Conotoxins and structural biology: A prospective paradigm for drug discovery

Current Protein and Peptide Science

Volumn 5, Issue 4, 2004, Pages 235-248

  Grant, M A ^a   Morelli, X J ^c   Rigby, A C ^a,b  

^a BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

^b MARINE BIOLOGICAL LABORATORY   (United States)

^c AIX MARSEILLE UNIVERSITÉ   (France)

Author keywords

Cone snail; Conopeptide; Conotoxin; Drug discovery; NMR; Posttranslationally modified amino acids

Indexed keywords

4 CARBOXYGLUTAMIC ACID; CONANTOKIN G; CONANTOKIN T; CONOTOXIN; ION CHANNEL; LEUCINE; NEUROTOXIN; OMEGA CONOTOXIN MVIIA; POTASSIUM CHANNEL; PROTEIN SUBUNIT; TRYPTOPHAN;

BLOOD BRAIN BARRIER; BROMINATION; CENTRAL NERVOUS SYSTEM DISEASE; COMPLEX FORMATION; COMPUTER MODEL; DISULFIDE BOND; DRUG DESIGN; DRUG RESEARCH; DRUG SELECTIVITY; DRUG SPECIFICITY; DRUG STRUCTURE; EPIMERIZATION; GENUS; GLYCOSYLATION; HUMAN; MEMBRANE PERMEABILITY; MOLECULAR MECHANICS; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PATHOPHYSIOLOGY; PHARMACOPHORE; PROSPECTIVE STUDY; PROTEIN INTERACTION; PROTEIN PROCESSING; PROTEIN STRUCTURE; PROTEIN TARGETING; REVIEW; SIDE EFFECT; SNAIL; SNAKE; SPIDER; STRUCTURE ACTIVITY RELATION; THREE DIMENSIONAL IMAGING;

ANIMALS; BINDING SITES; CONOTOXINS; DRUG DESIGN; HUMANS; MODELS, MOLECULAR; PROTEIN PROCESSING, POST-TRANSLATIONAL;

ANIMALIA; ARANEAE; GASTROPODA; SERPENTES;

EID: 3442894756     PISSN: 13892037     EISSN: None     Source Type: Journal    
DOI: 10.2174/1389203043379710     Document Type: Review

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