Inhibition of growth and p21(ras) methylation in vascular endothelial cells by homocysteine but not cysteine

Journal of Biological Chemistry

Volumn 272, Issue 40, 1997, Pages 25380-25385

  Wang, Hong ^a   Yoshizumi, Masao ^b   Lai, Kaihua ^a   Tsai, Jer Chia ^a   Perrella, Mark A ^b,c,d   Haber, Edgar ^b   Lee, Mu En ^a,b,d  

^a HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c Pulmonary Division   (United States)

^d BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYSTEINE; HOMOCYSTEINE; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN P21; RAS PROTEIN; DNA; GUANOSINE DIPHOSPHATE; GUANOSINE TRIPHOSPHATE; HRAS PROTEIN, HUMAN; PROTEIN KINASE (CALCIUM,CALMODULIN); S ADENOSYLHOMOCYSTEINE;

ARTERIOSCLEROSIS; ARTICLE; CELL GROWTH; CONTROLLED STUDY; DNA SYNTHESIS; ENDOTHELIUM CELL; HEART INFARCTION; HUMAN; HUMAN CELL; HYPERHOMOCYSTEINEMIA; ONCOGENE RAS; PRIORITY JOURNAL; PROTEIN METHYLATION; STROKE; VASCULAR ENDOTHELIUM; BIOSYNTHESIS; CELL CULTURE; CELL CYCLE; CELL CYCLE G1 PHASE; CELL DIVISION; CELL MEMBRANE; COMPARATIVE STUDY; CYTOLOGY; DRUG EFFECT; FLOW CYTOMETRY; KINETICS; METABOLISM; METHYLATION; PHYSIOLOGY; TIME; UMBILICAL VEIN; VASCULAR SMOOTH MUSCLE;

CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; CELL CYCLE; CELL DIVISION; CELL MEMBRANE; CELLS, CULTURED; CYSTEINE; DNA; ENDOTHELIUM, VASCULAR; FLOW CYTOMETRY; G1 PHASE; GUANOSINE DIPHOSPHATE; GUANOSINE TRIPHOSPHATE; HOMOCYSTEINE; HUMANS; KINETICS; METHYLATION; MUSCLE, SMOOTH, VASCULAR; PROTO-ONCOGENE PROTEINS P21(RAS); S-ADENOSYLHOMOCYSTEINE; TIME FACTORS; UMBILICAL VEINS;

EID: 0030610589     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.272.40.25380     Document Type: Article

References (45)

1. Ross, R. (1993) Nature 362, 801-809
2. Stampfer, M. J., and Malinow, M. R. (1995) N. Engl. J. Med. 332, 328-329
3. Stampfer, M. J., and Willett, W. C. (1993) J. Am. Med. Assoc. 270, 2726-2727
4. Stampfer, M. J., Malinow, M. R., Willett, W. C., Newcomer, L. M., Upson, B., Ullmann, D., Tishler, P. V., and Hennekens, C. H. (1992) J. Am. Med. Assoc. 268, 877-881
5. Selhub, J., Jacques, P. F., Wilson, P. W., Rush, D., and Rosenberg, I. H. (1993) J. Am. Med. Assoc. 270, 2693-2698
6. Selhub, J., Jacques, P. F., Bostom, A. G., D'Agostino, R. B., Wilson, P. W., Belanger, A. J., O'Leary, D. H., Wolf, P. A., Schaefer, E. J., and Rosenberg, I. H. (1995) N. Engl. J. Med. 332, 286-291
7. Malinow, M. R., Nieto, F. J., Szklo, M., Chambless, L. E., and Bond, G. (1993) Circulation 87, 1107-1113
8. Harker, L. A., Harlan, J. M., and Ross, R. (1993) Arterioscler. Thromb. 13, 512-516
9. Dudman, N. P., Hicks, C., Wang, J., and Wilcken, D. E. (1991) Atherosclerosis 91, 77-83
10. Lentz, S. R., and Sadler, J. E. (1993) Blood 81, 683-689
11. Hajjar, K. A. (1993) J. Clin. Invest. 91, 2873-2879
12. Rodgers, G. M., and Conn, M. T. (1990) Blood 75, 895-901
13. Stamler, J. S., Osborne, J. A., Jaraki, O., Rabbani, L. E., Mullins, M., Singel, D., and Loscalzo, J. (1993) J. Clin. Invest. 91, 308-318
14. Harpel, P. C., Chang, V. T., and Borth, W. (1992) Proc. Natl. Acad. Sci. U. S. A. 89, 10193-10197
15. Bird, A. P., Taggart, M. H., Nicholls, R. D., and Higgs, D. R. (1987) EMBO J. 6, 999-1004
16. Cedar, H. (1988) Cell 53, 3-4
17. Clarke, S. (1993) Curr. Opin. Cell Biol. 5, 977-983
18. Hancock, J. F., Cadwallader, K., and Marshall, C. J. (1991) EMBO J. 10, 641-646
19. Parish, C. A., and Rando, R. R. (1994) Biochemistry 33, 9986-9991
20. Philips, M. R., Pillinger, M. H., Staud, R., Volker, C., Rosenfeld, M. G., Weissmann, G., and Stock, J. B. (1993) Science 259, 977-980
21. Clarke, S. (1992) Annu. Rev. Biochem. 61, 355-386
22. Bergmann, S., Shatrov, V., Ratter, F., Schiemann, S., Schulze-Osthoff, K., and Lehmann, V. (1994) J. Immunol. 153, 1736-1743
23. Barber, J. R., and Clarke, S. (1984) J. Biol. Chem. 259, 7115-7122
24. Paik, W. K., Farooqui, J. Z., and Kim, S. (1980) Adv. Enzyme Regul. 19, 471-486
25. Tsai, J.-C., Perrella, M. A., Yoshizumi, M., Hsieh, C.-M., Haber, E., Schlegel, R., and Lee, M.-E. (1994) Proc. Natl. Acad. Sci. U. S. A. 91, 6369-6373
26. Tsai, J.-C., Wang, H., Perrella, M. A., Yoshizumi, M., Sibinga, N. E. S., Tan, L. C., Haber, E., Chang, T.-H., Schlegel, R., and Lee, M.-E. (1996) J. Clin. Invest. 97, 146-153
27. Lai, K., Wang, H., Lee, W. S., Jain, M. K., Lee, M. E., and Haber, E. (1996) J. Clin. Invest. 98, 1560-1567
28. Jakubowski, H. (1991) EMBO J 10, 593-598
29. Jakubowski, H., and Goldman, E. (1993) FEBS Lett. 317, 237-240
30. Clarke, S., Vogel, J. P., Deschenes, R. J., and Stock, J. (1988) Proc. Natl. Acad. Sci. U. S. A. 85, 4643-4647
31. Chao, T.-S. O., Byron, K. L., Lee, K.-M., Villereal, M., and Rosner, M. R. (1992) J. Biol. Chem. 267, 19876-19883
32. Borchardt, R. T. (1980) J. Med. Chem. 23, 347-357
33. Paik, W. K., and Kim, S. (1980) Protein Methylation, pp. 82-127, John Wiley & Sons, New York
34. Croteau, S., and Menezo, Y. (1994) Zygote 2, 47-52
35. Gormand, F., Cordier, G., Fonlupt, P., Pacheco, Y., and Revillard, J. P. (1990) Life Sci. 47, 1793-1799
36. Vizirianakis, I. S., and Tsiftsoglou, A. S. (1995) Biochem. Pharmacol. 50, 1807-1814
37. Philips, M. R., Staud, R., Pillinger, M., Feoktistov, A., Volker, C., Stock, J. B., and Weissmann, G. (1995) Proc. Natl. Acad. Sci. U. S. A. 92, 2283-2287
38. Ruderman, J. V. (1993) Curr. Opin. Cell Biol. 5, 207-213
39. Pelech, S. L., and Sanghera, J. S. (1992) Science 257, 1355-1356
40. Olszewski, A. J., and McCully, K. S. (1993) Free Radical Biol. Med. 14, 683-693
41. Malinow, M. R. (1995) Clin. Chem. 41, 173-176
42. Fortin, L. J., and Genest, J., Jr. (1995) Clin. Biochem. 28, 155-162
43. Tan, E. W., Pérez-Sala, D., Canada, F. J., and Rando, R. R. (1991) J. Biol. Chem. 266, 10719-10722
44. Sobotka-Briner, C., and Chelsky, D. (1992) J. Biol. Chem. 267, 12116-12122
45. Xie, H., and Clarke, S. (1994) J. Biol. Chem. 269, 1981-1984