-
1
-
-
0033528072
-
Trends in infectious disease mortality in the United States during the 20th century
-
Jan 6;
-
Armstrong GL, Conn LA, Pinner RW. Trends in infectious disease mortality in the United States during the 20th century. JAMA 1999 Jan 6; 281 (1): 61-6
-
(1999)
JAMA
, vol.281
, Issue.1
, pp. 61-66
-
-
Armstrong, G.L.1
Conn, L.A.2
Pinner, R.W.3
-
2
-
-
0037439518
-
Bacterial resistance: Origins, epidemiology, and impact
-
Livermore DM. Bacterial resistance: origins, epidemiology, and impact. Clin Infect Dis 2003; 36 Suppl.: S11-23
-
(2003)
Clin Infect Dis
, vol.36
, Issue.SUPPL.
-
-
Livermore, D.M.1
-
3
-
-
10944272743
-
Antibacterial resistance worldwide: Causes, challenges and responses
-
Levy SB, Marshall, B. Antibacterial resistance worldwide: causes, challenges and responses. Nat Med 2004; 10 (12 Suppl.): S122-9
-
(2004)
Nat Med
, vol.10
, Issue.12 SUPPL.
-
-
Levy, S.B.1
Marshall, B.2
-
4
-
-
0242291985
-
Why is big Pharma getting out of antibacterial drug discovery?
-
Projan SJ. Why is big Pharma getting out of antibacterial drug discovery? Curr Opin Microbiol 2003; 6 (5): 427-30
-
(2003)
Curr Opin Microbiol
, vol.6
, Issue.5
, pp. 427-430
-
-
Projan, S.J.1
-
5
-
-
34347402226
-
-
IDSA Report: Bad bugs, no drugs, as antibiotic discovery stag nates, a public health crisis brews: July 2004 [online]. Available from URL: http://www.idsociety.org [Accessed 2007 Jun 13 ]
-
IDSA Report: Bad bugs, no drugs, as antibiotic discovery stag nates, a public health crisis brews: July 2004 [online]. Available from URL: http://www.idsociety.org [Accessed 2007 Jun 13 ]
-
-
-
-
6
-
-
0345549544
-
Antibacterials: Are the new entries enough to deal with the emerging resistance problems?
-
Barrett CT, Barrett JF. Antibacterials: are the new entries enough to deal with the emerging resistance problems? Curr Opin Biotechnol 2003; 14 (6): 621-5
-
(2003)
Curr Opin Biotechnol
, vol.14
, Issue.6
, pp. 621-625
-
-
Barrett, C.T.1
Barrett, J.F.2
-
7
-
-
0029653518
-
Whole-genome random sequencing and assembly of Haemophilus influenzae Rd
-
Fleischmann RD, Adams MD, White O, et al. Whole-genome random sequencing and assembly of Haemophilus influenzae Rd. Science 1995; 269 (5223): 496-512
-
(1995)
Science
, vol.269
, Issue.5223
, pp. 496-512
-
-
Fleischmann, R.D.1
Adams, M.D.2
White, O.3
-
8
-
-
24044455869
-
Genome sequencing in microfabricated high-density picolitre reactors
-
Marguiles M, Egholm M, Altman WE, et al. Genome sequencing in microfabricated high-density picolitre reactors. Nature 2005; 437 (7057): 376-80
-
(2005)
Nature
, vol.437
, Issue.7057
, pp. 376-380
-
-
Marguiles, M.1
Egholm, M.2
Altman, W.E.3
-
9
-
-
23144455925
-
-
Fox JA, Butland SL, McMillan, et al. The Bioinformatics Links Directory: a compilation of molecular biology web servers. Nucleic Acids Res 2006; 34 (Web Server issue): W3-W24
-
Fox JA, Butland SL, McMillan, et al. The Bioinformatics Links Directory: a compilation of molecular biology web servers. Nucleic Acids Res 2006; 34 (Web Server issue): W3-W24
-
-
-
-
10
-
-
5444251009
-
DNA microarrays: Experimental issues, data analysis, and application to bacterial systems
-
Dharmadi Y, Gonzalez R. DNA microarrays: experimental issues, data analysis, and application to bacterial systems. Biotechnol Prog 2004; 20: 1309-24
-
(2004)
Biotechnol Prog
, vol.20
, pp. 1309-1324
-
-
Dharmadi, Y.1
Gonzalez, R.2
-
11
-
-
0037417075
-
Proteomic approach to understanding antibiotic drug discovery
-
Bandow JE, Brotz H, Leichert LI, et al. Proteomic approach to understanding antibiotic drug discovery. Antimicrob Agents Chemother 2003; 47 (3): 948-55
-
(2003)
Antimicrob Agents Chemother
, vol.47
, Issue.3
, pp. 948-955
-
-
Bandow, J.E.1
Brotz, H.2
Leichert, L.I.3
-
12
-
-
33646112903
-
Antibacterial drug discovery and structure-based design
-
Barker JJ. Antibacterial drug discovery and structure-based design. Drug Discov Today 2006; 11 (9-10): 391-404
-
(2006)
Drug Discov Today
, vol.11
, Issue.9-10
, pp. 391-404
-
-
Barker, J.J.1
-
13
-
-
33845708150
-
New antibiotics from bacterial natural products
-
Clardy J, Fischbach MA, Walsh CT. New antibiotics from bacterial natural products. Nat Biotechnol 2006; 24 (12): 1541-50
-
(2006)
Nat Biotechnol
, vol.24
, Issue.12
, pp. 1541-1550
-
-
Clardy, J.1
Fischbach, M.A.2
Walsh, C.T.3
-
14
-
-
32244438669
-
Targeting virulence for antibacterial chemotherapy
-
Marra A. Targeting virulence for antibacterial chemotherapy. Drugs R D 2006; 7 (1): 1-16
-
(2006)
Drugs R D
, vol.7
, Issue.1
, pp. 1-16
-
-
Marra, A.1
-
15
-
-
33845311869
-
Signature-tagged mutagenesis: Barcoding mutants for genome-wide screens
-
Mazurkiewicz P, Tang CM, Boone C, et al. Signature-tagged mutagenesis: barcoding mutants for genome-wide screens. Nature Rev Genet 2006; 7 (12): 929-39
-
(2006)
Nature Rev Genet
, vol.7
, Issue.12
, pp. 929-939
-
-
Mazurkiewicz, P.1
Tang, C.M.2
Boone, C.3
-
16
-
-
32944464059
-
Bacterial genomics and pathogen evolution
-
Raskin DM, Seshadri R, Pukatzki SU, et al. Bacterial genomics and pathogen evolution. Cell 2006; 124: 703-14
-
(2006)
Cell
, vol.124
, pp. 703-714
-
-
Raskin, D.M.1
Seshadri, R.2
Pukatzki, S.U.3
-
17
-
-
34347374657
-
-
Web Server Issue. Nucleic Acids Res 2006; 34: W1-W752
-
Web Server Issue. Nucleic Acids Res 2006; 34: W1-W752
-
-
-
-
18
-
-
33846076511
-
The online bioinformatics resources collection at the University of Pittburgh Health Sciences Library System: A one-step gateway to online bioinformatics databases and software tools
-
Chen YB, Chattopadhyay A, Bergen P, et al. The online bioinformatics resources collection at the University of Pittburgh Health Sciences Library System: a one-step gateway to online bioinformatics databases and software tools. Nucleic Acids Res 2007; 35: D780-5
-
(2007)
Nucleic Acids Res
, vol.35
-
-
Chen, Y.B.1
Chattopadhyay, A.2
Bergen, P.3
-
19
-
-
0030801002
-
Gapped BLAST and PSI-BLAST: A new generation of protein database search programs
-
Altschul SF, Madden TL, Schäffer AA, et al. Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. Nucleic Acids Res 1997; 25 (17): 3389-402
-
(1997)
Nucleic Acids Res
, vol.25
, Issue.17
, pp. 3389-3402
-
-
Altschul, S.F.1
Madden, T.L.2
Schäffer, A.A.3
-
20
-
-
0042121237
-
Multiple sequence alignment with the Clustal series of programs
-
Chenna R, Sugawara H, Koike T, et al. Multiple sequence alignment with the Clustal series of programs. Nucleic Acids Res 2003; 31 (13): 3497-500
-
(2003)
Nucleic Acids Res
, vol.31
, Issue.13
, pp. 3497-3500
-
-
Chenna, R.1
Sugawara, H.2
Koike, T.3
-
21
-
-
0031854952
-
DIALIGN: Finding local similarities by multiple sequence alignment
-
Morgenstern B, Frech K, Dress A, et al. DIALIGN: finding local similarities by multiple sequence alignment. Bioinformatics 1998; 14 (3): 290-4
-
(1998)
Bioinformatics
, vol.14
, Issue.3
, pp. 290-294
-
-
Morgenstern, B.1
Frech, K.2
Dress, A.3
-
22
-
-
0037398368
-
LAGAN and Multi-LAGAN: Efficient tools for large-scale multiple alignment of genomic DNA
-
Brudno M, Do CB, Cooper GM, et al. LAGAN and Multi-LAGAN: efficient tools for large-scale multiple alignment of genomic DNA. Genome Res 2003; 13 (4): 721-31
-
(2003)
Genome Res
, vol.13
, Issue.4
, pp. 721-731
-
-
Brudno, M.1
Do, C.B.2
Cooper, G.M.3
-
24
-
-
33746234722
-
Detecting non-orthology in the COGs database and other approaches grouping orthologs using genome-specific best hits
-
Dessimoz C, Boeckmann B, Roth AC, et al. Detecting non-orthology in the COGs database and other approaches grouping orthologs using genome-specific best hits. Nucleic Acids Res 2006; 34 (11): 3309-16
-
(2006)
Nucleic Acids Res
, vol.34
, Issue.11
, pp. 3309-3316
-
-
Dessimoz, C.1
Boeckmann, B.2
Roth, A.C.3
-
25
-
-
33644877904
-
-
Caspi R, Foerster H, Fulcher CA, et al. Meta Cyc: a multiorganism database of metabolic pathway enzymes. Nucleic Acids Res 2006; 34 (Database issue): D511-6
-
Caspi R, Foerster H, Fulcher CA, et al. Meta Cyc: a multiorganism database of metabolic pathway enzymes. Nucleic Acids Res 2006; 34 (Database issue): D511-6
-
-
-
-
26
-
-
13444262374
-
-
EcoCyc Kessler IM, Collado-Vides J, Gama-Castro S. EcoCyc: a comprehensive database resource for Escherichia coli. Nucleic Acids Res 2005; 33 (Database issue): D334-7
-
EcoCyc Kessler IM, Collado-Vides J, Gama-Castro S. EcoCyc: a comprehensive database resource for Escherichia coli. Nucleic Acids Res 2005; 33 (Database issue): D334-7
-
-
-
-
27
-
-
33745165967
-
The impact of comparative genomics on infectious disease research
-
Zhang R, Zhang C-T. The impact of comparative genomics on infectious disease research. Microbes Infect 2006; 8 (6): 1613-22
-
(2006)
Microbes Infect
, vol.8
, Issue.6
, pp. 1613-1622
-
-
Zhang, R.1
Zhang, C.-T.2
-
28
-
-
0033552961
-
Genomic-sequence comparison of two unrelated isolates of the human gastric pathogen Helicobacter pylori
-
Alm RA, Ling LS, Moir DT, et al. Genomic-sequence comparison of two unrelated isolates of the human gastric pathogen Helicobacter pylori. Nature 1999; 397 (6715): 176-80
-
(1999)
Nature
, vol.397
, Issue.6715
, pp. 176-180
-
-
Alm, R.A.1
Ling, L.S.2
Moir, D.T.3
-
29
-
-
0035961748
-
Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and genomic comparison with a laboratory strain K-12
-
Hayashi T, Makino K, Ohnishi M, et al. Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and genomic comparison with a laboratory strain K-12. DNA Res 2001; 8 (1): 11-22
-
(2001)
DNA Res
, vol.8
, Issue.1
, pp. 11-22
-
-
Hayashi, T.1
Makino, K.2
Ohnishi, M.3
-
30
-
-
0035945586
-
Genome sequence of enterohaemorrhagic Escherichia coli O157:H7
-
Perna NT, Plunkett 3rd G, Burland V, et al. Genome sequence of enterohaemorrhagic Escherichia coli O157:H7. Nature 2001; 409 (6819): 529-33
-
(2001)
Nature
, vol.409
, Issue.6819
, pp. 529-533
-
-
Perna, N.T.1
Plunkett 3rd, G.2
Burland, V.3
-
31
-
-
33745112085
-
Genome-wide detection and analysis of homologous recombination among sequenced stains of Escherichia coli
-
Mau B, Glasner JD, Darling AE, et al. Genome-wide detection and analysis of homologous recombination among sequenced stains of Escherichia coli. Genome Biol 2006; 7 (5): R44
-
(2006)
Genome Biol
, vol.7
, Issue.5
-
-
Mau, B.1
Glasner, J.D.2
Darling, A.E.3
-
32
-
-
33745081753
-
Understanding the rise of the superbug: Investigation of the evolution and genomic variation of Staphylococcus aureus
-
Lindsay JA, Holden MT. Understanding the rise of the superbug: investigation of the evolution and genomic variation of Staphylococcus aureus. Funct Integr Genomics 2006; 6 (3): 186-201
-
(2006)
Funct Integr Genomics
, vol.6
, Issue.3
, pp. 186-201
-
-
Lindsay, J.A.1
Holden, M.T.2
-
33
-
-
3042718925
-
Complete genomes of two clinical Staphylococcus aureus strains: Evidence for the rapid evolution of virulence and drug resistance
-
Holden MT, Feil RJ, Lindsay JA, et al. Complete genomes of two clinical Staphylococcus aureus strains: evidence for the rapid evolution of virulence and drug resistance. Proc Natl Acad Sci U S A 2004; 101 (26): 9786-91
-
(2004)
Proc Natl Acad Sci U S A
, vol.101
, Issue.26
, pp. 9786-9791
-
-
Holden, M.T.1
Feil, R.J.2
Lindsay, J.A.3
-
34
-
-
20144372744
-
Insights on evolution of virulence and resistance from the complete genome analysis of an early methicillin-resistant Staphylococcus aureus strain and a biofilm-producing methicillin-resistant Staphylococcus epidermidis strain
-
Gill SR, Fouts DE, Archer GL, et al. Insights on evolution of virulence and resistance from the complete genome analysis of an early methicillin-resistant Staphylococcus aureus strain and a biofilm-producing methicillin-resistant Staphylococcus epidermidis strain. J Bacteriol 2005; 187 (7): 2426-38
-
(2005)
J Bacteriol
, vol.187
, Issue.7
, pp. 2426-2438
-
-
Gill, S.R.1
Fouts, D.E.2
Archer, G.L.3
-
35
-
-
33750056032
-
Comparative genomics of metabolic pathways in Mycobacterium species: Gene duplication, gene decay and lateral gene transfer
-
Marri PR, Bannantine JP, Golding GB. Comparative genomics of metabolic pathways in Mycobacterium species: gene duplication, gene decay and lateral gene transfer. FEMS Microbiol Rev 2006; 30 (6): 906-25
-
(2006)
FEMS Microbiol Rev
, vol.30
, Issue.6
, pp. 906-925
-
-
Marri, P.R.1
Bannantine, J.P.2
Golding, G.B.3
-
36
-
-
33748742263
-
Comparative and functional genomics of Listeria spp
-
Hain T, Steinweg C, Chakraborty T. Comparative and functional genomics of Listeria spp. J Biotechnol 2006; 126 (1): 37-51
-
(2006)
J Biotechnol
, vol.126
, Issue.1
, pp. 37-51
-
-
Hain, T.1
Steinweg, C.2
Chakraborty, T.3
-
37
-
-
33645760951
-
Comparative genomics of emerging human ehrlichiosis agents
-
Hotopp JC, Lin M, Madupu R, et al. Comparative genomics of emerging human ehrlichiosis agents. PLoS Genet 2006; 2 (2): e21
-
(2006)
PLoS Genet
, vol.2
, Issue.2
-
-
Hotopp, J.C.1
Lin, M.2
Madupu, R.3
-
38
-
-
0042355274
-
Comparative analysis of the genome sequences of Bordetella pertussis, Bordetella parapertussis and Bordetella bronchiseptica
-
Parkhill J, Sebaihia A, Preston A, et al. Comparative analysis of the genome sequences of Bordetella pertussis, Bordetella parapertussis and Bordetella bronchiseptica. Nat Genet 2003; 35 (1): 32-40
-
(2003)
Nat Genet
, vol.35
, Issue.1
, pp. 32-40
-
-
Parkhill, J.1
Sebaihia, A.2
Preston, A.3
-
39
-
-
15944417910
-
Genomics of the Bacillus cereus group of organisms
-
Rasko DA, Altherr MR, Han CS, et al. Genomics of the Bacillus cereus group of organisms. FEMS Microbiol Rev 2005; 29 (2): 303-29
-
(2005)
FEMS Microbiol Rev
, vol.29
, Issue.2
, pp. 303-329
-
-
Rasko, D.A.1
Altherr, M.R.2
Han, C.S.3
-
40
-
-
23944515302
-
Comparative genome analysis of Bacillus cereus group genomes with Bacillus subtilis
-
Anderson I, Sorokin A, Kapatrol V, et al. Comparative genome analysis of Bacillus cereus group genomes with Bacillus subtilis. FEMS Microbiol Lett 2005; 250 (2): 175-84
-
(2005)
FEMS Microbiol Lett
, vol.250
, Issue.2
, pp. 175-184
-
-
Anderson, I.1
Sorokin, A.2
Kapatrol, V.3
-
41
-
-
33845903833
-
Drugs for bad drugs: Confronting the challenges of antibacterial discovery
-
Payne DJ, Gywnn MN, Holmes DJ, et al. Drugs for bad drugs: confronting the challenges of antibacterial discovery. Nat Rev Drug Discov 2007; 6 (1): 29-40
-
(2007)
Nat Rev Drug Discov
, vol.6
, Issue.1
, pp. 29-40
-
-
Payne, D.J.1
Gywnn, M.N.2
Holmes, D.J.3
-
42
-
-
33644514658
-
Use of genomics to select antibacterial targets
-
Pucci MJ, Dougherty TD. Use of genomics to select antibacterial targets. Biochem Pharmacol 2006; 71 (7): 1066-72
-
(2006)
Biochem Pharmacol
, vol.71
, Issue.7
, pp. 1066-1072
-
-
Pucci, M.J.1
Dougherty, T.D.2
-
44
-
-
21544464022
-
Functional genomics in antibacterial drug discovery
-
Freiberg C, Brotz-Oesterhelt H. Functional genomics in antibacterial drug discovery. Drug Discov Today 10 (13): 927-935
-
Drug Discov Today
, vol.10
, Issue.13
, pp. 927-935
-
-
Freiberg, C.1
Brotz-Oesterhelt, H.2
-
45
-
-
0037100683
-
Identification of 113 conserved essential genes using a high-throughput gene disruption system in Streptococcus pneumoniae
-
Thanassi JA, Hartman-Neumann SL, Dougherty TJ, et al. Identification of 113 conserved essential genes using a high-throughput gene disruption system in Streptococcus pneumoniae. Nucleic Acids Res 2002; 30: 3152-62
-
(2002)
Nucleic Acids Res
, vol.30
, pp. 3152-3162
-
-
Thanassi, J.A.1
Hartman-Neumann, S.L.2
Dougherty, T.J.3
-
46
-
-
0141504252
-
Experimental determination and system level analysis of essential genes in Escherichia coli MG1655
-
Gerdes SY, Scholle MD, Campbell JW, et al. Experimental determination and system level analysis of essential genes in Escherichia coli MG1655. J Bacteriol 2003; 185 (19): 5673-84
-
(2003)
J Bacteriol
, vol.185
, Issue.19
, pp. 5673-5684
-
-
Gerdes, S.Y.1
Scholle, M.D.2
Campbell, J.W.3
-
47
-
-
0037154255
-
A genome-scale analysis for identification of genes required for growth or survival of Haemophilus influenzae
-
Akerley BJ, Rubin EJ, Novick VL, et al. A genome-scale analysis for identification of genes required for growth or survival of Haemophilus influenzae. Proc Natl Acad Sci U S A 2002; 99 (2): 966-71
-
(2002)
Proc Natl Acad Sci U S A
, vol.99
, Issue.2
, pp. 966-971
-
-
Akerley, B.J.1
Rubin, E.J.2
Novick, V.L.3
-
48
-
-
0036271625
-
A genome-wide strategy for the identification of essential genes in Staphylococcus aureus
-
Forsyth RA, Haselbeck RJ, Ohlsen KL, et al. A genome-wide strategy for the identification of essential genes in Staphylococcus aureus. Mol Microbiol 2002; 43 (6): 1387-400
-
(2002)
Mol Microbiol
, vol.43
, Issue.6
, pp. 1387-1400
-
-
Forsyth, R.A.1
Haselbeck, R.J.2
Ohlsen, K.L.3
-
49
-
-
0035929121
-
Identification of critical staphylococcal genes using conditional phenotypes generated by antisense RNA
-
Ji Y, Zhang B, Van SF, et al. Identification of critical staphylococcal genes using conditional phenotypes generated by antisense RNA. Science 2001; 293 (5538): 2266-9
-
(2001)
Science
, vol.293
, Issue.5538
, pp. 2266-2269
-
-
Ji, Y.1
Zhang, B.2
Van, S.F.3
-
50
-
-
0036256037
-
An array of target-specific screening strains for antibacterial discovery
-
May;
-
DeVito JA, Mills JA, Liu VG, et al. An array of target-specific screening strains for antibacterial discovery. Nat Biotechnol 2002 May; 20 (5): 478-83
-
(2002)
Nat Biotechnol
, vol.20
, Issue.5
, pp. 478-483
-
-
DeVito, J.A.1
Mills, J.A.2
Liu, V.G.3
-
51
-
-
0034687158
-
Regulated gene expression in Staphylococcus aureus for identifying conditional lethal phenotypes and antibiotic mode of action
-
Zhang L, Fan F, Palmer LM, et al. Regulated gene expression in Staphylococcus aureus for identifying conditional lethal phenotypes and antibiotic mode of action. Gene 2000; 255 (2): 297-305
-
(2000)
Gene
, vol.255
, Issue.2
, pp. 297-305
-
-
Zhang, L.1
Fan, F.2
Palmer, L.M.3
-
52
-
-
10744225004
-
Novel chromosomally encoded multidrug efflux transporter MdeA in Staphylococcus aureus
-
Huang J, O'Toole PW, Shen W, et al. Novel chromosomally encoded multidrug efflux transporter MdeA in Staphylococcus aureus. Antimicrob Agents Chemother 2004; 48 (3): 909-17
-
(2004)
Antimicrob Agents Chemother
, vol.48
, Issue.3
, pp. 909-917
-
-
Huang, J.1
O'Toole, P.W.2
Shen, W.3
-
53
-
-
24644505760
-
Structural analysis of a set of proteins resulting from a bacterial genomics project. Proteins: Struct Funct
-
Badger J, Sauder JM, Adams JM, et al. Structural analysis of a set of proteins resulting from a bacterial genomics project. Proteins: Struct Funct Bioinform 2005; 60: 787-96
-
(2005)
Bioinform
, vol.60
, pp. 787-796
-
-
Badger, J.1
Sauder, J.M.2
Adams, J.M.3
-
54
-
-
33749536221
-
Application of the use of high-throughput technologies to the determination of protein structures of bacterial and viral pathogens
-
Fogg MJ, Alzari P, Bahar M, et al. Application of the use of high-throughput technologies to the determination of protein structures of bacterial and viral pathogens. Acta Crystallogr D Biol Crystallogr 2006; 62 (Pt 10): 1196-207
-
(2006)
Acta Crystallogr D Biol Crystallogr
, vol.62
, Issue.PART 10
, pp. 1196-1207
-
-
Fogg, M.J.1
Alzari, P.2
Bahar, M.3
-
55
-
-
33749529377
-
Application of high-throughput technologies to a structural proteomics-type analysis of Bacillus anthracis
-
Au K, Berrow NS, Blagova E, et al. Application of high-throughput technologies to a structural proteomics-type analysis of Bacillus anthracis. Acta Crystallogr D Biol Crystallogr 2006; 62 (Pt 10): 1267-75
-
(2006)
Acta Crystallogr D Biol Crystallogr
, vol.62
, Issue.PART 10
, pp. 1267-1275
-
-
Au, K.1
Berrow, N.S.2
Blagova, E.3
-
56
-
-
33746425844
-
A large-scale, high-efficiency and low-cost platform for structural genomics studies
-
Su XD, Liang Y, Li L, et al. A large-scale, high-efficiency and low-cost platform for structural genomics studies. Acta Crystallogr D Biol Crystallogr 2006; 62 (Pt 8): 843-51
-
(2006)
Acta Crystallogr D Biol Crystallogr
, vol.62
, Issue.PART 8
, pp. 843-851
-
-
Su, X.D.1
Liang, Y.2
Li, L.3
-
57
-
-
20444495201
-
Drugs targeting the ribosome
-
Hermann T. Drugs targeting the ribosome. Curr Opin Struct Biol 2005; 15 (3): 355-66
-
(2005)
Curr Opin Struct Biol
, vol.15
, Issue.3
, pp. 355-366
-
-
Hermann, T.1
-
58
-
-
25144480034
-
Improving on nature: Antibiotics that target the ribosome
-
Sutcliffe JA. Improving on nature: antibiotics that target the ribosome. Curr Opin Microbiol 2005; 8 (5): 534-42
-
(2005)
Curr Opin Microbiol
, vol.8
, Issue.5
, pp. 534-542
-
-
Sutcliffe, J.A.1
-
59
-
-
33644610182
-
Structure-based drug design meets the ribosome
-
Franceschi F, Duffy EM. Structure-based drug design meets the ribosome. Biochem Pharmacol 2006; 71 (7): 1016-25
-
(2006)
Biochem Pharmacol
, vol.71
, Issue.7
, pp. 1016-1025
-
-
Franceschi, F.1
Duffy, E.M.2
-
60
-
-
33846582343
-
Dual targeting of GyrB and ParE by a novel aminobenzimidazole class of antibacterial compounds
-
Grossman TH, Bartels DJ, Mullin S, et al. Dual targeting of GyrB and ParE by a novel aminobenzimidazole class of antibacterial compounds. Antimicrob Agents Chemother 2007; 51 (2): 657-66
-
(2007)
Antimicrob Agents Chemother
, vol.51
, Issue.2
, pp. 657-666
-
-
Grossman, T.H.1
Bartels, D.J.2
Mullin, S.3
-
61
-
-
11144237579
-
A novel class of inhibitors of peptide deformylase discovered through high-concentrations throughput screening and virtual ligand screening
-
Howard MH, Cenizal T, Gutteridge S, et al. A novel class of inhibitors of peptide deformylase discovered through high-concentrations throughput screening and virtual ligand screening. J Med Chem 2004; 47 (27): 6669-72
-
(2004)
J Med Chem
, vol.47
, Issue.27
, pp. 6669-6672
-
-
Howard, M.H.1
Cenizal, T.2
Gutteridge, S.3
-
62
-
-
20144370577
-
Structure-based design, synthesis, and study of potent inhibitors of beta-ketoacyl-acyl carrier protein synthase III as potential antimicrobial agents
-
Nie Z, Perretta C, Lu J, et al. Structure-based design, synthesis, and study of potent inhibitors of beta-ketoacyl-acyl carrier protein synthase III as potential antimicrobial agents. J Med Chem 2005; 48 (5): 1596-609
-
(2005)
J Med Chem
, vol.48
, Issue.5
, pp. 1596-1609
-
-
Nie, Z.1
Perretta, C.2
Lu, J.3
-
63
-
-
33744994317
-
Platensimycin is a selective FabF inhibitor with potent antibiotic properties
-
Wang J, Soisson SM, Young K, et al. Platensimycin is a selective FabF inhibitor with potent antibiotic properties. Nature 2006; 441 (7091): 358-61
-
(2006)
Nature
, vol.441
, Issue.7091
, pp. 358-361
-
-
Wang, J.1
Soisson, S.M.2
Young, K.3
-
64
-
-
0037464456
-
Indole naphthyridinones as inhibitors of bacterial enoyl-ACP reductases FabI and FabK
-
Seefeld MA, Miller WH, Newlander KA, et al. Indole naphthyridinones as inhibitors of bacterial enoyl-ACP reductases FabI and FabK. J Med Chem 2003; 46 (9): 1627-35
-
(2003)
J Med Chem
, vol.46
, Issue.9
, pp. 1627-1635
-
-
Seefeld, M.A.1
Miller, W.H.2
Newlander, K.A.3
-
65
-
-
12344293492
-
Identification of 4-substituted 1,2,3-triazoles as novel oxazolidinone antibacterial agents with reduced activity against monoamine oxidase A
-
Reck F, Zhou F, Giradot M, et al. Identification of 4-substituted 1,2,3-triazoles as novel oxazolidinone antibacterial agents with reduced activity against monoamine oxidase A. J Med Chem 2005; 48 (2): 499-506
-
(2005)
J Med Chem
, vol.48
, Issue.2
, pp. 499-506
-
-
Reck, F.1
Zhou, F.2
Giradot, M.3
-
66
-
-
2342525085
-
Heterogeneity and inaccuracy in protein structures solved by x-ray crystallography
-
Depristo MA, deBakker PI, Blundell TL. Heterogeneity and inaccuracy in protein structures solved by x-ray crystallography. Structure 2004; 12 (5): 831-8
-
(2004)
Structure
, vol.12
, Issue.5
, pp. 831-838
-
-
Depristo, M.A.1
deBakker, P.I.2
Blundell, T.L.3
-
68
-
-
0029836953
-
Discovering high-coming affinity ligands for proteins: SAR by NMR
-
Shuker SB, Hadjuk PJ, Meadows RP, et al. Discovering high-coming affinity ligands for proteins: SAR by NMR. Science 1996; 274 (5292): 1531-4
-
(1996)
Science
, vol.274
, Issue.5292
, pp. 1531-1534
-
-
Shuker, S.B.1
Hadjuk, P.J.2
Meadows, R.P.3
-
69
-
-
33750067690
-
Discovery of novel inhibitors of the ZipA/FtsZ complex by NMR fragment screening coupled with structure-based design
-
Tsao DH, Sutherland AG, Jennings LD, et al. Discovery of novel inhibitors of the ZipA/FtsZ complex by NMR fragment screening coupled with structure-based design. Bioorg Med Chem 2006; 14 (23): 7953-61
-
(2006)
Bioorg Med Chem
, vol.14
, Issue.23
, pp. 7953-7961
-
-
Tsao, D.H.1
Sutherland, A.G.2
Jennings, L.D.3
-
70
-
-
24344497940
-
Therapeutic potential of peptide deformylase inhibitors
-
Chen D, Yuan Z. Therapeutic potential of peptide deformylase inhibitors. Expert Opin Investig Drugs 2005; 14 (9): 1107-16
-
(2005)
Expert Opin Investig Drugs
, vol.14
, Issue.9
, pp. 1107-1116
-
-
Chen, D.1
Yuan, Z.2
-
71
-
-
21544464022
-
Functional genomics in antibacterial drug discovery
-
Freiberg C, Brotz-Oesterhelt H. Functional genomics in antibacterial drug discovery. Drug Discov Today 2005; 10 (13): 927-35
-
(2005)
Drug Discov Today
, vol.10
, Issue.13
, pp. 927-935
-
-
Freiberg, C.1
Brotz-Oesterhelt, H.2
-
72
-
-
0037323796
-
Microarray expression profiling: Capturing a genome-wide portrait of the transcriptome
-
Conway T, Schoolnik GK. Microarray expression profiling: capturing a genome-wide portrait of the transcriptome. Mol Microbiol 2003; 47 (4): 879-89
-
(2003)
Mol Microbiol
, vol.47
, Issue.4
, pp. 879-889
-
-
Conway, T.1
Schoolnik, G.K.2
-
73
-
-
0036051847
-
Microarray analysis of bacterial pathogenicity
-
Schoolnik GK. Microarray analysis of bacterial pathogenicity. Adv Microb Physiol 2002; 46: 1-45
-
(2002)
Adv Microb Physiol
, vol.46
, pp. 1-45
-
-
Schoolnik, G.K.1
-
74
-
-
0034810821
-
Global analysis of the general stress response of Bacillus subtilis
-
Petersohn A, Brigulla M, Haas S. Global analysis of the general stress response of Bacillus subtilis. J Bacteriol 2001; 183 (19): 5617-31
-
(2001)
J Bacteriol
, vol.183
, Issue.19
, pp. 5617-5631
-
-
Petersohn, A.1
Brigulla, M.2
Haas, S.3
-
75
-
-
0032828757
-
Diagnosis of cellular states of microbial organisms using proteomics
-
Van Bogelen RA, Schiller EE, Thomas JD, et al. Diagnosis of cellular states of microbial organisms using proteomics. Electrophoresis 1999; 20 (11): 2149-59
-
(1999)
Electrophoresis
, vol.20
, Issue.11
, pp. 2149-2159
-
-
Van Bogelen, R.A.1
Schiller, E.E.2
Thomas, J.D.3
-
76
-
-
33745127048
-
The Escherichia coli proteome: Past, present, and future prospects
-
Han MJ, Lee SY. The Escherichia coli proteome: past, present, and future prospects. Microbiol Mol Biol Rev 2006; 70 (2): 362-439
-
(2006)
Microbiol Mol Biol Rev
, vol.70
, Issue.2
, pp. 362-439
-
-
Han, M.J.1
Lee, S.Y.2
-
77
-
-
10644274361
-
Towards a comprehensive understanding of Bacillus subtilis cell physiology by physiological proteomics
-
Hecker M, Volker U. Towards a comprehensive understanding of Bacillus subtilis cell physiology by physiological proteomics. Proteomics 2004; 4 (12): 3727-50
-
(2004)
Proteomics
, vol.4
, Issue.12
, pp. 3727-3750
-
-
Hecker, M.1
Volker, U.2
-
78
-
-
11144293517
-
Mycobacterium tuberculosis functional network analysis by global subcellular protein profiling
-
Mawuenyega KG, Forst CV, Dobos KM, et al. Mycobacterium tuberculosis functional network analysis by global subcellular protein profiling. Mol Biol Cell 2005; 16 (1): 396-404
-
(2005)
Mol Biol Cell
, vol.16
, Issue.1
, pp. 396-404
-
-
Mawuenyega, K.G.1
Forst, C.V.2
Dobos, K.M.3
-
79
-
-
26244440553
-
Using microarray gene signatures to elucidate mechanisms of antibiotic action and resistance
-
Brazas MD, Hancock RE. Using microarray gene signatures to elucidate mechanisms of antibiotic action and resistance. Drug Discov Today 2005; 10 (18): 1245-52
-
(2005)
Drug Discov Today
, vol.10
, Issue.18
, pp. 1245-1252
-
-
Brazas, M.D.1
Hancock, R.E.2
-
80
-
-
0037214411
-
Transcriptional regulation and signature patterns revealed by microarray analyses of Streptococcus pneumoniae R6 challenged with sublethal concentrations of translation inhibitors
-
Ng WL, Kazmierczak KM, Robertson GT. Transcriptional regulation and signature patterns revealed by microarray analyses of Streptococcus pneumoniae R6 challenged with sublethal concentrations of translation inhibitors. J Bacteriol 2003; 185 (1): 359-70
-
(2003)
J Bacteriol
, vol.185
, Issue.1
, pp. 359-370
-
-
WL, N.1
Kazmierczak, K.M.2
Robertson, G.T.3
-
81
-
-
18244409616
-
Global transcriptional response of Bacillus subtilis to treatment with subinhibitory concentrations of antibiotics that inhibit protein synthesis
-
Lin JT, Connelly MB, Amolo C, et al. Global transcriptional response of Bacillus subtilis to treatment with subinhibitory concentrations of antibiotics that inhibit protein synthesis. Antimicrob Agents Chemother 2005; 49 (5): 1915-26
-
(2005)
Antimicrob Agents Chemother
, vol.49
, Issue.5
, pp. 1915-1926
-
-
Lin, J.T.1
Connelly, M.B.2
Amolo, C.3
-
82
-
-
12944327876
-
Discovering the mechanism of action of novel antibacterial agents through transcriptional profiling of conditional mutants
-
Freiberg C, Fischer HP, Brunner NA. Discovering the mechanism of action of novel antibacterial agents through transcriptional profiling of conditional mutants. Antimicrob Agents Chemother 2005; 49 (2): 749-59
-
(2005)
Antimicrob Agents Chemother
, vol.49
, Issue.2
, pp. 749-759
-
-
Freiberg, C.1
Fischer, H.P.2
Brunner, N.A.3
-
83
-
-
14544284148
-
Application of microbial genomic science to advanced therapeutics
-
Fraser CM, Rappouli R. Application of microbial genomic science to advanced therapeutics. Annu Rev Med 2005; 56: 459-74
-
(2005)
Annu Rev Med
, vol.56
, pp. 459-474
-
-
Fraser, C.M.1
Rappouli, R.2
-
84
-
-
33745159656
-
The impact of genomics on discovering drugs against infectious diseases
-
Boshoff HIM, Manjunatha UH. The impact of genomics on discovering drugs against infectious diseases. Microbes Infect 2006; 8: 1654-61
-
(2006)
Microbes Infect
, vol.8
, pp. 1654-1661
-
-
Boshoff, H.I.M.1
Manjunatha, U.H.2
-
85
-
-
24344497940
-
Therapeutic potential of peptide deformylase inhibitors
-
Chen D, Yuan Z. Therapeutic potential of peptide deformylase inhibitors. Expert Opin Investig Drugs 2005; 14 (9): 1107-16
-
(2005)
Expert Opin Investig Drugs
, vol.14
, Issue.9
, pp. 1107-1116
-
-
Chen, D.1
Yuan, Z.2
-
86
-
-
13344259234
-
Finding the gems using genomic discovery: Antibacterial drug discovery strategies: the successes and the challenges
-
Chan PF, Holmes DJ, Payne DJ. Finding the gems using genomic discovery: antibacterial drug discovery strategies: the successes and the challenges. Drug Discov Today: Ther Strategies 2004; 1 (4): 519-27
-
(2004)
Drug Discov Today: Ther Strategies
, vol.1
, Issue.4
, pp. 519-527
-
-
Chan, P.F.1
Holmes, D.J.2
Payne, D.J.3
-
87
-
-
33744973283
-
Microbial genomics and drug discovery: Exploring innovative routes of drug discovery in the postgenomic era
-
Dougherty TJ, Miller PF. Microbial genomics and drug discovery: exploring innovative routes of drug discovery in the postgenomic era. IDrugs 2006; 9 (6): 420-2
-
(2006)
IDrugs
, vol.9
, Issue.6
, pp. 420-422
-
-
Dougherty, T.J.1
Miller, P.F.2
-
88
-
-
22144455317
-
Novel target sites in bacteria for overcoming antibiotic resistance
-
Black MT, Hodgson J. Novel target sites in bacteria for overcoming antibiotic resistance. Adv Drug Deliv Rev 2005; 57: 1528-38
-
(2005)
Adv Drug Deliv Rev
, vol.57
, pp. 1528-1538
-
-
Black, M.T.1
Hodgson, J.2
-
89
-
-
0442307441
-
Efflux-mediated drug resistance in bacteria
-
Li XZ, Nikaido H. Efflux-mediated drug resistance in bacteria. Drugs 2004; 64 (2): 159-204
-
(2004)
Drugs
, vol.64
, Issue.2
, pp. 159-204
-
-
Li, X.Z.1
Nikaido, H.2
-
90
-
-
9144257927
-
Recent advances in chemical genomics
-
Darvas F, Gorman G, Krajcsi P, et al. Recent advances in chemical genomics. Curr Med Chem 2004; 11 (23): 3119-45
-
(2004)
Curr Med Chem
, vol.11
, Issue.23
, pp. 3119-3145
-
-
Darvas, F.1
Gorman, G.2
Krajcsi, P.3
-
91
-
-
0035289779
-
Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings
-
Lipinski CA, Lombardo F, Dominy BW, et al. Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings. Adv Drug Deliv Rev 2001; 46 (1-3): 3-26
-
(2001)
Adv Drug Deliv Rev
, vol.46
, Issue.1-3
, pp. 3-26
-
-
Lipinski, C.A.1
Lombardo, F.2
Dominy, B.W.3
-
92
-
-
33644544089
-
Empirical antibacterial drug discovery: Foundation in natural products
-
Singh SB, Barrett JF. Empirical antibacterial drug discovery: foundation in natural products. Biochem Pharmacol 2006; 71 (7): 1006-15
-
(2006)
Biochem Pharmacol
, vol.71
, Issue.7
, pp. 1006-1015
-
-
Singh, S.B.1
Barrett, J.F.2
-
94
-
-
33845707975
-
Antibiotics: An investment worth making?
-
Christoffersen RE. Antibiotics: an investment worth making? Nat Biotechnol 2006; 24 (12): 1512-4
-
(2006)
Nat Biotechnol
, vol.24
, Issue.12
, pp. 1512-1514
-
-
Christoffersen, R.E.1
-
95
-
-
33845706771
-
The business of developing antibacterials
-
Fox JL. The business of developing antibacterials. Nat Biotechnol 2006; 24 (12): 1521-8
-
(2006)
Nat Biotechnol
, vol.24
, Issue.12
, pp. 1521-1528
-
-
Fox, J.L.1
-
96
-
-
33845719937
-
Antibacterial discovery and development: The failure of success?
-
Fernandes P. Antibacterial discovery and development: the failure of success? Nat Biotechnol 2006; 24 (12): 1497-503
-
(2006)
Nat Biotechnol
, vol.24
, Issue.12
, pp. 1497-1503
-
-
Fernandes, P.1
-
97
-
-
33645030241
-
Robust Salmonella metabolism limits possibilities for new antimicrobials
-
Becker D, Selbach M, Rollenhagen C, et al. Robust Salmonella metabolism limits possibilities for new antimicrobials. Nature 2006; 440: 303-7
-
(2006)
Nature
, vol.440
, pp. 303-307
-
-
Becker, D.1
Selbach, M.2
Rollenhagen, C.3
-
98
-
-
33644767089
-
Recent developments in antibacterial drug discovery: Microbe-derived natural products: from collection to the clinic
-
Leeds JA, Schmitt EK, Krastel P. Recent developments in antibacterial drug discovery: microbe-derived natural products: from collection to the clinic. Expert Opin Investig Drugs 2006; 15 (3): 211-26
-
(2006)
Expert Opin Investig Drugs
, vol.15
, Issue.3
, pp. 211-226
-
-
Leeds, J.A.1
Schmitt, E.K.2
Krastel, P.3
-
99
-
-
11144323163
-
Virtual screening of chemical libraries
-
Shoichet BK. Virtual screening of chemical libraries. Nature 2004; 432: 862-5
-
(2004)
Nature
, vol.432
, pp. 862-865
-
-
Shoichet, B.K.1
-
101
-
-
33750090037
-
The fallacies of hope: Will we discover new antibiotics to combat pathogenic bacteria in time?
-
Vicente M, Hodgson J, Massidda O, et al. The fallacies of hope: will we discover new antibiotics to combat pathogenic bacteria in time? FEMS Microbiol Rev 2006; 30: 841-52
-
(2006)
FEMS Microbiol Rev
, vol.30
, pp. 841-852
-
-
Vicente, M.1
Hodgson, J.2
Massidda, O.3
|