Structure-activity relationships of de novo designed cyclic antimicrobial peptides based on gramicidin S

Biopolymers - Peptide Science Section

Volumn 71, Issue 1, 2003, Pages 28-48

  Lee, Darin L ^a,b   Hodges, Robert S ^a,b  

^a UNIVERSITY OF ALBERTA   (Canada)

^b UNIVERSITY OF COLORADO   (United States)

Author keywords

sheet; Amphipathicity; Antibiotic resistance; Antimicrobial peptide; Cyclic peptide; Gramicidin S; Hemolysis; Hydrophobicity; NMR; Solid phase peptide synthesis; Structure activity relationship

Indexed keywords

ANTIBIOTICS; BLOOD; HYDROPHOBICITY; SPECTRUM ANALYSIS;

STRUCTURE-ACTIVITY;

BIOPOLYMERS;

AMINO ACID; AMPHOPHILE; CYCLOPEPTIDE; GRAMICIDIN S; PEPTIDE; PEPTIDE GS14; PEPTIDE GS14 K3L4; PEPTIDE GS14K4; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ANTIMICROBIAL ACTIVITY; BACTERIAL MEMBRANE; BETA SHEET; CONFERENCE PAPER; CYTOTOXICITY; DIASTEREOISOMER; DRUG SENSITIVITY; ENANTIOMER; ERYTHROCYTE; EUKARYOTE; FUNGUS; GRAM NEGATIVE BACTERIUM; GRAM POSITIVE BACTERIUM; HEMOLYSIS; HYDROPHOBICITY; METHODOLOGY; MINIMUM INHIBITORY CONCENTRATION; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PEPTIDE SYNTHESIS; PROKARYOTE; PROTEIN CONFORMATION; PROTEIN STRUCTURE; PROTON NUCLEAR MAGNETIC RESONANCE; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; THERAPEUTIC INDEX; THERAPY; YEAST;

AMINO ACID SEQUENCE; ANTI-BACTERIAL AGENTS; DRUG DESIGN; FUNGI; GRAM-NEGATIVE BACTERIA; GRAM-POSITIVE BACTERIA; GRAMICIDIN; ISOMERISM; MICROBIAL SENSITIVITY TESTS; MODELS, MOLECULAR; PEPTIDES, CYCLIC; PROTEIN CONFORMATION; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

BACTERIA (MICROORGANISMS); EUKARYOTA; FUNGI; MAMMALIA; NEGIBACTERIA; POSIBACTERIA; PROKARYOTA;

EID: 0037539998     PISSN: 00063525     EISSN: None     Source Type: Journal    
DOI: 10.1002/bip.10374     Document Type: Conference Paper

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