A Dual Fluorochrome Probe for Imaging Proteases

Bioconjugate Chemistry

Volumn 15, Issue 2, 2004, Pages 242-248

  Kircher, Moritz F ^a   Weissleder, Ralph ^a   Josephson, Lee ^a,b  

^a HARVARD MEDICAL SCHOOL   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ENZYME ACTIVITY; FLUORESCENCE; INFRARED DEVICES; IRON OXIDES; NONINVASIVE MEDICAL PROCEDURES;

ENZYMES ACTIVITY; FLUOROCHROMES; IN-VITRO; INTERNAL STANDARDS; LESION SIZE; NEAR-INFRARED FLUORESCENCE; NON-INVASIVE ASSESSMENTS; OPTICAL PROBE; PROTEASE ACTIVITIES; VITRO AND IN VIVO;

PROBES;

AMINE; CROSS LINKED IRON OXIDE; FLUOROCHROME; FLUOROCHROME CY5.5; FLUOROCHROME CY7; IRON OXIDE; NANOPARTICLE; POLYARGININE; PROTEINASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; FLUORESCENCE; GLIOSARCOMA; IMAGING; IN VITRO STUDY; IN VIVO STUDY; MOLECULAR PROBE; MOUSE; NEAR INFRARED FLUORESCENCE; NONHUMAN; OPTICS; PATHOLOGY; RAT; STANDARD; TUMOR DIAGNOSIS; TUMOR VOLUME;

ANIMALIA; CLIO;

EID: 1642377967     PISSN: 10431802     EISSN: None     Source Type: Journal    
DOI: 10.1021/bc034151d     Document Type: Article

References (26)

1. Takahashi, A., Camacho, P., Lechleiter, J. D., and Herman, B. (1999) Measurement of intracellular calcium. Physiol. Rev. 79, 1089-125.
2. Li, W. H., Parigi, G., Fragai, M., Luchinat, C., and Meade, T. J. (2002) Mechanistic studies of a calcium-dependent MRI contrast agent. Inorg. Chem. 41, 4018-24.
3. Louie, A. Y., Huber, M. M., Ahrens, E. T., Rothbacher, U., Moats, R., and Jacobs, R. E., et al. (2000) In vivo visualization of gene expression using magnetic resonance imaging. Nat. Biotechnol. 18, 321-5.
4. Haugland, R. P. (1995) Detecting enzymatic activity in cells using fluorogenic substrates. Biotech Histochem. 70, 243-51.
5. Weissleder, R., and Ntziachristos, V. (2003) Shedding light onto live molecular targets. Nat. Med. 9, 123-8.
6. Weissleder, R., Tung, C. H., Mahmood, U., and Bogdanov, A., Jr. (1999) In vivo imaging of tumors with protease-activated near-infrared fluorescent probes. Nat. Biotechnol. 17, 375-8.
7. Tung, C. H., Bredow, S., Mahmood, U., and Weissleder, R. (1999) Preparation of a cathepsin D sensitive near-infrared fluorescence probe for imaging. Bioconjugate Chem. 10, 892-6.
8. Bremer, C., Tung, C. H., and Weissleder, R. (2001) In vivo molecular target assessment of matrix metalloproteinase inhibition. Nat. Med. 7, 743-8.
9. Jaffer, F. A., Tung, C. H., Gerszten, R. E., and Weissleder, R. (2002) In vivo imaging of thrombin activity in experimental thrombi with thrombin-sensitive near-infrared molecular probe. Arterioscler. Thromb. Vasc. Biol. 22, 1929-35.
10. Josephson, L., Kircher, M. F., Mahmood, U., Tang, Y., and Weissleder, R. (2002) Near-infrared fluorescent nanoparticles as combined MR/optical imaging probes. Bioconjugate Chem. 13, 554-560.
11. Mahmood, U., Tung, C. H., Bogdanov, A. Jr., and Weissleder, R. (1999) Near-infrared optical imaging of protease activity for tumor detection. Radiology 213, 866-70.
12. Ntziachristos, V., Tung, C. H., Bremer, C., and Weissleder, R. (2002) Fluorescence molecular tomography resolves protease activity in vivo. Nat. Med. 8, 757-60.
13. Kircher, M. F., Josephson, L., and Weissleder, R. (2002) Ratio imaging of enzyme activity using dual wavelength optical reporters. Mol. Imaging 1, 89-95.
14. Josephson, L., Tung, C. H., Moore, A., and Weissleder, R. (1999) High-efficiency intracellular magnetic labeling with novel superparamagnetic-Tat peptide conjugates. Bioconjugate Chem. 10, 186-91.
15. Josephson, L., Perez, J. M., and Weissleder, R. (2001) Magnetic nanosensors for the detection of oligonucleotide sequences. Angew. Chem., Int. Ed. 40, 3204-3206.
16. Shen, T., Weissleder, R., Papisov, M., Bogdanov, A., Jr., and Brady, T. J. (1993) Monocrystalline iron oxide nanocompounds (MION): physicochemical properties. Magn. Reson. Med. 29, 599-604.
17. Moore, A., Weissleder, R., and Bogdanov, A., Jr. (1997) Uptake of dextran-coated monocrystalline iron oxides in tumor cells and macrophages. J. Magn. Reson. Imaging 7, 1140-5.
18. Petrovsky, A., Schellenberger, E., Josephson, L., Weissleder, R., and Bogdanov, A., Jr. (2003) Near-infrared fluorescent imaging of tumor apoptosis. Cancer Res. 63, 1936-42.
19. Dubertret, B., Calame, M., and Libchaber, A. J. (2001) Single-mismatch detection using gold-quenched fluorescent oligonucleotides. Nat. Biotechnol. 19, 365-70.
20. Ii, K., Hizawa, K., Kominami, E., Bando, Y., and Katunuma, N. (1985) Different immunolocalizations of cathepsins B, H, and L in the liver. J. Histochem. Cytochem. 33, 1173-5.
21. Lesser, M., Chang, J. C., and Orlowski, M. (1985) Cathepsin B and D activity in stimulated peritoneal macrophages. Mol. Cell Biochem. 69, 67-73.
22. Crocker, J., Burnett, D., and Jones, E. L. (1984) Immunohistochemical demonstration of cathepsin B in the macrophages of benign and malignant lymphoid tissue. J. Pathol. 142, 87-94.
23. Wunderbaldinger, P., Josephson, L., and Weissleder, R. (2002) Tat Peptide Directs Enhanced Clearance and Hepatic Permeability of Magnetic Nanoparticles. Bioconjugate Chem. 13, 264-268.
24. Weissleder, R., Heautot, J. F., Schaffer, B. K., Nossiff, N., Papisov, M. I., and Bogdanov, A., Jr., et al. (1994) MR lymphography: study of a high-efficiency lymphotrophic agent. Radiology 191, 225-30.
25. Melo, R. L., Barbosa Pozzo, R. C., Alves, L. C., Perissutti, E., Caliendo, G., and Santagada, V., et al. (2001) Synthesis and hydrolysis by cathepsin B of fluorogenic substrates with the general structure benzoyl-X-ARG-MCA containing nonnatural basic amino acids at position X. Biochim Biophys Acta 1547, 82-94.
26. Bromme, D., Bonneau, P. R., Lachance, P., and Storer, A. C. (1994) Engineering the S2 subsite specificity of human cathepsin S to a cathepsin L- and cathepsin B-like specificity. J. Biol. Chem. 269, 30238-42.