Chromatin breakdown by deoxyribonuclease1 promotes acetaminophen-induced liver necrosis: An ultrastructural and histochemical study on male CD-1 mice

Histochemistry and Cell Biology

Volumn 128, Issue 1, 2007, Pages 19-33

  Jacob, Monika ^a   Mannherz, Hans Georg ^a   Napirei, Markus ^a  

^a RUHR UNIVERSITY BOCHUM   (Germany)

Author keywords

Acetaminophen; Deoxyribonuclease 1; Dnase1 knockout mice; Liver necrosis

Indexed keywords

AMINOTRANSFERASE; DEOXYRIBONUCLEASE I; EOSIN; HEMATOXYLIN; PARACETAMOL;

AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL ENERGY; CELL NUCLEUS; CELL STRUCTURE; CELLULAR DISTRIBUTION; CHROMATIN; CONTROLLED STUDY; DETOXIFICATION; DNA DAMAGE; DRUG INTOXICATION; DRUG TISSUE LEVEL; ELECTRON MICROSCOPY; ENDOPLASMIC RETICULUM; ENERGY; HISTOCHEMISTRY; HISTOPATHOLOGY; IMMUNOGOLD ELECTRON MICROSCOPY; IMMUNOHISTOCHEMISTRY; KNOCKOUT MOUSE; LIVER CELL; LIVER CELL DAMAGE; LIVER NECROSIS; MALE; MICROSCOPY; MITOCHONDRION SWELLING; MOUSE; MOUSE STRAIN; NICK END LABELING; NONHUMAN; PRIORITY JOURNAL; SINGLE DRUG DOSE; ULTRASTRUCTURE; WILD TYPE;

ACETAMINOPHEN; ALANINE TRANSAMINASE; ANALGESICS, NON-NARCOTIC; ANIMALS; ASPARTATE AMINOTRANSFERASES; CHROMATIN; DEOXYRIBONUCLEASE I; HEPATITIS, TOXIC; IMMUNOHISTOCHEMISTRY; IN SITU NICK-END LABELING; LIVER; LIVER FUNCTION TESTS; MALE; MICE; MICE, KNOCKOUT; NECROSIS;

ANIMALIA; MUS;

EID: 34250792789     PISSN: 09486143     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00418-007-0289-3     Document Type: Article

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