development of a Drosophila seizure model for in vivo high-throughput drug screening
    • Stilwell GE, Saraswati S, Littleton JT, Chouinard SW: Development of a Drosophila seizure model for in vivo high-throughput drug screening. Eur. J. Neurosci. 24(8), 2211-2222 (2006).
    • (2006) Eur. J. Neurosci , vol.24 , Issue.8 , pp. 2211-2222
    • Stilwell, G.E.1    Saraswati, S.2    Littleton, J.T.3    Chouinard, S.W.4
  • 50
    • 26444528514 scopus 로고    scopus 로고
    • The blood-brain barrier - lessons from moody flies
    • Daneman R, Barres BA: The blood-brain barrier - lessons from moody flies. Cell 123(1), 9-12 (2005).
    • (2005) Cell , vol.123 , Issue.1 , pp. 9-12
    • Daneman, R.1    Barres, B.A.2
  • 51
    • 15544363784 scopus 로고    scopus 로고
    • Toll-deficient Drosophila flies as a fast, high-throughput model for the study of antifungal drug efficacy against invasive aspergillosis and Aspergillus virulence
    • Lionakis MS, Lewis RE, May GS et al.: Toll-deficient Drosophila flies as a fast, high-throughput model for the study of antifungal drug efficacy against invasive aspergillosis and Aspergillus virulence. J. Infect. Dis. 191(7), 1188-1195 (2005).
    • (2005) J. Infect. Dis , vol.191 , Issue.7 , pp. 1188-1195
    • Lionakis, M.S.1    Lewis, R.E.2    May, G.S.3
  • 52
    • 33745239787 scopus 로고    scopus 로고
    • Biologically active molecules that reduce polyglutamine aggregation and toxicity
    • Desai UA, Pallos J, Ma AA et al.: Biologically active molecules that reduce polyglutamine aggregation and toxicity. Hum. Mol. Genet. 15(13), 2114-2124 (2006).
    • (2006) Hum. Mol. Genet , vol.15 , Issue.13 , pp. 2114-2124
    • Desai, U.A.1    Pallos, J.2    Ma, A.A.3
  • 53
    • 14844341251 scopus 로고    scopus 로고
    • Identification of combinatorial drug regimens for treatment of Huntington's disease using Drosophila
    • Agrawal N, Pallos J, Slepko N et al.: Identification of combinatorial drug regimens for treatment of Huntington's disease using Drosophila. Proc. Natl Acad. Sci. USA 102 (10), 3777-3781 (2005).
    • (2005) Proc. Natl Acad. Sci. USA , vol.102 , Issue.10 , pp. 3777-3781
    • Agrawal, N.1    Pallos, J.2    Slepko, N.3


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