Effects of homocysteine on smooth muscle cell proliferation in both cell culture and artery perfusion culture models

Journal of Surgical Research

Volumn 88, Issue 1, 2000, Pages 26-33

  Halkos, Michael E ^a,b   Surowiec, Scott M ^a,b   Conklin, Brian S ^a,b   Lin, Peter H ^a,b   Lumsden, Alan B ^a,b  

^a ATLANTA VA MEDICAL CENTER   (United States)

^b EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Artery perfusion culture; Endothelial cell; Homocysteine; Smooth muscle cell

Indexed keywords

ANIMAL CELL; ARTERY PERFUSION; ARTICLE; CAROTID ARTERY; CELL CULTURE; CELL PROLIFERATION; CONTROLLED STUDY; DOSE RESPONSE; ENDOTHELIUM CELL; HUMAN; HUMAN CELL; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; SMOOTH MUSCLE FIBER;

EID: 0033980003     PISSN: 00224804     EISSN: None     Source Type: Journal    
DOI: 10.1006/jsre.1999.5756     Document Type: Article

References (43)

1. McCully K. S. Vascular pathology of homocysteinemia: Implications for the pathogenesis of arteriosclerosis. Am. J. Pathol. 56:1969;111
2. Clarke R., Daly L., Robinson K. Hyperhomocysteinemia: An independent risk factor for vascular disease. N. Engl. J. Med. 324:1991;1149
3. Stampfer M. J., Malinow M. R., Willett W. C. A prospective study of plasma homocyst(e)ine and risk of myocardial infarction in US physicians. JAMA. 268:1992;877
4. Arnesen E., Refsum H., Bonaa K. H., Ueland P. M., Forde O. H., Nordrehaug J. E. Serum total homocysteine and coronary heart disease. Int. J. Epidemiol. 24:1995;704
5. Taylor L. M. Jr., DeFrang R. D., Harris E. J. Jr., Porter J. M. The association of elevated plasma homocyst(e)ine with progression of symptomatic peripheral arterial disease. J. Vasc. Surg. 13:1991;128
6. Nygard O., Nordrehaug J. E., Refsum H., Ueland P. M., Farstad M., Vollset S. E. Plasma homocysteine levels and mortality in patients with coronary artery disease. N. Engl. J. Med. 337:1997;230
7. Nobuyoshi M., Kimura K., Nosaka H., Mioka S., Ueno K., Yokoi H. Restenosis after successful percutaneous transluminal coronary angioplasty: Serial angiographic follow-up of 229 patients. J. Am. Coll. Cardiol. 12:1998;616
8. N. Engl. J. Med. 325:1991;445
9. JAMA. 273:1995;1421
10. Norrving B., Nilsson G., Olson J. E. Progression of carotid disease after endarterectomy: A Doppler ultrasound study. Ann. Neurol. 12:1982;548
11. Zierler R. E., Bandyk D. F., Thiele B. L., Strandness E. Carotid artery stenosis following endarterectomy. Arch. Surg. 117:1982;1408
12. Ohno T., Gordon D., San H., Pompili V. J., Imperiale M. J., Nabel G. J., Nabel E. G. Gene therapy for vascular smooth muscle cell proliferation after arterial injury. Science. 265:1994;781
13. Thyberg J., Hedin U., Sjvlind M., Palmberg L., Bottger B. A. Regulation of differentiated properties and proliferation of arterial smooth muscle cells. Arteriosclerosis. 10:1990;966
14. Mazur W., Ali N. M., Grinstead W. C., Schulz D. G., Raizner A. E., French B. A. Lipofectin-mediated versus adenovirus-mediated gene transfer in vitro and in vivo: Comparison of canine and porcine model systems. Coronary Artery Dis. 5:1994;779
15. Chen C., Li J., Mattar S. G., Pierce G. F., Aukerman L., Hanson S. R., Ku D. N., Lumsden A. B. Boundary layer infusion of basic fibroblast growth factor accelerates intimal hyperplasia in endarterectomized canine artery. J. Surg. Res. 69:1997;300
16. Chen C., Li J., Micko C. J., Pierce G. F., Cunninghan M. R., Lumsden A. B. Cytotoxic effects of basic FGF and heparin binding EGF conjugated with cytotoxin saproin on vascular cell cultures. J. Surg. Res. 75:1998;35
17. Chen C., Hughes E., Li J., Micko C. J., Morsy A. H., Kulbaski M. J., Lumsden A. B. Perfusion culture of porcine carotid artery for study of smooth muscle cell proliferation. Surg. Forum. 48:1997;368
18. Chen C., Hanson S. R., Keefer L., Saavedra J. E., Davies K. M., Hutsell T. C., Hughes J. D., Mattar S. G., Ku D. N., Lumsden A. B. Boundary layer infusion of nitric oxide reduces smooth muscle cell proliferation of injured arteries in a canine model. J. Surg. Res. 67:1997;24
19. Stampeer M. I., Malinow M. R. Can lowering homocyst(e)ine levels reduce cardiovascular risk. N. Engl. J. Med. 333:1995;325
20. Ueland P. M., Refsum H., Stabler S. P., Malinow M. R., Andersson A., Allen R. H. Total homocysteine in plasma or serum: Methods and clinical applications. Clin. Chem. 39:1993;1764
21. Kang S. S., Wong P. W., Malinow M. R. Hyperhomocyst(e)inemia as a risk factor for occlusive vascular disease. Annu. Rev. Nutr. 12:1992;279
22. McCully K. S. Homocysteine and vascular disease. Nature Med. 2:1996;386
23. Ross R. The pathogenesis of atherosclerosis: A perspective for the 1990's. Nature. 362:1993;801
24. Dudman N. P. B., Hicks C., Wang J., Wilcken D. E. L. Human arterial endothelial cell detachment in vitro: Its promotion by homocysteine and cysteine. Atherosclerosis. 91:1991;77
25. Tsai J. C., Perrella M. A., Yoshizumi M., Hsieh C. M., Haber E., Schlegel R., Lee M. E. Promotion of vascular smooth muscle cell growth by homocysteine: A link to atherosclerosis. Proc. Natl. Acad. Science USA. 91:1994;6369
26. Ratnoff O. D. Activation of Hageman factor by L-homocystine. Science. 162:1968;1007
27. Rodgers G. M., Kane W. H. Activation of endogenous factor V by a homocysteine-induced vascular endothelial cell activator. J. Clin. Invest. 77:1986;1909
28. Rodgers G. M., Conn M. T. Homocysteine, an atherogenic stimulus, reduces protein C activation by arterial and venous endothelial cells. Blood. 75:1990;895
29. Lentz S. R., Sadler J. E. Inhibition of thrombomodulin surface expression and protein C activation by the thrombogenic agent homocysteine. J. Clin. Invest. 88:1991;1906
30. Fryer R. H., Wilson B. D., Gubler D. B., Fitzgerald L. A., Rodgers G. M. Homocysteine, a risk factor for premature vascular disease and thrombosis, induces tissue factor activity in endothelial cells. Arterioscler. Thromb. 13:1993;1327
31. Nishinaga M., Ozawa T., Shimada K. Homocysteine, a thrombogenic agent, suppresses anticoagulant heparan sulfate expression in cultured porcine aortic endothelial cells. J. Clin. Invest. 92:1993;1381
32. Harker L. A., Ross R., Slichter S. J., Scott. C. R. Homocysteine-induced arteriosclerosis: The role of endothelial cell injury and platelet response in its genesis. J. Clin. Invest. 58:1976;731
33. Lentz S. R., Sobey C. G., Piegors D. J., Bhopatkar M. Y., Faraci F. M., Malinow M. R., Heistad D. D. Vascular dysfunction in monkeys with diet-induced hyperhomocyst(e)inemia. J. Clin. Invest. 98:1996;24
34. Celermajer D. S., Sorensen K., Ryalls M., Robinson J., Thomas O., Leonard J. V., Deanfield J. E. Impaired endothelial function occurs in the systemic arteries of children with homozygous homocystinuria but not their heterozygous parents. J. Am. Coll. Cardiol. 22:1993;854
35. Tawakol A., Omland T., Gerhard M., Wu J. T., Creager M. A. Hyperhomocyst(e)inemia is associated with impaired endothelium-dependent vasodilation in humans. Circulation. 95:1997;1119
36. Woo K. S., Chook P., Lolin. Y. I., Cheung A. S. P., Chan L. T., Sun Y. Y., Sanderson J. E., Metreweli C., Celermajer D. S. Hyperhomocyst(e)inemia is a risk factor for arterial endothelial dysfunction in humans. Circulation. 96:1997;2542
37. Bellamy M. F., Ramsey M. W., Goodfellow J., Brownlee M., Gorman S., McDowell I. F., Lewis M. J. Hyperhomocysteinemia and endothelial dysfunction with low vitamin B12/folate status. Circulation. 94:1996
38. Tang L., Mamotte C. D. S., Bockxmeer F. M. V., Taylor R. R. The effect of homocysteine on DNA synthesis in cultured human vascular smooth muscle. Artherosclerosis. 136:1998;169
39. Southern F. N., Cruz N., Fink L. M., Cooney C. A., Barone G. W., Eidt J. F., Moursi M. M. Hyperhomocysteinemia increases intimal hyperplasia in a rat carotid endarterectomy model. J. Vasc. Surg. 28:1998;909
40. Tsai J. C., Wang H., Perrella M. A., Yoshizumi M., Sibinga N. E., Tan L. C., Haber E., Chang T. H., Schlegel R., Lee M. E. Induction of cyclin A gene expression by homocysteine in vascular smooth muscle cells. J. Clin. Invest. 97:1996;146
41. Nishio E., Watanabe Y. Homocysteine as a modulator of platelet-derived growth factor action in vascular smooth muscle cells: A possible role for hydrogen peroxide. Br. J. Pharm. 122:1997;269
42. Lobo A., Naso A., Arheart K. Reduction of homocysteine levels in coronary artery disease by low-dose folic acid combined with vitamins B6 and B12. Am. J. Cardiol. 83:1999;821
43. den Heijer M., Brouwer I. A., Bos G. M. Vitamin supplementation reduces blood homocysteine levels: A controlled trial in patients with venous thrombosis and healthy volunteers. Arterioscler. Thromb. Vasc. Biol. 18:1998;356