메뉴 건너뛰기




Volumn 131, Issue 6, 2007, Pages 872-884

Hyperhomocysteinemia and thrombosis: An overview

Author keywords

[No Author keywords available]

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); BLOOD CLOTTING FACTOR 5 LEIDEN; CYANOCOBALAMIN; FOLIC ACID; HOMOCYSTEINE; PYRIDOXINE;

EID: 34250333053     PISSN: 00039985     EISSN: 15432165     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (135)

References (211)
  • 1
    • 0001517759 scopus 로고
    • Formation of a homologue of cystine by the decomposition of methionine with sulfuric acid
    • Butz LW, Du Vigneaud V. Formation of a homologue of cystine by the decomposition of methionine with sulfuric acid. J Biol Chem. 1932;99:135-142.
    • (1932) J Biol Chem , vol.99 , pp. 135-142
    • Butz, L.W.1    Du Vigneaud, V.2
  • 2
    • 0014545138 scopus 로고
    • Vascular pathology of homocysteinemia; implications for the pathogenesis of arteriosclerosis
    • McCully KS. Vascular pathology of homocysteinemia; implications for the pathogenesis of arteriosclerosis. Am J Pathol. 1969;56:111-128.
    • (1969) Am J Pathol , vol.56 , pp. 111-128
    • McCully, K.S.1
  • 3
    • 0032771346 scopus 로고    scopus 로고
    • Homocysteine metabolism
    • Selhub J. Homocysteine metabolism. Annu Rev Nutr. 1999;19:217-246.
    • (1999) Annu Rev Nutr , vol.19 , pp. 217-246
    • Selhub, J.1
  • 4
    • 0025362827 scopus 로고
    • Methionine metabolism in mammals
    • Finkelstein JD. Methionine metabolism in mammals. J Nutr Biochem. 1990;1:228-237.
    • (1990) J Nutr Biochem , vol.1 , pp. 228-237
    • Finkelstein, J.D.1
  • 5
    • 0007903236 scopus 로고    scopus 로고
    • The influence of nutrition on rat liver betaine-homocysteine methyltransferase expression and preliminary characterization of recombinant human BHMT as a zinc metalloenzyme
    • Mato JM, Caballero A, eds, Madrid, Spain: Consejo Superior de Investigaciones Cientificas Publishers;
    • Garrow TA, Millian NS, Park EL, et al. The influence of nutrition on rat liver betaine-homocysteine methyltransferase expression and preliminary characterization of recombinant human BHMT as a zinc metalloenzyme. In: Mato JM, Caballero A, eds. Proceedings of the 4th Workshop on Methionine Metabolism. Madrid, Spain: Consejo Superior de Investigaciones Cientificas Publishers; 1998:63-76.
    • (1998) Proceedings of the 4th Workshop on Methionine Metabolism , pp. 63-76
    • Garrow, T.A.1    Millian, N.S.2    Park, E.L.3
  • 6
    • 4243649591 scopus 로고    scopus 로고
    • Methylenetetrahydrofolate reductase in vascular disease, neural tube defects and colon cancer
    • Mato JM, Caballero A, eds, Madrid, Spain: Consejo Superior de Investigaciones Cientificas Publishers;
    • Rozen R. Methylenetetrahydrofolate reductase in vascular disease, neural tube defects and colon cancer. In: Mato JM, Caballero A, eds. Proceedings of the 4th Workshop on Methionine Metabolism. Madrid, Spain: Consejo Superior de Investigaciones Cientificas Publishers; 1998:51-61.
    • (1998) Proceedings of the 4th Workshop on Methionine Metabolism , pp. 51-61
    • Rozen, R.1
  • 7
    • 0016371704 scopus 로고
    • Methionine metabolism in mammals: Regulatory effects of S-adenosylhomocysteine
    • Finkelstein JD, Kyle WE, Harris B. Methionine metabolism in mammals: regulatory effects of S-adenosylhomocysteine. Arch Biochem Biophys. 1974;165:774-779.
    • (1974) Arch Biochem Biophys , vol.165 , pp. 774-779
    • Finkelstein, J.D.1    Kyle, W.E.2    Harris, B.3
  • 8
    • 0023732986 scopus 로고
    • Methionine metabolism in mammals: The methionine-sparing effects of cystine
    • Finkelstein JD, Martin JJ, Harris BJ. Methionine metabolism in mammals: the methionine-sparing effects of cystine. J Biol Chem. 1988;263:11750-11754.
    • (1988) J Biol Chem , vol.263 , pp. 11750-11754
    • Finkelstein, J.D.1    Martin, J.J.2    Harris, B.J.3
  • 9
    • 0014197917 scopus 로고    scopus 로고
    • Finkelstein JD, Mudd SH. Transsulfuration in mammals. The methionine sparing effect of cysteine. J Biol Chem. 1967;242:873-880.
    • Finkelstein JD, Mudd SH. Transsulfuration in mammals. The methionine sparing effect of cysteine. J Biol Chem. 1967;242:873-880.
  • 10
    • 0026045338 scopus 로고
    • Betaine-homocysteine methyltransferase: Organ distribution in man, pig and rat and subcellular distribution in the rat
    • McKeever MP, Weir DG, Molloy A, Scott JM. Betaine-homocysteine methyltransferase: organ distribution in man, pig and rat and subcellular distribution in the rat. Clin Sci. 1991;81:551-556.
    • (1991) Clin Sci , vol.81 , pp. 551-556
    • McKeever, M.P.1    Weir, D.G.2    Molloy, A.3    Scott, J.M.4
  • 11
    • 0026101992 scopus 로고    scopus 로고
    • Homocysteine export from cells cultured in the presence of physiological or superfluous levels of methionine: Methionine loading of nontransformed, transformed, proliferating, and quiescent cells in culture
    • Christensen B, Refsum H, Vintermyr O, Ueland PM. Homocysteine export from cells cultured in the presence of physiological or superfluous levels of methionine: methionine loading of nontransformed, transformed, proliferating, and quiescent cells in culture. J Cell Biol. 1999;146:52-62.
    • (1999) J Cell Biol , vol.146 , pp. 52-62
    • Christensen, B.1    Refsum, H.2    Vintermyr, O.3    Ueland, P.M.4
  • 12
    • 0022479557 scopus 로고
    • Disposition of endogenous homocysteine by mouse fibroblast C3H/10T1/2 Cl 8 and the chemically transformed C3H/10T1/2 MCA Cl 16 cells following methotrexate exposure
    • Ueland PM, Refsum H, Male R, Lillehaug JR. Disposition of endogenous homocysteine by mouse fibroblast C3H/10T1/2 Cl 8 and the chemically transformed C3H/10T1/2 MCA Cl 16 cells following methotrexate exposure. J Natl Cancer Inst. 1986;77:283-289.
    • (1986) J Natl Cancer Inst , vol.77 , pp. 283-289
    • Ueland, P.M.1    Refsum, H.2    Male, R.3    Lillehaug, J.R.4
  • 13
    • 0033812945 scopus 로고    scopus 로고
    • Genetic modulation of homocysteinemia
    • Rozen R. Genetic modulation of homocysteinemia. Semin Thromb Hemost. 2000;26:255-261.
    • (2000) Semin Thromb Hemost , vol.26 , pp. 255-261
    • Rozen, R.1
  • 14
    • 0000236060 scopus 로고
    • 12 and folic metabolism: Folic acid clearance studies
    • 12 and folic metabolism: folic acid clearance studies. J Clin Invest. 1962;41:1263-1276.
    • (1962) J Clin Invest , vol.41 , pp. 1263-1276
    • Herbert, V.1    Zalusky, R.2
  • 15
    • 0000167774 scopus 로고
    • Disorders of transsulfuration
    • Scriver CR, Beaudet AL, Sly WS, Valle D, eds, New York, NY: McGraw-Hill;
    • Mudd SH, Levy HL, Skovby F. Disorders of transsulfuration. In: Scriver CR, Beaudet AL, Sly WS, Valle D, eds. The Metabolic and Molecular Basis of Inherited Disease. New York, NY: McGraw-Hill; 1995:1279-1327.
    • (1995) The Metabolic and Molecular Basis of Inherited Disease , pp. 1279-1327
    • Mudd, S.H.1    Levy, H.L.2    Skovby, F.3
  • 16
    • 0032915831 scopus 로고    scopus 로고
    • Cystathionine B-synthase mutations in homocystinuria
    • Kraus JP, Miroslav J, Viktor K, et al. Cystathionine B-synthase mutations in homocystinuria. Hum Mutat. 1999;13:362-375.
    • (1999) Hum Mutat , vol.13 , pp. 362-375
    • Kraus, J.P.1    Miroslav, J.2    Viktor, K.3
  • 17
    • 0000443712 scopus 로고
    • Inherited disorders of folate transport and metabolism
    • Scriver CR, Beaudet AL, Sly WS, Valle D, eds, 7th ed. New York, NY: McGraw-Hill;
    • Rosenblatt DS. Inherited disorders of folate transport and metabolism. In: Scriver CR, Beaudet AL, Sly WS, Valle D, eds. The Metabolic and Molecular Bases of Inherited Disease. 7th ed. New York, NY: McGraw-Hill; 1995:3111-3128.
    • (1995) The Metabolic and Molecular Bases of Inherited Disease , pp. 3111-3128
    • Rosenblatt, D.S.1
  • 19
    • 0009572838 scopus 로고
    • A new form of homocystinuria due to 5,10-methylenetetrohydrofolate reductase deficiency
    • Shih VE, Salam MZ, Mudd SH, Uhlendorf BW, Adams RD. A new form of homocystinuria due to 5,10-methylenetetrohydrofolate reductase deficiency. Pediatr Res. 1972;6:395.
    • (1972) Pediatr Res , vol.6 , pp. 395
    • Shih, V.E.1    Salam, M.Z.2    Mudd, S.H.3    Uhlendorf, B.W.4    Adams, R.D.5
  • 20
    • 0029049553 scopus 로고
    • A candidate genetic risk factor for vascular disease. A common mutation in methylenetetrahydrofolate reductase
    • Frosst P, Blom HJ, Milos R, et al. A candidate genetic risk factor for vascular disease. A common mutation in methylenetetrahydrofolate reductase. Nat Genet. 1995;10:111-113.
    • (1995) Nat Genet , vol.10 , pp. 111-113
    • Frosst, P.1    Blom, H.J.2    Milos, R.3
  • 21
    • 0028905178 scopus 로고
    • Seven novel mutations in the methylenetetrahydrofolate reductase gene and genotype/phenotype correlations in severe MTHFR deficiency
    • Goyette P, Frosst P, Rosenblatt DS, Rozen R. Seven novel mutations in the methylenetetrahydrofolate reductase gene and genotype/phenotype correlations in severe MTHFR deficiency. Am J Hum Genet. 1995;56:1052-1059.
    • (1995) Am J Hum Genet , vol.56 , pp. 1052-1059
    • Goyette, P.1    Frosst, P.2    Rosenblatt, D.S.3    Rozen, R.4
  • 22
    • 0029847109 scopus 로고    scopus 로고
    • Severe and mild mutations in cis for the methylenetetrahydrofolate reductase MTHFR) gene, and description of 5 novel mutations in MTHFR
    • Goyette P, Christensen B, Rosenblatt DS, Rozen R. Severe and mild mutations in cis for the methylenetetrahydrofolate reductase MTHFR) gene, and description of 5 novel mutations in MTHFR. Am J Hum Genet. 1996;59:1268-1275.
    • (1996) Am J Hum Genet , vol.59 , pp. 1268-1275
    • Goyette, P.1    Christensen, B.2    Rosenblatt, D.S.3    Rozen, R.4
  • 23
    • 0031971515 scopus 로고    scopus 로고
    • A second common mutation in the methylenetetrahydrofolate reductase gene: An additional risk factor for neural-tube defects?
    • van der Put NMJ, Gabreels F, Stevens EMB, et al. A second common mutation in the methylenetetrahydrofolate reductase gene: an additional risk factor for neural-tube defects? Am J Hum Genet. 1998;62:1046-1051.
    • (1998) Am J Hum Genet , vol.62 , pp. 1046-1051
    • van der Put, N.M.J.1    Gabreels, F.2    Stevens, E.M.B.3
  • 24
    • 0030993597 scopus 로고    scopus 로고
    • Loss of heterozygosity at the 5,10-methylenetetrahydrofolate reductase locus in human ovarian carcinomas
    • Viel A, Dall'Agnese I, Simone F, et al. Loss of heterozygosity at the 5,10-methylenetetrahydrofolate reductase locus in human ovarian carcinomas. Br J Cancer. 1997;75:1105-1110.
    • (1997) Br J Cancer , vol.75 , pp. 1105-1110
    • Viel, A.1    Dall'Agnese, I.2    Simone, F.3
  • 25
    • 0031687887 scopus 로고    scopus 로고
    • A second genetic polymorphism in methylenetetrahydrofolate reductase (MTHFR) associated with decreased enzyme activity
    • Weisberg I, Tran P, Christensen B, Sibani S, Rozen R. A second genetic polymorphism in methylenetetrahydrofolate reductase (MTHFR) associated with decreased enzyme activity. Mol Genet Metab. 1998;64:169-172.
    • (1998) Mol Genet Metab , vol.64 , pp. 169-172
    • Weisberg, I.1    Tran, P.2    Christensen, B.3    Sibani, S.4    Rozen, R.5
  • 26
    • 0026034240 scopus 로고
    • Thermolabile methylenetetrahydrofolate reductase: An inherited risk factor for coronary disease
    • Kang S-S, Wong PWK, Susmano A, et al. Thermolabile methylenetetrahydrofolate reductase: an inherited risk factor for coronary disease. Am J Hum Genet. 1991;48:536-545.
    • (1991) Am J Hum Genet , vol.48 , pp. 536-545
    • Kang, S.-S.1    Wong, P.W.K.2    Susmano, A.3
  • 27
    • 0030934392 scopus 로고    scopus 로고
    • Correlation of a common mutation in the methylenetetrahydrofolate reductase (MTHFR) gene with plasma homocysteine in patients with premature coronary artery disease
    • Christensen B, Frosst P, Lussier-Cacan S, et al. Correlation of a common mutation in the methylenetetrahydrofolate reductase (MTHFR) gene with plasma homocysteine in patients with premature coronary artery disease. Arterioscler Thromb Vasc Biol. 1997;17:569-573.
    • (1997) Arterioscler Thromb Vasc Biol , vol.17 , pp. 569-573
    • Christensen, B.1    Frosst, P.2    Lussier-Cacan, S.3
  • 28
    • 0028844492 scopus 로고
    • Mutated methylenetetrahydrofolate reductase as a risk factor for spina bifida
    • van der Put NMJ, Steegers-Theunissen RPM, Frosst P, et al. Mutated methylenetetrahydrofolate reductase as a risk factor for spina bifida. Lancet. 1995;346:1070-1071.
    • (1995) Lancet , vol.346 , pp. 1070-1071
    • van der Put, N.M.J.1    Steegers-Theunissen, R.P.M.2    Frosst, P.3
  • 29
    • 0028487161 scopus 로고
    • Human methylenetetrahydrofolate reductase: Isolation of cDNA, mapping and mutation identification
    • Goyette P, Sumner JS, Milos R, et al. Human methylenetetrahydrofolate reductase: isolation of cDNA, mapping and mutation identification. Nat Genet. 1994;7:195-200.
    • (1994) Nat Genet , vol.7 , pp. 195-200
    • Goyette, P.1    Sumner, J.S.2    Milos, R.3
  • 30
    • 0030027668 scopus 로고    scopus 로고
    • Relation between folate status, a common mutation in methylenetetrahydrofolate reductase, and plasma homocysteine concentrations
    • Jacques PF, Bostom AG, Williams RR, et al. Relation between folate status, a common mutation in methylenetetrahydrofolate reductase, and plasma homocysteine concentrations. Circulation. 1996;93:7-9.
    • (1996) Circulation , vol.93 , pp. 7-9
    • Jacques, P.F.1    Bostom, A.G.2    Williams, R.R.3
  • 31
    • 0029806746 scopus 로고    scopus 로고
    • Methylenetetrahydrofolate reductase polymorphism, plasma folate, homocysteine, and risk of myocardial infarction in U.S. physicians
    • Ma J, Stampfer MJ, Hennekens CH, et al. Methylenetetrahydrofolate reductase polymorphism, plasma folate, homocysteine, and risk of myocardial infarction in U.S. physicians. Circulation. 1996;94:2410-2416.
    • (1996) Circulation , vol.94 , pp. 2410-2416
    • Ma, J.1    Stampfer, M.J.2    Hennekens, C.H.3
  • 32
    • 0034743914 scopus 로고    scopus 로고
    • The 1298A→C polymorphism in methylenetetrahydrofolate reductase (MTHFR): In vitro expression and association with homocysteine
    • Weisberg IS, lacques PF, Selhub J, et al. The 1298A→C polymorphism in methylenetetrahydrofolate reductase (MTHFR): in vitro expression and association with homocysteine. Atherosclerosis. 2001;156:409-415.
    • (2001) Atherosclerosis , vol.156 , pp. 409-415
    • Weisberg, I.S.1    lacques, P.F.2    Selhub, J.3
  • 33
    • 0032125774 scopus 로고    scopus 로고
    • Maternal vitamin use: Genetic variation of infant methylenetetrahydrofolate reductase and risk for spina bifida
    • Shaw GM, Rozen R, Finnell RH, Wasserman CR, Lammer EJ. Maternal vitamin use: genetic variation of infant methylenetetrahydrofolate reductase and risk for spina bifida. Am J Epidemiol. 1998;148:30-37.
    • (1998) Am J Epidemiol , vol.148 , pp. 30-37
    • Shaw, G.M.1    Rozen, R.2    Finnell, R.H.3    Wasserman, C.R.4    Lammer, E.J.5
  • 34
    • 0029655527 scopus 로고    scopus 로고
    • Nutritional ecogenetics: Homocysteine-related arteriosclerotic vascular disease, neural tube defects, and folic acid
    • Motulsky AG. Nutritional ecogenetics: homocysteine-related arteriosclerotic vascular disease, neural tube defects, and folic acid. Am J Hum Genet. 1996;58:17-20.
    • (1996) Am J Hum Genet , vol.58 , pp. 17-20
    • Motulsky, A.G.1
  • 35
    • 0028890671 scopus 로고
    • Thermolabile 5,10-methylenetetrahydrofolate reductase as a cause of mild hyperhomocysteinemia
    • Engbersen AM, Franken DG, Boers GH, Stevens EM, Trijbels FJ. Thermolabile 5,10-methylenetetrahydrofolate reductase as a cause of mild hyperhomocysteinemia. Am J Hum Genet. 1995;56:142-150.
    • (1995) Am J Hum Genet , vol.56 , pp. 142-150
    • Engbersen, A.M.1    Franken, D.G.2    Boers, G.H.3    Stevens, E.M.4    Trijbels, F.J.5
  • 36
    • 0029974036 scopus 로고    scopus 로고
    • Determinants and vitamin responsiveness of intermediate hyperhomocysteinemia (≥ 40 μmol/liter)
    • Guttormsen AB, Ueland PM, Nesthus I, et al. Determinants and vitamin responsiveness of intermediate hyperhomocysteinemia (≥ 40 μmol/liter). J Clin Invest. 1996;98:2174-2183.
    • (1996) J Clin Invest , vol.98 , pp. 2174-2183
    • Guttormsen, A.B.1    Ueland, P.M.2    Nesthus, I.3
  • 37
    • 0029738540 scopus 로고    scopus 로고
    • The common "thermolabile" variant of methylenetetrahydrofolate reductase is a major determinant of mild hyperhomocysteinaemia
    • Harmon DL, Woodside JV, Yarnell JWG, et al. The common "thermolabile" variant of methylenetetrahydrofolate reductase is a major determinant of mild hyperhomocysteinaemia. Q J Med. 1996;89:571-577.
    • (1996) Q J Med , vol.89 , pp. 571-577
    • Harmon, D.L.1    Woodside, J.V.2    Yarnell, J.W.G.3
  • 38
    • 0030476385 scopus 로고    scopus 로고
    • Common mutation in methylenetetrahydrofolate reductase. Correlation with homocysteine metabolism and late-onset vascular disease
    • Deloughery TG, Evans A, Sadeghi A, et al. Common mutation in methylenetetrahydrofolate reductase. Correlation with homocysteine metabolism and late-onset vascular disease. Circulation. 1996;94:3074-3078.
    • (1996) Circulation , vol.94 , pp. 3074-3078
    • Deloughery, T.G.1    Evans, A.2    Sadeghi, A.3
  • 39
    • 0030975769 scopus 로고    scopus 로고
    • The effects of folic acid supplementation on plasma total homocysteine are modulated by multivitamin use and methylenetetrahydrofolate reductase genotypes
    • Malinow MR, Niero FJ, Kruger WD, et al. The effects of folic acid supplementation on plasma total homocysteine are modulated by multivitamin use and methylenetetrahydrofolate reductase genotypes. Arterioscler Thromb Vasc Biol. 1997;17:1157-1162.
    • (1997) Arterioscler Thromb Vasc Biol , vol.17 , pp. 1157-1162
    • Malinow, M.R.1    Niero, F.J.2    Kruger, W.D.3
  • 40
    • 0030610090 scopus 로고    scopus 로고
    • The mutation Ala677→Val in the methylenetetrahydrofolate reductase gene: A risk factor for arterial disease and venous thrombosis
    • Arruda VR, von Zuben PM, Chiaparini LC, Annichino-Bizzacchi JM, Costa FF. The mutation Ala677→Val in the methylenetetrahydrofolate reductase gene: a risk factor for arterial disease and venous thrombosis. Thromb Haemost. 1997;77:818-821.
    • (1997) Thromb Haemost , vol.77 , pp. 818-821
    • Arruda, V.R.1    von Zuben, P.M.2    Chiaparini, L.C.3    Annichino-Bizzacchi, J.M.4    Costa, F.F.5
  • 41
    • 0029655724 scopus 로고    scopus 로고
    • Molecular genetic analysis in mild hyperhomocysteinemia: A common mutation in the methylenetetrahydrofolate reductase gene is a genetic risk factor for cardiovascular disease
    • Kluijtmans LAJ, van den Heuvel LP, Boers GHJ, et al. Molecular genetic analysis in mild hyperhomocysteinemia: a common mutation in the methylenetetrahydrofolate reductase gene is a genetic risk factor for cardiovascular disease. Am J Hum Genet. 1996;58:35-41.
    • (1996) Am J Hum Genet , vol.58 , pp. 35-41
    • Kluijtmans, L.A.J.1    van den Heuvel, L.P.2    Boers, G.H.J.3
  • 42
    • 0031751437 scopus 로고    scopus 로고
    • Homocystinuria (methylenetetrahydrofolate reductase deficiency) and mutation of factor V gene
    • Goyette P, Rosenblatt D, Rozen R. Homocystinuria (methylenetetrahydrofolate reductase deficiency) and mutation of factor V gene. J Inherit Metab Dis. 1998;21:690-691.
    • (1998) J Inherit Metab Dis , vol.21 , pp. 690-691
    • Goyette, P.1    Rosenblatt, D.2    Rozen, R.3
  • 43
    • 0029933176 scopus 로고    scopus 로고
    • Coexistence of hereditary homocystinuria and factor V Leiden: Effect on thrombosis
    • Mandel H, Brenner B, Berant M, et al. Coexistence of hereditary homocystinuria and factor V Leiden: effect on thrombosis. N Engl J Med. 1996;334:763-768.
    • (1996) N Engl J Med , vol.334 , pp. 763-768
    • Mandel, H.1    Brenner, B.2    Berant, M.3
  • 44
    • 0028803474 scopus 로고
    • A genetic defect in 5,10 methylenetetrahydrofolate reductase in neural tube defects
    • Whitehead AS, Gallagher P, Mills JL, et al. A genetic defect in 5,10 methylenetetrahydrofolate reductase in neural tube defects. Q J Med. 1995;88:763-766.
    • (1995) Q J Med , vol.88 , pp. 763-766
    • Whitehead, A.S.1    Gallagher, P.2    Mills, J.L.3
  • 45
    • 0031066138 scopus 로고    scopus 로고
    • Is the common 677C-T mutation in the methylenetetrahydrofolate reductase gene a risk factor for neutral tube defects? A meta-analysis
    • van der Put NMJ, Eskes TKAB, Blom HJ. Is the common 677C-T mutation in the methylenetetrahydrofolate reductase gene a risk factor for neutral tube defects? A meta-analysis. Q J Med. 1997;90:111-115.
    • (1997) Q J Med , vol.90 , pp. 111-115
    • van der Put, N.M.J.1    Eskes, T.K.A.B.2    Blom, H.J.3
  • 46
    • 0033365197 scopus 로고    scopus 로고
    • The thermolabile variant of methylenetetrahydrofolate reductase and neural tube defects: An evaluation of genetic risk and the relative importance of the genotypes of the embryo and the mother
    • Shields DC, Kirke PN, Mills JL, et al. The thermolabile variant of methylenetetrahydrofolate reductase and neural tube defects: an evaluation of genetic risk and the relative importance of the genotypes of the embryo and the mother. Am J Hum Genet. 1999;64:1045-1055.
    • (1999) Am J Hum Genet , vol.64 , pp. 1045-1055
    • Shields, D.C.1    Kirke, P.N.2    Mills, J.L.3
  • 47
    • 0027080461 scopus 로고
    • Prevention of the first occurrence of neural tube defects by periconceptional vitamin supplementation
    • Czeizel AE, Dudas I. Prevention of the first occurrence of neural tube defects by periconceptional vitamin supplementation. N Engl J Med. 1992;327:1832-1835.
    • (1992) N Engl J Med , vol.327 , pp. 1832-1835
    • Czeizel, A.E.1    Dudas, I.2
  • 48
    • 34250359810 scopus 로고
    • Prevention of neural-tube defects: Results of the Medical Research Council vitamin study
    • MRC, Vitamin Study Research Group
    • MRC, Vitamin Study Research Group. Prevention of neural-tube defects: results of the Medical Research Council vitamin study. Lancet. 1991;332:1120-1121.
    • (1991) Lancet , vol.332 , pp. 1120-1121
  • 49
    • 0030743692 scopus 로고    scopus 로고
    • Factor V Leiden, C→T MTHFR polymorphism and genetic susceptibility to preeclampsia
    • Grandone E, Margaglione M, Colaizzo D, et al. Factor V Leiden, C→T MTHFR polymorphism and genetic susceptibility to preeclampsia. Thromb Haemost. 1997;77:1052-1054.
    • (1997) Thromb Haemost , vol.77 , pp. 1052-1054
    • Grandone, E.1    Margaglione, M.2    Colaizzo, D.3
  • 50
    • 0033531184 scopus 로고    scopus 로고
    • Increased frequency of genetic thrombophilia in women with complications of pregnancy
    • Kupferminc MJ, Eldor A, Steinman N, et al. Increased frequency of genetic thrombophilia in women with complications of pregnancy. N Engl J Med. 1999;340:9-13.
    • (1999) N Engl J Med , vol.340 , pp. 9-13
    • Kupferminc, M.J.1    Eldor, A.2    Steinman, N.3
  • 52
    • 0030919077 scopus 로고    scopus 로고
    • Methylenetetrahydrofolate reductase polymorphism and pre-eclampsia
    • Sohda S, Arinami T, Hamada H, et al. Methylenetetrahydrofolate reductase polymorphism and pre-eclampsia. J Med Genet. 1997;34:525-526.
    • (1997) J Med Genet , vol.34 , pp. 525-526
    • Sohda, S.1    Arinami, T.2    Hamada, H.3
  • 54
    • 0030615085 scopus 로고    scopus 로고
    • Methylenetetrahydrofolate reductase polymorphism, reduced risk of colorectal cancer and dietary interactions
    • Ma J, Sfampfer MJ, Giovannucci E, et al. Methylenetetrahydrofolate reductase polymorphism, reduced risk of colorectal cancer and dietary interactions. Cancer Res. 1997;57:1098-1102.
    • (1997) Cancer Res , vol.57 , pp. 1098-1102
    • Ma, J.1    Sfampfer, M.J.2    Giovannucci, E.3
  • 55
    • 0033125654 scopus 로고    scopus 로고
    • Loss of heterozygosity of methylenetetrahydrofolate reductase in colon carcinomas
    • Pereira P, Stanton V, Jothy S, et al. Loss of heterozygosity of methylenetetrahydrofolate reductase in colon carcinomas. Oncol Rep. 1999;6:597-599.
    • (1999) Oncol Rep , vol.6 , pp. 597-599
    • Pereira, P.1    Stanton, V.2    Jothy, S.3
  • 56
    • 0030813123 scopus 로고    scopus 로고
    • Methionine synthase and neural tube defects
    • Morrison K, Edwards YH, Lynch SA, et al. Methionine synthase and neural tube defects. J Med Genet. 1997;34:958-960.
    • (1997) J Med Genet , vol.34 , pp. 958-960
    • Morrison, K.1    Edwards, Y.H.2    Lynch, S.A.3
  • 57
    • 0032954923 scopus 로고    scopus 로고
    • Infant methionine synthase variants and risk for spina bifida
    • Shaw GM, Todoroff K, Finnell RH, et al. Infant methionine synthase variants and risk for spina bifida. J Med Genet. 1999;36:86-87.
    • (1999) J Med Genet , vol.36 , pp. 86-87
    • Shaw, G.M.1    Todoroff, K.2    Finnell, R.H.3
  • 58
    • 0030804226 scopus 로고    scopus 로고
    • Sequence analysis of the coding region of human methionine synthase: Relevance to hyperhomocysteinaemia in neural-tube defects and vascular disease
    • van der Put NMJ, van der Molen EF, Kluijtmans LAJ, et al. Sequence analysis of the coding region of human methionine synthase: relevance to hyperhomocysteinaemia in neural-tube defects and vascular disease. Q J Med. 1997;90:511-517.
    • (1997) Q J Med , vol.90 , pp. 511-517
    • van der Put, N.M.J.1    van der Molen, E.F.2    Kluijtmans, L.A.J.3
  • 59
    • 20244366362 scopus 로고    scopus 로고
    • Genetic causes of mild hyperhomocysteinemia in patients with premature occlusive coronary artery diseases
    • Tsai MY, Welge BG, Hanson NQ, et al. Genetic causes of mild hyperhomocysteinemia in patients with premature occlusive coronary artery diseases. Atherosclerosis. 1999;143:163-170.
    • (1999) Atherosclerosis , vol.143 , pp. 163-170
    • Tsai, M.Y.1    Welge, B.G.2    Hanson, N.Q.3
  • 61
    • 0033599973 scopus 로고    scopus 로고
    • Nonfasting plasma total homocysteine levels and all-cause and cardiovascular disease mortality in elderly Framingham men and women
    • Bostom AG, Silbershatz H, Rosenberg IH, et al. Nonfasting plasma total homocysteine levels and all-cause and cardiovascular disease mortality in elderly Framingham men and women. Arch Intern Med. 1999;159:1077-1080.
    • (1999) Arch Intern Med , vol.159 , pp. 1077-1080
    • Bostom, A.G.1    Silbershatz, H.2    Rosenberg, I.H.3
  • 62
    • 0034972871 scopus 로고    scopus 로고
    • Plasma total homocysteine and cardiovascular and noncardiovascular mortality: The Hordaland Homocysteine Study
    • Vollset SE, Refsum H, Tverdal A, et al. Plasma total homocysteine and cardiovascular and noncardiovascular mortality: the Hordaland Homocysteine Study. Am J Clin Nutr. 2001;74:130-136.
    • (2001) Am J Clin Nutr , vol.74 , pp. 130-136
    • Vollset, S.E.1    Refsum, H.2    Tverdal, A.3
  • 63
    • 0028855901 scopus 로고
    • Hyperhomocysteinemia and low pyridoxal phosphate. Common and independent reversible risk factors for coronary artery disease
    • Robinson K, Mayer EL, Miller DP, et al. Hyperhomocysteinemia and low pyridoxal phosphate. Common and independent reversible risk factors for coronary artery disease. Circulation. 1995;92:2825-2830.
    • (1995) Circulation , vol.92 , pp. 2825-2830
    • Robinson, K.1    Mayer, E.L.2    Miller, D.P.3
  • 64
    • 0034622608 scopus 로고    scopus 로고
    • Effect of plasma homocysteine concentration on early and late events in patients with acute coronary syndromes
    • Stubbs PJ, Al-Obaidi MK, Conroy RM, et al. Effect of plasma homocysteine concentration on early and late events in patients with acute coronary syndromes. Circulation. 2000;102:605-610.
    • (2000) Circulation , vol.102 , pp. 605-610
    • Stubbs, P.J.1    Al-Obaidi, M.K.2    Conroy, R.M.3
  • 66
    • 0037166647 scopus 로고    scopus 로고
    • Plasma total homocysteine and hospitalizations for cardiovascular disease: The Hordaland Homocysteine Study
    • Nurk E, Tell GS, Vollset SE, et al. Plasma total homocysteine and hospitalizations for cardiovascular disease: the Hordaland Homocysteine Study. Arch Intern Med. 2002;162:1374-1381.
    • (2002) Arch Intern Med , vol.162 , pp. 1374-1381
    • Nurk, E.1    Tell, G.S.2    Vollset, S.E.3
  • 67
    • 0037769606 scopus 로고    scopus 로고
    • Emerging risk factors for ischemic stroke
    • Abbate R, Sofi F, Brogi D, Marcucci R. Emerging risk factors for ischemic stroke. Neurol Sci. 2003;24(suppl 1):S11-S12.
    • (2003) Neurol Sci , vol.24 , Issue.SUPPL. 1
    • Abbate, R.1    Sofi, F.2    Brogi, D.3    Marcucci, R.4
  • 68
    • 0038313220 scopus 로고    scopus 로고
    • Homocysteine and cerebral infarction in Finnish male smokers
    • Fallon UB, Virtamo J, Young I, et al. Homocysteine and cerebral infarction in Finnish male smokers. Stroke. 2003;34:1359-1363.
    • (2003) Stroke , vol.34 , pp. 1359-1363
    • Fallon, U.B.1    Virtamo, J.2    Young, I.3
  • 69
    • 0038680324 scopus 로고    scopus 로고
    • 6 but not homocyst(e)ine is associated with increased risk of stroke and transient ischemic attack in the era of folic acid grain fortification
    • 6 but not homocyst(e)ine is associated with increased risk of stroke and transient ischemic attack in the era of folic acid grain fortification. Stroke. 2003;34:e5l-54.
    • (2003) Stroke , vol.34
    • Kelly, P.J.1    Shih, V.E.2    Kistler, J.P.3
  • 70
    • 0037830396 scopus 로고    scopus 로고
    • Blood homocysteine levels in stroke patients undergoing rehabilitation
    • Sacher Y, Soroker N, Motin M, et al. Blood homocysteine levels in stroke patients undergoing rehabilitation. Med Sci Monit. 2003;9:CR201-207.
    • (2003) Med Sci Monit , vol.9
    • Sacher, Y.1    Soroker, N.2    Motin, M.3
  • 71
    • 0037075257 scopus 로고    scopus 로고
    • Plasma homocysteine as a risk factor for dementia and Alzheimer's disease
    • Seshadri S, Beiser A, Selhub J, et al. Plasma homocysteine as a risk factor for dementia and Alzheimer's disease. N Engl J Med. 2002;346:476-483.
    • (2002) N Engl J Med , vol.346 , pp. 476-483
    • Seshadri, S.1    Beiser, A.2    Selhub, J.3
  • 73
    • 0034953737 scopus 로고    scopus 로고
    • Homocysteine and cognitive decline in healthy elderly
    • McCaddon A, Hudson P, Davies G, et al. Homocysteine and cognitive decline in healthy elderly. Dement Geriatr Cogn Disord. 2001;12:309-313.
    • (2001) Dement Geriatr Cogn Disord , vol.12 , pp. 309-313
    • McCaddon, A.1    Hudson, P.2    Davies, G.3
  • 74
    • 0031597388 scopus 로고    scopus 로고
    • 12, and serum total homocysteine levels in confirmed Alzheimer disease
    • 12, and serum total homocysteine levels in confirmed Alzheimer disease. Arch Neurol. 1998;55:1449-1455.
    • (1998) Arch Neurol , vol.55 , pp. 1449-1455
    • Clarke, R.1    Smith, A.D.2    Jobst, K.A.3
  • 75
    • 0141889853 scopus 로고    scopus 로고
    • Risk factors for mild cognitive impairment in the Cardiovascular Health Study Cognition Study
    • Lopez O, Jagust WJ, Dulberg C, et al. Risk factors for mild cognitive impairment in the Cardiovascular Health Study Cognition Study. Arch Neurol. 2003;60:1394-1399.
    • (2003) Arch Neurol , vol.60 , pp. 1394-1399
    • Lopez, O.1    Jagust, W.J.2    Dulberg, C.3
  • 76
    • 0032889343 scopus 로고    scopus 로고
    • Identification of cognitive impairment in the elderly: Homocysteine is an early marker
    • Lehmann M, Gottfries CG, Regland B. Identification of cognitive impairment in the elderly: homocysteine is an early marker. Dement Geriatr Cogn Disord. 1999;10:12-20.
    • (1999) Dement Geriatr Cogn Disord , vol.10 , pp. 12-20
    • Lehmann, M.1    Gottfries, C.G.2    Regland, B.3
  • 77
    • 0034603841 scopus 로고    scopus 로고
    • Hyperhomocysteinemia increases risk of death, especially in type 2 diabetes: 5-year follow-up of the Hoorn Study
    • Hoogeveen EK, Kostense PJ, Jakobs C, et al. Hyperhomocysteinemia increases risk of death, especially in type 2 diabetes: 5-year follow-up of the Hoorn Study. Circulation. 2000;101:1506-1511.
    • (2000) Circulation , vol.101 , pp. 1506-1511
    • Hoogeveen, E.K.1    Kostense, P.J.2    Jakobs, C.3
  • 78
    • 0036294472 scopus 로고    scopus 로고
    • Hyperhomocysteinemia is a risk factor for cancer and a new potential tumor marker
    • Wu LL, Wu JT. Hyperhomocysteinemia is a risk factor for cancer and a new potential tumor marker. Clin Chim Acta. 2002;322:21-28.
    • (2002) Clin Chim Acta , vol.322 , pp. 21-28
    • Wu, L.L.1    Wu, J.T.2
  • 79
    • 0642287656 scopus 로고    scopus 로고
    • Medical hypothesis: Hyperhomocysteinemia is a risk factor for estrogen-induced hormonal cancer
    • Zhu BT. Medical hypothesis: hyperhomocysteinemia is a risk factor for estrogen-induced hormonal cancer. Int J Oncol. 2003;22:499-508.
    • (2003) Int J Oncol , vol.22 , pp. 499-508
    • Zhu, B.T.1
  • 80
    • 0038798681 scopus 로고    scopus 로고
    • Oxidative damage to cellular and isolated DNA by homocysteine: Implications for carcinogenesis
    • Oikawa S, Murakami K, Kawanishi S. Oxidative damage to cellular and isolated DNA by homocysteine: implications for carcinogenesis. Oncogene. 2003;22:3530-3538.
    • (2003) Oncogene , vol.22 , pp. 3530-3538
    • Oikawa, S.1    Murakami, K.2    Kawanishi, S.3
  • 82
    • 0033554459 scopus 로고    scopus 로고
    • Role of oxidant stress in endothelial dysfunction produced by experimental hyperhomocyst(e)inemia in humans
    • Kanani PM, Sinkey CA, Browning RL, et al. Role of oxidant stress in endothelial dysfunction produced by experimental hyperhomocyst(e)inemia in humans. Circulation. 1999;100:1161-1168.
    • (1999) Circulation , vol.100 , pp. 1161-1168
    • Kanani, P.M.1    Sinkey, C.A.2    Browning, R.L.3
  • 83
    • 0033537653 scopus 로고    scopus 로고
    • Demonstration of rapid onset vascular endothelial dysfunction after hyperhomocysteinemia: An effect reversible with vitamin C therapy
    • Chambers JC, McGregor A, Jean-Marie J, Obeid OA, Kooner JS. Demonstration of rapid onset vascular endothelial dysfunction after hyperhomocysteinemia: an effect reversible with vitamin C therapy. Circulation. 1999;99:1156-1160.
    • (1999) Circulation , vol.99 , pp. 1156-1160
    • Chambers, J.C.1    McGregor, A.2    Jean-Marie, J.3    Obeid, O.A.4    Kooner, J.S.5
  • 84
    • 0032724347 scopus 로고    scopus 로고
    • On the role of vitamin C and other antioxidants in atherogenesis and vascular dysfunction
    • Frei B. On the role of vitamin C and other antioxidants in atherogenesis and vascular dysfunction. Proc Soc Exp Biol Med. 1999;222:196-204.
    • (1999) Proc Soc Exp Biol Med , vol.222 , pp. 196-204
    • Frei, B.1
  • 85
    • 0036380213 scopus 로고    scopus 로고
    • Lipoic acid and vitamin C potentiate nitric oxide synthesis in human aortic endothelial cells independently of cellular glutathione status
    • Visioli F, Smith A, Zhang W, et al. Lipoic acid and vitamin C potentiate nitric oxide synthesis in human aortic endothelial cells independently of cellular glutathione status. Redox Rep. 2002;7:223-227.
    • (2002) Redox Rep , vol.7 , pp. 223-227
    • Visioli, F.1    Smith, A.2    Zhang, W.3
  • 86
    • 0014859783 scopus 로고
    • Production of arteriosclerosis by homocysteinemia
    • McCully K, Ragsdale B. Production of arteriosclerosis by homocysteinemia. Am J Pathol. 1970;61:1-8.
    • (1970) Am J Pathol , vol.61 , pp. 1-8
    • McCully, K.1    Ragsdale, B.2
  • 87
    • 0016743933 scopus 로고
    • Homocysteine theory of arteriosclerosis
    • McCully K, Wilson R. Homocysteine theory of arteriosclerosis. Atherosclerosis. 1975;22:215-227.
    • (1975) Atherosclerosis , vol.22 , pp. 215-227
    • McCully, K.1    Wilson, R.2
  • 88
    • 1842378618 scopus 로고    scopus 로고
    • Homocysteine, oxidative stress and vascular disease
    • Welch G, Upchurch G, Loscalzo J. Homocysteine, oxidative stress and vascular disease. Hosp Pract. 1997;32:81-92.
    • (1997) Hosp Pract , vol.32 , pp. 81-92
    • Welch, G.1    Upchurch, G.2    Loscalzo, J.3
  • 89
    • 1842411860 scopus 로고    scopus 로고
    • Homocyst(e)ine decreases bioavailable nitric oxide by a mechanism involving glutathione peroxidase
    • Upchurch GJ, Welch G, Fabian A, et al. Homocyst(e)ine decreases bioavailable nitric oxide by a mechanism involving glutathione peroxidase. J Biol Chem. 1997;272:17012-17017.
    • (1997) J Biol Chem , vol.272 , pp. 17012-17017
    • Upchurch, G.J.1    Welch, G.2    Fabian, A.3
  • 90
    • 0022552919 scopus 로고
    • Endothelial cell injury due to copper-catalyzed hydrogen peroxide generation from homocysteine
    • Starkekbaum G, Harlan J. Endothelial cell injury due to copper-catalyzed hydrogen peroxide generation from homocysteine. J Clin Invest. 1986;77:1370-1376.
    • (1986) J Clin Invest , vol.77 , pp. 1370-1376
    • Starkekbaum, G.1    Harlan, J.2
  • 91
    • 0021041780 scopus 로고
    • Effect of sulfinpyrazone on homocysteine-induced endothelial injury and arteriosclerosis in baboons
    • Harker L, Harian J, Ross R. Effect of sulfinpyrazone on homocysteine-induced endothelial injury and arteriosclerosis in baboons. Circ Res. 1983;53:731-739.
    • (1983) Circ Res , vol.53 , pp. 731-739
    • Harker, L.1    Harian, J.2    Ross, R.3
  • 92
    • 0027092328 scopus 로고
    • Endothelium-derived relaxing factor modulates the atherothrombogenic effects of homocysteine
    • Stamler J, Loscallzo J. Endothelium-derived relaxing factor modulates the atherothrombogenic effects of homocysteine. J Cardiol Pharmacol. 1992;20:S202-S204.
    • (1992) J Cardiol Pharmacol , vol.20
    • Stamler, J.1    Loscallzo, J.2
  • 93
    • 0042666891 scopus 로고    scopus 로고
    • Effects of homocysteine on L-arginine transport and nitric oxide formation in human platelets
    • Leoncini G, Pascale R, Signorello MG. Effects of homocysteine on L-arginine transport and nitric oxide formation in human platelets. Eur J Clin Invest. 2003;33:713-719.
    • (2003) Eur J Clin Invest , vol.33 , pp. 713-719
    • Leoncini, G.1    Pascale, R.2    Signorello, M.G.3
  • 94
    • 0038645125 scopus 로고    scopus 로고
    • Endothelial nitric oxide synthase gene polymorphism, homocysteine, cholesterol and vascular endothelial function
    • Bilsborough W, Green DJ, Mamotte CD, et al. Endothelial nitric oxide synthase gene polymorphism, homocysteine, cholesterol and vascular endothelial function. Atherosclerosis. 2003;169:131-138.
    • (2003) Atherosclerosis , vol.169 , pp. 131-138
    • Bilsborough, W.1    Green, D.J.2    Mamotte, C.D.3
  • 95
    • 0041357001 scopus 로고    scopus 로고
    • Endothelial dysfunction induced by hyperhomocyst(e)inemia: Role of asymmetric dimethylarginine
    • Stuhlinger MC, Oka RK, Graf EE, et al. Endothelial dysfunction induced by hyperhomocyst(e)inemia: role of asymmetric dimethylarginine. Circulation. 2003;108:933-938.
    • (2003) Circulation , vol.108 , pp. 933-938
    • Stuhlinger, M.C.1    Oka, R.K.2    Graf, E.E.3
  • 96
    • 0142062109 scopus 로고    scopus 로고
    • Asymmetric dimethylarginine and total homocysteine in plasma after oral methionine loading
    • Wanby P, Brattstrom L, Brudin L, Hultberg B, Teerlink T. Asymmetric dimethylarginine and total homocysteine in plasma after oral methionine loading. Scand J Clin Lab Invest. 2003;63:347-353.
    • (2003) Scand J Clin Lab Invest , vol.63 , pp. 347-353
    • Wanby, P.1    Brattstrom, L.2    Brudin, L.3    Hultberg, B.4    Teerlink, T.5
  • 97
    • 0038787783 scopus 로고    scopus 로고
    • Hyperhomocysteinaemia is not associated with increased levels of asymmetric dimethylarginine in patients with ischaemic heart disease
    • Jonasson TF, Hedner T, Hultberg B, Ohlin H. Hyperhomocysteinaemia is not associated with increased levels of asymmetric dimethylarginine in patients with ischaemic heart disease. Eur J Clin Invest. 2003;33:543-549.
    • (2003) Eur J Clin Invest , vol.33 , pp. 543-549
    • Jonasson, T.F.1    Hedner, T.2    Hultberg, B.3    Ohlin, H.4
  • 98
    • 0029866820 scopus 로고    scopus 로고
    • Homocysteine EDRF and endothelial function
    • Upchurch GJ, Welch G, Loscalzo J. Homocysteine EDRF and endothelial function. J Nutr. 1996;126:1290S-1294S.
    • (1996) J Nutr , vol.126
    • Upchurch, G.J.1    Welch, G.2    Loscalzo, J.3
  • 99
    • 0028298171 scopus 로고
    • Promotion of vascular smooth muscle cell growth by homocysteine: A link to atherosclerosis
    • Tsai J, Perrella M, Yoshizumi M, et al. Promotion of vascular smooth muscle cell growth by homocysteine: a link to atherosclerosis. Proc Natl Acad Sci U S A. 1994;91:6369-6373.
    • (1994) Proc Natl Acad Sci U S A , vol.91 , pp. 6369-6373
    • Tsai, J.1    Perrella, M.2    Yoshizumi, M.3
  • 100
    • 13344270367 scopus 로고    scopus 로고
    • Induction of cyclin A gene expression by homocysteine in vascular smooth muscle cells
    • Tsai J-C, Wang H, Perrella M, et al. Induction of cyclin A gene expression by homocysteine in vascular smooth muscle cells. J Clin Invest. 1996;97:146-153.
    • (1996) J Clin Invest , vol.97 , pp. 146-153
    • Tsai, J.-C.1    Wang, H.2    Perrella, M.3
  • 101
    • 0031965641 scopus 로고    scopus 로고
    • Homocysteine-induced nitric oxide production in vascular smooth muscle cells by NF-κB dependent transcriptional activation of Nos 2
    • Welch G, Upchurch G, Farivar R, et al. Homocysteine-induced nitric oxide production in vascular smooth muscle cells by NF-κB dependent transcriptional activation of Nos 2. Proc Am Assoc Phys. 1998;110:22-31.
    • (1998) Proc Am Assoc Phys , vol.110 , pp. 22-31
    • Welch, G.1    Upchurch, G.2    Farivar, R.3
  • 102
    • 17344368557 scopus 로고    scopus 로고
    • Homocysteine as a risk factor for vascular disease. Enhanced collagen production and accumulation by smooth muscle cells
    • Majors A, Ehrhart L, Pezacka E. Homocysteine as a risk factor for vascular disease. Enhanced collagen production and accumulation by smooth muscle cells. Arterioscler Thromb Vasc Biol. 1997;17:2074-2081.
    • (1997) Arterioscler Thromb Vasc Biol , vol.17 , pp. 2074-2081
    • Majors, A.1    Ehrhart, L.2    Pezacka, E.3
  • 103
    • 0030610589 scopus 로고    scopus 로고
    • ras methylation in vascular endothelial cells by homocysteine but not cysteine
    • ras methylation in vascular endothelial cells by homocysteine but not cysteine. J Biol Chem. 199;272:25380-25385.
    • J Biol Chem , vol.199 , Issue.272 , pp. 25380-25385
    • Wang, H.1    Yoshizumi, M.2    Lai, K.3
  • 104
    • 0017197285 scopus 로고
    • Homocystine-induced arteriosclerosis: The role of endothelial cell injury and platelet response in its genesis
    • Harker L, Ross R, Slichter S, Scott C. Homocystine-induced arteriosclerosis: the role of endothelial cell injury and platelet response in its genesis. J Clin Invest. 1976;58:731-741.
    • (1976) J Clin Invest , vol.58 , pp. 731-741
    • Harker, L.1    Ross, R.2    Slichter, S.3    Scott, C.4
  • 105
    • 0027247803 scopus 로고
    • Abnormally high thromboxane biosynthesis in homozygous homocystinuria. Evidence for platelet involvement and probucol-sensitive mechanism
    • Di Minno G, Davi G, Margaglione M, et al. Abnormally high thromboxane biosynthesis in homozygous homocystinuria. Evidence for platelet involvement and probucol-sensitive mechanism. J Clin Invest. 1993;92:1400-1406.
    • (1993) J Clin Invest , vol.92 , pp. 1400-1406
    • Di Minno, G.1    Davi, G.2    Margaglione, M.3
  • 106
    • 0027531427 scopus 로고
    • Adverse vascular effects of homocysteine are modulated by endothelium-derived relaxing factor and related oxides of nitrogen
    • Stamler J, Osborne J, Jaraki O, et al. Adverse vascular effects of homocysteine are modulated by endothelium-derived relaxing factor and related oxides of nitrogen. J Clin Invest. 1993;91:308-318.
    • (1993) J Clin Invest , vol.91 , pp. 308-318
    • Stamler, J.1    Osborne, J.2    Jaraki, O.3
  • 107
    • 0030119805 scopus 로고    scopus 로고
    • Homocysteine and hemostasis: Pathogenetic mechanisms predisposing to thrombosis
    • Harpel P, Zhang X, Borth W. Homocysteine and hemostasis: pathogenetic mechanisms predisposing to thrombosis. J Nutr. 1996;126:1285S-1289S.
    • (1996) J Nutr , vol.126
    • Harpel, P.1    Zhang, X.2    Borth, W.3
  • 108
    • 0029928653 scopus 로고    scopus 로고
    • Pro-thrombotic effects of a folic acid deficient diet in rat platelets and macrophages related to elevated homocysteine and decreased n-3 polyunsaturated fatty acids
    • Durand P, Prost M, Blache D. Pro-thrombotic effects of a folic acid deficient diet in rat platelets and macrophages related to elevated homocysteine and decreased n-3 polyunsaturated fatty acids. Atherosclerosis. 1996;121:231-243.
    • (1996) Atherosclerosis , vol.121 , pp. 231-243
    • Durand, P.1    Prost, M.2    Blache, D.3
  • 109
    • 0030728675 scopus 로고    scopus 로고
    • Acute methionine load induced hyperhomocysteinemia enhances platelet aggregation, thromboxane biosynthesis, and macrophage-derived tissue factor activity in rats
    • Durand P, Lussier-Cacan S, Blache D. Acute methionine load induced hyperhomocysteinemia enhances platelet aggregation, thromboxane biosynthesis, and macrophage-derived tissue factor activity in rats. FASEB Lett. 1997;11:1157-1168.
    • (1997) FASEB Lett , vol.11 , pp. 1157-1168
    • Durand, P.1    Lussier-Cacan, S.2    Blache, D.3
  • 110
    • 0014434483 scopus 로고
    • Activation of Hageman factor by L-homocystine
    • Ratnoff O. Activation of Hageman factor by L-homocystine. Science. 1968;162:1007-1009.
    • (1968) Science , vol.162 , pp. 1007-1009
    • Ratnoff, O.1
  • 111
    • 0025190042 scopus 로고
    • Homocysteine, an atherogenic stimulus, reduces protein C activation by arterial and venous endothelial cells
    • Rodgers G, Conn M. Homocysteine, an atherogenic stimulus, reduces protein C activation by arterial and venous endothelial cells. Blood. 1990;75:895-901.
    • (1990) Blood , vol.75 , pp. 895-901
    • Rodgers, G.1    Conn, M.2
  • 112
    • 0027250615 scopus 로고
    • Homocysteine, a risk factor for premature vascular disease and thrombosis, induces tissue factor activity in endothelial cells
    • Fryer R, Wilson B, Gubler D, Fitzgerald L, Rodgers G. Homocysteine, a risk factor for premature vascular disease and thrombosis, induces tissue factor activity in endothelial cells. Arterioscler Thromb Vasc Biol. 1993;13:405-410.
    • (1993) Arterioscler Thromb Vasc Biol , vol.13 , pp. 405-410
    • Fryer, R.1    Wilson, B.2    Gubler, D.3    Fitzgerald, L.4    Rodgers, G.5
  • 113
    • 0027319970 scopus 로고
    • Homocysteine, a thrombogenic agent, suppresses anticoagulant heparan sulfate expression in cultured porcine aortic endothelial cells
    • Nishinaga M, Ozawa T, Shimada K. Homocysteine, a thrombogenic agent, suppresses anticoagulant heparan sulfate expression in cultured porcine aortic endothelial cells. J Clin Invest. 1993;92:1381-1386.
    • (1993) J Clin Invest , vol.92 , pp. 1381-1386
    • Nishinaga, M.1    Ozawa, T.2    Shimada, K.3
  • 114
    • 0032540276 scopus 로고    scopus 로고
    • Tissue plasminogen activator binding to the annexin II tail domain
    • Hajjar K, Mauri L, Jacovina A, et al. Tissue plasminogen activator binding to the annexin II tail domain. J Biol Chem. 1998;273:9987-9993.
    • (1998) J Biol Chem , vol.273 , pp. 9987-9993
    • Hajjar, K.1    Mauri, L.2    Jacovina, A.3
  • 115
    • 0026345948 scopus 로고
    • Inhibition of thrombomodulin surface expression and protein C activation by the thrombogenic agent homocysteine
    • Lentz S, Sadler J. Inhibition of thrombomodulin surface expression and protein C activation by the thrombogenic agent homocysteine. J Clin Invest. 1991;88:1906-1914.
    • (1991) J Clin Invest , vol.88 , pp. 1906-1914
    • Lentz, S.1    Sadler, J.2
  • 116
    • 0031452131 scopus 로고    scopus 로고
    • Platelet and monocyte variables in homocystinuria due to cystathionine-beta-synthase deficiency
    • Coppola A, Albisinni R, Madonna P, et al. Platelet and monocyte variables in homocystinuria due to cystathionine-beta-synthase deficiency. Haematologica. 1997;92:189-190.
    • (1997) Haematologica , vol.92 , pp. 189-190
    • Coppola, A.1    Albisinni, R.2    Madonna, P.3
  • 117
    • 0030015522 scopus 로고    scopus 로고
    • Vascular dysfunction in monkeys with diet-induced hyperhomocyst(e)inenia
    • Lentz S, Sobey C, Piegors D, et al. Vascular dysfunction in monkeys with diet-induced hyperhomocyst(e)inenia. J Clin Invest. 1996;98:24-29.
    • (1996) J Clin Invest , vol.98 , pp. 24-29
    • Lentz, S.1    Sobey, C.2    Piegors, D.3
  • 118
    • 14044276314 scopus 로고    scopus 로고
    • Mechanisms of increased vascular oxidant stress in hyperhomocysteinemia and its impact on endothelial function
    • Weiss N. Mechanisms of increased vascular oxidant stress in hyperhomocysteinemia and its impact on endothelial function. Curr Drug Metab. 2005;6:27-36.
    • (2005) Curr Drug Metab , vol.6 , pp. 27-36
    • Weiss, N.1
  • 119
    • 2942558814 scopus 로고    scopus 로고
    • Homocysteine induces oxidative stress by uncoupling of NO synthase through reduction of tetrahydrobiopterin
    • Topol G, Brunet A, Millanvoye E, et al. Homocysteine induces oxidative stress by uncoupling of NO synthase through reduction of tetrahydrobiopterin. Free Radic Biol Med. 2004;36:1532-1541.
    • (2004) Free Radic Biol Med , vol.36 , pp. 1532-1541
    • Topol, G.1    Brunet, A.2    Millanvoye, E.3
  • 120
    • 0033188148 scopus 로고    scopus 로고
    • Homocysteine induces DNA synthesis and proliferation of vascular smooth muscle cells by a hydrogen-peroxide-independent mechanism
    • Fall
    • Taha S, Azzi A, Ozer NK. Homocysteine induces DNA synthesis and proliferation of vascular smooth muscle cells by a hydrogen-peroxide-independent mechanism. Antioxid Redox Signal. 1999;Fall(3):365-369.
    • (1999) Antioxid Redox Signal , vol.3 , pp. 365-369
    • Taha, S.1    Azzi, A.2    Ozer, N.K.3
  • 121
    • 0033980003 scopus 로고    scopus 로고
    • Effects of homocysteine on smooth muscle cell proliferation in both cell culture and artery perfusion culture models
    • Chen C, Halkos ME, Surowiec SM, et al. Effects of homocysteine on smooth muscle cell proliferation in both cell culture and artery perfusion culture models. J Surg Rex. 2000;88(1):26-33.
    • (2000) J Surg Rex , vol.88 , Issue.1 , pp. 26-33
    • Chen, C.1    Halkos, M.E.2    Surowiec, S.M.3
  • 123
    • 0017284939 scopus 로고
    • The pathogenesis of coronary artery disease. A possible role for methionine metabolism
    • Wilcken D, Wilcken B. The pathogenesis of coronary artery disease. A possible role for methionine metabolism. J. Clin Invest. 1976;57:1079-1082.
    • (1976) J. Clin Invest , vol.57 , pp. 1079-1082
    • Wilcken, D.1    Wilcken, B.2
  • 124
    • 0029066299 scopus 로고
    • A quantitative assessment of plasma homocysteine as a risk factor for vascular disease
    • Boushey C, Beresford S, Omenn G, Motulsky A. A quantitative assessment of plasma homocysteine as a risk factor for vascular disease. JAMA. 1995;274:1049-1057.
    • (1995) JAMA , vol.274 , pp. 1049-1057
    • Boushey, C.1    Beresford, S.2    Omenn, G.3    Motulsky, A.4
  • 125
    • 1842331509 scopus 로고    scopus 로고
    • Plasma homocysteine as a risk factor for vascular disease: The European Concerted Action Project
    • Graham I, Daly L, Refsum H, et al. Plasma homocysteine as a risk factor for vascular disease: the European Concerted Action Project. JAMA. 1997;277:1775-1781.
    • (1997) JAMA , vol.277 , pp. 1775-1781
    • Graham, I.1    Daly, L.2    Refsum, H.3
  • 126
    • 0031426012 scopus 로고    scopus 로고
    • High plasma homocysteine: A risk factor for arterial and venous thrombosis in patients with normal coagulation profiles
    • Kottke-Marchant K, Green R, Jacobsen D, et al. High plasma homocysteine: a risk factor for arterial and venous thrombosis in patients with normal coagulation profiles. Clin Appl Thromb Hemost. 1997;3:239-244.
    • (1997) Clin Appl Thromb Hemost , vol.3 , pp. 239-244
    • Kottke-Marchant, K.1    Green, R.2    Jacobsen, D.3
  • 127
    • 0031801972 scopus 로고    scopus 로고
    • Association between elevated plasma total homocysteine and increased common carotid artery wall thickness
    • Voutilainen S, Alfthan G, Nyyssonen K, Salonen R, Salonen J. Association between elevated plasma total homocysteine and increased common carotid artery wall thickness. Ann Med. 1998;30:300-306.
    • (1998) Ann Med , vol.30 , pp. 300-306
    • Voutilainen, S.1    Alfthan, G.2    Nyyssonen, K.3    Salonen, R.4    Salonen, J.5
  • 128
    • 0025093062 scopus 로고
    • Plasma homocyst(e)ine levels in men with premature coronary artery disease
    • Genest JJ, McNamara JR, Salem DN, et al. Plasma homocyst(e)ine levels in men with premature coronary artery disease. J Am Coll Cardiol. 1990;16:1114-1119.
    • (1990) J Am Coll Cardiol , vol.16 , pp. 1114-1119
    • Genest, J.J.1    McNamara, J.R.2    Salem, D.N.3
  • 129
    • 0026552225 scopus 로고
    • Hyperhomocysteinaemia in stroke: Prevalence cause, and relationships to type of stroke and stroke risk factors
    • Brattstrom L, Lindgren A, Israelsson B, et al. Hyperhomocysteinaemia in stroke: prevalence cause, and relationships to type of stroke and stroke risk factors. Eur J Clin Invest. 1992;22:214-221.
    • (1992) Eur J Clin Invest , vol.22 , pp. 214-221
    • Brattstrom, L.1    Lindgren, A.2    Israelsson, B.3
  • 130
    • 0027523674 scopus 로고
    • Carotid artery intimal-medial wall thickening and plasma homocyst(e)ine in asymptomatic adults: The Atherosclerosis in Communities (ARIC) Study
    • Malinow MR, Nieto FJ, Sklo M, Chambless LE, Bond G. Carotid artery intimal-medial wall thickening and plasma homocyst(e)ine in asymptomatic adults: the Atherosclerosis in Communities (ARIC) Study. Circulation. 1993;87:1107-1113.
    • (1993) Circulation , vol.87 , pp. 1107-1113
    • Malinow, M.R.1    Nieto, F.J.2    Sklo, M.3    Chambless, L.E.4    Bond, G.5
  • 131
    • 0028966321 scopus 로고
    • Association between plasma homocysteine concentrations and extracranial carotid-artery stenosis
    • Selhub J, lacques PF, Bostom AG, et al. Association between plasma homocysteine concentrations and extracranial carotid-artery stenosis. N Engl J Med. 1995;332:286-291.
    • (1995) N Engl J Med , vol.332 , pp. 286-291
    • Selhub, J.1    lacques, P.F.2    Bostom, A.G.3
  • 132
    • 0032501963 scopus 로고    scopus 로고
    • Low circulating folate and vitamin B6 concentrations. Risk factors for stroke, peripheral vascular disease, and coronary artery disease
    • for the European COMAC Group
    • Robinson K, Arheart K, Refsum H, et al. for the European COMAC Group. Low circulating folate and vitamin B6 concentrations. Risk factors for stroke, peripheral vascular disease, and coronary artery disease. Circulation. 1998;97:437-443.
    • (1998) Circulation , vol.97 , pp. 437-443
    • Robinson, K.1    Arheart, K.2    Refsum, H.3
  • 133
    • 0032555167 scopus 로고    scopus 로고
    • Prospective study of coronary heart disease incidence in relation to fasting total homocysteine, related genetic polymorphisms, and B vitamins. The Atherosclerosis Risk in Communities (ARIC) Study
    • Folsom AR, Nieto FJ, McGovern PG, et al. Prospective study of coronary heart disease incidence in relation to fasting total homocysteine, related genetic polymorphisms, and B vitamins. The Atherosclerosis Risk in Communities (ARIC) Study. Circulation. 1998;98:204-210.
    • (1998) Circulation , vol.98 , pp. 204-210
    • Folsom, A.R.1    Nieto, F.J.2    McGovern, P.G.3
  • 134
    • 0021998698 scopus 로고
    • Heterozygosity for homocystinuria in premature peripheral and cerebral occlusive arterial disease
    • Boers G, Smals A, Trijbels F, et al. Heterozygosity for homocystinuria in premature peripheral and cerebral occlusive arterial disease. N Engl J Med. 1985;313:709-715.
    • (1985) N Engl J Med , vol.313 , pp. 709-715
    • Boers, G.1    Smals, A.2    Trijbels, F.3
  • 135
    • 0024391453 scopus 로고
    • Prevalence of hyperhomocyst(e)inemia in patients with peripheral arterial occlusive disease
    • Malinow M, Kang S, Taylor L, et al. Prevalence of hyperhomocyst(e)inemia in patients with peripheral arterial occlusive disease. Circulation. 1989;79:1180-1188.
    • (1989) Circulation , vol.79 , pp. 1180-1188
    • Malinow, M.1    Kang, S.2    Taylor, L.3
  • 136
    • 0026684554 scopus 로고
    • A prospective study of plasma homocyst(e)ine and risk of myocardial infarction in US physicians
    • Stampfer M, Malinow M, Willett W, et al. A prospective study of plasma homocyst(e)ine and risk of myocardial infarction in US physicians. JAMA. 1992;268:877-881.
    • (1992) JAMA , vol.268 , pp. 877-881
    • Stampfer, M.1    Malinow, M.2    Willett, W.3
  • 137
    • 0027523674 scopus 로고
    • Carotid artery intimal-medial wall thickening and plasma homocyst(e)ine in asymptomatic adults
    • Malinow M, Nieto F, Szklo M, Chambless L, Bond G. Carotid artery intimal-medial wall thickening and plasma homocyst(e)ine in asymptomatic adults. Circulation. 1993;87:1107-1113.
    • (1993) Circulation , vol.87 , pp. 1107-1113
    • Malinow, M.1    Nieto, F.2    Szklo, M.3    Chambless, L.4    Bond, G.5
  • 138
    • 0030912329 scopus 로고    scopus 로고
    • Correlation between plasma homocyst(e)ine and aortic atherosclerosis
    • Konechy N, Malinow M, Tunick P, et al. Correlation between plasma homocyst(e)ine and aortic atherosclerosis. Am Heart. 1997;133:534-540.
    • (1997) Am Heart , vol.133 , pp. 534-540
    • Konechy, N.1    Malinow, M.2    Tunick, P.3
  • 139
    • 0028210769 scopus 로고
    • Plasma homocyst(e)ine as a risk factor for early familial coronary artery disease
    • Wu L, Wu J, Hunt S, et al. Plasma homocyst(e)ine as a risk factor for early familial coronary artery disease. Clin Chem. 1994;40:552-561.
    • (1994) Clin Chem , vol.40 , pp. 552-561
    • Wu, L.1    Wu, J.2    Hunt, S.3
  • 140
    • 0029088620 scopus 로고
    • Higher plasma homocyst(e)ine and increased susceptibility to adverse effects of low folate in early familial coronary artery disease
    • Hopkins P, Wu L, Wu J, et al. Higher plasma homocyst(e)ine and increased susceptibility to adverse effects of low folate in early familial coronary artery disease. Arterioscler Thromb Vasc Biol. 1995;15:1314-1320.
    • (1995) Arterioscler Thromb Vasc Biol , vol.15 , pp. 1314-1320
    • Hopkins, P.1    Wu, L.2    Wu, J.3
  • 143
    • 0030994488 scopus 로고    scopus 로고
    • Plasma total homocysteine, B vitamins, and risk of coronary atherosclerosis
    • Verhoef P, Kok F, Kruyssen D, et al. Plasma total homocysteine, B vitamins, and risk of coronary atherosclerosis. Arterioscler Thromb Vasc Biol. 1997;17:989-995.
    • (1997) Arterioscler Thromb Vasc Biol , vol.17 , pp. 989-995
    • Verhoef, P.1    Kok, F.2    Kruyssen, D.3
  • 144
    • 1842370239 scopus 로고    scopus 로고
    • Plasma homocysteine levels and mortality in patients with coronary artery disease
    • Nygard O, Nordrehaug J, Refsum H, et al. Plasma homocysteine levels and mortality in patients with coronary artery disease. N Engl J Med. 1997;1337:230-236.
    • (1997) N Engl J Med , vol.1337 , pp. 230-236
    • Nygard, O.1    Nordrehaug, J.2    Refsum, H.3
  • 145
    • 0032571596 scopus 로고    scopus 로고
    • Homocysteine and ischemic heart disease
    • Wald N, Watt H, Law M, et al. Homocysteine and ischemic heart disease. Arch Intern Med. 1998;1158:862-867.
    • (1998) Arch Intern Med , vol.1158 , pp. 862-867
    • Wald, N.1    Watt, H.2    Law, M.3
  • 146
    • 0028219672 scopus 로고
    • Relation of serum homocysteine and lipoprotein (a) concentrations to atherosclerotic disease in a prospective Finnish population based study
    • Alfthan G, Pekkanen J, Jauhiainen M, et al. Relation of serum homocysteine and lipoprotein (a) concentrations to atherosclerotic disease in a prospective Finnish population based study. Atherosclerosis. 1994;106:9-19.
    • (1994) Atherosclerosis , vol.106 , pp. 9-19
    • Alfthan, G.1    Pekkanen, J.2    Jauhiainen, M.3
  • 147
    • 0031457858 scopus 로고    scopus 로고
    • Evans R, Shaten J, Hempel J, Cutler J, Kuller L. for the MRFIT Research Group. Homocyst(e)ine and risk of cardiovascular disease in the multiple risk factor intervention trial. Arterioscler Thromb Vasc Biol. 1997;17:1947-1953.
    • Evans R, Shaten J, Hempel J, Cutler J, Kuller L. for the MRFIT Research Group. Homocyst(e)ine and risk of cardiovascular disease in the multiple risk factor intervention trial. Arterioscler Thromb Vasc Biol. 1997;17:1947-1953.
  • 148
    • 0032555167 scopus 로고    scopus 로고
    • Prospective study of coronary heart disease incidence in relation to fasting total homocysteine, related genetic polymorphisms, and B vitamins
    • Folsom A, Nieto F, McGovern P, et al. Prospective study of coronary heart disease incidence in relation to fasting total homocysteine, related genetic polymorphisms, and B vitamins. Circulation. 1998;98:204-210.
    • (1998) Circulation , vol.98 , pp. 204-210
    • Folsom, A.1    Nieto, F.2    McGovern, P.3
  • 149
    • 0026520124 scopus 로고
    • Hyperhomocyst(e)inemia: An independent risk factor for claudication
    • Molgaard J, Malinow M, Lassvik C, et al. Hyperhomocyst(e)inemia: an independent risk factor for claudication. J Intern Med. 1992;231:273-279.
    • (1992) J Intern Med , vol.231 , pp. 273-279
    • Molgaard, J.1    Malinow, M.2    Lassvik, C.3
  • 150
    • 0032481152 scopus 로고    scopus 로고
    • 6, from diet and supplements in relation to risk of coronary heart disease among women
    • 6, from diet and supplements in relation to risk of coronary heart disease among women. JAMA. 1998;279:359-364.
    • (1998) JAMA , vol.279 , pp. 359-364
    • Rimm, E.1    Willett, W.2    Hu, F.3
  • 151
    • 0027382008 scopus 로고
    • Vitamin status and intake as primary determinants of homocysteinemia in an elderly population
    • Selhub J, Jacques P, Wilson P, Rush D, Rosenberg I. Vitamin status and intake as primary determinants of homocysteinemia in an elderly population. JAMA. 1993;270:2693-2698.
    • (1993) JAMA , vol.270 , pp. 2693-2698
    • Selhub, J.1    Jacques, P.2    Wilson, P.3    Rush, D.4    Rosenberg, I.5
  • 152
    • 0031909758 scopus 로고    scopus 로고
    • Plasma total homocysteine levels in patients with early-onset coronary heart disease and low cardiovascular risk profile
    • Donner MG, Klein GK, Mathes PB, Schandt P, Richter WO. Plasma total homocysteine levels in patients with early-onset coronary heart disease and low cardiovascular risk profile. Metabolism. 1998;47:273-279.
    • (1998) Metabolism , vol.47 , pp. 273-279
    • Donner, M.G.1    Klein, G.K.2    Mathes, P.B.3    Schandt, P.4    Richter, W.O.5
  • 153
    • 0030826587 scopus 로고    scopus 로고
    • Thermolabile methylenetetrahydrofolate reductase in coronary artery disease
    • Kluijtmans LAJ, Kastelein JJP, Lindemans J, et al. Thermolabile methylenetetrahydrofolate reductase in coronary artery disease. Circulation. 1997;96:2573-2577.
    • (1997) Circulation , vol.96 , pp. 2573-2577
    • Kluijtmans, L.A.J.1    Kastelein, J.J.P.2    Lindemans, J.3
  • 154
    • 0030775334 scopus 로고    scopus 로고
    • Common mutation in the methylenetetrahydrofolate reductase gene offers no support for mild hyperhomocysteinemia being a causal risk factor for cardiovascular disease
    • Brattström L. Common mutation in the methylenetetrahydrofolate reductase gene offers no support for mild hyperhomocysteinemia being a causal risk factor for cardiovascular disease. Circulation. 1997;96:3805-3806.
    • (1997) Circulation , vol.96 , pp. 3805-3806
    • Brattström, L.1
  • 156
    • 0029921114 scopus 로고    scopus 로고
    • Hyperhomocysteinemia as a risk factor for deep-vein thrombosis
    • den Heijer M, Koster T, Blom HJ, et al. Hyperhomocysteinemia as a risk factor for deep-vein thrombosis. N Engl J Med. 1996;334:759-762.
    • (1996) N Engl J Med , vol.334 , pp. 759-762
    • den Heijer, M.1    Koster, T.2    Blom, H.J.3
  • 157
    • 17344370074 scopus 로고    scopus 로고
    • Vitamin supplementation reduces blood homocysteine levels. A controlled trial in patients with venous thrombosis and healthy volunteers
    • den Heijer M, Brouwer I, Bos G, et al. Vitamin supplementation reduces blood homocysteine levels. A controlled trial in patients with venous thrombosis and healthy volunteers. Arterioscler Thromb Vasc Biol. 1998;18:356-361.
    • (1998) Arterioscler Thromb Vasc Biol , vol.18 , pp. 356-361
    • den Heijer, M.1    Brouwer, I.2    Bos, G.3
  • 158
    • 0030299976 scopus 로고    scopus 로고
    • Hyperhomocysteinemia and deep-vein thrombosis: A case control study
    • Simioni P, Prandoni P, Burlina A, et al. Hyperhomocysteinemia and deep-vein thrombosis: a case control study. Thromb Haemost. 1996;76:883-886.
    • (1996) Thromb Haemost , vol.76 , pp. 883-886
    • Simioni, P.1    Prandoni, P.2    Burlina, A.3
  • 160
    • 0031754849 scopus 로고    scopus 로고
    • Hyperhomocysteinemia is a risk factor of recurrent venous thromboembolism
    • Eichinger S, Stümpfen A, Hirschl M, et al. Hyperhomocysteinemia is a risk factor of recurrent venous thromboembolism. Thromb Haemost. 1998;80:566-569.
    • (1998) Thromb Haemost , vol.80 , pp. 566-569
    • Eichinger, S.1    Stümpfen, A.2    Hirschl, M.3
  • 162
    • 0028853921 scopus 로고
    • Prevalence of moderate hyperhomocysteinemia in patients with early-onset venous and arterial occlusive disease
    • Fermo I, Vigano' D'Angelo V, Paroni R, et al. Prevalence of moderate hyperhomocysteinemia in patients with early-onset venous and arterial occlusive disease. Ann Intern Med. 1995;123:747-753.
    • (1995) Ann Intern Med , vol.123 , pp. 747-753
    • Fermo, I.1    Vigano' D'Angelo, V.2    Paroni, R.3
  • 163
    • 0030953866 scopus 로고    scopus 로고
    • Interrelation of hyperhomocyst(e)inemia, factor V Leiden, and risk of future venous thromboembolism
    • Ridker P, Hennekens C, Selhub J, et al. Interrelation of hyperhomocyst(e)inemia, factor V Leiden, and risk of future venous thromboembolism. Circulation. 1997;95:1777-1782.
    • (1997) Circulation , vol.95 , pp. 1777-1782
    • Ridker, P.1    Hennekens, C.2    Selhub, J.3
  • 164
    • 17344369482 scopus 로고    scopus 로고
    • Hyperhomocyst(e)mia and a common methylenetetrahydrofolate reductase mutation (Ala223Val MTHFR) in patients with inherited thrombophilic coagulation defects
    • Legnani C, Palareti G, Grauso F, et al. Hyperhomocyst(e)mia and a common methylenetetrahydrofolate reductase mutation (Ala223Val MTHFR) in patients with inherited thrombophilic coagulation defects. Arterioscler Thromb Vasc Biol. 1997;17:2924-2929.
    • (1997) Arterioscler Thromb Vasc Biol , vol.17 , pp. 2924-2929
    • Legnani, C.1    Palareti, G.2    Grauso, F.3
  • 165
    • 0030610090 scopus 로고    scopus 로고
    • The mutation ALA677→VAL in the methylenetetrahydrofolate reductase gene: A risk factor for arterial disease and venous thrombosis
    • Arruda VR, von Zuben PM, Chiaparini LC, Annichino-Bizzacchi JM, Costa FF. The mutation ALA677→VAL in the methylenetetrahydrofolate reductase gene: a risk factor for arterial disease and venous thrombosis. Thromb Haemost. 1997;77:818-821.
    • (1997) Thromb Haemost , vol.77 , pp. 818-821
    • Arruda, V.R.1    von Zuben, P.M.2    Chiaparini, L.C.3    Annichino-Bizzacchi, J.M.4    Costa, F.F.5
  • 166
    • 0009642783 scopus 로고    scopus 로고
    • Homozygous methylenetetrahydrofolate reductase thermolability (MTHFR-T) is an independent risk factor for idiopathic deep-vein thrombosis (DVT) [abstract]
    • June
    • Salomon O, Dardik R, Zivelin A, et al. Homozygous methylenetetrahydrofolate reductase thermolability (MTHFR-T) is an independent risk factor for idiopathic deep-vein thrombosis (DVT) [abstract]. Thromb Haemost. June 1997;(suppl):568-569.
    • (1997) Thromb Haemost , Issue.SUPPL. , pp. 568-569
    • Salomon, O.1    Dardik, R.2    Zivelin, A.3
  • 167
    • 18344398980 scopus 로고    scopus 로고
    • The methylenetetrahydrofolate reductase TT677 genotype is associated with venous thrombosis independently of the coexistence of the FV Leiden and the prothrombin A20210 mutation
    • Margaglione M, D'Andrea G, d'Addedda M, et al. The methylenetetrahydrofolate reductase TT677 genotype is associated with venous thrombosis independently of the coexistence of the FV Leiden and the prothrombin A20210 mutation. Thromb Haemost. 1998;79:907-911.
    • (1998) Thromb Haemost , vol.79 , pp. 907-911
    • Margaglione, M.1    D'Andrea, G.2    d'Addedda, M.3
  • 168
    • 0033813145 scopus 로고    scopus 로고
    • Interaction between hyperhomocysteinemia and inherited thrombophilic factors in venous thromboembolism
    • De Stefano V, Casorelli I, Rossi E, et al. Interaction between hyperhomocysteinemia and inherited thrombophilic factors in venous thromboembolism. Semin Thromb Hemost. 2000;26:305-311.
    • (2000) Semin Thromb Hemost , vol.26 , pp. 305-311
    • De Stefano, V.1    Casorelli, I.2    Rossi, E.3
  • 169
    • 0000182299 scopus 로고    scopus 로고
    • Thermolabile methylenetetrahydrofolate reductase (MTHFR) does not modify the risk for venous thromboembolism in subjects with heterozygous factor V Leiden
    • Trillot N, Preudhomme C, Alhenc-Gelas M, et al. Thermolabile methylenetetrahydrofolate reductase (MTHFR) does not modify the risk for venous thromboembolism in subjects with heterozygous factor V Leiden. Blood. 1996;10(suppl 1):284a.
    • (1996) Blood , vol.10 , Issue.SUPPL. 1
    • Trillot, N.1    Preudhomme, C.2    Alhenc-Gelas, M.3
  • 170
    • 34250326225 scopus 로고    scopus 로고
    • Interelation of hyperhomocyst(e)inemia, factor V Leiden, and risk of future venous thromboembolism
    • Cattaneo M, Monzani ML, Martinelli I, Falcon CR, Mannucci PM. Interelation of hyperhomocyst(e)inemia, factor V Leiden, and risk of future venous thromboembolism. Circulation. 1998;52(suppl):S21.
    • (1998) Circulation , vol.52 , Issue.SUPPL.
    • Cattaneo, M.1    Monzani, M.L.2    Martinelli, I.3    Falcon, C.R.4    Mannucci, P.M.5
  • 171
    • 0030760946 scopus 로고    scopus 로고
    • A common mutation in the methylenetetrahydrofolate reductase gene (C677T) increases the risk for deep-vein thrombosis in patients with mutant factor V (factor V:Q506)
    • Cattaneo M, Tsai MY, Bucciarelli P, et al. A common mutation in the methylenetetrahydrofolate reductase gene (C677T) increases the risk for deep-vein thrombosis in patients with mutant factor V (factor V:Q506). Arterioscler Thromb Vasc Biol. 1997;17:1662-1666.
    • (1997) Arterioscler Thromb Vasc Biol , vol.17 , pp. 1662-1666
    • Cattaneo, M.1    Tsai, M.Y.2    Bucciarelli, P.3
  • 172
    • 0031886677 scopus 로고    scopus 로고
    • Thermolabile methylenetetrahydrofolate reductase and factor V Leiden in the risk of deep-vein thrombosis
    • Kluijtmans LAJ, den Heijer M, Reitsma PH, et al. Thermolabile methylenetetrahydrofolate reductase and factor V Leiden in the risk of deep-vein thrombosis. Thromb Haemost. 1998;79:254-258.
    • (1998) Thromb Haemost , vol.79 , pp. 254-258
    • Kluijtmans, L.A.J.1    den Heijer, M.2    Reitsma, P.H.3
  • 173
    • 0032521543 scopus 로고    scopus 로고
    • Homozygous cystathionine β-synthase deficiency, combined with factor V Leiden or thermolabile methylenetetrahydrofolate reductase in the risk of venous thrombosis
    • Kluijtmans L, Boers G, Verbruggen B, et al. Homozygous cystathionine β-synthase deficiency, combined with factor V Leiden or thermolabile methylenetetrahydrofolate reductase in the risk of venous thrombosis. Blood. 1998;91:2015-2018.
    • (1998) Blood , vol.91 , pp. 2015-2018
    • Kluijtmans, L.1    Boers, G.2    Verbruggen, B.3
  • 174
    • 0032485522 scopus 로고    scopus 로고
    • 677C to T mutation in the 5,10-methylenetetrahydrofolate reductase (MTHFR) gene and plasma homocyst(e)ine levels in patients with TIA or minor stroke
    • Lalouschek W, Aull S, Korninger L, et al. 677C to T mutation in the 5,10-methylenetetrahydrofolate reductase (MTHFR) gene and plasma homocyst(e)ine levels in patients with TIA or minor stroke. Neurol Sci. 1998;155:156-162.
    • (1998) Neurol Sci , vol.155 , pp. 156-162
    • Lalouschek, W.1    Aull, S.2    Korninger, L.3
  • 175
    • 33645796222 scopus 로고    scopus 로고
    • Homocysteine lowering and cardiovascular events after acute myocardial infarction
    • Bonaa KH, Njølstad I, Ueland PM, et al. Homocysteine lowering and
    • (2006) N Engl J Med , vol.354 , pp. 1578-1588
    • Bonaa, K.H.1    Njølstad, I.2    Ueland, P.M.3
  • 176
    • 0038648465 scopus 로고    scopus 로고
    • Secondary prevention with folic acid: Effects on clinical outcomes
    • Liem A, Reynierse-Buitenwerf GH, Zwinderman AH, et al. Secondary prevention with folic acid: effects on clinical outcomes. J Am Coll Cardiol. 2003;12:2105-2113.
    • (2003) J Am Coll Cardiol , vol.12 , pp. 2105-2113
    • Liem, A.1    Reynierse-Buitenwerf, G.H.2    Zwinderman, A.H.3
  • 177
    • 1242278327 scopus 로고    scopus 로고
    • Blinded comparison of folic acid and placebo in patients with ischemic heart disease: An outcome trial [abstract]
    • Baker F, Picton D, Blackwood S, et al. Blinded comparison of folic acid and placebo in patients with ischemic heart disease: an outcome trial [abstract]. Circulation. 2002;106(suppl II):741.
    • (2002) Circulation , vol.106 , Issue.SUPPL. II , pp. 741
    • Baker, F.1    Picton, D.2    Blackwood, S.3
  • 178
    • 2942752021 scopus 로고    scopus 로고
    • Folate therapy and in stent restenosis after coronary stenting
    • Lange H, Suryapranata H, De Luca G, et al. Folate therapy and in stent restenosis after coronary stenting. N Engl J Med. 2004;26:2673-2681.
    • (2004) N Engl J Med , vol.26 , pp. 2673-2681
    • Lange, H.1    Suryapranata, H.2    De Luca, G.3
  • 179
    • 1342309318 scopus 로고    scopus 로고
    • Lowering homocysteine in patients with ischemic stroke to prevent recurrent stroke, myocardial infarction, and death. The Vitamin Intervention for Stroke Prevention (VISP) Randomized Controlled Trial
    • Toole JF, Malinow MR, Chambless LE, et al. Lowering homocysteine in patients with ischemic stroke to prevent recurrent stroke, myocardial infarction, and death. The Vitamin Intervention for Stroke Prevention (VISP) Randomized Controlled Trial. JAMA. 2005;5:565-575.
    • (2005) JAMA , vol.5 , pp. 565-575
    • Toole, J.F.1    Malinow, M.R.2    Chambless, L.E.3
  • 180
    • 27744471516 scopus 로고    scopus 로고
    • Meta-analysis of MTHFR 677C→T polymorphism and coronary heart disease: Does totality of evidence support causal role for homocysteine and preventive potential of folate?
    • Lewis SJ, Ebrahim S, Smith GD. Meta-analysis of MTHFR 677C→T polymorphism and coronary heart disease: does totality of evidence support causal role for homocysteine and preventive potential of folate? BMJ. 2005;331:1053.
    • (2005) BMJ , vol.331 , pp. 1053
    • Lewis, S.J.1    Ebrahim, S.2    Smith, G.D.3
  • 181
    • 23444452249 scopus 로고    scopus 로고
    • Folic acid supplementation for 3 weeks reduces pulse pressure and large artery stiffness independent of MTHFR phenotype
    • Williams C, Kingwell BA, Burke K, McPherson J, Dart AM. Folic acid supplementation for 3 weeks reduces pulse pressure and large artery stiffness independent of MTHFR phenotype. Am J Clin Nutr. 2005;82:26-31.
    • (2005) Am J Clin Nutr , vol.82 , pp. 26-31
    • Williams, C.1    Kingwell, B.A.2    Burke, K.3    McPherson, J.4    Dart, A.M.5
  • 182
    • 0142184375 scopus 로고    scopus 로고
    • Folic acid and vitamin E supplementation effects on homocysteinemia, endothelial function and plasma anti-oxidant capacity in young myocardial infarction patients
    • Assanelli D, Bonanome A, Pezzini A, et al. Folic acid and vitamin E supplementation effects on homocysteinemia, endothelial function and plasma anti-oxidant capacity in young myocardial infarction patients. Pharmacol Res. 2004;49:79-84.
    • (2004) Pharmacol Res , vol.49 , pp. 79-84
    • Assanelli, D.1    Bonanome, A.2    Pezzini, A.3
  • 183
    • 33644693101 scopus 로고    scopus 로고
    • Randomized controlled trial of homocysteine-lowering vitamin treatment in elderly patients with vascular disease
    • Stott DJ, MacIntosh G, Lowe G, et al. Randomized controlled trial of homocysteine-lowering vitamin treatment in elderly patients with vascular disease. Am J Clin Nutr. 2005;82:1320-1326.
    • (2005) Am J Clin Nutr , vol.82 , pp. 1320-1326
    • Stott, D.J.1    MacIntosh, G.2    Lowe, G.3
  • 184
    • 28544447509 scopus 로고    scopus 로고
    • Plasma total homocysteine and memory in the elderly: The Hordaland Homocysteine Study
    • Nurk E, Refusm H, Tell GS, et al. Plasma total homocysteine and memory in the elderly: the Hordaland Homocysteine Study. Ann Neurol. 2005;6:847-857.
    • (2005) Ann Neurol , vol.6 , pp. 847-857
    • Nurk, E.1    Refusm, H.2    Tell, G.S.3
  • 185
    • 0037354318 scopus 로고    scopus 로고
    • Plasma homocysteine concentration is decreased by dietary intervention
    • Silaste M, Rantala M, Alfthan G, et al. Plasma homocysteine concentration is decreased by dietary intervention. Br J Nutr. 2003;89:295-301.
    • (2003) Br J Nutr , vol.89 , pp. 295-301
    • Silaste, M.1    Rantala, M.2    Alfthan, G.3
  • 186
    • 0037995375 scopus 로고    scopus 로고
    • Betaine supplementation lowers plasma homocysteine in healthy men and women
    • Steenge GR, Verhoef P, Katan MB. Betaine supplementation lowers plasma homocysteine in healthy men and women. J Nutr. 2003;133:1291-1295.
    • (2003) J Nutr , vol.133 , pp. 1291-1295
    • Steenge, G.R.1    Verhoef, P.2    Katan, M.B.3
  • 187
    • 0034638064 scopus 로고    scopus 로고
    • Betaine supplementation and plasma homocysteine in healthy volunteers
    • Brouwer IA, Verhoef P, Urgert R. Betaine supplementation and plasma homocysteine in healthy volunteers. Arch Intern Med. 2000;160:2546-2547.
    • (2000) Arch Intern Med , vol.160 , pp. 2546-2547
    • Brouwer, I.A.1    Verhoef, P.2    Urgert, R.3
  • 188
    • 0036829164 scopus 로고    scopus 로고
    • Betaine supplementation decreases plasma homocysteine concentrations but do not affect body weight, body composition, or resting energy expenditure in human subjects
    • Schwab U, Torronen A, Toppinen L, et al. Betaine supplementation decreases plasma homocysteine concentrations but do not affect body weight, body composition, or resting energy expenditure in human subjects. Am J Clin Nutr. 2002;76:961-967.
    • (2002) Am J Clin Nutr , vol.76 , pp. 961-967
    • Schwab, U.1    Torronen, A.2    Toppinen, L.3
  • 189
    • 0345373768 scopus 로고    scopus 로고
    • Urinary and plasma homocysteine and cysteine levels during prolonged oral N-acetylcysteine therapy
    • Ventura P, Panini R, Abbati G, et al. Urinary and plasma homocysteine and cysteine levels during prolonged oral N-acetylcysteine therapy. Pharmacology. 2003;68:1005-1014.
    • (2003) Pharmacology , vol.68 , pp. 1005-1014
    • Ventura, P.1    Panini, R.2    Abbati, G.3
  • 191
    • 0027250615 scopus 로고
    • Homocysteine, a risk factor for premature vascular disease and thrombosis, induces tissue factor activity in endothelial cells
    • Fryer RH, Wilson BD, Gubler DB, et al. Homocysteine, a risk factor for premature vascular disease and thrombosis, induces tissue factor activity in endothelial cells. Arterioscler Thromb. 1993;13:1327-1333.
    • (1993) Arterioscler Thromb , vol.13 , pp. 1327-1333
    • Fryer, R.H.1    Wilson, B.D.2    Gubler, D.B.3
  • 192
    • 0020615207 scopus 로고
    • Diet-responsive proconvertin (factor VII) deficiency in homocystinuria
    • Munnich A, Saudubray J-M, Dautzenberg M-D, et al. Diet-responsive proconvertin (factor VII) deficiency in homocystinuria. J. Pediatr. 1983;102:730-734.
    • (1983) J. Pediatr , vol.102 , pp. 730-734
    • Munnich, A.1    Saudubray, J.-M.2    Dautzenberg, M.-D.3
  • 193
    • 0034141698 scopus 로고    scopus 로고
    • Relationships between homocysteine, factor VIIa, and thrombin generation in acute coronary syndromes
    • Al-Obaidi MK, Philippou H, Stubbs PJ, et al. Relationships between homocysteine, factor VIIa, and thrombin generation in acute coronary syndromes. Circulation. 2000;101:372-377.
    • (2000) Circulation , vol.101 , pp. 372-377
    • Al-Obaidi, M.K.1    Philippou, H.2    Stubbs, P.J.3
  • 195
    • 0032851935 scopus 로고    scopus 로고
    • Treatment of hyperhomocysteinemia with folic acid and vitamin B12 and B6 attenuates thrombin generation
    • Undas A, Domagala TB, Jankowski M, et al. Treatment of hyperhomocysteinemia with folic acid and vitamin B12 and B6 attenuates thrombin generation. Thromb Res. 1999;95:281-288.
    • (1999) Thromb Res , vol.95 , pp. 281-288
    • Undas, A.1    Domagala, T.B.2    Jankowski, M.3
  • 196
    • 27844503815 scopus 로고    scopus 로고
    • Thrombin generation in response to methionine loading test in patients with ischemic heart disease [poster]
    • Domagala TB, Undas A, Celinska-Lowenhoff M, et al. Thrombin generation in response to methionine loading test in patients with ischemic heart disease [poster]. J Thromb Haemost. 2003;1(suppl 1):P0435.
    • (2003) J Thromb Haemost , vol.1 , Issue.SUPPL. 1
    • Domagala, T.B.1    Undas, A.2    Celinska-Lowenhoff, M.3
  • 197
    • 0026345948 scopus 로고
    • Inhibition of thrombomodulin surface expression and protein C activation by the thrombogenic agent homocysteine
    • Lentz SR, Sadler JE. Inhibition of thrombomodulin surface expression and protein C activation by the thrombogenic agent homocysteine. J Clin Invest. 1991;88:1901-1914.
    • (1991) J Clin Invest , vol.88 , pp. 1901-1914
    • Lentz, S.R.1    Sadler, J.E.2
  • 198
    • 0022472013 scopus 로고
    • Activation of endogenous factor V by a homocysteine-induced vascular endothelial cell activator
    • Rodgers GM, Kane WH. Activation of endogenous factor V by a homocysteine-induced vascular endothelial cell activator. J Clin Invest. 1986;77:1909-1916.
    • (1986) J Clin Invest , vol.77 , pp. 1909-1916
    • Rodgers, G.M.1    Kane, W.H.2
  • 199
    • 0141450396 scopus 로고    scopus 로고
    • Elevated plasma homocysteine leads to alterations in fibrin clot structure and stability: Implications for the mechanism of thrombosis in hyperhomocysteinemia
    • Sauls DL, Wolberg As, Hoffman M. Elevated plasma homocysteine leads to alterations in fibrin clot structure and stability: implications for the mechanism of thrombosis in hyperhomocysteinemia. J Thromb Haemost. 2003;1:300-306.
    • (2003) J Thromb Haemost , vol.1 , pp. 300-306
    • Sauls, D.L.1    Wolberg, A.2    Hoffman, M.3
  • 200
    • 0037101570 scopus 로고    scopus 로고
    • Effects of homocysteine thiol group on fibrin networks: Another possible mechanism of harm
    • Lauricella AM, Quintana IL, Kordich LC. Effects of homocysteine thiol group on fibrin networks: another possible mechanism of harm. Thromb Res. 2002;107:75-79.
    • (2002) Thromb Res , vol.107 , pp. 75-79
    • Lauricella, A.M.1    Quintana, I.L.2    Kordich, L.C.3
  • 201
    • 0026773724 scopus 로고
    • An atherogenic stimulus homocysteine inhibits cofactor activity of thrombomodulin and enhances thrombomodulin expression in human umbilical vein endothelial cells
    • Hayashi T, Honda G, Suzuki K. An atherogenic stimulus homocysteine inhibits cofactor activity of thrombomodulin and enhances thrombomodulin expression in human umbilical vein endothelial cells. Blood. 1992;79:2930-2936.
    • (1992) Blood , vol.79 , pp. 2930-2936
    • Hayashi, T.1    Honda, G.2    Suzuki, K.3
  • 202
    • 0025190042 scopus 로고
    • Homocysteine, an atherogenic stimulus, reduces protein C activation by arterial and venous endothelial cells
    • Rodgers GM, Conn MT. Homocysteine, an atherogenic stimulus, reduces protein C activation by arterial and venous endothelial cells. Blood. 1990;75:895-901.
    • (1990) Blood , vol.75 , pp. 895-901
    • Rodgers, G.M.1    Conn, M.T.2
  • 203
    • 0035830874 scopus 로고    scopus 로고
    • Homocysteine inhibits inactivation of factor Va by activated protein C
    • Undas A, Williams EB, Butenas S, et al. Homocysteine inhibits inactivation of factor Va by activated protein C. J Biol Chem. 2001;276:4389-4397.
    • (2001) J Biol Chem , vol.276 , pp. 4389-4397
    • Undas, A.1    Williams, E.B.2    Butenas, S.3
  • 204
    • 0037105496 scopus 로고    scopus 로고
    • Effect of hyperhomocysteinemia on protein C activation and activity
    • Lentz SR, Piegors DJ, Fernandez JA, et al. Effect of hyperhomocysteinemia on protein C activation and activity. Blood. 2002;100:2108-2112.
    • (2002) Blood , vol.100 , pp. 2108-2112
    • Lentz, S.R.1    Piegors, D.J.2    Fernandez, J.A.3
  • 205
    • 3042536588 scopus 로고    scopus 로고
    • Plasma homocysteine concentration is not associated with activated protein C resistance in patients investigated for hypercoagulability
    • Zarychanski R, Houston DS. Plasma homocysteine concentration is not associated with activated protein C resistance in patients investigated for hypercoagulability. Thromb Haemost. 2004;91:1115-1122.
    • (2004) Thromb Haemost , vol.91 , pp. 1115-1122
    • Zarychanski, R.1    Houston, D.S.2
  • 206
    • 0034047523 scopus 로고    scopus 로고
    • Tissue factor and homocysteine levels in ischemic heart disease are associated with angiographically documented clinical recurrences after coronary angioplasty
    • Marcucci R, Prisco D, Brunelli T, et al. Tissue factor and homocysteine levels in ischemic heart disease are associated with angiographically documented clinical recurrences after coronary angioplasty. Thromb Haemost. 2000;83:826-832.
    • (2000) Thromb Haemost , vol.83 , pp. 826-832
    • Marcucci, R.1    Prisco, D.2    Brunelli, T.3
  • 207
    • 0034213789 scopus 로고    scopus 로고
    • Tissue factor pathway inhibitor levels in patients with homocystinuria
    • Cella G, Burlina A, Sbarai A, et al. Tissue factor pathway inhibitor levels in patients with homocystinuria. Thromb Res. 2000;98:375-381.
    • (2000) Thromb Res , vol.98 , pp. 375-381
    • Cella, G.1    Burlina, A.2    Sbarai, A.3
  • 208
    • 0027288252 scopus 로고
    • Homocysteine-induced modulation of tissue plasminogen activator binding to its endothelial cell membrane receptor
    • Hajjar KA. Homocysteine-induced modulation of tissue plasminogen activator binding to its endothelial cell membrane receptor. J Clin Invest. 1993;91:2873-2879.
    • (1993) J Clin Invest , vol.91 , pp. 2873-2879
    • Hajjar, K.A.1
  • 209
    • 0036847628 scopus 로고    scopus 로고
    • Association between increased homocysteine levels and impaired fibrinolytic potential: Potential mechanism for cardiovascular risk
    • Tofler GH, D'Agostine RB, Jacques PF, et al. Association between increased homocysteine levels and impaired fibrinolytic potential: potential mechanism for cardiovascular risk. Thromb Haemost. 2002;88:799-804.
    • (2002) Thromb Haemost , vol.88 , pp. 799-804
    • Tofler, G.H.1    D'Agostine, R.B.2    Jacques, P.F.3
  • 210
    • 0026486960 scopus 로고
    • Homocysteine and other sulfhydryl compounds enhance the binding of lipoprotein(a) to fibrin: A potential biochemical link between thrombosis, atherogenesis and sulfhydryl compound metabolism
    • Harpel PC, Change VT, Borth W. Homocysteine and other sulfhydryl compounds enhance the binding of lipoprotein(a) to fibrin: a potential biochemical link between thrombosis, atherogenesis and sulfhydryl compound metabolism. Proc Natl Acad Sci U S A. 1992;89:10193-10197.
    • (1992) Proc Natl Acad Sci U S A , vol.89 , pp. 10193-10197
    • Harpel, P.C.1    Change, V.T.2    Borth, W.3
  • 211
    • 30744464433 scopus 로고    scopus 로고
    • NORVIT: Randomized trial of homocysteine-lowering with B vitamins for secondary prevention of cardiovascular disease after acute myocardial infarction
    • for the Norwegian Vitamin (NORVIT) Study Group, Presented at the, Stockholm, Sweden, September 3-7
    • Bonaa KH, for the Norwegian Vitamin (NORVIT) Study Group. NORVIT: randomized trial of homocysteine-lowering with B vitamins for secondary prevention of cardiovascular disease after acute myocardial infarction. Presented at the European Society of Cardiology Congress, Stockholm, Sweden, September 3-7, 2005.
    • (2005) European Society of Cardiology Congress
    • Bonaa, K.H.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.