Hyperhomocysteinemia is a risk factor for cancer and a new potential tumor marker

Clinica Chimica Acta

Volumn 322, Issue 1-2, 2002, Pages 21-28

  Wu, Lily L ^a   Wu, James T ^a  

^a ARUP LABORATORIES   (United States)

Author keywords

Cancer; Cell death; Folate; Oxidative stress; Risk factor; Tissue culture; Total serum homocysteine; Tumor marker

Indexed keywords

DNA; FOLIC ACID; FOLIC ACID ANTAGONIST; HOMOCYSTEINE; HOMOCYSTEINE THIOLACTONE; TUMOR MARKER;

CANCER; CANCER DIAGNOSIS; CANCER PATIENT; CANCER RISK; CANCER THERAPY; CARCINOGENESIS; CARDIOVASCULAR RISK; CELL DEATH; CELL PROLIFERATION; CIRCULATION; CORRELATION ANALYSIS; DIAGNOSTIC ACCURACY; DIAGNOSTIC VALUE; DISEASE ASSOCIATION; DNA METHYLATION; FOLIC ACID DEFICIENCY; HEMOCONCENTRATION; HUMAN; HYPERHOMOCYSTEINEMIA; ISCHEMIC HEART DISEASE; OXIDATIVE STRESS; PATIENT MONITORING; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN DETERMINATION; PROTEIN METABOLISM; REVIEW; RISK FACTOR; TUMOR CELL CULTURE; TUMOR GROWTH;

HOMOCYSTEINE; HUMANS; HYPERHOMOCYSTEINEMIA; NEOPLASMS; OXIDATIVE STRESS; RISK FACTORS; TUMOR MARKERS, BIOLOGICAL;

EID: 0036294472     PISSN: 00098981     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0009-8981(02)00174-2     Document Type: Review

References (31)

1. Perturbation of homocysteine metabolism by pharmacological agents in experimental and clinical use
2. Determination of free and total homocysteine in human plasma by high-performance liquid chromatography with fluorescence detection
3. Dynamic relation between reduced, oxidized, and protein-bound homocysteine and other thiol components in plasma during methionine loading in healthy men
4. Plasma homocyst(e)ine or homocysteine
5. Homocysteine and vitamins in cardiovascular disease
6. Plasma homocysteine, a risk factor for vascular disease: Plasma levels in health, disease, and drug therapy
7. Differential regulation of polyamine synthesis and transmethylation reactions in methylthioadenosine phosphorylase deficient mammalian cells
8. Methylene tetrahydrofolate reductase (MTHFR) and nitric oxide synthase (NOS) genes and risks of peripheral arterial disease and coronary heart disease: Edinburgh Artery Study
9. Homocysteine accumulation in human ovarian carcinoma ascitic/cystic fluids possibly caused by metabolic alteration of the methionine cycle in ovarian carcinoma cells
10. Serum folate, homocysteine and colorectal cancer risk in women: A nested case-control study
11. Methylenetetrahydrofolate reductase polymorphism, dietary interactions, and risk of colorectal cancer
12. A prospective study of methylenetetrahydrofolate reductase and methionine synthase gene polymorphisms, and risk of colorectal adenoma
13. DNA methylation and cancer
14. Folate deficiency causes uracil misincorporaion into human DNA and chromosome breakage: Implications for cancer and neuronal damage
15. Pancreatic cancer risk and nutrition-related methyl-group availability indicators in male smokers
16. Serum folate, homocysteine and colorectal cancer risk in women: A nested case-control study
17. Plasma homocysteine in children with acute lymphoblastic leukemia: Changes during a chemotherapeutic regimen including methotrexate
18. Plasma homocysteine, a risk factor for vascular disease: Plasma levels in health, disease, and drug therapy
19. Role of vitamin B12 and folate deficiencies in carcinogenesis
20. Folate deficiency in vitro induces uracil misincorporation and DNA hypomethylation and inhibits DNA excision repair in immortalized normal human colon epithelial cells
21. Mutations of the p53 tumor suppressor gene and ras oncogenes in aflatoxin hepatocarcinogenesis
22. Repair of oxidative damage to nuclear and mitochondrial DNA in mammalian cells
23. Evidence for hypomethylation in two children with acute lymphoblastic leukemia and leukoencephalopathy
24. Localized folate and vitamin B-12 deficiency in squamous cell lung cancer is associated with global DNA hypomethylation
25. Genomic instability: First step to carcinogenesis
26. DNA global hypomethylation in EBV-transformed interphase nuclei
27. Evaluation of global DNA hypomethylation in human colon cancer tissues by immunohistochemistry and image analysis
28. High frequency of alterations in DNA methylation in adenocarcinoma of the prostate
29. Genomic instability: First step to carcinogenesis
30. Synthesis of homocysteine thiolactone by methionyl-tRNA synthetase in cultured mammalian cells