α-Conotoxins

International Journal of Biochemistry and Cell Biology

Volumn 32, Issue 10, 2000, Pages 1017-1028

  Arias, Hugo R ^a   Blanton, Michael P ^a  

^a TEXAS TECH UNIVERSITY HEALTH SCIENCES CENTER SCHOOL OF MEDICINE   (United States)

Author keywords

Conotoxins; Competitive antagonists; Nicotinic acetylcholine receptors

Indexed keywords

ALPHA CONOTOXIN; CHOLINERGIC RECEPTOR; CONOTOXIN; RECEPTOR SUBUNIT; UNCLASSIFIED DRUG;

BINDING AFFINITY; BINDING SITE; DRUG RECEPTOR BINDING; DRUG SPECIFICITY; DRUG STRUCTURE; NONHUMAN; PROTEIN STRUCTURE; REVIEW; SNAIL;

AMINO ACID SEQUENCE; ANIMALS; CONOTOXINS; HUMANS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUSCLES; NEURONS; NICOTINIC ANTAGONISTS; PROTEIN STRUCTURE, SECONDARY; RECEPTORS, NICOTINIC; SNAILS; SUBSTRATE SPECIFICITY;

GASTROPODA;

EID: 0033714035     PISSN: 13572725     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1357-2725(00)00051-0     Document Type: Review

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14. Crystal structure at 1.1 A resolution of α-conotoxin PnIB: Comparison with α-conotoxins PnIA and GI
15. 2 neuronal nicotinic acetylcholine receptor-targeted ligand
16. Three-dimensional solution structure of α-conotoxin MII by NMR spectroscopy: Effects of solution environment on helicity
17. 1H-NMR spectroscopy and molecular dynamics simulation with the explicit solvent water
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20. NMR solution structure of α-conotoxin ImI and comparison to other conotoxins specific for neuronal nicotinic acetylcholine receptors
21. 15]EpI, a novel α-conotoxin from Conus espicopatus, solved by direct methods
22. Two distinct structures of α-conotoxin GI in aqueous solution
23. Three-dimensional structure of the α-conotoxin GI at 1.2 A resolution
24. Structure determination of the three disulfide bond isomers of α-conotoxin GI: A model for the role of disulfide bonds in structural stability
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29. α-Conotoxins selectively inhibit one of the two acetylcholine binding sites of nicotinic receptors
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31. Glycosylation sites selectively interfere with α-toxin binding to the nicotinic acetylcholine receptor
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34. Two distinct nicotinic receptors, one pharmacologically similar to the vertebrate α7-containing receptor, mediate Cl currents in Aplysia neurons
35. 3H]dopamine release from rat striatal synaptosomes and slices
36. α-Conotoxin AuIB selectively blocks α3β4 nicotinic acetylcholine receptors and nicotine-evoked norepinephrine release
37. Benzophenone-type photoactivatable derivatives of α-neurotoxins and α-conotoxins in studies on Torpedo nicotinic acetylcholine receptor
38. Identification of equivalent residues in the γ, δ, and ε subunits of the nicotinic acetylcholine receptor that contribute to α-bungarotoxin binding
39. Structure of the agonist-binding sites of the Torpedo nicotinic acetylcholine receptor: Affinity-labeling and mutational analyses identify γTyr-111/δArg-113 as antagonist affinity determinants
40. Molecular dissection of subunit interfaces in the acetylcholine receptor. Identification of residues that determine agonist selectivity
41. Residues at the subunit interfaces of the nicotinic acetylcholine receptor that contribute to α-conotoxin M1 binding
42. Critical residues influence the affinity and selectivity of α-conotoxin MI for nicotinic acetylcholine receptors
43. Determinants involved in the affinity of α-conotoxins GI and SI for the muscle subtype of the nicotinic acetylcholine receptors
44. The 9-arginine residue of α-conotoxin GI is responsible for its selective high affinity for the αγ agonist site on the electric organ acetylcholine receptor
45. Determinants of specificity for α-conotoxin MII on α3β2 neuronal nicotinic receptors
46. 7 acetylcholine receptor that confer selectivity for conotoxin ImI
47. 7 receptors
48. 7 acetylcholine receptors and α-conotoxin ImI
49. Single amino acid substitutions in α-conotoxin PnIA shift selectivity for subtypes of the mammalian neuronal nicotinic acetylcholine receptor
50. Single-residue alteration in α-conotoxin PnIA switches its nAChR subtype selectively
51. 10 of α-conotoxin PnIB confers potency for neuronal nicotinic responses in bovine chromaffin cells
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56. Novel α- and ω-conotoxins from Conus striatus venom
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58. Characterization of α-conotoxin interactions with the nicotinic acetylcholine receptor and monoclonal antibodies
59. 7 nicotinic receptor by using short pulses of acetylcholine and selective blockers
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63. In vitro and in vivo characterization of conantokin-R, a selective NMDA receptor antagonist isolated from the venom of the fish-hunting snail Conus radiatus
64. Calcium channel diversity and neurotransmitter release: The ω-conotoxins and ω-agatoxins