Quantum dots spectrally distinguish multiple species within the tumor milieu in vivo

Nature Medicine

Volumn 11, Issue 6, 2005, Pages 678-682

  Stroh, Mark ^a   Zimmer, John P ^b   Duda, Dan G ^a   Levchenko, Tatyana S ^c   Cohen, Kenneth S ^a   Brown, Edward B ^a   Scadden, David T ^a   Torchilin, Vladimir P ^c   Bawendi, Moungi G ^b   Fukumura, Dai ^a   Jain, Rakesh K ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^c NORTHEASTERN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

QUANTUM DOT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; EXTRACELLULAR MATRIX; HEMATOPOIETIC STEM CELL; MOUSE; MULTIPHOTON MICROSCOPY; NANOTECHNOLOGY; NONHUMAN; PARTICLE SIZE; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN EXPRESSION; SEMICONDUCTOR; SOLID TUMOR; SPECIES DIFFERENTIATION; TRANSGENIC MOUSE; TUMOR VASCULARIZATION;

ANIMALS; ANTINEOPLASTIC AGENTS; BONE MARROW CELLS; CELL MOVEMENT; CELLS, CULTURED; DRUG DELIVERY SYSTEMS; ENDOTHELIAL CELLS; EXTRACELLULAR MATRIX; MICE; MICE, INBRED C3H; MICE, TRANSGENIC; MICROSCOPY, FLUORESCENCE, MULTIPHOTON; NEOPLASMS, EXPERIMENTAL; QUANTUM DOTS;

ANIMALIA; MUS MUSCULUS;

EID: 20944451139     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/nm1247     Document Type: Article

References (30)

1. Jain, R.K., Munn, L.L. & Fukumura, D. Dissecting tumour pathophysiology using intravital microscopy. Nat. Rev. Cancer 2, 266-276 (2002).
2. Brown, E.B. et al. In vivo measurement of gene expression, angiogenesis and physiological function in tumors using multiphoton laser scanning microscopy. Nat. Med. 7, 864-868 (2001).
3. Fukumura, D. et al. Tumor induction of VEGF promoter activity in stromal cells. Cell 94, 715-725 (1998).
4. Zipfel, W.R., Williams, R.M. & Webb, W.W. Nonlinear magic: multiphoton microscopy in the biosciences. Nat. Biotechnol. 21, 1369-1377 (2003).
5. Brown, E. et al. Dynamic imaging of collagen and its modulation in tumors in vivo using second-harmonic generation. Nat. Med. 9, 796-800 (2003).
6. Murray, C.B., Norris, D.J. & Bawendi, M.G. Synthesis and characterization of nearly monodisperse CdE (E = S, Se, Te) semiconductor nanocrystallites. J. Am. Chem. Soc. 115, 8706-8715 (1993).
7. Larson, D.R. et al. Water-soluble quantum dots for multiphoton fluorescence imaging in vivo. Science 300, 1434-1436 (2003).
8. Wu, X. et al. Immunofluorescent labeling of cancer marker Her2 and other cellular targets with semiconductor quantum dots. Nat. Biotechnol. 21, 41-46 (2003).
9. Gao, X., Cui, Y., Levenson, R.M. Chung, L.W. & Nie, S. In vivo cancer targeting and imaging with semiconductor quantum dots. Nat. Biotechnol. 22, 969-976 (2004).
10. Jain, R.K. & Stroh, M. Zooming In and out with quantum dots. Nat. Biotechnol. 22, 959-960 (2004).
11. Steckel, J.S. et al. Blue luminescence from (CdS)ZnS core-shell nanocrystals. Angewandte Chemie-International Edition 43, 2154-2158 (2004).
12. Fisher, B.R., Eisler, H.J., Stott, N.E. & Bawendi, M.G. Emission intensity dependence and single-exponential behavior in single colloidal quantum dot fluorescence lifetimes. J. Phys. Chem. B 108, 143-148 (2004).
13. Pluen, A., Netti, P.A., Jain, R.K. & Berk, D.A. Diffusion of macromolecules in agarose gels: Comparison of linear and globular configurations. Biophys. J. 77, 542-552 (1999).
14. Dubertret, B. et al. In vivo imaging of quantum dots encapsulated in phospholipid micelles. Science 298, 1759-1762 (2002).
15. Hobbs, S.K. et al. Regulation of transport pathways in tumor vessels: role of tumor type and microenvironment. Proc. Natl. Acad. Sci. USA 95, 4607-4612 (1998).
16. Chan, Y.T. et al. Incorporation of luminescent nanocrystals into monodisperse core-shell silica microspheres. Adv. Mater. 16, 2092-2097 (2004).
17. Carmeliet, P. & Jain, R.K. Angiogenesis in cancer and other diseases. Nature 407, 249-257 (2000).
18. Rafii, S., Lyden, D., Benezra, R., Hattori, K. & Heissig, B. Vascular and haematopoietic stem cells: novel targets for anti-angiogenesis therapy? Nat. Rev. Cancer 2, 826-835 (2002).
19. Jain, R.K. & Duda, D.G. Role of bone marrow-derived cells in tumor angiogenesis and treatment. Cancer Cell 3, 515-516 (2003).
20. Bestvater, F. et al. Two-photon fluorescence absorption and emission spectra of dyes relevant for cell imaging. J. Microsc. 208, 108-115 (2002).
21. Torchilin, V.P., Rammohan, R., Weissig, V. & Levchenko, T.S. TAT peptide on the surface of liposomes affords their efficient intracellular delivery even at low temperature and in the presence of metabolic inhibitors. Proc. Natl. Acad. Sci. USA 98, 8786-8791 (2001).
22. Lewin, M. et al. Tat peptide-derivatized magnetic nanoparticles allow in vivo tracking and recovery of progenitor cells. Nat. Biotechnol. 18, 410-414 (2000).
23. Cheng, T. et al. Hematopoietic stem cell quiescence maintained by p21cip1/waf1. Science 287, 1804-1808 (2000).
24. Koike, N. et al. Tissue engineering: creation of long-lasting blood vessels. Nature 428, 138-139 (2004).
25. Jaiswal, J.K., Mattoussi, H., Mauro, J.M. & Simon, S.M. Long-term multiple color imaging of live cells using quantum dot bioconjugates. Nat. Biotechnol. 21, 47-51 (2003).
26. Hines, M.A. & Guyot-Sionnest, P. Synthesis and characterization of strongly luminescing ZnS-Capped CdSe nanocrystals. J. Phys. Chem. 100, 468-471 (1996).
27. Dabbousi, B.O. et al. (CdSe)ZnS core-shell quantum dots: synthesis and characterization of a size series of highly luminescent nanocrystallites. J. Phys. Chem. B 101, 9463-9475 (1997).
28. Leunig, M. et al. Angiogenesis, microvascular architecture, microhemodynamics, and interstitial fluid pressure during early growth of human adenocarcinoma LS174T in SCID mice. Cancer Res. 52, 6553-6560 (1992).
29. Yuan, F. et al. Vascular permeability and microcirculation of gliomas and mammary carcinomas transplanted in rat and mouse cranial windows. Cancer Res. 54, 4564-4568 (1994).
30. Melder, R.J., Salehi, H.A. & Jain, R.K. Interaction of activated natural killer cells with normal and tumor vessels in cranial windows in mice. Microvasc. Res. 50, 35-44 (1995).