메뉴 건너뛰기




Volumn 33, Issue 8, 2005, Pages 1113-1124

Targeting drugs to combinations of receptors: A modeling analysis of potential specificity

Author keywords

Biomaterial; Drug delivery; Mathematical model; Multivalent

Indexed keywords

CELL SURFACE; DRUG DELIVERY; MULTIVALENT; RECEPTORS;

EID: 23844436235     PISSN: 00906964     EISSN: 15739686     Source Type: Journal    
DOI: 10.1007/s10439-005-5779-1     Document Type: Article
Times cited : (54)

References (23)
  • 2
    • 0346996532 scopus 로고    scopus 로고
    • Design of a multivalent galactoside ligand for selective targeting of HPMA copolymer-doxorubicin conjugates to human colon cancer cells
    • David, A., P. Kopeckova, T. Minko, A. Rubinstein, and J. Kopecek. Design of a multivalent galactoside ligand for selective targeting of HPMA copolymer-doxorubicin conjugates to human colon cancer cells. Ear. J. Cancer 40:148-157, 2004.
    • (2004) Ear. J. Cancer , vol.40 , pp. 148-157
    • David, A.1    Kopeckova, P.2    Minko, T.3    Rubinstein, A.4    Kopecek, J.5
  • 3
    • 0037399124 scopus 로고    scopus 로고
    • Expression-driven reverse engineering of targeted imaging and therapeutic agents
    • Gillies, R. J., and V. J. Hruby. Expression-driven reverse engineering of targeted imaging and therapeutic agents. Expert Opin. Therap. Targets 7(2): 137-139, 2003.
    • (2003) Expert Opin. Therap. Targets , vol.7 , Issue.2 , pp. 137-139
    • Gillies, R.J.1    Hruby, V.J.2
  • 4
    • 0001975128 scopus 로고
    • Desensitization, histamine release and the aggregation of IgE on human basophils
    • edited by A. S. Perelson. Redwood City, CA: Addison-Wesley
    • Goldstein, B. Desensitization, histamine release and the aggregation of IgE on human basophils. In: Theoretical Immunology, Part One: SFI Studies in the Sciences of Complexity, edited by A. S. Perelson. Redwood City, CA: Addison-Wesley, 1988, pp. 3-40.
    • (1988) Theoretical Immunology, Part One: SFI Studies in the Sciences of Complexity , pp. 3-40
    • Goldstein, B.1
  • 6
    • 0033002586 scopus 로고    scopus 로고
    • Steric effects on multivalent ligand-receptor binding: Exclusion of ligand sites by bound cell surface receptors
    • Hlavacek, W. S., R. G. Posner, and A. S. Perelson. Steric effects on multivalent ligand-receptor binding: Exclusion of ligand sites by bound cell surface receptors. Biophys. J. 76:3031-3043, 1999.
    • (1999) Biophys. J. , vol.76 , pp. 3031-3043
    • Hlavacek, W.S.1    Posner, R.G.2    Perelson, A.S.3
  • 8
    • 0032531947 scopus 로고    scopus 로고
    • Spanning binding sites on allosteric proteins with polymer-linked ligand dimers
    • Kramer, R. H., and J. W. Karpen. Spanning binding sites on allosteric proteins with polymer-linked ligand dimers. Nature 395:710-713, 1998.
    • (1998) Nature , vol.395 , pp. 710-713
    • Kramer, R.H.1    Karpen, J.W.2
  • 11
    • 0032476812 scopus 로고    scopus 로고
    • Polyvalent interactions in biological systems: Implications for design and use of multivalent ligands and inhibitors
    • Mammen, M., S.-K. Choi, and G. M. Whitesides. Polyvalent interactions in biological systems: Implications for design and use of multivalent ligands and inhibitors. Angew. Chem. Int. Edn. 37:2754-2794, 1998.
    • (1998) Angew. Chem. Int. Edn. , vol.37 , pp. 2754-2794
    • Mammen, M.1    Choi, S.-K.2    Whitesides, G.M.3
  • 13
    • 0034702667 scopus 로고    scopus 로고
    • Synthesis of norbornenyl polymers with bioactive oligopeptides by ringopening metathesis polymerization
    • Maynard, H. D., S. Y. Okada, and R. H. Grubbs. Synthesis of norbornenyl polymers with bioactive oligopeptides by ringopening metathesis polymerization. Macromolecules 33:6239-6248, 2000.
    • (2000) Macromolecules , vol.33 , pp. 6239-6248
    • Maynard, H.D.1    Okada, S.Y.2    Grubbs, R.H.3
  • 14
    • 0035925162 scopus 로고    scopus 로고
    • Inhibition of cell adhesion to fibronectin by oligopeptide-substituted polynor-bornenes
    • Maynard, H. D., S. Y Okada, and R. H. Grubbs. Inhibition of cell adhesion to fibronectin by oligopeptide-substituted polynor-bornenes. J. Am. Chem. Soc. 123:1275-1279, 2001.
    • (2001) J. Am. Chem. Soc. , vol.123 , pp. 1275-1279
    • Maynard, H.D.1    Okada, S.Y.2    Grubbs, R.H.3
  • 15
    • 0012980377 scopus 로고    scopus 로고
    • Drug targeting: Basic concepts and novel advances
    • edited by G. Molema and D. K. Meijer. Weinheim: Wiley
    • Molema, G. Drug targeting: Basic concepts and novel advances. In: Drug Targeting: Organ Specific. Strategies, edited by G. Molema and D. K. Meijer. Weinheim: Wiley, 2001, pp. 1-22.
    • (2001) Drug Targeting: Organ Specific. Strategies , pp. 1-22
    • Molema, G.1
  • 17
    • 0001505146 scopus 로고
    • Some mathematical models of receptor clustering by multivalent ligands
    • edited by A. S. Perelson, C. DeLisi, and F. W. Wiegel. New York: Marcel Dekker
    • Perelson, A. S. Some mathematical models of receptor clustering by multivalent ligands. In: Cell Surface Dynamics: Concepts and Models, edited by A. S. Perelson, C. DeLisi, and F. W. Wiegel. New York: Marcel Dekker, 1984, pp. 223-276.
    • (1984) Cell Surface Dynamics: Concepts and Models , pp. 223-276
    • Perelson, A.S.1
  • 18
    • 0035363488 scopus 로고    scopus 로고
    • In vivo gene expression revealed by cDNA arrays: The pattern in relapsing-remitting multiple sclerosis patients compared with normal subjects
    • Ramanathan, M., B. Weinstock-Guttman, L. T. Nguyen, D. Badgett, C. Miller, K. Patrick, C. Brownscheidle, and L. Jacobs. In vivo gene expression revealed by cDNA arrays: The pattern in relapsing-remitting multiple sclerosis patients compared with normal subjects. J. Neuroimmunol. 116(2):213-219, 2001.
    • (2001) J. Neuroimmunol. , vol.116 , Issue.2 , pp. 213-219
    • Ramanathan, M.1    Weinstock-Guttman, B.2    Nguyen, L.T.3    Badgett, D.4    Miller, C.5    Patrick, K.6    Brownscheidle, C.7    Jacobs, L.8
  • 20
    • 0000448866 scopus 로고
    • 4-Norleucine, 7-D-phenylalanine-a-melanocyte-stimulating hormone: A highly potent of-melanotropin with ultralong biological activity
    • Sawyer, T. K., P. J. Sanfilippo, V. J. Hruby, M. H. Engel, C. B. Heward, J. B. Bumett, and M. E. Hadley. 4-Norleucine, 7-D-phenylalanine-a-melanocyte-stimulating hormone: A highly potent of-melanotropin with ultralong biological activity. Proc. Natl. Acad. Sci. U.S.A. 77(10):5754-5758, 1980.
    • (1980) Proc. Natl. Acad. Sci. U.S.A. , vol.77 , Issue.10 , pp. 5754-5758
    • Sawyer, T.K.1    Sanfilippo, P.J.2    Hruby, V.J.3    Engel, M.H.4    Heward, C.B.5    Bumett, J.B.6    Hadley, M.E.7
  • 21
    • 0842312445 scopus 로고    scopus 로고
    • Selective targeting of cancer cells using synthetic peptides
    • Shadidi, M., and M. Sioud. Selective targeting of cancer cells using synthetic peptides. Drug Resist. Updates 6:363-371, 2003.
    • (2003) Drug Resist. Updates , vol.6 , pp. 363-371
    • Shadidi, M.1    Sioud, M.2
  • 22
    • 0347517810 scopus 로고    scopus 로고
    • Novel targeting strategy based on multimeric ligands for drug delivery and molecular imaging: Homooligomers of alpha-MSH
    • Vagner, J., H. L. Handl, R. J. Gillies, and V. J. Hruby. Novel targeting strategy based on multimeric ligands for drug delivery and molecular imaging: Homooligomers of alpha-MSH. Bioorg. Med. Chem. Lett. 14:211-215, 2004.
    • (2004) Bioorg. Med. Chem. Lett. , vol.14 , pp. 211-215
    • Vagner, J.1    Handl, H.L.2    Gillies, R.J.3    Hruby, V.J.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.