메뉴 건너뛰기




Volumn 8, Issue 4, 2007, Pages 201-212

Novel genetic techniques and approaches in the microbial genomics era: Identification and/or validation of targets for the discovery of new antibacterial agents

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFECTIVE AGENT; BENZOIC ACID DERIVATIVE; BENZOYLAMINOBENZOIC ACID; COMPLEMENTARY RNA; DNA TOPOISOMERASE (ATP HYDROLYSING) B; PEPTIDE DEFORMYLASE INHIBITOR; PLATENSIMYCIN; PROTEIN INHIBITOR; PROTEIN PARE; UNCLASSIFIED DRUG;

EID: 34347387986     PISSN: 11745886     EISSN: None     Source Type: Journal    
DOI: 10.2165/00126839-200708040-00001     Document Type: Review
Times cited : (17)

References (101)
  • 1
    • 0033528072 scopus 로고    scopus 로고
    • Trends in infectious disease mortality in the United States during the 20th century
    • Jan 6;
    • Armstrong GL, Conn LA, Pinner RW. Trends in infectious disease mortality in the United States during the 20th century. JAMA 1999 Jan 6; 281 (1): 61-6
    • (1999) JAMA , vol.281 , Issue.1 , pp. 61-66
    • Armstrong, G.L.1    Conn, L.A.2    Pinner, R.W.3
  • 2
    • 0037439518 scopus 로고    scopus 로고
    • Bacterial resistance: Origins, epidemiology, and impact
    • Livermore DM. Bacterial resistance: origins, epidemiology, and impact. Clin Infect Dis 2003; 36 Suppl.: S11-23
    • (2003) Clin Infect Dis , vol.36 , Issue.SUPPL.
    • Livermore, D.M.1
  • 3
    • 10944272743 scopus 로고    scopus 로고
    • Antibacterial resistance worldwide: Causes, challenges and responses
    • Levy SB, Marshall, B. Antibacterial resistance worldwide: causes, challenges and responses. Nat Med 2004; 10 (12 Suppl.): S122-9
    • (2004) Nat Med , vol.10 , Issue.12 SUPPL.
    • Levy, S.B.1    Marshall, B.2
  • 4
    • 0242291985 scopus 로고    scopus 로고
    • Why is big Pharma getting out of antibacterial drug discovery?
    • Projan SJ. Why is big Pharma getting out of antibacterial drug discovery? Curr Opin Microbiol 2003; 6 (5): 427-30
    • (2003) Curr Opin Microbiol , vol.6 , Issue.5 , pp. 427-430
    • Projan, S.J.1
  • 5
    • 34347402226 scopus 로고    scopus 로고
    • IDSA Report: Bad bugs, no drugs, as antibiotic discovery stag nates, a public health crisis brews: July 2004 [online]. Available from URL: http://www.idsociety.org [Accessed 2007 Jun 13 ]
    • IDSA Report: Bad bugs, no drugs, as antibiotic discovery stag nates, a public health crisis brews: July 2004 [online]. Available from URL: http://www.idsociety.org [Accessed 2007 Jun 13 ]
  • 6
    • 0345549544 scopus 로고    scopus 로고
    • Antibacterials: Are the new entries enough to deal with the emerging resistance problems?
    • Barrett CT, Barrett JF. Antibacterials: are the new entries enough to deal with the emerging resistance problems? Curr Opin Biotechnol 2003; 14 (6): 621-5
    • (2003) Curr Opin Biotechnol , vol.14 , Issue.6 , pp. 621-625
    • Barrett, C.T.1    Barrett, J.F.2
  • 7
    • 0029653518 scopus 로고
    • Whole-genome random sequencing and assembly of Haemophilus influenzae Rd
    • Fleischmann RD, Adams MD, White O, et al. Whole-genome random sequencing and assembly of Haemophilus influenzae Rd. Science 1995; 269 (5223): 496-512
    • (1995) Science , vol.269 , Issue.5223 , pp. 496-512
    • Fleischmann, R.D.1    Adams, M.D.2    White, O.3
  • 8
    • 24044455869 scopus 로고    scopus 로고
    • Genome sequencing in microfabricated high-density picolitre reactors
    • Marguiles M, Egholm M, Altman WE, et al. Genome sequencing in microfabricated high-density picolitre reactors. Nature 2005; 437 (7057): 376-80
    • (2005) Nature , vol.437 , Issue.7057 , pp. 376-380
    • Marguiles, M.1    Egholm, M.2    Altman, W.E.3
  • 9
    • 23144455925 scopus 로고    scopus 로고
    • Fox JA, Butland SL, McMillan, et al. The Bioinformatics Links Directory: a compilation of molecular biology web servers. Nucleic Acids Res 2006; 34 (Web Server issue): W3-W24
    • Fox JA, Butland SL, McMillan, et al. The Bioinformatics Links Directory: a compilation of molecular biology web servers. Nucleic Acids Res 2006; 34 (Web Server issue): W3-W24
  • 10
    • 5444251009 scopus 로고    scopus 로고
    • DNA microarrays: Experimental issues, data analysis, and application to bacterial systems
    • Dharmadi Y, Gonzalez R. DNA microarrays: experimental issues, data analysis, and application to bacterial systems. Biotechnol Prog 2004; 20: 1309-24
    • (2004) Biotechnol Prog , vol.20 , pp. 1309-1324
    • Dharmadi, Y.1    Gonzalez, R.2
  • 11
    • 0037417075 scopus 로고    scopus 로고
    • Proteomic approach to understanding antibiotic drug discovery
    • Bandow JE, Brotz H, Leichert LI, et al. Proteomic approach to understanding antibiotic drug discovery. Antimicrob Agents Chemother 2003; 47 (3): 948-55
    • (2003) Antimicrob Agents Chemother , vol.47 , Issue.3 , pp. 948-955
    • Bandow, J.E.1    Brotz, H.2    Leichert, L.I.3
  • 12
    • 33646112903 scopus 로고    scopus 로고
    • Antibacterial drug discovery and structure-based design
    • Barker JJ. Antibacterial drug discovery and structure-based design. Drug Discov Today 2006; 11 (9-10): 391-404
    • (2006) Drug Discov Today , vol.11 , Issue.9-10 , pp. 391-404
    • Barker, J.J.1
  • 13
    • 33845708150 scopus 로고    scopus 로고
    • New antibiotics from bacterial natural products
    • Clardy J, Fischbach MA, Walsh CT. New antibiotics from bacterial natural products. Nat Biotechnol 2006; 24 (12): 1541-50
    • (2006) Nat Biotechnol , vol.24 , Issue.12 , pp. 1541-1550
    • Clardy, J.1    Fischbach, M.A.2    Walsh, C.T.3
  • 14
    • 32244438669 scopus 로고    scopus 로고
    • Targeting virulence for antibacterial chemotherapy
    • Marra A. Targeting virulence for antibacterial chemotherapy. Drugs R D 2006; 7 (1): 1-16
    • (2006) Drugs R D , vol.7 , Issue.1 , pp. 1-16
    • Marra, A.1
  • 15
    • 33845311869 scopus 로고    scopus 로고
    • Signature-tagged mutagenesis: Barcoding mutants for genome-wide screens
    • Mazurkiewicz P, Tang CM, Boone C, et al. Signature-tagged mutagenesis: barcoding mutants for genome-wide screens. Nature Rev Genet 2006; 7 (12): 929-39
    • (2006) Nature Rev Genet , vol.7 , Issue.12 , pp. 929-939
    • Mazurkiewicz, P.1    Tang, C.M.2    Boone, C.3
  • 16
    • 32944464059 scopus 로고    scopus 로고
    • Bacterial genomics and pathogen evolution
    • Raskin DM, Seshadri R, Pukatzki SU, et al. Bacterial genomics and pathogen evolution. Cell 2006; 124: 703-14
    • (2006) Cell , vol.124 , pp. 703-714
    • Raskin, D.M.1    Seshadri, R.2    Pukatzki, S.U.3
  • 17
    • 34347374657 scopus 로고    scopus 로고
    • Web Server Issue. Nucleic Acids Res 2006; 34: W1-W752
    • Web Server Issue. Nucleic Acids Res 2006; 34: W1-W752
  • 18
    • 33846076511 scopus 로고    scopus 로고
    • The online bioinformatics resources collection at the University of Pittburgh Health Sciences Library System: A one-step gateway to online bioinformatics databases and software tools
    • Chen YB, Chattopadhyay A, Bergen P, et al. The online bioinformatics resources collection at the University of Pittburgh Health Sciences Library System: a one-step gateway to online bioinformatics databases and software tools. Nucleic Acids Res 2007; 35: D780-5
    • (2007) Nucleic Acids Res , vol.35
    • Chen, Y.B.1    Chattopadhyay, A.2    Bergen, P.3
  • 19
    • 0030801002 scopus 로고    scopus 로고
    • Gapped BLAST and PSI-BLAST: A new generation of protein database search programs
    • Altschul SF, Madden TL, Schäffer AA, et al. Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. Nucleic Acids Res 1997; 25 (17): 3389-402
    • (1997) Nucleic Acids Res , vol.25 , Issue.17 , pp. 3389-3402
    • Altschul, S.F.1    Madden, T.L.2    Schäffer, A.A.3
  • 20
    • 0042121237 scopus 로고    scopus 로고
    • Multiple sequence alignment with the Clustal series of programs
    • Chenna R, Sugawara H, Koike T, et al. Multiple sequence alignment with the Clustal series of programs. Nucleic Acids Res 2003; 31 (13): 3497-500
    • (2003) Nucleic Acids Res , vol.31 , Issue.13 , pp. 3497-3500
    • Chenna, R.1    Sugawara, H.2    Koike, T.3
  • 21
    • 0031854952 scopus 로고    scopus 로고
    • DIALIGN: Finding local similarities by multiple sequence alignment
    • Morgenstern B, Frech K, Dress A, et al. DIALIGN: finding local similarities by multiple sequence alignment. Bioinformatics 1998; 14 (3): 290-4
    • (1998) Bioinformatics , vol.14 , Issue.3 , pp. 290-294
    • Morgenstern, B.1    Frech, K.2    Dress, A.3
  • 22
    • 0037398368 scopus 로고    scopus 로고
    • LAGAN and Multi-LAGAN: Efficient tools for large-scale multiple alignment of genomic DNA
    • Brudno M, Do CB, Cooper GM, et al. LAGAN and Multi-LAGAN: efficient tools for large-scale multiple alignment of genomic DNA. Genome Res 2003; 13 (4): 721-31
    • (2003) Genome Res , vol.13 , Issue.4 , pp. 721-731
    • Brudno, M.1    Do, C.B.2    Cooper, G.M.3
  • 24
    • 33746234722 scopus 로고    scopus 로고
    • Detecting non-orthology in the COGs database and other approaches grouping orthologs using genome-specific best hits
    • Dessimoz C, Boeckmann B, Roth AC, et al. Detecting non-orthology in the COGs database and other approaches grouping orthologs using genome-specific best hits. Nucleic Acids Res 2006; 34 (11): 3309-16
    • (2006) Nucleic Acids Res , vol.34 , Issue.11 , pp. 3309-3316
    • Dessimoz, C.1    Boeckmann, B.2    Roth, A.C.3
  • 25
    • 33644877904 scopus 로고    scopus 로고
    • Caspi R, Foerster H, Fulcher CA, et al. Meta Cyc: a multiorganism database of metabolic pathway enzymes. Nucleic Acids Res 2006; 34 (Database issue): D511-6
    • Caspi R, Foerster H, Fulcher CA, et al. Meta Cyc: a multiorganism database of metabolic pathway enzymes. Nucleic Acids Res 2006; 34 (Database issue): D511-6
  • 26
    • 13444262374 scopus 로고    scopus 로고
    • EcoCyc Kessler IM, Collado-Vides J, Gama-Castro S. EcoCyc: a comprehensive database resource for Escherichia coli. Nucleic Acids Res 2005; 33 (Database issue): D334-7
    • EcoCyc Kessler IM, Collado-Vides J, Gama-Castro S. EcoCyc: a comprehensive database resource for Escherichia coli. Nucleic Acids Res 2005; 33 (Database issue): D334-7
  • 27
    • 33745165967 scopus 로고    scopus 로고
    • The impact of comparative genomics on infectious disease research
    • Zhang R, Zhang C-T. The impact of comparative genomics on infectious disease research. Microbes Infect 2006; 8 (6): 1613-22
    • (2006) Microbes Infect , vol.8 , Issue.6 , pp. 1613-1622
    • Zhang, R.1    Zhang, C.-T.2
  • 28
    • 0033552961 scopus 로고    scopus 로고
    • Genomic-sequence comparison of two unrelated isolates of the human gastric pathogen Helicobacter pylori
    • Alm RA, Ling LS, Moir DT, et al. Genomic-sequence comparison of two unrelated isolates of the human gastric pathogen Helicobacter pylori. Nature 1999; 397 (6715): 176-80
    • (1999) Nature , vol.397 , Issue.6715 , pp. 176-180
    • Alm, R.A.1    Ling, L.S.2    Moir, D.T.3
  • 29
    • 0035961748 scopus 로고    scopus 로고
    • Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and genomic comparison with a laboratory strain K-12
    • Hayashi T, Makino K, Ohnishi M, et al. Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and genomic comparison with a laboratory strain K-12. DNA Res 2001; 8 (1): 11-22
    • (2001) DNA Res , vol.8 , Issue.1 , pp. 11-22
    • Hayashi, T.1    Makino, K.2    Ohnishi, M.3
  • 30
    • 0035945586 scopus 로고    scopus 로고
    • Genome sequence of enterohaemorrhagic Escherichia coli O157:H7
    • Perna NT, Plunkett 3rd G, Burland V, et al. Genome sequence of enterohaemorrhagic Escherichia coli O157:H7. Nature 2001; 409 (6819): 529-33
    • (2001) Nature , vol.409 , Issue.6819 , pp. 529-533
    • Perna, N.T.1    Plunkett 3rd, G.2    Burland, V.3
  • 31
    • 33745112085 scopus 로고    scopus 로고
    • Genome-wide detection and analysis of homologous recombination among sequenced stains of Escherichia coli
    • Mau B, Glasner JD, Darling AE, et al. Genome-wide detection and analysis of homologous recombination among sequenced stains of Escherichia coli. Genome Biol 2006; 7 (5): R44
    • (2006) Genome Biol , vol.7 , Issue.5
    • Mau, B.1    Glasner, J.D.2    Darling, A.E.3
  • 32
    • 33745081753 scopus 로고    scopus 로고
    • Understanding the rise of the superbug: Investigation of the evolution and genomic variation of Staphylococcus aureus
    • Lindsay JA, Holden MT. Understanding the rise of the superbug: investigation of the evolution and genomic variation of Staphylococcus aureus. Funct Integr Genomics 2006; 6 (3): 186-201
    • (2006) Funct Integr Genomics , vol.6 , Issue.3 , pp. 186-201
    • Lindsay, J.A.1    Holden, M.T.2
  • 33
    • 3042718925 scopus 로고    scopus 로고
    • Complete genomes of two clinical Staphylococcus aureus strains: Evidence for the rapid evolution of virulence and drug resistance
    • Holden MT, Feil RJ, Lindsay JA, et al. Complete genomes of two clinical Staphylococcus aureus strains: evidence for the rapid evolution of virulence and drug resistance. Proc Natl Acad Sci U S A 2004; 101 (26): 9786-91
    • (2004) Proc Natl Acad Sci U S A , vol.101 , Issue.26 , pp. 9786-9791
    • Holden, M.T.1    Feil, R.J.2    Lindsay, J.A.3
  • 34
    • 20144372744 scopus 로고    scopus 로고
    • Insights on evolution of virulence and resistance from the complete genome analysis of an early methicillin-resistant Staphylococcus aureus strain and a biofilm-producing methicillin-resistant Staphylococcus epidermidis strain
    • Gill SR, Fouts DE, Archer GL, et al. Insights on evolution of virulence and resistance from the complete genome analysis of an early methicillin-resistant Staphylococcus aureus strain and a biofilm-producing methicillin-resistant Staphylococcus epidermidis strain. J Bacteriol 2005; 187 (7): 2426-38
    • (2005) J Bacteriol , vol.187 , Issue.7 , pp. 2426-2438
    • Gill, S.R.1    Fouts, D.E.2    Archer, G.L.3
  • 35
    • 33750056032 scopus 로고    scopus 로고
    • Comparative genomics of metabolic pathways in Mycobacterium species: Gene duplication, gene decay and lateral gene transfer
    • Marri PR, Bannantine JP, Golding GB. Comparative genomics of metabolic pathways in Mycobacterium species: gene duplication, gene decay and lateral gene transfer. FEMS Microbiol Rev 2006; 30 (6): 906-25
    • (2006) FEMS Microbiol Rev , vol.30 , Issue.6 , pp. 906-925
    • Marri, P.R.1    Bannantine, J.P.2    Golding, G.B.3
  • 36
    • 33748742263 scopus 로고    scopus 로고
    • Comparative and functional genomics of Listeria spp
    • Hain T, Steinweg C, Chakraborty T. Comparative and functional genomics of Listeria spp. J Biotechnol 2006; 126 (1): 37-51
    • (2006) J Biotechnol , vol.126 , Issue.1 , pp. 37-51
    • Hain, T.1    Steinweg, C.2    Chakraborty, T.3
  • 37
    • 33645760951 scopus 로고    scopus 로고
    • Comparative genomics of emerging human ehrlichiosis agents
    • Hotopp JC, Lin M, Madupu R, et al. Comparative genomics of emerging human ehrlichiosis agents. PLoS Genet 2006; 2 (2): e21
    • (2006) PLoS Genet , vol.2 , Issue.2
    • Hotopp, J.C.1    Lin, M.2    Madupu, R.3
  • 38
    • 0042355274 scopus 로고    scopus 로고
    • Comparative analysis of the genome sequences of Bordetella pertussis, Bordetella parapertussis and Bordetella bronchiseptica
    • Parkhill J, Sebaihia A, Preston A, et al. Comparative analysis of the genome sequences of Bordetella pertussis, Bordetella parapertussis and Bordetella bronchiseptica. Nat Genet 2003; 35 (1): 32-40
    • (2003) Nat Genet , vol.35 , Issue.1 , pp. 32-40
    • Parkhill, J.1    Sebaihia, A.2    Preston, A.3
  • 39
    • 15944417910 scopus 로고    scopus 로고
    • Genomics of the Bacillus cereus group of organisms
    • Rasko DA, Altherr MR, Han CS, et al. Genomics of the Bacillus cereus group of organisms. FEMS Microbiol Rev 2005; 29 (2): 303-29
    • (2005) FEMS Microbiol Rev , vol.29 , Issue.2 , pp. 303-329
    • Rasko, D.A.1    Altherr, M.R.2    Han, C.S.3
  • 40
    • 23944515302 scopus 로고    scopus 로고
    • Comparative genome analysis of Bacillus cereus group genomes with Bacillus subtilis
    • Anderson I, Sorokin A, Kapatrol V, et al. Comparative genome analysis of Bacillus cereus group genomes with Bacillus subtilis. FEMS Microbiol Lett 2005; 250 (2): 175-84
    • (2005) FEMS Microbiol Lett , vol.250 , Issue.2 , pp. 175-184
    • Anderson, I.1    Sorokin, A.2    Kapatrol, V.3
  • 41
    • 33845903833 scopus 로고    scopus 로고
    • Drugs for bad drugs: Confronting the challenges of antibacterial discovery
    • Payne DJ, Gywnn MN, Holmes DJ, et al. Drugs for bad drugs: confronting the challenges of antibacterial discovery. Nat Rev Drug Discov 2007; 6 (1): 29-40
    • (2007) Nat Rev Drug Discov , vol.6 , Issue.1 , pp. 29-40
    • Payne, D.J.1    Gywnn, M.N.2    Holmes, D.J.3
  • 42
    • 33644514658 scopus 로고    scopus 로고
    • Use of genomics to select antibacterial targets
    • Pucci MJ, Dougherty TD. Use of genomics to select antibacterial targets. Biochem Pharmacol 2006; 71 (7): 1066-72
    • (2006) Biochem Pharmacol , vol.71 , Issue.7 , pp. 1066-1072
    • Pucci, M.J.1    Dougherty, T.D.2
  • 44
    • 21544464022 scopus 로고    scopus 로고
    • Functional genomics in antibacterial drug discovery
    • Freiberg C, Brotz-Oesterhelt H. Functional genomics in antibacterial drug discovery. Drug Discov Today 10 (13): 927-935
    • Drug Discov Today , vol.10 , Issue.13 , pp. 927-935
    • Freiberg, C.1    Brotz-Oesterhelt, H.2
  • 45
    • 0037100683 scopus 로고    scopus 로고
    • Identification of 113 conserved essential genes using a high-throughput gene disruption system in Streptococcus pneumoniae
    • Thanassi JA, Hartman-Neumann SL, Dougherty TJ, et al. Identification of 113 conserved essential genes using a high-throughput gene disruption system in Streptococcus pneumoniae. Nucleic Acids Res 2002; 30: 3152-62
    • (2002) Nucleic Acids Res , vol.30 , pp. 3152-3162
    • Thanassi, J.A.1    Hartman-Neumann, S.L.2    Dougherty, T.J.3
  • 46
    • 0141504252 scopus 로고    scopus 로고
    • Experimental determination and system level analysis of essential genes in Escherichia coli MG1655
    • Gerdes SY, Scholle MD, Campbell JW, et al. Experimental determination and system level analysis of essential genes in Escherichia coli MG1655. J Bacteriol 2003; 185 (19): 5673-84
    • (2003) J Bacteriol , vol.185 , Issue.19 , pp. 5673-5684
    • Gerdes, S.Y.1    Scholle, M.D.2    Campbell, J.W.3
  • 47
    • 0037154255 scopus 로고    scopus 로고
    • A genome-scale analysis for identification of genes required for growth or survival of Haemophilus influenzae
    • Akerley BJ, Rubin EJ, Novick VL, et al. A genome-scale analysis for identification of genes required for growth or survival of Haemophilus influenzae. Proc Natl Acad Sci U S A 2002; 99 (2): 966-71
    • (2002) Proc Natl Acad Sci U S A , vol.99 , Issue.2 , pp. 966-971
    • Akerley, B.J.1    Rubin, E.J.2    Novick, V.L.3
  • 48
    • 0036271625 scopus 로고    scopus 로고
    • A genome-wide strategy for the identification of essential genes in Staphylococcus aureus
    • Forsyth RA, Haselbeck RJ, Ohlsen KL, et al. A genome-wide strategy for the identification of essential genes in Staphylococcus aureus. Mol Microbiol 2002; 43 (6): 1387-400
    • (2002) Mol Microbiol , vol.43 , Issue.6 , pp. 1387-1400
    • Forsyth, R.A.1    Haselbeck, R.J.2    Ohlsen, K.L.3
  • 49
    • 0035929121 scopus 로고    scopus 로고
    • Identification of critical staphylococcal genes using conditional phenotypes generated by antisense RNA
    • Ji Y, Zhang B, Van SF, et al. Identification of critical staphylococcal genes using conditional phenotypes generated by antisense RNA. Science 2001; 293 (5538): 2266-9
    • (2001) Science , vol.293 , Issue.5538 , pp. 2266-2269
    • Ji, Y.1    Zhang, B.2    Van, S.F.3
  • 50
    • 0036256037 scopus 로고    scopus 로고
    • An array of target-specific screening strains for antibacterial discovery
    • May;
    • DeVito JA, Mills JA, Liu VG, et al. An array of target-specific screening strains for antibacterial discovery. Nat Biotechnol 2002 May; 20 (5): 478-83
    • (2002) Nat Biotechnol , vol.20 , Issue.5 , pp. 478-483
    • DeVito, J.A.1    Mills, J.A.2    Liu, V.G.3
  • 51
    • 0034687158 scopus 로고    scopus 로고
    • Regulated gene expression in Staphylococcus aureus for identifying conditional lethal phenotypes and antibiotic mode of action
    • Zhang L, Fan F, Palmer LM, et al. Regulated gene expression in Staphylococcus aureus for identifying conditional lethal phenotypes and antibiotic mode of action. Gene 2000; 255 (2): 297-305
    • (2000) Gene , vol.255 , Issue.2 , pp. 297-305
    • Zhang, L.1    Fan, F.2    Palmer, L.M.3
  • 52
    • 10744225004 scopus 로고    scopus 로고
    • Novel chromosomally encoded multidrug efflux transporter MdeA in Staphylococcus aureus
    • Huang J, O'Toole PW, Shen W, et al. Novel chromosomally encoded multidrug efflux transporter MdeA in Staphylococcus aureus. Antimicrob Agents Chemother 2004; 48 (3): 909-17
    • (2004) Antimicrob Agents Chemother , vol.48 , Issue.3 , pp. 909-917
    • Huang, J.1    O'Toole, P.W.2    Shen, W.3
  • 53
    • 24644505760 scopus 로고    scopus 로고
    • Structural analysis of a set of proteins resulting from a bacterial genomics project. Proteins: Struct Funct
    • Badger J, Sauder JM, Adams JM, et al. Structural analysis of a set of proteins resulting from a bacterial genomics project. Proteins: Struct Funct Bioinform 2005; 60: 787-96
    • (2005) Bioinform , vol.60 , pp. 787-796
    • Badger, J.1    Sauder, J.M.2    Adams, J.M.3
  • 54
    • 33749536221 scopus 로고    scopus 로고
    • Application of the use of high-throughput technologies to the determination of protein structures of bacterial and viral pathogens
    • Fogg MJ, Alzari P, Bahar M, et al. Application of the use of high-throughput technologies to the determination of protein structures of bacterial and viral pathogens. Acta Crystallogr D Biol Crystallogr 2006; 62 (Pt 10): 1196-207
    • (2006) Acta Crystallogr D Biol Crystallogr , vol.62 , Issue.PART 10 , pp. 1196-1207
    • Fogg, M.J.1    Alzari, P.2    Bahar, M.3
  • 55
    • 33749529377 scopus 로고    scopus 로고
    • Application of high-throughput technologies to a structural proteomics-type analysis of Bacillus anthracis
    • Au K, Berrow NS, Blagova E, et al. Application of high-throughput technologies to a structural proteomics-type analysis of Bacillus anthracis. Acta Crystallogr D Biol Crystallogr 2006; 62 (Pt 10): 1267-75
    • (2006) Acta Crystallogr D Biol Crystallogr , vol.62 , Issue.PART 10 , pp. 1267-1275
    • Au, K.1    Berrow, N.S.2    Blagova, E.3
  • 56
    • 33746425844 scopus 로고    scopus 로고
    • A large-scale, high-efficiency and low-cost platform for structural genomics studies
    • Su XD, Liang Y, Li L, et al. A large-scale, high-efficiency and low-cost platform for structural genomics studies. Acta Crystallogr D Biol Crystallogr 2006; 62 (Pt 8): 843-51
    • (2006) Acta Crystallogr D Biol Crystallogr , vol.62 , Issue.PART 8 , pp. 843-851
    • Su, X.D.1    Liang, Y.2    Li, L.3
  • 57
    • 20444495201 scopus 로고    scopus 로고
    • Drugs targeting the ribosome
    • Hermann T. Drugs targeting the ribosome. Curr Opin Struct Biol 2005; 15 (3): 355-66
    • (2005) Curr Opin Struct Biol , vol.15 , Issue.3 , pp. 355-366
    • Hermann, T.1
  • 58
    • 25144480034 scopus 로고    scopus 로고
    • Improving on nature: Antibiotics that target the ribosome
    • Sutcliffe JA. Improving on nature: antibiotics that target the ribosome. Curr Opin Microbiol 2005; 8 (5): 534-42
    • (2005) Curr Opin Microbiol , vol.8 , Issue.5 , pp. 534-542
    • Sutcliffe, J.A.1
  • 59
    • 33644610182 scopus 로고    scopus 로고
    • Structure-based drug design meets the ribosome
    • Franceschi F, Duffy EM. Structure-based drug design meets the ribosome. Biochem Pharmacol 2006; 71 (7): 1016-25
    • (2006) Biochem Pharmacol , vol.71 , Issue.7 , pp. 1016-1025
    • Franceschi, F.1    Duffy, E.M.2
  • 60
    • 33846582343 scopus 로고    scopus 로고
    • Dual targeting of GyrB and ParE by a novel aminobenzimidazole class of antibacterial compounds
    • Grossman TH, Bartels DJ, Mullin S, et al. Dual targeting of GyrB and ParE by a novel aminobenzimidazole class of antibacterial compounds. Antimicrob Agents Chemother 2007; 51 (2): 657-66
    • (2007) Antimicrob Agents Chemother , vol.51 , Issue.2 , pp. 657-666
    • Grossman, T.H.1    Bartels, D.J.2    Mullin, S.3
  • 61
    • 11144237579 scopus 로고    scopus 로고
    • A novel class of inhibitors of peptide deformylase discovered through high-concentrations throughput screening and virtual ligand screening
    • Howard MH, Cenizal T, Gutteridge S, et al. A novel class of inhibitors of peptide deformylase discovered through high-concentrations throughput screening and virtual ligand screening. J Med Chem 2004; 47 (27): 6669-72
    • (2004) J Med Chem , vol.47 , Issue.27 , pp. 6669-6672
    • Howard, M.H.1    Cenizal, T.2    Gutteridge, S.3
  • 62
    • 20144370577 scopus 로고    scopus 로고
    • Structure-based design, synthesis, and study of potent inhibitors of beta-ketoacyl-acyl carrier protein synthase III as potential antimicrobial agents
    • Nie Z, Perretta C, Lu J, et al. Structure-based design, synthesis, and study of potent inhibitors of beta-ketoacyl-acyl carrier protein synthase III as potential antimicrobial agents. J Med Chem 2005; 48 (5): 1596-609
    • (2005) J Med Chem , vol.48 , Issue.5 , pp. 1596-1609
    • Nie, Z.1    Perretta, C.2    Lu, J.3
  • 63
    • 33744994317 scopus 로고    scopus 로고
    • Platensimycin is a selective FabF inhibitor with potent antibiotic properties
    • Wang J, Soisson SM, Young K, et al. Platensimycin is a selective FabF inhibitor with potent antibiotic properties. Nature 2006; 441 (7091): 358-61
    • (2006) Nature , vol.441 , Issue.7091 , pp. 358-361
    • Wang, J.1    Soisson, S.M.2    Young, K.3
  • 64
    • 0037464456 scopus 로고    scopus 로고
    • Indole naphthyridinones as inhibitors of bacterial enoyl-ACP reductases FabI and FabK
    • Seefeld MA, Miller WH, Newlander KA, et al. Indole naphthyridinones as inhibitors of bacterial enoyl-ACP reductases FabI and FabK. J Med Chem 2003; 46 (9): 1627-35
    • (2003) J Med Chem , vol.46 , Issue.9 , pp. 1627-1635
    • Seefeld, M.A.1    Miller, W.H.2    Newlander, K.A.3
  • 65
    • 12344293492 scopus 로고    scopus 로고
    • Identification of 4-substituted 1,2,3-triazoles as novel oxazolidinone antibacterial agents with reduced activity against monoamine oxidase A
    • Reck F, Zhou F, Giradot M, et al. Identification of 4-substituted 1,2,3-triazoles as novel oxazolidinone antibacterial agents with reduced activity against monoamine oxidase A. J Med Chem 2005; 48 (2): 499-506
    • (2005) J Med Chem , vol.48 , Issue.2 , pp. 499-506
    • Reck, F.1    Zhou, F.2    Giradot, M.3
  • 66
    • 2342525085 scopus 로고    scopus 로고
    • Heterogeneity and inaccuracy in protein structures solved by x-ray crystallography
    • Depristo MA, deBakker PI, Blundell TL. Heterogeneity and inaccuracy in protein structures solved by x-ray crystallography. Structure 2004; 12 (5): 831-8
    • (2004) Structure , vol.12 , Issue.5 , pp. 831-838
    • Depristo, M.A.1    deBakker, P.I.2    Blundell, T.L.3
  • 68
    • 0029836953 scopus 로고    scopus 로고
    • Discovering high-coming affinity ligands for proteins: SAR by NMR
    • Shuker SB, Hadjuk PJ, Meadows RP, et al. Discovering high-coming affinity ligands for proteins: SAR by NMR. Science 1996; 274 (5292): 1531-4
    • (1996) Science , vol.274 , Issue.5292 , pp. 1531-1534
    • Shuker, S.B.1    Hadjuk, P.J.2    Meadows, R.P.3
  • 69
    • 33750067690 scopus 로고    scopus 로고
    • Discovery of novel inhibitors of the ZipA/FtsZ complex by NMR fragment screening coupled with structure-based design
    • Tsao DH, Sutherland AG, Jennings LD, et al. Discovery of novel inhibitors of the ZipA/FtsZ complex by NMR fragment screening coupled with structure-based design. Bioorg Med Chem 2006; 14 (23): 7953-61
    • (2006) Bioorg Med Chem , vol.14 , Issue.23 , pp. 7953-7961
    • Tsao, D.H.1    Sutherland, A.G.2    Jennings, L.D.3
  • 70
    • 24344497940 scopus 로고    scopus 로고
    • Therapeutic potential of peptide deformylase inhibitors
    • Chen D, Yuan Z. Therapeutic potential of peptide deformylase inhibitors. Expert Opin Investig Drugs 2005; 14 (9): 1107-16
    • (2005) Expert Opin Investig Drugs , vol.14 , Issue.9 , pp. 1107-1116
    • Chen, D.1    Yuan, Z.2
  • 71
    • 21544464022 scopus 로고    scopus 로고
    • Functional genomics in antibacterial drug discovery
    • Freiberg C, Brotz-Oesterhelt H. Functional genomics in antibacterial drug discovery. Drug Discov Today 2005; 10 (13): 927-35
    • (2005) Drug Discov Today , vol.10 , Issue.13 , pp. 927-935
    • Freiberg, C.1    Brotz-Oesterhelt, H.2
  • 72
    • 0037323796 scopus 로고    scopus 로고
    • Microarray expression profiling: Capturing a genome-wide portrait of the transcriptome
    • Conway T, Schoolnik GK. Microarray expression profiling: capturing a genome-wide portrait of the transcriptome. Mol Microbiol 2003; 47 (4): 879-89
    • (2003) Mol Microbiol , vol.47 , Issue.4 , pp. 879-889
    • Conway, T.1    Schoolnik, G.K.2
  • 73
    • 0036051847 scopus 로고    scopus 로고
    • Microarray analysis of bacterial pathogenicity
    • Schoolnik GK. Microarray analysis of bacterial pathogenicity. Adv Microb Physiol 2002; 46: 1-45
    • (2002) Adv Microb Physiol , vol.46 , pp. 1-45
    • Schoolnik, G.K.1
  • 74
    • 0034810821 scopus 로고    scopus 로고
    • Global analysis of the general stress response of Bacillus subtilis
    • Petersohn A, Brigulla M, Haas S. Global analysis of the general stress response of Bacillus subtilis. J Bacteriol 2001; 183 (19): 5617-31
    • (2001) J Bacteriol , vol.183 , Issue.19 , pp. 5617-5631
    • Petersohn, A.1    Brigulla, M.2    Haas, S.3
  • 75
    • 0032828757 scopus 로고    scopus 로고
    • Diagnosis of cellular states of microbial organisms using proteomics
    • Van Bogelen RA, Schiller EE, Thomas JD, et al. Diagnosis of cellular states of microbial organisms using proteomics. Electrophoresis 1999; 20 (11): 2149-59
    • (1999) Electrophoresis , vol.20 , Issue.11 , pp. 2149-2159
    • Van Bogelen, R.A.1    Schiller, E.E.2    Thomas, J.D.3
  • 76
    • 33745127048 scopus 로고    scopus 로고
    • The Escherichia coli proteome: Past, present, and future prospects
    • Han MJ, Lee SY. The Escherichia coli proteome: past, present, and future prospects. Microbiol Mol Biol Rev 2006; 70 (2): 362-439
    • (2006) Microbiol Mol Biol Rev , vol.70 , Issue.2 , pp. 362-439
    • Han, M.J.1    Lee, S.Y.2
  • 77
    • 10644274361 scopus 로고    scopus 로고
    • Towards a comprehensive understanding of Bacillus subtilis cell physiology by physiological proteomics
    • Hecker M, Volker U. Towards a comprehensive understanding of Bacillus subtilis cell physiology by physiological proteomics. Proteomics 2004; 4 (12): 3727-50
    • (2004) Proteomics , vol.4 , Issue.12 , pp. 3727-3750
    • Hecker, M.1    Volker, U.2
  • 78
    • 11144293517 scopus 로고    scopus 로고
    • Mycobacterium tuberculosis functional network analysis by global subcellular protein profiling
    • Mawuenyega KG, Forst CV, Dobos KM, et al. Mycobacterium tuberculosis functional network analysis by global subcellular protein profiling. Mol Biol Cell 2005; 16 (1): 396-404
    • (2005) Mol Biol Cell , vol.16 , Issue.1 , pp. 396-404
    • Mawuenyega, K.G.1    Forst, C.V.2    Dobos, K.M.3
  • 79
    • 26244440553 scopus 로고    scopus 로고
    • Using microarray gene signatures to elucidate mechanisms of antibiotic action and resistance
    • Brazas MD, Hancock RE. Using microarray gene signatures to elucidate mechanisms of antibiotic action and resistance. Drug Discov Today 2005; 10 (18): 1245-52
    • (2005) Drug Discov Today , vol.10 , Issue.18 , pp. 1245-1252
    • Brazas, M.D.1    Hancock, R.E.2
  • 80
    • 0037214411 scopus 로고    scopus 로고
    • Transcriptional regulation and signature patterns revealed by microarray analyses of Streptococcus pneumoniae R6 challenged with sublethal concentrations of translation inhibitors
    • Ng WL, Kazmierczak KM, Robertson GT. Transcriptional regulation and signature patterns revealed by microarray analyses of Streptococcus pneumoniae R6 challenged with sublethal concentrations of translation inhibitors. J Bacteriol 2003; 185 (1): 359-70
    • (2003) J Bacteriol , vol.185 , Issue.1 , pp. 359-370
    • WL, N.1    Kazmierczak, K.M.2    Robertson, G.T.3
  • 81
    • 18244409616 scopus 로고    scopus 로고
    • Global transcriptional response of Bacillus subtilis to treatment with subinhibitory concentrations of antibiotics that inhibit protein synthesis
    • Lin JT, Connelly MB, Amolo C, et al. Global transcriptional response of Bacillus subtilis to treatment with subinhibitory concentrations of antibiotics that inhibit protein synthesis. Antimicrob Agents Chemother 2005; 49 (5): 1915-26
    • (2005) Antimicrob Agents Chemother , vol.49 , Issue.5 , pp. 1915-1926
    • Lin, J.T.1    Connelly, M.B.2    Amolo, C.3
  • 82
    • 12944327876 scopus 로고    scopus 로고
    • Discovering the mechanism of action of novel antibacterial agents through transcriptional profiling of conditional mutants
    • Freiberg C, Fischer HP, Brunner NA. Discovering the mechanism of action of novel antibacterial agents through transcriptional profiling of conditional mutants. Antimicrob Agents Chemother 2005; 49 (2): 749-59
    • (2005) Antimicrob Agents Chemother , vol.49 , Issue.2 , pp. 749-759
    • Freiberg, C.1    Fischer, H.P.2    Brunner, N.A.3
  • 83
    • 14544284148 scopus 로고    scopus 로고
    • Application of microbial genomic science to advanced therapeutics
    • Fraser CM, Rappouli R. Application of microbial genomic science to advanced therapeutics. Annu Rev Med 2005; 56: 459-74
    • (2005) Annu Rev Med , vol.56 , pp. 459-474
    • Fraser, C.M.1    Rappouli, R.2
  • 84
    • 33745159656 scopus 로고    scopus 로고
    • The impact of genomics on discovering drugs against infectious diseases
    • Boshoff HIM, Manjunatha UH. The impact of genomics on discovering drugs against infectious diseases. Microbes Infect 2006; 8: 1654-61
    • (2006) Microbes Infect , vol.8 , pp. 1654-1661
    • Boshoff, H.I.M.1    Manjunatha, U.H.2
  • 85
    • 24344497940 scopus 로고    scopus 로고
    • Therapeutic potential of peptide deformylase inhibitors
    • Chen D, Yuan Z. Therapeutic potential of peptide deformylase inhibitors. Expert Opin Investig Drugs 2005; 14 (9): 1107-16
    • (2005) Expert Opin Investig Drugs , vol.14 , Issue.9 , pp. 1107-1116
    • Chen, D.1    Yuan, Z.2
  • 86
    • 13344259234 scopus 로고    scopus 로고
    • Finding the gems using genomic discovery: Antibacterial drug discovery strategies: the successes and the challenges
    • Chan PF, Holmes DJ, Payne DJ. Finding the gems using genomic discovery: antibacterial drug discovery strategies: the successes and the challenges. Drug Discov Today: Ther Strategies 2004; 1 (4): 519-27
    • (2004) Drug Discov Today: Ther Strategies , vol.1 , Issue.4 , pp. 519-527
    • Chan, P.F.1    Holmes, D.J.2    Payne, D.J.3
  • 87
    • 33744973283 scopus 로고    scopus 로고
    • Microbial genomics and drug discovery: Exploring innovative routes of drug discovery in the postgenomic era
    • Dougherty TJ, Miller PF. Microbial genomics and drug discovery: exploring innovative routes of drug discovery in the postgenomic era. IDrugs 2006; 9 (6): 420-2
    • (2006) IDrugs , vol.9 , Issue.6 , pp. 420-422
    • Dougherty, T.J.1    Miller, P.F.2
  • 88
    • 22144455317 scopus 로고    scopus 로고
    • Novel target sites in bacteria for overcoming antibiotic resistance
    • Black MT, Hodgson J. Novel target sites in bacteria for overcoming antibiotic resistance. Adv Drug Deliv Rev 2005; 57: 1528-38
    • (2005) Adv Drug Deliv Rev , vol.57 , pp. 1528-1538
    • Black, M.T.1    Hodgson, J.2
  • 89
    • 0442307441 scopus 로고    scopus 로고
    • Efflux-mediated drug resistance in bacteria
    • Li XZ, Nikaido H. Efflux-mediated drug resistance in bacteria. Drugs 2004; 64 (2): 159-204
    • (2004) Drugs , vol.64 , Issue.2 , pp. 159-204
    • Li, X.Z.1    Nikaido, H.2
  • 90
    • 9144257927 scopus 로고    scopus 로고
    • Recent advances in chemical genomics
    • Darvas F, Gorman G, Krajcsi P, et al. Recent advances in chemical genomics. Curr Med Chem 2004; 11 (23): 3119-45
    • (2004) Curr Med Chem , vol.11 , Issue.23 , pp. 3119-3145
    • Darvas, F.1    Gorman, G.2    Krajcsi, P.3
  • 91
    • 0035289779 scopus 로고    scopus 로고
    • Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings
    • Lipinski CA, Lombardo F, Dominy BW, et al. Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings. Adv Drug Deliv Rev 2001; 46 (1-3): 3-26
    • (2001) Adv Drug Deliv Rev , vol.46 , Issue.1-3 , pp. 3-26
    • Lipinski, C.A.1    Lombardo, F.2    Dominy, B.W.3
  • 92
    • 33644544089 scopus 로고    scopus 로고
    • Empirical antibacterial drug discovery: Foundation in natural products
    • Singh SB, Barrett JF. Empirical antibacterial drug discovery: foundation in natural products. Biochem Pharmacol 2006; 71 (7): 1006-15
    • (2006) Biochem Pharmacol , vol.71 , Issue.7 , pp. 1006-1015
    • Singh, S.B.1    Barrett, J.F.2
  • 93
    • 31944450795 scopus 로고    scopus 로고
    • Discovery of FabH/FabF inhibitors from natural products
    • Young K, Jayasuriya H, Ondeyka JG, et al. Discovery of FabH/FabF inhibitors from natural products. Antimicrob Agents Chemother 2006; 50 (2): 519-26
    • (2006) Antimicrob Agents Chemother , vol.50 , Issue.2 , pp. 519-526
    • Young, K.1    Jayasuriya, H.2    Ondeyka, J.G.3
  • 94
    • 33845707975 scopus 로고    scopus 로고
    • Antibiotics: An investment worth making?
    • Christoffersen RE. Antibiotics: an investment worth making? Nat Biotechnol 2006; 24 (12): 1512-4
    • (2006) Nat Biotechnol , vol.24 , Issue.12 , pp. 1512-1514
    • Christoffersen, R.E.1
  • 95
    • 33845706771 scopus 로고    scopus 로고
    • The business of developing antibacterials
    • Fox JL. The business of developing antibacterials. Nat Biotechnol 2006; 24 (12): 1521-8
    • (2006) Nat Biotechnol , vol.24 , Issue.12 , pp. 1521-1528
    • Fox, J.L.1
  • 96
    • 33845719937 scopus 로고    scopus 로고
    • Antibacterial discovery and development: The failure of success?
    • Fernandes P. Antibacterial discovery and development: the failure of success? Nat Biotechnol 2006; 24 (12): 1497-503
    • (2006) Nat Biotechnol , vol.24 , Issue.12 , pp. 1497-1503
    • Fernandes, P.1
  • 97
    • 33645030241 scopus 로고    scopus 로고
    • Robust Salmonella metabolism limits possibilities for new antimicrobials
    • Becker D, Selbach M, Rollenhagen C, et al. Robust Salmonella metabolism limits possibilities for new antimicrobials. Nature 2006; 440: 303-7
    • (2006) Nature , vol.440 , pp. 303-307
    • Becker, D.1    Selbach, M.2    Rollenhagen, C.3
  • 98
    • 33644767089 scopus 로고    scopus 로고
    • Recent developments in antibacterial drug discovery: Microbe-derived natural products: from collection to the clinic
    • Leeds JA, Schmitt EK, Krastel P. Recent developments in antibacterial drug discovery: microbe-derived natural products: from collection to the clinic. Expert Opin Investig Drugs 2006; 15 (3): 211-26
    • (2006) Expert Opin Investig Drugs , vol.15 , Issue.3 , pp. 211-226
    • Leeds, J.A.1    Schmitt, E.K.2    Krastel, P.3
  • 99
    • 11144323163 scopus 로고    scopus 로고
    • Virtual screening of chemical libraries
    • Shoichet BK. Virtual screening of chemical libraries. Nature 2004; 432: 862-5
    • (2004) Nature , vol.432 , pp. 862-865
    • Shoichet, B.K.1
  • 101
    • 33750090037 scopus 로고    scopus 로고
    • The fallacies of hope: Will we discover new antibiotics to combat pathogenic bacteria in time?
    • Vicente M, Hodgson J, Massidda O, et al. The fallacies of hope: will we discover new antibiotics to combat pathogenic bacteria in time? FEMS Microbiol Rev 2006; 30: 841-52
    • (2006) FEMS Microbiol Rev , vol.30 , pp. 841-852
    • Vicente, M.1    Hodgson, J.2    Massidda, O.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.