Modeling the structure of agitoxin in complex with the Shaker K+ channel: A computational approach based on experimental distance restraints extracted from thermodynamic mutant cycles

Biophysical Journal

Volumn 83, Issue 5, 2002, Pages 2595-2609

  Eriksson, Mats A L ^a   Roux, Benoît ^a  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AGITOXIN; POTASSIUM CHANNEL; POTASSIUM ION; TOXIN; UNCLASSIFIED DRUG; AGITOXIN 2; ION; PEPTIDE; SCORPION VENOM; SHAKER POTASSIUM CHANNEL; WATER;

ARTICLE; BINDING AFFINITY; BINDING SITE; COMPUTER SIMULATION; ENERGY; HIGH TEMPERATURE PROCEDURES; MOLECULAR DYNAMICS; MOLECULAR MODEL; NONHUMAN; PROTEIN PROTEIN INTERACTION; THERMODYNAMICS; TOXIN ANALYSIS; ANIMAL; BIOPHYSICS; CHEMICAL STRUCTURE; CHEMISTRY; METABOLISM; MUTATION; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PROTEIN BINDING; PROTEIN CONFORMATION; SCORPION; SITE DIRECTED MUTAGENESIS; STREPTOMYCES; X RAY CRYSTALLOGRAPHY;

SCORPIONES;

ANIMALS; BIOPHYSICS; COMPUTER SIMULATION; CRYSTALLOGRAPHY, X-RAY; IONS; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; MUTATION; PEPTIDES; POTASSIUM CHANNELS; PROTEIN BINDING; PROTEIN CONFORMATION; SCORPION VENOMS; SCORPIONS; SHAKER SUPERFAMILY OF POTASSIUM CHANNELS; STREPTOMYCES; THERMODYNAMICS; WATER;

EID: 0036840108     PISSN: 00063495     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-3495(02)75270-3     Document Type: Article

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