Genetic risk factor for unexplained recurrent early pregnancy loss [1]

Lancet

Volumn 350, Issue 9081, 1997, Pages 861-

  Nelen, Willianne L D M ^b   Steegers, Eric A P ^b   Eskes, Tom K A B ^b   Blom, Henk J ^a  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

5 METHYLTETRAHYDROFOLIC ACID; 5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); HOMOCYSTEINE;

BLOOD LEVEL; FEMALE; GENE MUTATION; GENETIC RISK; HOMOZYGOSITY; HUMAN; LETTER; MAJOR CLINICAL STUDY; METABOLIC DISORDER; NEURAL TUBE DEFECT; PRIORITY JOURNAL; RECURRENT ABORTION; RISK FACTOR;

EID: 0343471524     PISSN: 01406736     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0140-6736(97)24038-9     Document Type: Article

References (5)

1. Jacques PF, Bostom AG, Williams RR, et al. Relation between folate status, a common mutation in methylenetetrahydrofolate reductase, and plasma homocysteine concentrations. Circulation 1996; 93: 7-9.
2. Van Der Put NM, Eskes TK, Blom HJ. Is the common 677 C→T mutation in the methylenetetrahydrofolate reductase gene a risk factor for neural tube defects? A meta-analysis. Q J Med 1997; 90: 111-15.
3. Kluijtmans LAJ, Kastelein JJP, Lindemans J, et al. Thermolabile methylenetetrahydrofolate reductase in coronary artery disease. Circulation (in press).
4. Wouters MGAJ, Boers GHJ, Blom HJ, et al. Hyperhomocysteinemia: a risk factor in women with unexplained recurrent early pregnancy loss. Fertil Steril 1993; 60: 820-25.
5. Frosst P, Blom HJ, Milos R, et al. A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase. Nat Genet 1995; 10: 111-13.