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Volumn 158, Issue 8, 1998, Pages 862-867

Homocysteine and ischemin heart disease: Results of a prospective study with implication regarding prevention

Author keywords

[No Author keywords available]

Indexed keywords

FOLIC ACID; HOMOCYSTEINE;

EID: 0032571596     PISSN: 00039926     EISSN: None     Source Type: Journal    
DOI: 10.1001/archinte.158.8.862     Document Type: Article
Times cited : (352)

References (63)
  • 1
    • 0014545138 scopus 로고
    • Vascular pathology of homocyst(e)inemia: Implications for the pathogenesis of arteriosclerosis
    • McCully KS. Vascular pathology of homocyst(e)inemia: implications for the pathogenesis of arteriosclerosis. Am J Pathol. 1969;56:111-128.
    • (1969) Am J Pathol , vol.56 , pp. 111-128
    • McCully, K.S.1
  • 4
    • 0025756673 scopus 로고
    • Hyperhomocysteinemia: An independent risk factor for vascular disease
    • Clarke R, Daly L, Robinson K, et al. Hyperhomocysteinemia: an independent risk factor for vascular disease. N Engl J Med. 1991;324:1149-1155.
    • (1991) N Engl J Med , vol.324 , pp. 1149-1155
    • Clarke, R.1    Daly, L.2    Robinson, K.3
  • 6
    • 0028267831 scopus 로고
    • Plasma homocyst(e)ine. folate, and vitamin B-12 concentrations and risk for early onset coronary artery disease
    • Pancharuniti N, Lewis CA, Sauberlich HE, et al. Plasma homocyst(e)ine. folate, and vitamin B-12 concentrations and risk for early onset coronary artery disease. Am J clin Nutr. 1994;59:940-948.
    • (1994) Am J Clin Nutr , vol.59 , pp. 940-948
    • Pancharuniti, N.1    Lewis, C.A.2    Sauberlich, H.E.3
  • 7
    • 0028210769 scopus 로고
    • Plasma homocyst(e)ine as a risk factor for early familial coronary artery disease
    • Wu LL, Wu J, Hunt SC, et al. Plasma homocyst(e)ine as a risk factor for early familial coronary artery disease. Clin Chem. 1994;40:552-561.
    • (1994) Clin Chem , vol.40 , pp. 552-561
    • Wu, L.L.1    Wu, J.2    Hunt, S.C.3
  • 8
    • 0029009175 scopus 로고
    • Homocysteine and coronary artery disease in French Canadian subjects: Relation with vitamins B12, B6. pyridoxal phosphate, and folate
    • Dalery K, Lusster-Cocan S, Selhub J, Davignon J, Latour Y, Genest J. Homocysteine and coronary artery disease in French Canadian subjects: relation with vitamins B12, B6. pyridoxal phosphate, and folate. Am J Cardiol. 1995;75:1107-1111.
    • (1995) Am J Cardiol , vol.75 , pp. 1107-1111
    • Dalery, K.1    Lusster-Cocan, S.2    Selhub, J.3    Davignon, J.4    Latour, Y.5    Genest, J.6
  • 9
    • 0029924647 scopus 로고    scopus 로고
    • Homocysteine metabolism and risk of myocardial infarction: Relation with vitamins B6, B12, and folate
    • Verhoef P, Stampfer MJ, Buring JE, et al. Homocysteine metabolism and risk of myocardial infarction: relation with vitamins B6, B12, and folate. Am J Epidemiol. 1996;143:845-859.
    • (1996) Am J Epidemiol , vol.143 , pp. 845-859
    • Verhoef, P.1    Stampfer, M.J.2    Buring, J.E.3
  • 10
    • 0029066299 scopus 로고
    • A quantitative assessment of plasma homocysteine as a risk factor for vascular disease
    • Boushey CJ, Beresford SAA, Omenn GS, Motulsky AG. A quantitative assessment of plasma homocysteine as a risk factor for vascular disease. JAMA. 1995; 274:1049-1057.
    • (1995) JAMA , vol.274 , pp. 1049-1057
    • Boushey, C.J.1    Beresford, S.A.A.2    Omenn, G.S.3    Motulsky, A.G.4
  • 11
    • 0342437489 scopus 로고    scopus 로고
    • Plasma homocysteine and cardiovascular disease mortality
    • Alfthan G, Aro A, Gey KF. Plasma homocysteine and cardiovascular disease mortality. Lancet. 1997;349:397.
    • (1997) Lancet , vol.349 , pp. 397
    • Alfthan, G.1    Aro, A.2    Gey, K.F.3
  • 13
    • 0026684554 scopus 로고
    • A prospective study of plasma homocysteine and risk of myocardial infarction in US physicians
    • Stampfer MJ, Malinow MR, Willett WC, et al. A prospective study of plasma homocysteine and risk of myocardial infarction in US physicians. JAMA. 1992;268: 877-881.
    • (1992) JAMA , vol.268 , pp. 877-881
    • Stampfer, M.J.1    Malinow, M.R.2    Willett, W.C.3
  • 14
    • 0028219672 scopus 로고
    • Relation of serum homocysteine and lipoprotein(a) concentrations to atherosclerotic disease in a prospective Finnish population based study
    • Alfthan G, Pekkanen J, Juahianen M, et al. Relation of serum homocysteine and lipoprotein(a) concentrations to atherosclerotic disease in a prospective Finnish population based study. Atherosclerosis. 1994;106:9-19.
    • (1994) Atherosclerosis , vol.106 , pp. 9-19
    • Alfthan, G.1    Pekkanen, J.2    Juahianen, M.3
  • 18
    • 0026036480 scopus 로고
    • The association of elevated plasma homocyst(e)ine with progression of symptomatic peripheral arterial disease
    • Taylor LM, DeFrang RD, Harris EJ, Porter JM. The association of elevated plasma homocyst(e)ine with progression of symptomatic peripheral arterial disease. J Vasc Surg. 1991;13:128-136.
    • (1991) J Vasc Surg , vol.13 , pp. 128-136
    • Taylor, L.M.1    DeFrang, R.D.2    Harris, E.J.3    Porter, J.M.4
  • 20
    • 0028845307 scopus 로고
    • Prospective study of serum total homocysteine concentrations and risk of stroke in middle aged British men
    • Perry IJ, Refseum H, Morrise RW, Ebrahim SB, Ueland PM, Shaper AC. Prospective study of serum total homocysteine concentrations and risk of stroke in middle aged British men. Lancet 1995;346:1395-1398.
    • (1995) Lancet , vol.346 , pp. 1395-1398
    • Perry, I.J.1    Refseum, H.2    Morrise, R.W.3    Ebrahim, S.B.4    Ueland, P.M.5    Shaper, A.C.6
  • 21
    • 0030603334 scopus 로고    scopus 로고
    • Plasma homocysteine as a risk factor for atherothrombotic events in systematic lupus erythematosus
    • Petri M, Roubenoff R, Dallal GE, Nadeau MR, Selhub J, Rosenberg IH. Plasma homocysteine as a risk factor for atherothrombotic events in systematic lupus erythematosus. Lancet. 1996;348:1120-1124.
    • (1996) Lancet , vol.348 , pp. 1120-1124
    • Petri, M.1    Roubenoff, R.2    Dallal, G.E.3    Nadeau, M.R.4    Selhub, J.5    Rosenberg, I.H.6
  • 22
    • 0028156929 scopus 로고
    • Apolipoproteins and ischaemic heart disease: Implications for screening
    • Wald NJ, Law M, Watt H, et al. Apolipoproteins and ischaemic heart disease: implications for screening. Lancet. 1994;343:75-79.
    • (1994) Lancet , vol.343 , pp. 75-79
    • Wald, N.J.1    Law, M.2    Watt, H.3
  • 23
    • 0023628783 scopus 로고
    • Determination of free and total homocysteine in human plasma by high performance chromatography with fluorescent detection
    • Araki A, Sako Y. Determination of free and total homocysteine in human plasma by high performance chromatography with fluorescent detection. J Chromatogr. 1987;422:43-52.
    • (1987) J Chromatogr , vol.422 , pp. 43-52
    • Araki, A.1    Sako, Y.2
  • 24
    • 0025848779 scopus 로고
    • Rapid high performance liquid chromatography assay for total homocysteine levels in human serum
    • Ubbink JB, Vermaak WJH, Bissbort S. Rapid high performance liquid chromatography assay for total homocysteine levels in human serum. J Chromatogr. 1991;565:441-446.
    • (1991) J Chromatogr , vol.565 , pp. 441-446
    • Ubbink, J.B.1    Vermaak, W.J.H.2    Bissbort, S.3
  • 25
    • 0028177431 scopus 로고
    • Effects of age, lipoproteins and hemostatic parameters on the role of homocyst(e)inemia as a cardiovascular risk factor in men
    • von Eckardstein A, Manilow MR, Upson B, et al. Effects of age, lipoproteins and hemostatic parameters on the role of homocyst(e)inemia as a cardiovascular risk factor in men. Arterioscler Thromb. 1994;14:460-464.
    • (1994) Arterioscler Thromb , vol.14 , pp. 460-464
    • Von Eckardstein, A.1    Manilow, M.R.2    Upson, B.3
  • 27
    • 0029739175 scopus 로고    scopus 로고
    • Hyperhomocysteinaemia and premature coronary artery disease in the Chinese
    • Lolin YI, Sanderson JE, Cheng SK, et al. Hyperhomocysteinaemia and premature coronary artery disease in the Chinese. Heart. 1996;76:117-122.
    • (1996) Heart , vol.76 , pp. 117-122
    • Lolin, Y.I.1    Sanderson, J.E.2    Cheng, S.K.3
  • 28
    • 1842331509 scopus 로고    scopus 로고
    • Plasma homocysteine as a risk factor for vascular disease
    • Graham IM, Daly LE, Refsum HM, et al. Plasma homocysteine as a risk factor for vascular disease. JAMA. 1997;277:1775-1781.
    • (1997) JAMA , vol.277 , pp. 1775-1781
    • Graham, I.M.1    Daly, L.E.2    Refsum, H.M.3
  • 30
    • 0025893209 scopus 로고
    • Floating absolute risk: An alternative to relative risk in survival and case-control analysis avoiding an arbitrary reference group
    • Easton DF, Peto J, Babiker AGAG. Floating absolute risk: an alternative to relative risk in survival and case-control analysis avoiding an arbitrary reference group. Stat Med. 1991;10:1025-1035.
    • (1991) Stat Med , vol.10 , pp. 1025-1035
    • Easton, D.F.1    Peto, J.2    Babiker, A.G.A.G.3
  • 31
    • 0027523674 scopus 로고
    • Carotid artery intimal medial thickening and plasma homocysteine in asymptomatic adults: The Atherosclerosis Risk in Communities Study
    • Malinow MR, Nieto FJ, Szklo M, Chambless LE, Bond G. Carotid artery intimal medial thickening and plasma homocysteine in asymptomatic adults: the Atherosclerosis Risk in Communities Study. Circulation. 1993;87:1107-1113.
    • (1993) Circulation , vol.87 , pp. 1107-1113
    • Malinow, M.R.1    Nieto, F.J.2    Szklo, M.3    Chambless, L.E.4    Bond, G.5
  • 32
    • 0028966321 scopus 로고
    • Association between plasma homocysteine concentration and extracranial carotid artery stenosis
    • Selhub J, Jacques PF, Boston AG, et al. Association between plasma homocysteine concentration and extracranial carotid artery stenosis. N Engl J Med. 1995; 332:286-291.
    • (1995) N Engl J Med , vol.332 , pp. 286-291
    • Selhub, J.1    Jacques, P.F.2    Boston, A.G.3
  • 33
    • 0028853667 scopus 로고
    • Prospective studies of homocysteine and cardiovascular disease
    • Verhoef P, Stampfer MJ. Prospective studies of homocysteine and cardiovascular disease. Nutr Rev. 1995;33:283-288.
    • (1995) Nutr Rev , vol.33 , pp. 283-288
    • Verhoef, P.1    Stampfer, M.J.2
  • 34
    • 0028181730 scopus 로고
    • By how much and how quickly does reducing serum cholesterol lower the risk of ischaemic heart disease?
    • Law MR, Wald NJ, Thompson SG. By how much and how quickly does reducing serum cholesterol lower the risk of ischaemic heart disease? BMJ. 1994;308: 367-372.
    • (1994) BMJ , vol.308 , pp. 367-372
    • Law, M.R.1    Wald, N.J.2    Thompson, S.G.3
  • 35
    • 0013870606 scopus 로고
    • The Dorn study of smoking and mortality among US veterans: Report on eight and one-half years of observation
    • Kahn HA. The Dorn study of smoking and mortality among US veterans: report on eight and one-half years of observation. Natl Cancer Inst Monogr. 1966;19: 1-125.
    • (1966) Natl Cancer Inst Monogr , vol.19 , pp. 1-125
    • Kahn, H.A.1
  • 36
    • 0026593243 scopus 로고
    • Serum cholesterol, blood pressure, cigarette smoking, and death from coronary heart disease
    • Neaton JD, Wentworth D. Serum cholesterol, blood pressure, cigarette smoking, and death from coronary heart disease. Arch Intern Med. 1992;152:56-64.
    • (1992) Arch Intern Med , vol.152 , pp. 56-64
    • Neaton, J.D.1    Wentworth, D.2
  • 37
    • 0000301767 scopus 로고
    • Clinical implications of hyperhomocysteinemia
    • Bailey L, ed. New York, NY: Marcel Decker
    • Green R, Jacobsen DW. Clinical implications of hyperhomocysteinemia. In: Bailey L, ed. Folate in Health and Disease. New York, NY: Marcel Decker; 1995:75-122.
    • (1995) Folate in Health and Disease , pp. 75-122
    • Green, R.1    Jacobsen, D.W.2
  • 38
    • 0026034240 scopus 로고
    • Thermolabile methylenetetrahydrofolate reductase: An inherited risk factor for coronary artery disease
    • Kang SS, Wong PWK, Susmando A, Sora J, Norusis M, Ruggie N. Thermolabile methylenetetrahydrofolate reductase: an inherited risk factor for coronary artery disease. Am J Hum Genet. 1991;48:536-545.
    • (1991) Am J Hum Genet , vol.48 , pp. 536-545
    • Kang, S.S.1    Wong, P.W.K.2    Susmando, A.3    Sora, J.4    Norusis, M.5    Ruggie, N.6
  • 39
    • 0029049553 scopus 로고
    • A candidate genetic risk factor for vascular disease: A common mutation in methylenetetrahydrofoate reductase
    • Frosst P, Blom HJ, Milos R, et al. A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofoate reductase. Nat Genet. 1995;10:111-113.
    • (1995) Nat Genet , vol.10 , pp. 111-113
    • Frosst, P.1    Blom, H.J.2    Milos, R.3
  • 40
    • 0028844492 scopus 로고
    • Mutated methylenetetrahydrofolate reductase as a risk factor for spina bifida
    • Van der Put NMJ, Steegers-Theunissen RPM, Frosst P, et al. Mutated methylenetetrahydrofolate reductase as a risk factor for spina bifida. Lancet. 1995; 346:1070-1071.
    • (1995) Lancet , vol.346 , pp. 1070-1071
    • Van der Put, N.M.J.1    Steegers-Theunissen, R.P.M.2    Frosst, P.3
  • 41
    • 0030027668 scopus 로고    scopus 로고
    • Relation between folate status, a common mutation in methylenetetrahydrofolate reductase, and plasma homocysteine concentrations
    • Jacques PF, Bostom AG, Williams RR, et al. Relation between folate status, a common mutation in methylenetetrahydrofolate reductase, and plasma homocysteine concentrations. Circulation. 1996;93:7-9.
    • (1996) Circulation , vol.93 , pp. 7-9
    • Jacques, P.F.1    Bostom, A.G.2    Williams, R.R.3
  • 42
    • 0029738540 scopus 로고    scopus 로고
    • The common "thermo-labile" variant of methylene-tetrahydrofolate reductase is a major determinant of mild hyperhomocysteinaemia
    • Harmon DL, Woodside JV, Yarrell JWG, et al. The common "thermo-labile" variant of methylene-tetrahydrofolate reductase is a major determinant of mild hyperhomocysteinaemia, QJM. 1996;89:571-577.
    • (1996) QJM , vol.89 , pp. 571-577
    • Harmon, D.L.1    Woodside, J.V.2    Yarrell, J.W.G.3
  • 43
    • 0023892344 scopus 로고
    • Thermolabile methylenetetrahydrofolate reductase in patients with coronary artery disease
    • Kang SS, Wong PWK, Zhou J, Sora J, Lessick M, Grcevich G. Thermolabile methylenetetrahydrofolate reductase in patients with coronary artery disease. Metabolism. 1988;37:611-613.
    • (1988) Metabolism , vol.37 , pp. 611-613
    • Kang, S.S.1    Wong, P.W.K.2    Zhou, J.3    Sora, J.4    Lessick, M.5    Grcevich, G.6
  • 44
    • 0027421353 scopus 로고
    • Thermolabile methylenetetrahydrofolate reductase in coronary artery disease
    • Kang SS, Passen EL, Ruggie N, Wong PWK, Sora H. Thermolabile methylenetetrahydrofolate reductase in coronary artery disease. Circulation. 1993;88:1463-1469.
    • (1993) Circulation , vol.88 , pp. 1463-1469
    • Kang, S.S.1    Passen, E.L.2    Ruggie, N.3    Wong, P.W.K.4    Sora, H.5
  • 46
    • 0029827313 scopus 로고    scopus 로고
    • Homocysteine and risk of premature coronary heart disease: Evidence for a common gene mutation
    • Gallagher PM, Meleady R, Shields DS, et al. Homocysteine and risk of premature coronary heart disease: evidence for a common gene mutation. Circulation. 1996;94:2154-2158.
    • (1996) Circulation , vol.94 , pp. 2154-2158
    • Gallagher, P.M.1    Meleady, R.2    Shields, D.S.3
  • 47
    • 0029975240 scopus 로고    scopus 로고
    • Genetic analysis of thermolabile methylenetetrahydrofolate reductase as a risk factor for myocardial infarction
    • Adams M, Smith PD, Martin D, Thompson JR, Lodwick D, Samani NJ. Genetic analysis of thermolabile methylenetetrahydrofolate reductase as a risk factor for myocardial infarction. QJM. 1996;89:437-444.
    • (1996) QJM , vol.89 , pp. 437-444
    • Adams, M.1    Smith, P.D.2    Martin, D.3    Thompson, J.R.4    Lodwick, D.5    Samani, N.J.6
  • 48
    • 0029806746 scopus 로고    scopus 로고
    • Methylenetetrahydrofolate reductase, polymorphism, plasma folate, homocysteine and risk of myocardial infarction in US physicians
    • Ma J, Stampfer MJ, Hennekens CH, et al. Methylenetetrahydrofolate reductase, polymorphism, plasma folate, homocysteine and risk of myocardial infarction in US physicians. Circulation. 1996;94:2410-2416.
    • (1996) Circulation , vol.94 , pp. 2410-2416
    • Ma, J.1    Stampfer, M.J.2    Hennekens, C.H.3
  • 49
    • 0029655724 scopus 로고    scopus 로고
    • Molecular genetic analysis in mild hyperhomocysteinemia: A common mutation in the methylenetetrahydrofolate reductase gene is a genetic risk factor for cardiovascular disease
    • Kluijtmans LAJ, van den Heuvel LPWJ, Boers GHJ, et al. Molecular genetic analysis in mild hyperhomocysteinemia: a common mutation in the methylenetetrahydrofolate reductase gene is a genetic risk factor for cardiovascular disease. Am J Hum Genet. 1996;58:35-41.
    • (1996) Am J Hum Genet , vol.58 , pp. 35-41
    • Kluijtmans, L.A.J.1    Van den Heuvel, L.P.W.J.2    Boers, G.H.J.3
  • 50
    • 0030476385 scopus 로고    scopus 로고
    • Common mutation in methylenetetrahydrofolate reductase
    • Deloughery TG, Evans A, Sadeghi A et al. Common mutation in methylenetetrahydrofolate reductase. Circulation. 1996;94:3074-3078.
    • (1996) Circulation , vol.94 , pp. 3074-3078
    • Deloughery, T.G.1    Evans, A.2    Sadeghi, A.3
  • 52
    • 0016390789 scopus 로고
    • Homocystinemia: Vascular injury and arterial thrombosis
    • Harker LA, Slighter SJ, Scott CR, Ross R. Homocystinemia: vascular injury and arterial thrombosis. N Engl J Med. 1974;291:537-543.
    • (1974) N Engl J Med , vol.291 , pp. 537-543
    • Harker, L.A.1    Slighter, S.J.2    Scott, C.R.3    Ross, R.4
  • 53
    • 0016743933 scopus 로고
    • Homocysteine theory of arteriosclerosis
    • McCully KS, Wilson RB. Homocysteine theory of arteriosclerosis. Arteriosclerosis. 1975;22:215-227.
    • (1975) Arteriosclerosis , vol.22 , pp. 215-227
    • McCully, K.S.1    Wilson, R.B.2
  • 54
    • 0017197285 scopus 로고
    • Homocysteine-induced arteriosclerosis: The role of endothelial cell injury and platelet response in its genesis
    • Harker LA, ROSS R, Slichter SJ, Scott CR. Homocysteine-induced arteriosclerosis: the role of endothelial cell injury and platelet response in its genesis. J Clin lnvest. 1976;58:731-741.
    • (1976) J Clin Lnvest , vol.58 , pp. 731-741
    • Harker, L.A.1    Ross, R.2    Slichter, S.J.3    Scott, C.R.4
  • 55
    • 0018858624 scopus 로고
    • Homocysteine-induced endothelial cell injury in vitro: A model for the study of vascular injury
    • Wall RT, Harlan JM, Harker LA, Striker GE. Homocysteine-induced endothelial cell injury in vitro: a model for the study of vascular injury. Thromb Res. 1980; 18:113-121.
    • (1980) Thromb Res , vol.18 , pp. 113-121
    • Wall, R.T.1    Harlan, J.M.2    Harker, L.A.3    Striker, G.E.4
  • 56
    • 0025095390 scopus 로고
    • Impaired homocysteine metabolism in early onset cerebral and peripheral occlusive arterial disease: Effect of pyridoxine and folic acid treatment
    • Brattstrom L, Israelsson B, Worrying B, etal. Impaired homocysteine metabolism in early onset cerebral and peripheral occlusive arterial disease: effect of pyridoxine and folic acid treatment. Atherosclerosis. 1990;81:51-60.
    • (1990) Atherosclerosis , vol.81 , pp. 51-60
    • Brattstrom, L.1    Israelsson, B.2    Worrying, B.3
  • 59
    • 0029069203 scopus 로고
    • Effects of vitamin B12. folate, and vitamin B6 supplements in elderly people with normal serum vitamin concentrations
    • Naurath HJ, Joosten E, Riezler R, Stabler SP, Allen RH, Lindenbaum J. Effects of vitamin B12. folate, and vitamin B6 supplements in elderly people with normal serum vitamin concentrations. Lancet. 1995;346:85-89.
    • (1995) Lancet , vol.346 , pp. 85-89
    • Naurath, H.J.1    Joosten, E.2    Riezler, R.3    Stabler, S.P.4    Allen, R.H.5    Lindenbaum, J.6
  • 61
    • 0030750822 scopus 로고    scopus 로고
    • Plasma homocysteine, a risk factor for cardiovascular disease, is lowered by physiological doses of folic acid
    • Ward M, McNulty H, McPartlin J, Strain JJ, Weir DG, Scott JM. Plasma homocysteine, a risk factor for cardiovascular disease, is lowered by physiological doses of folic acid. QJM. 1997;90:519-524.
    • (1997) QJM , vol.90 , pp. 519-524
    • Ward, M.1    McNulty, H.2    McPartlin, J.3    Strain, J.J.4    Weir, D.G.5    Scott, J.M.6
  • 63
    • 0027382008 scopus 로고
    • Vitamin status and intake as primary determinants of homocysteinemia in an elderly population
    • Selhub J, Jacques PF, Wilson PWF, Rush D, Rosenberg IH. Vitamin status and intake as primary determinants of homocysteinemia in an elderly population. JAMA. 1993;270:2693-2698.
    • (1993) JAMA , vol.270 , pp. 2693-2698
    • Selhub, J.1    Jacques, P.F.2    Wilson, P.W.F.3    Rush, D.4    Rosenberg, I.H.5


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