Quantum dots and multifunctional nanoparticles: New contrast agents for tumor imaging

Nanomedicine

Volumn 1, Issue 2, 2006, Pages 209-217

  Rhyner, Matthew N ^a   Smith, Andrew M ^a   Goo, Xiaohu ^b   Mao, Hui ^c   Yang, Lily ^c   Nie, Shuming ^a,d  

^a EMORY UNIVERSITY   (United States)

^b University of Washington   (United States)

^c EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d HUNAN UNIVERSITY   (China)

Author keywords

Contrast agents; Fluorescence; Magnetic resonance imaging; Nanoparticles; Positron emission tomography; Quantum dots; Tumor imaging

Indexed keywords

CONTRAST MEDIUM; NANOPARTICLE; QUANTUM DOT;

ANIMAL; DIAGNOSTIC IMAGING; HUMAN; METHODOLOGY; NANOTECHNOLOGY; NEOPLASM; REVIEW; SCINTISCANNING;

ANIMALS; CONTRAST MEDIA; DIAGNOSTIC IMAGING; HUMANS; NANOPARTICLES; NANOTECHNOLOGY; NEOPLASMS; QUANTUM DOTS;

EID: 34447258534     PISSN: 17435889     EISSN: 17486963     Source Type: Journal    
DOI: 10.2217/17435889.1.2.209     Document Type: Review

References (72)

1. Chan WCW, Maxwell DJ, Gao XH, Bailey RE, Han MY, Nie SM: Luminescent quantum dots fot multiplexed biological detection and imaging. Curr. Opin. Biotechnol 13, 40-46(2002).
2. Bruchez M, Moronne M, Gin P, Weiss S, Alivisatos AP: Semiconductor nanocrystals as fluorescent biological labels. Science 281, 2013-2016(1998).
3. Chan WCW, Nie SM: Quantum dot bioconjugates for ultrasensitive nonisotopic detection. Science 281, 2016-2018 (1998).
4. Mattoussi H, Mauro JM, Goldman ER et al.: Self-assembly of CdSe-ZnS quantum dot bioconjugates using an engineered recombinant protein. J. Am. Chem. Soc. 122, 12142-12150(2000).
5. Akerman ME, Chan WCW, Laakkonen P, Bhatia SN, Ruoslahti E: Nanocrystal targeting in vivo. Proc. Natl Acad. Sci. USA 99, 12617-12621 (2002).
6. Dubertret B, Skourides P, Norris DJ, Noireaux V, Brivanlou AH, Libchaber A: In vivo imaging of quantum dots encapsulated in phospholipid micelles. Science 298, 1759-1762 (2002).
7. Wu XY, Liu HJ, Liu JQ et al.: Immunofluorescent labeling of cancer marker Her2 and other cellular targets with semiconductor quantum dots. Nat. Biotecbnol. 21, 41-46 (2003).
8. Jaiswal JK, Mattoussi H, Mauro JM, Simon SM: Long-term multiple color imaging of live cells using quantum dot bioconjugates. Nat. Biotechnol. 21, 47-51 (2003).
9. Larson DR, Zipfel WR, Williams RM et al.: Water-soluble quantum dots for multiphoton fluorescence imaging in vivo. Science 300, 1434-1436 (2003).
10. Ishii D, Kinbara K, Ishida Y et al.: Chaperonin-mediated stabilization and ATP-triggered release of semiconductor nanoparticles. Nature 421, 628-632 (2003).
11. Medintz IL, Clapp AR, Mattoussi H, Goldman ER, Fisher B, Mauro JM: Self-assembled nanoscale biosensors based on quantum dot FRET donors. Nat. Mater. 2, 630-638 (2003).
12. Dahan M, Levi S, Luccardini C, Rostaing P, Riveau B, Triller A: Diffusion dynamics of glycine receptors revealed by single-quantum dot tracking. Science 302, 442-445 (2003).
13. Lidke DS, Nagy P, Heintzmann Ret ab Quantum dot ligands provide new insights into erbB/HER receptor-mediated signal transduction. Nat. Biotechnol. 22, 198-203 (2004).
14. Smith A, Ruan G, Rhyner MN, Nie SM: Engineering luminescent quantum dots for in vivo molecular and cellular imaging. Ann. Biomed Eng. 34, 1-12 (2006).
15. Gao XH, Yang LL, Petros JA, Marshal FF, Simons JW, Nie SM: In vivo molecular and cellular imaging with quantum dots. Curr. Opin. Biotechnol. 16, 63-72 (2005).
16. Smith AM, Gao XH, Nie SM: Quantum dot nanocrystals for in vivo molecular and cellular imaging. Photochem. Photobiol. 80, 377-385 (2004).
17. Pinaud F, Michalet X, Bentolila L.A et al.: Advances in fluorescence imaging with quantum dot bio-probes. Biomaterials 27, 1679-1687 (2006).
18. Alivisatos AP, Gu WW, Larabell C: Quantum dors as cellular probes. Annu. Rev. Biomed. Eng. 7, 55-76 (2005).
19. Michalet X, Pinaud FF. Bentolila LA et al.: Quantum dots for live cells, in vivo imaging, and diagnostics. Science 307, 538-544 (2005).
20. Stroh M, Zimmer JP, Duda DG et al.: Quantum dots spectrally distinguish multiple species within the tumor milieu in vivo. Nat. Med. 11, 678-682 (2005).
21. Goldman ER, Medina IL, Whidey JL et al.: A hybrid quantum dot-antibody fragment fluorescence resonance energy transfer-based TNT sensor. J. Am. Chem. Soc. 127, 6744-6751 (2005).
22. Josephson L, Tung CH, Moore A, Weissleder R: High-efficiency intracellular magnetic labeling with novel superparamagnetic-tat peptide conjugates. Bioconjug. Chem. 10, 186-191 (1999).
23. Bulte, JWM, Douglas T, Witwer B et al.: Magnerodendrimers allow endosomal magnetic labeling and in vivo tracking of stem cells. Nat. Biotechnol. 19, 1141-1147 (2001).
24. Curtis A, Wilkinson C: Nantotechniques and approaches in biotechnology. Trends Biotechnol. 19, 97-101 (2001).
25. Gref R, Minamitake Y, Peracchia MT, Trubetskoy V, Torchilin V, Langer R: Biodegradable long-circulating polymeric nanospheres. Science 263, 1600-1603 (1994).
26. Alivisatos AP: Semiconductor clusters, nanocrystals, and quantum dots. Science 271, 933-937 (1996).
27. Duncan R, Discovery NRD: The dawning era of polymer therapeutics. Nat. Rev. Drug Discov. 2, 347-360 (2003).
28. Jain RK: Understanding barriers to drug delivery: high resolution in vivo imaging is key. Clin. Cancer Res. 5, 1605-1606(1999).
29. Jain RK: Delivery of molecular medicine to solid tumors: lessons from in vivo imaging of gene expression and function. J. Control. Release 74, 7-25 (2001).
30. Lemon BI, Crooks RM: Preparation and characterization of dendrimer-encapsulated CdS semiconductor quantum dots. J. Am. Chem. Soc. 122, 12886-12887 (2000).
31. Murray CB, Sun SH, Gaschler W, Doyle H, Betley TA, Kagan CR: Colloidal synthesis of nanocrystals and nanocrystal superlattices. IBM. J. Res. Dev. 45, 47-56 (2001).
32. Rogach A, Kershaw S, Burt M et al.: Colloidally prepared HgTe nanocrystals with strong room-temperature infrared luminescence. Adv. Mater. Weinheim 11, 552 (1999).
33. Gao XH, Nie SM: Doping mesoporous materials with multicolor quantum dots. J. Phys. Chem. B 107, 11575-11578 (2003).
34. Han MY, Gao XH, Su JZ, Nie S: Quantum-dot-tagged microbeads for multiplexed optical coding of biomolecules. Nat. Biotechnol. 19, 631-635 (2001).
35. Yu WW, Qu LH, Guo WZ, Peng XG: Experimental determination of the extinction coefficient of CdTe, CdSe, and CdS nanocrystals. Chem. Mater. 15, 2854-2860 (2003).
36. Kim SW, Zimmer JP, Ohnishi S, Tracy JB, Frangioni JV, Bawendi MG: Engineering InAsxP1-x/InP/ZnSe III-V alloyed core/shell quantum dots for the near-infrared. J. Am. Chem. Soc. 127, 10526-10532 (2005).
37. Gao XH, Cui YY, Levenson RM, Chung LWK, Nie SM: In vivo cancer targeting and imaging with semiconductor quantum dots. Nat. Biotechnol. 22, 969-976 (2004).
38. Weissleder R, Kelly K, Sun EY, Shtatland T, Josephson L: Cell-specific targeting of nanoparticles by multivalent attachment of small molecules. Nat. Biotechnol. 23, 1418-1423 (2005).
39. Caplan MR, Rosea EV: Targeting drugs to combinations of receptors: a modeling analysis of potential specificity. Ann. Biomed. Eng. 33, 1113-1124 (2005).
40. Vu TQ, Maddipati R, Blute TA, Nehilla BJ, Nusblat L, Desai TA: Peptide-conjugated quantum dots activate neuronal receptors and initiate downstream signaling of neurite growth. Nano Lett. 5, 603-607 (2005).
41. Fu AH, Micheel CM, Cha J, Chang H, Yang H, Alivisatos AP: Discrete nanostructures of quantum dots/Au with DNA. J. Am. Chem Soc. 126, 10832-10833 (2004).
42. Nehilla BJ, Vu TQ, Desai TA: Stoichiometry-dependent formation of quantum dot-antibody bioconjugates: a complementary atomic force microscopy and agarose gel electrophoresis study. J. Phys. Chem. B 109, 20724-20730 (2005).
43. Ntziachristos V, Bremer C, Weissleder R: Fluorescence imaging with near-infrared light: new technological advances that enable in vivo molecular imaging. Eur. Radiol. 13, 195-208 (2003).
44. Ntziachristos V, Schellenberger EA, Ripoll J et al.: Visualization of antitumor treatment by means of fluorescence molecular tomography with an annexin V-Cy5.5 conjugate. Proc. Natl Acad. Sci. USA 101, 12294-12299 (2004).
45. Kircher MF, Weissleder R, Josephson L: A dual fluorochrome probe for imaging proteases. Bioconjug. Chem. 15, 242-248 (2004).
46. Schellenberger EA, Sosnovik D, Weissleder R, Josephson L: Magneto/optical annexin V, a multimodal protein. Bioconjug. Chem. 15, 1062-1067(2004).
47. 3 beads-CdSe/ZnS quantum dots core-shell nanocomposite particles for cell separation. Nano Lett. 4, 409-413 (2004).
48. Gu HW, Zheng RK, Zhang XX, Xu B: Facile one-pot synthesis of bifuncrional heterodimers of nanoparticles: a conjugate of quantum dot and magnetic nanoparticles. J. Am. Chem. Soc. 126, 5664-5665 (2004).
49. Patri AK, Myc A, Beals J, Thomas TP, Bander NH, Baker JR: Synthesis and in vitro testing of J591 antibody-dendrimer conjugates for targeted prostate cancer therapy. Bioconjug. Chem. 15, 1174-1181 (2004).
50. Mulder WJ, Koole R, Brandwijk RJ et al.: Quantum dots with a paramagnetic coating as a bimodal molecular imaging probe. Nano Lett. 6, 1-6 (2006).
51. van Tilborg GAF, Mulder WJM, Chin PTK et al.: Annexin A5-conjugated quantum dots with a paramagnetic lipidic coating for the multimodal detection of apoptotic cells. Bioconjug. Chem. 17, 865-868 (2006).
52. Quintana A, Raczka E, Piehler L et al.: Design and function of a dendrimer-based therapeutic nanodevice targeted to tumor cells through the folate receptor. Pharm. Res. 19, 1310-1316(2002).
53. Torchilin VP, Trubetskoy VS, Milshteyn AM et al.: Targeted delivery of diagnostic agents by surface-modified liposomes. J. Control Release 28, 45-58 (1994).
54. Torchilin V, Babich J, Weissig V: Liposomes and micelles to target the blood pool for imaging purposes. J. Liposome Res. 10, 483-499 (2000).
55. Buck SM, Koo YEL, Park E et al.: Optochemical nanosensor PEBBLEs: photonic explorers for bioanalysis with biologically localized embedding. Curr. Opin. Chem. Biol 8, 540-546 (2004).
56. Voura EB, Jaiswal JK, Mattoussi H, Simon SM: Tracking metastatic tumor cell extravasation with quantum dot nanocrystals and fluorescence emission-scanning microscopy. Nat. Med. 10, 993-998 (2004).
57. Hoshino A, Hanaki K, Suzuki K, Yamamoto K: Applications of T-lymphoma labeled with fluorescent quantum dots to cell tracing markers in mouse body. Biochem. Biophys. Res. Commun. 314, 46-53 (2004).
58. Ballou B, Lagerholm BC, Ernst LA, Bruchez MP, Waggoner AS: Noninvasive imaging of quantum dots in mice. Bioconjug. Chem. 15, 79-86 (2004).
59. Kim S, Lim YT, Soltesz EG et al.: Near-infrared fluorescent type II quantum dots for sentinel lymph node mapping. Nat. Biotechnol. 22, 93-97 (2004).
60. Parungo CP, Colson YL, Kim SW et al.: Sentinel lymph node mapping of the pleural space. Chest 127, 1799-1804 (2005).
61. Soltesz EG, Kim S, Laurence RG et al.: Intraoperative sentinel lymph node mapping of the lung using near-infrared fluorescent quantum dots. Ann. Thorac. Surg. 79, 269-277 (2005).
62. So MK, Xu CJ, Loening AM, Gambhir SS, Rao JH: Self-illuminating quantum dot conjugates for in vivo imaging. Nat. Biotechnol. 24, 339-343 (2006).
63. Bander NH, Trabulsi EJ, Kostakoglu L et al.: Targeting metastatic prostate cancer with radiolabeled monoclonal antibody J591 to the extracellular domain of prostate specific membrane antigen. J. Urol. 170, 1717-1721 (2003).
64. Cai WB, Shin DW, Chen K et al.: Peptide-labeled near-infrared quantum dots for imaging tumor vasculature in living subjects. Nano Lett. 6, 669-676 (2006).
65. Goldman ER, Clapp AR, Anderson GP et al.: Multiplexed toxin analysis using four colors of quantum dot fluororeagents. Anal Chem. 76, 684-688 (2004).
66. Ungcrfelt BM, Mattoussi H, Goldman ER, Mauro JM, Anderson GP: Preparation of quantum dot-biotin conjugates and their use in immunochromatography assays. Anal Chem. 75, 4043-4049 (2003).
67. Medintz IL, Konnen JH, Clapp AR et al.: A fluorescence resonance energy transfer-derived structure of a quantum dot-protein bioconjugate nanoassembly. Proc. Natl Acad Sci. USA 101, 9612-9617 (2004).
68. Lovric J, Bazzi HS, Cuie Y, Fortin GRA, Winnik FM, Maysinger D: Differences in subcellular distribution and toxicity of green and red emitting CdTe quantum dots. J. MoL Med. 83, 377-385 (2005).
69. Hoshino A, Fujioka K, Oku T et al.: Physicochemical properties and cellular toxicity of nanocrystal quantum dots depend on their surface modification. Nanoletters 4, 2163-2169 (2004).
70. Derfus AM, Chan WCW, Bhatia SN: Probing the cytotoxicity of semiconductor quantum dots. Nano Lett. 4, 11-18 (2004).
71. Ipe BI, Lehnig M, Niemeyer CM: On the generation of free radical species from quantum dots. Small 1, 706-709 (2005).
72. Kirchner C, Uedl T, Kudera S et al.: Cytotoxicity of colloidal CdSe and CdSe/ZnS nanoparticles. Nano Lett. 5, 331-338 (2005).