Acute methionine load-induced hyperhomocysteinemia enhances platelet aggregation, thromboxane biosynthesis, and macrophage-derived tissue factor activity in rats

FASEB Journal

Volumn 11, Issue 13, 1997, Pages 1157-1168

  Durand, Philippe ^a   Lussier Cacan, Suzanne ^b   Blache, Denis ^a  

^a UNIVERSITÉ DE BOURGOGNE   (France)

^b CLIN RESEARCH INSTITUTE OF MONTREAL   (Canada)

Author keywords

Atherogenesis; Folic acid; Lipid peroxidation; Thrombosis

Indexed keywords

ALKADIENE; AMINOTHIOL; FOLIC ACID; HOMOCYSTEINE; LIPID HYDROPEROXIDE; MALONALDEHYDE; METHIONINE; THIOBARBITURIC ACID REACTIVE SUBSTANCE; THROMBIN; THROMBOXANE B2;

ANIMAL CELL; ANIMAL MODEL; ARTICLE; ATHEROGENESIS; ATHEROSCLEROSIS; CONTROLLED STUDY; FOLIC ACID DEFICIENCY; HYPERCOAGULABILITY; HYPERHOMOCYSTEINEMIA; LIPID PEROXIDATION; MALE; NONHUMAN; PERITONEUM MACROPHAGE; PRIORITY JOURNAL; RAT; THROMBOCYTE AGGREGATION; THROMBOGENESIS; THROMBOSIS; VITAMIN DEFICIENCY;

EID: 0030728675     PISSN: 08926638     EISSN: None     Source Type: Journal    
DOI: 10.1096/fasebj.11.13.9367351     Document Type: Article

References (57)

1. McCully, K. S. (1983) Homocysteine theory of arteriosclerosis development and current status. Atherosclerosis Rev. 11, 157-246
2. Mudd, S. H., Levy, H. L., and Scovby, F. (1989) Disorders of transsulfuration. In Metabolic Basis of Inherited Disease (Scriver, C. R., Beauded, A. L., Sly, W. S., and Valle, D. eds) pp. 693-734, MacGraw Hill, New York
3. Ueland, P. M., and Refsum, H. (1989) Plasma homocysteine, a risk factor for vascular disease : plasma levels in health, disease, and drug therapy. J. Lab. Clin. Med. 114, 473-501
4. Boushey, C. J., Beresford, S. A. A., Omenn, G. S., and Motulsky, A. G. (1995) A quantitative assessment of plasma homocysteine as a risk factor for vascular disease - Probable benefits of increasing folic acid intakes. J. Am. Med. Assoc. 274, 1049-1057
5. Harker, L. A., Ross, R., Slichter, S. J., and Scott, C. R. (1976) Homocystine-induced arterioslerosis. The role of endothelial cell injury and platelet response in its genesis. J. Clin. Invest. 58, 731-741
6. Starkebaum, G., and Harlan, J. M. (1986) Endothelial cell injury due to copper-catalyzed hydrogen peroxide generation from homocysteine. J. Clin. Invest. 77, 1370-1376
7. Fryer, R. H., Wilson, B. D., Gubler, D. B., Fitzgerald, L. A., and Rodgers, G. M. (1993) Homocysteine, a risk factor for premature vascular disease and thrombosis, induces tissue factor activity in endothelial cells. Arterioscler. Thromb. 13, 1327-1333
8. Stamler, J. S., Osborne, J. A., Jaraki, O., Rabbani, L. E., Mullins, M., Singel, D., and Loscalzo, J. (1993) Adverse vascular effects of homocysteine are modulated by endothelium-derived relaxing factor and related oxides of nitrogen. J. Clin. Invest. 91, 308-318
9. Harpel, P. C., Zhang, X. X., and Borth, W. (1996) Homocysteine and hemostasis: Pathogenetic mechanisms predisposing to thrombosis. J. Nutr. 126, 1285S-1289S
10. Di Minno, G., Davì, G., Margaglione, M., Cirillo, F., Grandone, E., Ciabattoni, G., Catalano, I., Strisciuglio, P., Andria, G., Patrono, C., and Mancini, M. (1993) Abnormally high thromboxane biosynthesis in homozygous homocystinuria. Evidence for platelet involvement and probucol-sensitive mechanism. J. Clin. Invest. 92, 1400-1406
11. Brattström, L. (1996) Vitamins as homocysteine-lowering agents. J. Nutr. 126, 1276S-1280S
12. 12, and folate. Am. J. Epidemiol. 143, 845-859
13. Morrison, H. I., Schaubel, D., Desmeules, M., and Wigle, D. T. (1996) Serum folate and risk of fatal coronary heart disease. J. Am. Med. Assoc. 275, 1893-1896
14. Jacques, P. F., Bostom, A. G., Williams, R. R., Ellison, R. C., Eckfeldt, J. H., Rosenberg, I. H., Selhub, J., and Rozen, R. (1996) Relation between folate status, a common mutation in methylenetetrahydrofolate reductase, and plasma homocysteine concentrations. Circulation 93, 7-9
15. Kritchevsky, D. (1993) Dietary protein and experimental atherosclerosis. Ann. NY Acad. Sci. USA 676, 180-187
16. Toborek, M., Kopieczna-Grzebieniak, E., Drózdz, M., and Wieczorek, M. (1995) Increased lipid peroxidation as a mechanism of methionine-induced atherosclerosis in rabbits. Atherosclerosis 115, 217-224
17. Matthias, D., Becker, C. H., Riezler, R., and Kindling, P. H. (1996) Homocysteine induced arteriosclerosis-like alterations of the aorta in normotensive and hypertensive rats following application of high doses of methionine. Atherosclerosis 122, 201-216
18. Mansoor, M. A., Svardal, A. M., Schneede, J., and Ueland, P. M. (1992) Dynamic relation between reduced, oxidized, and protein-bound homocysteine and other thiol components in plasma during methionine loading in healthy men. Clin. Chem. 38, 1316-1321
19. Ueland, P. M., Mansoor, M. A., Guttormsen, A. B., Múller, F., Aukrust, P., Refsum, H., and Svardal, A. M. (1996) Reduced, oxidized and protein-bound forms of homocysteine and other aminothiols in plasma comprise the redox thiol status - A possible element of the extracellular antioxidant defense system. J. Nutr. 126, 1281S-1284S
20. Guttormsen, A. B., Schneede, J., Fiskerstrand, T., Ueland, P. M., and Refsum, H. M. (1994) Plasma concentrations of homocysteine and other aminothiol compounds are related to food intake in healthy human subjects. J. Nutr. 124, 1934-1941
21. Toborek, M., and Hennig, B. (1996) Dietary methionine imbalance, endothelial cell dysfunction and atherosclerosis. Nutr. Res. 16, 1251-1266
22. Durand, P., Prost, M., and Blache, D. (1996) Pro-thrombotic effects of a folic acid deficient diet in rat platelets and macrophages related to elevated homocysteine and decreased n-3 polyunsaturated fatty acids. Atheroclerosis 121, 231-243
23. Heinecke, J. W., Kawamura, M., Suzuki, L., and Chait, A. (1993) Oxidation of low density lipoprotein by thiols: Superoxide-dependent and -independent mechanisms. J. Lipid Res. 34, 2051-2061
24. James, S. J., Cross, D. R., and Miller, B. J. (1992) Alterations in nucleotide pools in rats fed diets deficient in choline, methionine and/or folic acid. Carcinogenesis 13, 2471-2474
25. Balaghi, M., Home, D. W., and Wagner, C. (1993) Hepatic one-carbon metabolism in early folate deficiency in rats. Biochem. J. 291, 145-149
26. Miller, J. W., Nadeau, M. R., Smith, J., Smith, D., and Selhub, J. (1994) Folate-deficiency-induced homocysteinaemia in rats: Disruption of S-adenosylmethionine's co-ordinate regulation of homocysteine metabolism. Biochem. J. 298, 415-419
27. Miller, J. W., Nadeau, M. R., Smith, D., and Selhub, J. (1994) Vitamin B-6 deficiency vs. folate deficiency: Comparison of responses to methionine loading in rats. Am. J. Clin. Nutr. 59, 1033-1039
28. Selhub, J., and Miller, J. W. (1992) The pathogenesis of homocysteinemia: Interruption of the coordinate regulation by S-adenosylmethionine of the remethylation and transsulfuration of homocysteine. Am. J. Clin. Nutr. 55, 131-138
29. Finkelstein, J. D. (1990) Methionine metabolism in mammals. J. Nutr. Biochem. 1, 228-237
30. Durand, P., and Blachc, D. (1996) Enhanced platelet thromboxane synthesis and reduced macrophage-dependent fibrinolytic activity related to oxidative stress in oral contraceptive-treated female rats. Atheroclerosis 121, 205-216
31. Polette, A., and Blache, D. (1992) Effect of vitamin E on acute iron load-potentiated aggregation, secretion, calcium uptake and thromboxane biosynthesis in rat platelets. Atheroclerosis 96, 171-179
32. Blache, D. (1995) Involvement of hydrogen and lipid peroxides in the acute tobacco smoking-induced platelet hyperactivity. Am. J. Physiol. 268, H679-H685
33. Ciavatti, M., Blache, D., and Renaud, S. (1989) Hormonal contraceptive increases plasma lipid peroxides in female rats. Relationship to platelet aggregation and lipid biosynthesis. Arteriosclerosis 9, 84-89
34. El-Saadani, M., Esterbauer, H., El-Sayed, M., Goher, M., Nassar, A. Y., and Jürgens, G. (1989) A spectrophotometric assay for lipid peroxides in serum lipoproteins using a commercially available reagent. J. Lipid Res. 30, 627-630
35. Durand, P., Fortin, L.-J., Lussier-Cacan, S., Davignon, J., and Blache, D. (1996) Hyperhomocysteinemia induced by folic acid deficiency and methionine load - Applications of a modified HPLC method. Clin. Chim. Acta 252, 83-93
36. Desgrès, J., Boisson, D., and Padieu, P. P. (1979) Gas-liquid chromatography of isobutyl ester, N(O)-heptafluoroburyrate derivatives of amino acids on a glass capillary column for quantitative separation in clinical biology. J. Chromatogr. 162, 133-152
37. Clarke, R., Daly, L., Robinson, K., Naughten, E., Cahalane, S., Fowler, B., and Graham, I. (1991) Hyperhomocysteinemia: An independent risk factor for vascular disease. N. Engl. J. Med. 324, 1149-1155
38. Frosst, P., Blom, H. J., Milos, R., Goyette, P., Sheppard, C. A., Matthews, R. G., Boers, G. J. H., Den Heijer, M., Kluijtmans, L. A. J., Van den Heuvel, L. P., and Rozen, R. (1995) A candidate genetic risk factor for vascular disease: A common mutation in methylenetetrahydrofolate reductase. Nature Genet. 10, 111-113
39. Durand, P., Prost, M., and Blache, D. (1997) Folic acid deficiency enhances oral contraceptive-induced platelet hyperactivity. Arterioscler. Thomb. Vasc. Biol. 17, In press
40. Ubbink, J. B., Vermaak, W. J. H., Van der Merwe, A., Becker, P. J., Delport, R., and Potgieter, H. C. (1994) Vitamin requirements for the treatment of hyperhomocysteinemia in humans. J. Nutr. 124, 1927-1933
41. Frontiera, M. S., Stabler, S. P., Kolhouse, J. F., and Allen, R. H. (1994) Regulation of methionine metabolism: Effects of nitrous oxide and excess dietary methionine. J. Nutr. Biochem. 5, 28-38
42. Bostom, A. G., Jacques, P. F., Nadeau, M. R., Williams, R. R., Ellison, R. C., and Selhub, J. (1995) Post-methionine load hyperhomocysteinemia in persons with normal fasting total plasma homocysteine: Initial results from the NHLBI Family Heart Study. Atheroclerosis 116, 147-151
43. Loehrer, F. M. T., Haefei, W. E., Angst, C. P., Browne, G., Frick, G., and Fowler, B. (1996) Effect of methionine loading on 5-methyltetrahydrofolate, S-adenosylmethionine and S-adenosylhomocysteine in plasma of healthy. Clin. Sci. 91, 79-86
44. Tsai, J.-C., Perrella, M. A., Yoshizurni, M., Hsieh, C.-M., Haber, E., Schlegel, R., and Lee, M.-E. (1994) Promotion of vascular smooth muscle cell growth by homocysteine: A link to atherosclerosis. Proc. Natl. Acad. Sci. USA 91, 6369-6373
45. Iuliano, L., Colavita, A. R., Camastra, C., Bello, V., Quintarelli, C., Alessandroni, M., Piovella, F., and Violi, F. (1996) Protection of low density lipoprotein oxidation at chemical and cellular level by the antioxidant drug dipyridamole. Br. J. Pharmacol. 119, 1438-1446
46. Dudman, N. P. B., Wilcken, D. E. L., and Stocker, R. (1993) Circulating lipid hydroperoxide levels in human hyperhomocysteinemia. Relevance to development of arteriosclerosis. Arterioscler. Thomb. Vasc. Biol. 13, 512-516
47. Blom, H. J., Kleinveld, H. A., Boers, G. H. J., Demacker, P. N. M., Hak-Lemmers, H. L. M., Te Poele Pothoff, M. T. W. B., and Trijbels, J. M. F. (1995) Lipid peroxidation and susceptibility of low-density lipoprotein to in vitro oxidation in hyperhomocysteinaemia. Eur. J. Clin. Invest. 25, 149-154
48. Andersson, A., Lindgren, A., and Hultberg, B. (1995) Effect of thiol oxidation and thiol export from erythrocytes on determination of redox status of homocysteine and other thiols in plasma from healthy subjects and patients with cerebral infarction. Clin. Chem. 41, 361-366
49. Pratico, D., Iuliano, L., Pulcinelli, F. M., Bonavita, M. S., Gazzaniga, P. P., and Violi, F. (1992) Hydrogen peroxide triggers activation of human platelets selectively exposed to nonaggregating concentrations of arachidonic acid and collagen. J. Lab. Clin. Med. 119, 364-370
50. 2 activation. Arch. Biorhem. Biophys. 289, 47-52
51. Freedman, J. E., Farhat, J. H., Loscalzo, J., and Keaney, J. F., Jr. (1996) α-Tocopherol inhibits aggregation of human platelets by a protein kinase C-dependent mechanism. Circulation 94, 2434-2440
52. Hennekens, C. H. (1994) Platelet inhibitors and antioxidant vitamins in cardiovascular disease. Am. Heart J. 128 (Suppl.), 1333-1336
53. Salonen, J. T., Salonen, R., Seppänen, K., Rinta-Kiikka, S., Kuukka, M., Korpela, H., Alfthan, G., Kantola, M., and Schalch, W. (1991) Effects of antioxidant supplementation on platelet function: A randomized pair-matched, placebo-controlled, double-blind trial in men with low antioxidant status. Am. J. Clin. Nutr. 53, 1222-1229
54. Schorer, A. E., Rick, P. D., Swaim, W. R., and Moldow, C. F. (1985) Structural features of endotoxin required for stimulation of endothelial cell tissue factor production: exposure of preformed tissue factor after oxidant-mediated endothelial cell injury. J. Lab. Clin. Med. 106, 38
55. Brisseau, G. F., Dackiw, A. P. B., Cheung, P. Y. C., Christie, N., and Rotstein, O. D. (1995) Posttranscriptional regulation of macrophage tissue factor expression by antioxidants. Blood 85, 1025-1035
56. Crutchley, D. J., and Que, B. G. (1995) Copper-induced tissue factor expression in human monocytic THP-1 cells and its inhibition by antioxidants. Circulation 92, 238-243
57. Richie, J. P.,Jr., Leutzinger, Y., Parthasarathy, S., Malloy, V., Orentreich, N., and Zimmerman, J. A. (1994) Methionine restriction increases blood glutathione and longevity in F344 rats. FASEB J. 8, 1302-1307