Nonfasting plasma total homocysteine levels and all-cause and cardiovascular disease mortality in elderly Framingham men and women

Archives of Internal Medicine

Volumn 159, Issue 10, 1999, Pages 1077-1080

  Bostom, Andrew G ^a,b   Silbershatz, Halit ^c   Rosenberg, Irwin H ^a   Selhub, Jacob ^a   D'Agostino, Ralph B ^c   Wolf, Philip A ^c   Jacques, Paul F ^a   Wilson, Peter W F ^d  

^a TUFTS UNIVERSITY   (United States)

^b MEMORIAL HOSPITAL OF RHODE ISLAND   (United States)

^c Boston University   (United States)

^d Framingham Study   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HIGH DENSITY LIPOPROTEIN CHOLESTEROL;

ADULT; AGED; ARTICLE; CARDIOVASCULAR DISEASE; CHOLESTEROL BLOOD LEVEL; COMORBIDITY; DIABETES MELLITUS; DISEASE ASSOCIATION; FEMALE; HUMAN; HYPERHOMOCYSTEINEMIA; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; RISK FACTOR; SMOKING; SYSTOLIC BLOOD PRESSURE;

AGED; AGED, 80 AND OVER; CARDIOVASCULAR DISEASES; CAUSE OF DEATH; FEMALE; HOMOCYSTEINE; HUMANS; MALE; MIDDLE AGED; MINNESOTA; RISK; RISK FACTORS;

EID: 0033599973     PISSN: 00039926     EISSN: None     Source Type: Journal    
DOI: 10.1001/archinte.159.10.1077     Document Type: Article

References (22)

1. McCully KS. Vascular pathology of homocysteinemia. Am J Pathol. 1969;56: 111-128.
2. Mudd SH, Skovby F, Levy HL, et al. The natural history of homocystinuria due to cystathionine beta synthase deficiency. Am J Hum Genet. 1985;37:1-31.
3. Wilcken DE, Wilcken B. The pathogenesis of coronary artery disease: possible role for methionine metabolism. J Clin Invest. 1976;57:1079-1082.
4. Boushey CJ, Beresford SAA, Omenn GS, Motulsky AG. A quantitative assessment of plasma homocysteine as a risk factor for vascular disease. JAMA. 1995; 274:1049-1057.
5. Beresford SA, Boushey CJ. Homocysteine, folic acid, and cardiovascular disease risk. In: Bendich A, Deckelbaum RJ, eds. Preventive Nutrition: The Comprehensive Guide for Health Professionals. Totowa, NJ: Humana Press; 1997: 193-224.
6. Omenn GS, Beresford SAA, Motulsky AG. Preventing coronary heart disease: B-vitamins and homocysteine. Circulation. 1998;97:421-424.
7. Nygard O, Nordrehaug JE, Relsum H, Ueland PM, Farstad M, Vollset SE. Plasma homocysteine levels and mortality in patients with coronary artery disease. N Engl J Med. 1997;337:230-236.
8. Kannel WB, Wolf PA, Garrison RJ. The Framingham Study: An Epidemiological Investigation of Cardiovascular Disease. Section 34: Some Risk Factors Related to the Annual Incidence of Cardiovascular Disease and Death Using Pooled Repeated Biennial Measurements: Framingham Heart Study 30-Year Follow-up. Springfield, Va: National Technical Information Service; 1987: 1-459.
9. Ueland PM, Refsum H, Stabler SP, Malinow MR, Andersson A, Allen RH. Total homocysteine in plasma or serum: methods and applications. Clin Chem. 1993; 39:1764-1773.
10. Husdan H, Rapoport A. Estimation of creatinine by the Jaffe reaction: a comparison of three methods. Clin Chem. 1968;14:222-238.
11. Fried LP, Kronmal RA, Newman AB, et al Risk factors for 5-year mortality in older adults: the Cardiovascular Health Study. JAMA. 1998;279:585-592.
12. Evans RW, Shaten BJ, Hempel JD, Cutler JA, Kuller LH. Homocysteine and risk of cardiovascular disease in the Multiple Risk Factor Intervention Trial. ArteriosclerThromb Vasc Biol. 1997;17:1947-1953.
13. Wilcken DE, Wilcken B. The natural history of vascular disease in homocystinuria and the effects of treatment. J Inherit Metab Dis. 1997;20:295-300.
14. Peterson JC, Spence JD. Vitamins and progression of atherosclerosis in hyperhomocysteinemia. Lancet. 1998;351:263.
15. Chambers JC, McGregor A, Jean-Marie J, Kooner JS. Acute hyperhomocysteinemia and endothelial dysfunction. Lancet. 1998;351:36-37.
16. Lentz SR, Sobey CG, Piegors DJ, et al. Vascular dysfunction in monkeys with diet-induced hyperhomocysteinemia. J Clin Invest. 1996;98:328-329.
17. Rolland PH, Friggi A, Barlaiter A, et al. Hyperhomocysteinemia-induced vascular damage in the minipig. Circulation. 1995;91:1161-1174.
18. Selhub J, Jacques PF, Wilson PWF, Rush D, Rosenberg IH. Vitamin status and intake as primary determinants of homocysteinemia in an elderly population. JAMA. 1993;270:2693-2697.
19. Gartler SM, Hornung SK, Motulsky AG. Effect of chronologic age on induction of cystathionine synthase, uroporphyrinogen I synthase, and glucose-6-phosphate dehydrogenase activities in lymphocytes. Proc Natl Acad Sci USA. 1981:78:1916-1919.
20. Bostom AG, Lathrop L. Hyperhomocysteinemia in end-stage renal disease: prevalence, etiology, and potential relationship to arteriosclerotic outcomes. Kidney Int. 1997;52:10-20.
21. Nedrebo BG, Ericsson UB, Nygard O, et al. Plasma total homocysteine levels in hypothyroid and hyperthyroid patients. Metabolism. 1998;47:89-93.
22. Food standards: amendment of standards of identity for enriched grain products to require addition of folic acid, 61. Federal Register. 8781-8797 (1996).