Antibacterial discovery and development - The failure of success?

Nature Biotechnology

Volumn 24, Issue 12, 2006, Pages 1497-1503

  Fernandes, Prabhavathi ^a  

^a Cempra Pharmaceuticals Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DISEASES; DRUG PRODUCTS;

DRUG INDUSTRY; INFECTIOUS DISEASES;

ANTIBIOTICS;

AKTOB; AMIKACIN; AMINOGLYCOSIDE; AMOXICILLIN PLUS CLAVULANIC ACID; ANTIINFECTIVE AGENT; AZITHROMYCIN; AZTREONAM; AZTRIN; CEPHALOSPORIN; CEPHALOSPORIN DERIVATIVE; CHLORAMPHENICOL; CIPROFLOXACIN; CLAVASEPTIN; CLAVULANIC ACID; DAPTOMYCIN; ERYTHROMYCIN DERIVATIVE; GENTAMICIN; GLYCOPEPTIDE; GRAMICIDIN D; ISONIAZID; LINEZOLID; MACROLIDE; METRONIDAZOLE; NALIDIXIC ACID; PENICILLIN G; QUINOLINE DERIVED ANTIINFECTIVE AGENT; QUINOLONE; QUINOLONE DERIVATIVE; RIFAMYCIN; ROZEX; SULFAMETHOXAZOLE; SULFAMIDOCHRYSOIDINE; SULFANILAMIDE; TEICOPLANIN; TETRACYCLINE; TIGECYCLINE; TOBRAMYCIN; TRIMETHOPRIM; TYROCIDINE; TYROTHRICIN; UNINDEXED DRUG; ZMAX;

ANIMAL FOOD; ANTIBIOTIC RESISTANCE; BACTERIAL INFECTION; BACTERIAL STRAIN; BACTERIUM ISOLATION; DRUG EFFICACY; DRUG INDUSTRY; DRUG MANUFACTURE; DRUG RESEARCH; DRUG USE; HOSPITAL INFECTION; HUMAN; MEDICAL RESEARCH; MEDICINE; MULTIDRUG RESISTANCE; NONHUMAN; PRIORITY JOURNAL; REVIEW; SOIL MICROFLORA; TREATMENT INDICATION; TUBERCULOSIS;

ANTI-BACTERIAL AGENTS; DRUG DESIGN; DRUG INDUSTRY; DRUG RESISTANCE, MICROBIAL; DRUGS, INVESTIGATIONAL; ETHNOPHARMACOLOGY; HISTORY, 20TH CENTURY; HISTORY, 21ST CENTURY; HUMANS; PHARMACOGNOSY; TECHNOLOGY, PHARMACEUTICAL;

EID: 33845719937     PISSN: 10870156     EISSN: 15461696     Source Type: Journal    
DOI: 10.1038/nbt1206-1497     Document Type: Review

References (80)

1. Ash, C. Trends Microbiol. 4, 371-372 (1996).
2. Fleming, A. Br. J. Exp. Pathol. 10, 226-236 (1929).
3. Cassell, G. et al. in Office of Technology Assessment, Congress of the United States. 1-31 (US Government Printing Office, OTA-H-629, Washington, DC, 1995).
4. Fernandes, P.B. & Chu, D.T.W. Annu. Rep. Med. Chem. 22, 117-126 (1987).
5. Andriole, V.T. Drugs 45 suppl 3, 1-7 (1993).
6. Jones, R.N., Rubino, C.M., Bhavnani, S.M. & Ambrose, P.G. Antimicrob. Agents Chemother. 47, 292-296 (2003).
7. Kosowska-Shick, K. et al. Antimicrob. Agents Chemother. 50, 2064-2071 (2006).
8. Fernandes, P.B. Curr. Opin. Mol. Ther. 2, 624-632 (2000).
9. Buysse, J.M. Curr. Med. Chem. 8, 1713-1726 (2001).
10. Selzer, P.M. et al. Int. J. Med. Microbiol. 290, 191-201 (2000).
11. Pucci, M.J. Biochem. Pharmacol. 71, 1066-1072 (2006).
12. Slauch, J.M., Mahan, M.J. & Mekalanos, J.J. Methods Enzymol. 235, 481-492 (1994).
13. Xu, H.H., Real, L. & Bailey, M.W. Biochem. Biophys. Res. Commun. 349, 1250-1257 (2006).
14. Yuan, Z. & White, R.J. Biochem. Pharmacol. 71, 1042-1047 (2006).
15. Zhou, Y. et al. Antimicrob. Agents Chemother. 49, 4942-4949 (2005).
16. Schmid, M.B. Biochem. Pharmacol. 71, 1048-1056 (2006).
17. Arcus, V.L. et al. Drug Discov. Today 11, 28-34 (2006).
18. Franceschi, F. & Duffy, E.M. Biochem. Pharmacol. 71, 1016-1025 (2006).
19. Floss, H.G. J. Biotechnol. 124, 242-257 (2006).
20. Zotchev, S.B. et al. J. Med. Chem. 49, 2077-2087 (2006).
21. Leontiadou, H., Mark, A.E. & Marrink, S.J. J. Am. Chem. Soc. 128, 12156-12161 (2006).
22. Palaniappan, N. et al. Chem. Biol. 13, 753-764 (2006).
23. Yan, K. et al. Antimicrob. Agents Chemother. 50, 3875-3881 (2006).
24. Butler, M.S. & Buss, A.D. Biochem. Pharmacol. 71, 919-929 (2006).
25. Pelaez, F. Biochem. Pharmacol. 71, 981-990 (2006).
26. Owens, R.C. & Ambrose, P.G. Clin. Infect. Dis. 41, Suppl 2, S144-S157 (2005).
27. Ball, P. J. Antimicrob. Chemother. 51, Suppl 1, 21-27 (2003).
28. Sutcliffe, J.A. Curr. Opin. Microbiol. 8, 534-542 (2005).
29. Petersen, P.J. et al. Antimicrob. Agents Chemother. 43, 738-744 (1999).
30. Sum, P.E., Ross, A.T., Petersen, P.J. & Testa, R.T. Bioorg. Med. Chem. Lett. 16, 400-403 (2006).
31. Singh, A., Mai, D., Kumar, A. & Steyn, A.J. Proc. Natl. Acad. Sci. USA 103, 11346-11351 (2006).
32. Schreiber, S.L. Science 287, 1964-1969 (2000).
33. Stover, C.K. et al. Nature 406, 959-964 (2000).
34. Demain, A.L. Nat. Biotechnol. 20, 331 (2002).
35. Marshall, B., Petrowski, D. & Levy, S.B. Proc. Natl. Acad. Sci. USA 87, 6609-6613 (1990).
36. Lenski, R.E. Int. Microbiol. 1, 265-270 (1998).
37. Matthew, K. & Waldor, M.K. N. Engl. J. Med. 354, 296-297 (2006).
38. Gregory, J. et al. N. Engl. J. Med. 355, 666-674 (2006).
39. Dhalla, I.A. et al. Antimicrob. Agents Chemother. 50, 3216-3219 (2006).
40. Loo, V.G. et al. N. Engl. J. Med. 353, 2444-2449 (2005).
41. Woodford, N. Clin. Microbiol. Infect. 11, Suppl 3, 2-21 (2005).
42. Giamarellou, H. Expert Rev. Anti Infect. Ther. 4, 601-618 (2006).
43. Alanis, A.J. Arch. Med. Res. 36, 697-705 (2005).
44. Meyer, A.L. Curr. Opin. Pharmacol. 5, 490-494 (2005).
45. Morens, D.M., Folkers, G.K. & Fauci, A.S. Nature 430, 242-249 (2004).
46. D'Costa, V.M., McGrann, K.M., Hughes, D.W. & Wright, G.D. Science 311, 374-377 (2006).
47. Mitscher, L.A. et al. in Horizons on Antibiotic Research (eds., Davis, B.D., Ichikawa, T., Maeda, K.& Mitscher, L.A.) 166-193 (Japan Antibiotics Research Association, Tokyo, 1988).
48. Fernandes, P.B. et al. J. Antimicrob. Chemother. 19, 449-466 (1987).
49. Robicsek, A., Jacoby, C.A. & Hooper, D.C. Lancet Infect. Dis. 10, 629-640 (2006).
50. Xiong, Y.Q., Yeaman, M.R. & Bayer, A.S. Drugs Today (Barc) 36, 631-639 (2003).
51. Meka, V.G. & Gold, H.S. Clin. Infect. Dis. 39, 1010-1015 (2004).
52. Fernandes, P.B. ASM News 62, 21-24 (1996).
53. Kollef, M.H. Clin. Infect. Dis. 43 Suppl 2, S82-S88 (2006).
54. Johnson, S. & Gerding, D.N. Clin. Infect. Dis. 26, 1027-1036 (1998).
55. Cimarusti, C.M. & Sykes, R.B. Med. Res. Rev. 4, 1-24 (1984).
56. Swanson, R.N. et al. Antimicrob. Agents Chemother. 35, 1108-1111 (1991).
57. Ackermann, G., Loffler, B., Adler, D. & Rodloff, A.C. Antimicrob. Agents Chemother. 48, 2280-2282 (2004).
58. Bushby, S.R. & Hitchings, G.H. Br. J. Pharmacol. 33, 72-90 (1968).
59. Neu, H.C. & Fu, K.P. Antimicrob. Agents Chemother. 14, 650-655 (1978).
60. Pannek, S. et al. J. Antimicrob. Chemother. 57, 970-974 (2006).
61. Nagiec, E.E. et al. Antimicrob. Agents Chemother. 49, 3896-3902 (2005).
62. Shen, L.L. et al. Biochemistry 28, 3886-3894 (1989).
63. Shen, L.L., Baranowski, J. & Pernet, A.G. Biochemistry 28, 3879-3885 (1989).
64. Data Monitor. Commercial Insights into Antibacterials (Data Monitor, New York, 2005).
65. Wenzel, R.P. N. Engl. J. Med. 351, 523-526 (2004).
66. Nathan, C. & Goldberg, F.M. Nat. Rev. Drug Discov. 4, 887-891 (2005).
67. Pace, J.L. & Yang, G. Biochem. Pharmacol. 71, 968-980 (2006).
68. Appelbaum, P.C. & Jacobs, M.R. Curr. Opin. Microbiol. 8, 510-517 (2005).
69. Halliday, J. et al. Biochem. Pharmacol. 71, 957-967 (2006).
70. Anonymous. FDC Rep. Prescript. Pharm. Biotechnol. 57, 6 (1995).
71. Singh, S.B. & Barrett, J.F. Biochem. Pharmacol. 71, 1006-1015 (2006).
72. Brazil, M. Nat. Rev. Drug Discov. 4, 279 (2005).
73. Wilhelm, S. et al. Nat. Rev. Drug Discov. 5, 835-844 (2005).
74. Payne, D.J., Wallis, N.G., Gentry, D.R. & Rosenberg, M. Curr. Opin. Drug Discov. Dev. 3, 177-190 (2003).
75. Dixon, B. ASM News 68, 106-107 (2002).
76. Schmid, M.B. Nat. Biotechnol. 24, 419-420 (2006).
77. Monaghan, R.L. & Barrett, J.F. Biochem. Pharmacol. 71, 901-919 (2006).
78. Mills, S.D. Biochem. Pharmacol. 71, 1096-1102 (2006).
79. Freiberg, C. & Brotz-Oesterhelt, H. Drug Discov. Today 10, 927-935 (2005).
80. Wang, J. et al. Nature 441, 358-361 (2006).