Minimized proteins

Current Opinion in Structural Biology

Volumn 7, Issue 4, 1997, Pages 457-462

  Cunningham, Brian C ^a   Wells, James A ^a  

^a GENENTECH INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN;

MOLECULAR SIZE; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; REVIEW; STRUCTURE ACTIVITY RELATION;

EID: 0030874705     PISSN: 0959440X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0959-440X(97)80107-8     Document Type: Article

References (23)

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3. Bondinell WE, Keenan RM, Miller WH, Ali FE, Allen AC, de Brosse CW, Eggleston DS, Erhard KF, Haltiwanger RC, Huffman WF. Design of a potent and orally active nonpeptide platelet fibrinogen receptor (GP11b/IIIa) antagonist. Bioorg Med Chem. 2:1994;897-908.
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5. Atassi MZ, Manshouri T. Design of peptide enzymes (pepzymes): surface-simulation synthetic peptides that mimic the chymotrypsin and trypsin active sites and exhibit the activity and specificity of the respective enzyme. Proc Natl Acad Sci USA. 90:1993;8282-8286.
6. Corey DR, Phillips MA. Cyclic peptides as proteases. Proc Natl Acad Sci USA. 91:1994;4106-4109.
7. Wells JA, Fairbrother WJ, Otlewski J, Laskowski M Jr, Burnier J. A reinvestigation of a synthetic peptide (TrPepz) designed to mimic trypsin. Proc Natl Acad Sci USA. 91:1994;4110-4114.
8. Struthers MD, Cheng RP, Imperiali B. Design of a monomeric 23-residue polypeptide with defined tertiary structure. of outstanding interest Science. 271:1996;342-345 This paper details the design process and iterative spectroscopic analysis that enables the production of a peptide with a metal-independent zinc-finger-like fold. The NMR structure of the final peptide design is compared with structure of a natural zinc finger peptide.
9. Struthers MD, Cheng RP, Imperiali B. Economy in protein design: evolution of a metal-independent bba motif based on the zinc finger domains. J Am Chem Soc. 118:1996;3073-3081.
10. Smith GP. Filamentous fusion phage: novel expression vectors that display cloned antigens on the virion surface. Science. 228:1985;1315-1317.
11. Scott JK, Smith GP. Searching for peptide ligands with an epitope library. Science. 249:1990;386-390.
12. Cwirla SE, Peters EA, Barrett RW, Dower WJ. Peptides on phage: a vast library of peptides for identifying ligands. Proc Natl Acad Sci USA. 87:1990;6378-6382.
13. Devlin JJ, Panganiban LC, Devlin PE. Random peptide libraries: a source of specific protein binding molecules. Science. 249:1990;404-406.
14. Yanofsky SD, Baldwin DN, Butler JH, Holden FR, Jacobs JW, Balasubramanian P, Chinn JP, Cwirla SE, Peters-Bhatt E, Whitehorn EA, et al. High affinity type I interleukin 1 receptor antagonists discovered by screening recombinant peptide libraries. of outstanding interest Proc Natl Acad Sci USA. 93:1996;7381-7386 This paper, along with [15], is the first to successfully mimic the binding of complex protein - protein interfaces with small peptides. In this case, a number of clever strategies are employed to isolate a linear 15-residue peptide that binds and antagonizes the IL-1 receptor.
15. Wrighton NC, Farrell FX, Chang R, Kashyap AK, Barbone FP, Mulcahy LS, Johnson DL, Barrett RW, Jolliffe LK, Dower WJ. Small peptides as potent mimetics of the protein hormone erythropoietin. of outstanding interest Science. 273:1996;458-463 This paper describes the isolation of a peptide agonist that binds to the EPO receptor to form an activated peptide - receptor dimeric complex. The structure of this complex is described in a companion paper [19].
16. Kang AS, Barbas CF III, Janda KD, Benkovic SJ, Lerner RA. Linkage of recognition and replication functions by assembling combinatorial antibody libraries along phage surfaces. Proc Natl Acad Sci USA. 88:1991;4363-4366.
17. Bass S, Greene R, Wells JA. Hormone phage: an enrichment method for variant proteins with altered binding properties. Proteins. 8:1990;309-314.
18. Schreuder H, Tardif C, Trump-Kallmeyer S, Soffientini A, Sarubbi E, Akeson A, Bowlin T, Yanofsky S, Barrett RW. A new cytokine-receptor binding mode revealed by the crystal structure of the IL-1 receptor with an antagonist. of special interest Nature. 386:1997;194-199 The structure of the naturally occurring IL-1 receptor antagonist (IL1RA) complexed with the extracellular domain of the IL-1 receptor is elaborated. Five critical IL1RA residues, previously identified in mutagenesis studies, are found to be localized at the center of the binding interface.
19. Livnah O, Stura EA, Johnson DL, Middleton SA, Mulcahy LS, Wrighton NC, Dower WJ, Jolliffe LK, Wilson IA. Functional mimicry of a protein hormone by a peptide agonist: the EPO receptor complex at 2.8 Å of outstanding interest Science. 273:1996;264-271 This paper presents the structural detail and mechanism by which a remarkable phage display derived 20-residue peptide is able to promote dimerization of the EPO receptor.
20. De Vos AM, Ultsch M, Kossiakoff AA. Human growth hormone and extracellular domain of its receptor: crystal structure of the complex. Science. 255:1992;306-312.
21. Li B, Tom JYK, Oare D, Yen R, Fairbrother WJ, Wells JA, Cunningham BC. Minimization of a polypeptide hormone. Science. 270:1994;1657-1660.
22. Braisted AC, Wells JA. Minimizing a binding domain from protein A. of outstanding interest Proc Natl Acad Sci USA. 93:1996;5688-5692 Structure-based design and phage display are used to iteratively improve the stability and affinity of a two-helix derivative of the three-helix Z-domain of protein A.
23. Cunningham BC, Lowe DG, Li B, Bennett BD, Wells JA. Production of an atrial natriuretic peptide variant that is specific for type A receptor. EMBO J. 13:1994;2508-2515.