-
1
-
-
33744520321
-
Cytochromes P450 as versatile biocatalysts
-
Bernhardt R. Cytochromes P450 as versatile biocatalysts. J. Biotechnol. 124 (2006) 128-145
-
(2006)
J. Biotechnol.
, vol.124
, pp. 128-145
-
-
Bernhardt, R.1
-
2
-
-
0036560522
-
Cytochrome P450 enzymes in the generation of commercial products
-
Guengerich F.P. Cytochrome P450 enzymes in the generation of commercial products. Nat. Rev. Drug Discov. 1 (2002) 359-366
-
(2002)
Nat. Rev. Drug Discov.
, vol.1
, pp. 359-366
-
-
Guengerich, F.P.1
-
3
-
-
31344438135
-
Enantioselective epoxidation of terminal alkenes to (R)- and (S)-epoxides by engineered cytochromes P450 BM-3
-
Kubo T., et al. Enantioselective epoxidation of terminal alkenes to (R)- and (S)-epoxides by engineered cytochromes P450 BM-3. Chemistry 12 (2006) 1216-1220
-
(2006)
Chemistry
, vol.12
, pp. 1216-1220
-
-
Kubo, T.1
-
4
-
-
33745203031
-
Heterotropic and homotropic cooperativity by a drug-metabolising mutant of cytochrome P450 BM3
-
van Vugt-Lussenburg B.M., et al. Heterotropic and homotropic cooperativity by a drug-metabolising mutant of cytochrome P450 BM3. Biochem. Biophys. Res. Commun. 346 (2006) 810-818
-
(2006)
Biochem. Biophys. Res. Commun.
, vol.346
, pp. 810-818
-
-
van Vugt-Lussenburg, B.M.1
-
5
-
-
18144389824
-
Evaluation of alkoxyresorufins as fluorescent substrates for cytochrome P450 BM3 and site-directed mutants
-
Lussenburg B.M., et al. Evaluation of alkoxyresorufins as fluorescent substrates for cytochrome P450 BM3 and site-directed mutants. Anal. Biochem. 341 (2005) 148-155
-
(2005)
Anal. Biochem.
, vol.341
, pp. 148-155
-
-
Lussenburg, B.M.1
-
6
-
-
0036558027
-
P450 BM3: the very model of a modern flavocytochrome
-
Munro A.W., et al. P450 BM3: the very model of a modern flavocytochrome. Trends Biochem. Sci. 27 (2002) 250-257
-
(2002)
Trends Biochem. Sci.
, vol.27
, pp. 250-257
-
-
Munro, A.W.1
-
7
-
-
33746021124
-
Preparative use of isolated CYP102 monooxygenases: a critical appraisal
-
Eiben S., et al. Preparative use of isolated CYP102 monooxygenases: a critical appraisal. J. Biotechnol. 124 (2006) 662-669
-
(2006)
J. Biotechnol.
, vol.124
, pp. 662-669
-
-
Eiben, S.1
-
8
-
-
33747624251
-
Non-enzymatic regeneration of nicotinamide and flavin cofactors for monooxygenase catalysis
-
Hollmann F., et al. Non-enzymatic regeneration of nicotinamide and flavin cofactors for monooxygenase catalysis. Trends Biotechnol. 24 (2006) 163-171
-
(2006)
Trends Biotechnol.
, vol.24
, pp. 163-171
-
-
Hollmann, F.1
-
9
-
-
33745652737
-
Cytochrome P450 monooxygenases: perspectives for synthetic application
-
Urlacher V.B., and Eiben S. Cytochrome P450 monooxygenases: perspectives for synthetic application. Trends Biotechnol. 24 (2006) 324-330
-
(2006)
Trends Biotechnol.
, vol.24
, pp. 324-330
-
-
Urlacher, V.B.1
Eiben, S.2
-
10
-
-
34147130326
-
Wild-type CYP102A1 as a biocatalyst: turnover of drugs usually metabolised by human liver enzymes
-
Di Nardo G., et al. Wild-type CYP102A1 as a biocatalyst: turnover of drugs usually metabolised by human liver enzymes. J. Biol. Inorg. Chem. 12 (2007) 313-323
-
(2007)
J. Biol. Inorg. Chem.
, vol.12
, pp. 313-323
-
-
Di Nardo, G.1
-
11
-
-
1942497956
-
Cytochromes P450, drugs and diseases
-
Guengerich F.P. Cytochromes P450, drugs and diseases. Mol. Interv. 3 (2003) 194-204
-
(2003)
Mol. Interv.
, vol.3
, pp. 194-204
-
-
Guengerich, F.P.1
-
12
-
-
30744438083
-
Radical intermediates in the catalytic oxidation of hydrocarbons by bacterial and human cytochrome P450 enzymes
-
Jiang Y., et al. Radical intermediates in the catalytic oxidation of hydrocarbons by bacterial and human cytochrome P450 enzymes. Biochemistry 45 (2006) 533-542
-
(2006)
Biochemistry
, vol.45
, pp. 533-542
-
-
Jiang, Y.1
-
13
-
-
32544436092
-
Preparation of human metabolites of propranolol using laboratory-evolved bacterial cytochromes P450
-
Otey C.R., et al. Preparation of human metabolites of propranolol using laboratory-evolved bacterial cytochromes P450. Biotechnol. Bioeng. 93 (2006) 494-499
-
(2006)
Biotechnol. Bioeng.
, vol.93
, pp. 494-499
-
-
Otey, C.R.1
-
14
-
-
33846931755
-
Identification of critical residues in novel drug-metabolizing mutants of cytochrome P450 BM3 using random mutagenesis
-
Vugt-Lussenburg B.M., et al. Identification of critical residues in novel drug-metabolizing mutants of cytochrome P450 BM3 using random mutagenesis. J. Med. Chem. 50 (2007) 455-461
-
(2007)
J. Med. Chem.
, vol.50
, pp. 455-461
-
-
Vugt-Lussenburg, B.M.1
-
15
-
-
33646505950
-
Enantioselective α-hydroxylation of 2-arylacetic acid derivatives and buspirone catalyzed by engineered cytochrome P450 BM-3
-
Landwehr M., et al. Enantioselective α-hydroxylation of 2-arylacetic acid derivatives and buspirone catalyzed by engineered cytochrome P450 BM-3. J. Am. Chem. Soc. 128 (2006) 6058-6059
-
(2006)
J. Am. Chem. Soc.
, vol.128
, pp. 6058-6059
-
-
Landwehr, M.1
-
16
-
-
4043109994
-
Functional evolution and structural conservation in chimeric cytochromes p450: calibrating a structure-guided approach
-
Otey C.R., et al. Functional evolution and structural conservation in chimeric cytochromes p450: calibrating a structure-guided approach. Chem. Biol. 11 (2004) 309-318
-
(2004)
Chem. Biol.
, vol.11
, pp. 309-318
-
-
Otey, C.R.1
-
17
-
-
0034973773
-
Common and uncommon cytochrome P450 reactions related to metabolism and chemical toxicity
-
Guengerich F.P. Common and uncommon cytochrome P450 reactions related to metabolism and chemical toxicity. Chem. Res. Toxicol. 14 (2001) 611-650
-
(2001)
Chem. Res. Toxicol.
, vol.14
, pp. 611-650
-
-
Guengerich, F.P.1
-
18
-
-
0242330792
-
Regio- and enantioselective alkane hydroxylation with engineered cytochromes P450 BM-3
-
Peters M.W., et al. Regio- and enantioselective alkane hydroxylation with engineered cytochromes P450 BM-3. J. Am. Chem. Soc. 125 (2003) 13442-13450
-
(2003)
J. Am. Chem. Soc.
, vol.125
, pp. 13442-13450
-
-
Peters, M.W.1
-
19
-
-
17644376530
-
Preparative synthesis of drug metabolites using human cytochrome P450s 3A4, 2C9 and 1A2 with NADPH-P450 reductase expressed in Escherichia coli
-
Vail R.B., et al. Preparative synthesis of drug metabolites using human cytochrome P450s 3A4, 2C9 and 1A2 with NADPH-P450 reductase expressed in Escherichia coli. J. Ind. Microbiol. Biotechnol. 32 (2005) 67-74
-
(2005)
J. Ind. Microbiol. Biotechnol.
, vol.32
, pp. 67-74
-
-
Vail, R.B.1
-
20
-
-
0034044068
-
Bioreactor systems in drug metabolism: synthesis of cytochrome P450-generated metabolites
-
Rushmore T.H., et al. Bioreactor systems in drug metabolism: synthesis of cytochrome P450-generated metabolites. Metab. Eng. 2 (2000) 115-125
-
(2000)
Metab. Eng.
, vol.2
, pp. 115-125
-
-
Rushmore, T.H.1
-
21
-
-
0021833801
-
Characterization of the enzymatic and nonenzymatic peroxidative degradation of iron porphyrins and cytochrome P-450 heme
-
Schaefer W.H., et al. Characterization of the enzymatic and nonenzymatic peroxidative degradation of iron porphyrins and cytochrome P-450 heme. Biochemistry 24 (1985) 3254-3263
-
(1985)
Biochemistry
, vol.24
, pp. 3254-3263
-
-
Schaefer, W.H.1
-
22
-
-
15344344076
-
Cytochrome P450 3A-mediated metabolism of buspirone in human liver microsomes
-
Zhu M., et al. Cytochrome P450 3A-mediated metabolism of buspirone in human liver microsomes. Drug Metab. Dispos. 33 (2005) 500-507
-
(2005)
Drug Metab. Dispos.
, vol.33
, pp. 500-507
-
-
Zhu, M.1
-
23
-
-
28844479959
-
Analysis of coumarin 7-hydroxylation activity of cytochrome P450 2A6 using random mutagenesis
-
Kim D., et al. Analysis of coumarin 7-hydroxylation activity of cytochrome P450 2A6 using random mutagenesis. J. Biol. Chem. 280 (2005) 40319-40327
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 40319-40327
-
-
Kim, D.1
-
24
-
-
33645244308
-
Recent advances in oxygenase-catalyzed biotransformations
-
Urlacher V.B., and Schmid R.D. Recent advances in oxygenase-catalyzed biotransformations. Curr. Opin. Chem. Biol. 10 (2006) 156-161
-
(2006)
Curr. Opin. Chem. Biol.
, vol.10
, pp. 156-161
-
-
Urlacher, V.B.1
Schmid, R.D.2
-
25
-
-
12144272238
-
Protein engineering of toluene ortho-monooxygenase of Burkholderia cepacia G4 for regiospecific hydroxylation of indole to form various indigoid compounds
-
Rui L., et al. Protein engineering of toluene ortho-monooxygenase of Burkholderia cepacia G4 for regiospecific hydroxylation of indole to form various indigoid compounds. Appl. Microbiol. Biotechnol. 66 (2005) 422-429
-
(2005)
Appl. Microbiol. Biotechnol.
, vol.66
, pp. 422-429
-
-
Rui, L.1
-
26
-
-
0038612856
-
Application of microscopic fungi isolated from polluted industrial areas for polycyclic aromatic hydrocarbons and pentachlorophenol reduction
-
Szewczyk R., et al. Application of microscopic fungi isolated from polluted industrial areas for polycyclic aromatic hydrocarbons and pentachlorophenol reduction. Biodegradation 14 (2003) 1-8
-
(2003)
Biodegradation
, vol.14
, pp. 1-8
-
-
Szewczyk, R.1
-
27
-
-
0036207217
-
Application of metabolic engineering to improve both the production and use of biotech indigo
-
Berry A., et al. Application of metabolic engineering to improve both the production and use of biotech indigo. J. Ind. Microbiol. Biotechnol. 28 (2002) 127-133
-
(2002)
J. Ind. Microbiol. Biotechnol.
, vol.28
, pp. 127-133
-
-
Berry, A.1
-
28
-
-
0034069318
-
Protein engineering of cytochrome p450(cam) (CYP101) for the oxidation of polycyclic aromatic hydrocarbons
-
Harford-Cross C.F., et al. Protein engineering of cytochrome p450(cam) (CYP101) for the oxidation of polycyclic aromatic hydrocarbons. Protein Eng. 13 (2000) 121-128
-
(2000)
Protein Eng.
, vol.13
, pp. 121-128
-
-
Harford-Cross, C.F.1
-
29
-
-
0034624234
-
Rational re-design of the substrate-binding site of flavocytochrome P450 BM3
-
Ost T.W., et al. Rational re-design of the substrate-binding site of flavocytochrome P450 BM3. FEBS Lett. 486 (2000) 173-177
-
(2000)
FEBS Lett.
, vol.486
, pp. 173-177
-
-
Ost, T.W.1
-
30
-
-
0035830723
-
Rational evolution of a medium chain-specific cytochrome P450 BM-3 variant
-
Li Q.S., et al. Rational evolution of a medium chain-specific cytochrome P450 BM-3 variant. Biochim. Biophys. Acta 1545 (2001) 114-121
-
(2001)
Biochim. Biophys. Acta
, vol.1545
, pp. 114-121
-
-
Li, Q.S.1
-
31
-
-
0036134828
-
Molecular Lego: design of molecular assemblies of P450 enzymes for nanobiotechnology
-
Gilardi G., et al. Molecular Lego: design of molecular assemblies of P450 enzymes for nanobiotechnology. Biosens. Bioelectron. 17 (2002) 133-145
-
(2002)
Biosens. Bioelectron.
, vol.17
, pp. 133-145
-
-
Gilardi, G.1
-
32
-
-
31544477181
-
Design and evolution of new catalytic activity with an existing protein scaffold
-
Park H.S., et al. Design and evolution of new catalytic activity with an existing protein scaffold. Science 311 (2006) 535-538
-
(2006)
Science
, vol.311
, pp. 535-538
-
-
Park, H.S.1
-
33
-
-
0036291145
-
Predicting changes in the stability of proteins and protein complexes: a study of more than 1000 mutations
-
Guerois R., et al. Predicting changes in the stability of proteins and protein complexes: a study of more than 1000 mutations. J. Mol. Biol. 320 (2002) 369-387
-
(2002)
J. Mol. Biol.
, vol.320
, pp. 369-387
-
-
Guerois, R.1
-
34
-
-
10444241949
-
Biotechnological applications for surface-engineered bacteria
-
Wernerus H., and Stahl S. Biotechnological applications for surface-engineered bacteria. Biotechnol. Appl. Biochem. 40 (2004) 209-228
-
(2004)
Biotechnol. Appl. Biochem.
, vol.40
, pp. 209-228
-
-
Wernerus, H.1
Stahl, S.2
-
35
-
-
0031013972
-
The structure of the cytochrome P450 BM-3 haem domain complexed with the fatty acid substrate palmitoleic acid
-
Li H., and Poulos T.L. The structure of the cytochrome P450 BM-3 haem domain complexed with the fatty acid substrate palmitoleic acid. Nat. Struct. Biol. 4 (1997) 140-146
-
(1997)
Nat. Struct. Biol.
, vol.4
, pp. 140-146
-
-
Li, H.1
Poulos, T.L.2
-
36
-
-
0027326717
-
Crystal structure of hemoprotein domain of P450BM-3, a prototype for microsomal P450s
-
Ravichandran K.G., et al. Crystal structure of hemoprotein domain of P450BM-3, a prototype for microsomal P450s. Science 261 (1993) 731-736
-
(1993)
Science
, vol.261
, pp. 731-736
-
-
Ravichandran, K.G.1
-
37
-
-
16544392183
-
Colorimetric high-throughput assay for alkene epoxidation catalyzed by cytochrome P450 BM-3 variant
-
Alcalde M., et al. Colorimetric high-throughput assay for alkene epoxidation catalyzed by cytochrome P450 BM-3 variant. J. Biomol. Screen. 9 (2004) 141-146
-
(2004)
J. Biomol. Screen.
, vol.9
, pp. 141-146
-
-
Alcalde, M.1
-
38
-
-
0034595354
-
Directed evolution of the fatty-acid hydroxylase P450 BM-3 into an indole-hydroxylating catalyst
-
Li Q.S., et al. Directed evolution of the fatty-acid hydroxylase P450 BM-3 into an indole-hydroxylating catalyst. Chemistry 6 (2000) 1531-1536
-
(2000)
Chemistry
, vol.6
, pp. 1531-1536
-
-
Li, Q.S.1
-
39
-
-
0035653258
-
Engineering cytochrome P450 BM-3 for oxidation of polycyclic aromatic hydrocarbons
-
Li Q.S., et al. Engineering cytochrome P450 BM-3 for oxidation of polycyclic aromatic hydrocarbons. Appl. Environ. Microbiol. 67 (2001) 5735-5739
-
(2001)
Appl. Environ. Microbiol.
, vol.67
, pp. 5735-5739
-
-
Li, Q.S.1
-
40
-
-
13244265817
-
Metabolism of polychlorinated dibenzo-p-dioxins by cytochrome P450 BM-3 and its mutant
-
Sulistyaningdyah W.T., et al. Metabolism of polychlorinated dibenzo-p-dioxins by cytochrome P450 BM-3 and its mutant. Biotechnol. Lett. 26 (2004) 1857-1860
-
(2004)
Biotechnol. Lett.
, vol.26
, pp. 1857-1860
-
-
Sulistyaningdyah, W.T.1
-
41
-
-
0036898132
-
Biotransformations using prokaryotic P450 monooxygenases
-
Urlacher V., and Schmid R.D. Biotransformations using prokaryotic P450 monooxygenases. Curr. Opin. Biotechnol. 13 (2002) 557-564
-
(2002)
Curr. Opin. Biotechnol.
, vol.13
, pp. 557-564
-
-
Urlacher, V.1
Schmid, R.D.2
-
42
-
-
0030602654
-
5 in the oxidation of 7-ethoxycoumarin, chlorzoxazone, aniline and N-nitrosodimethylamine by recombinant cytochrome P450 2E1 and by human liver microsomes
-
5 in the oxidation of 7-ethoxycoumarin, chlorzoxazone, aniline and N-nitrosodimethylamine by recombinant cytochrome P450 2E1 and by human liver microsomes. Biochem. Pharmacol. 52 (1996) 301-309
-
(1996)
Biochem. Pharmacol.
, vol.52
, pp. 301-309
-
-
Yamazaki, H.1
-
43
-
-
0037216623
-
Analysis of differential substrate selectivities of CYP2B6 and CYP2E1 by site-directed mutagenesis and molecular modeling
-
Spatzenegger M., et al. Analysis of differential substrate selectivities of CYP2B6 and CYP2E1 by site-directed mutagenesis and molecular modeling. J. Pharmacol. Exp. Ther. 304 (2003) 477-487
-
(2003)
J. Pharmacol. Exp. Ther.
, vol.304
, pp. 477-487
-
-
Spatzenegger, M.1
-
44
-
-
0036707625
-
Catalytic specificity of CYP2D isoforms in rat and human
-
Hiroi T., et al. Catalytic specificity of CYP2D isoforms in rat and human. Drug Metab. Dispos. 30 (2002) 970-976
-
(2002)
Drug Metab. Dispos.
, vol.30
, pp. 970-976
-
-
Hiroi, T.1
-
45
-
-
0036154008
-
Amodiaquine clearance and its metabolism to N-desethylamodiaquine is mediated by CYP2C8: a new high-affinity and -turnover enzyme-specific probe substrate
-
Li X.Q., et al. Amodiaquine clearance and its metabolism to N-desethylamodiaquine is mediated by CYP2C8: a new high-affinity and -turnover enzyme-specific probe substrate. J. Pharmacol. Exp. Ther. 300 (2002) 399-407
-
(2002)
J. Pharmacol. Exp. Ther.
, vol.300
, pp. 399-407
-
-
Li, X.Q.1
-
46
-
-
24944497676
-
The role of phenylalanine 483 in cytochrome P450 2D6 is strongly substrate dependent
-
Lussenburg B.M., et al. The role of phenylalanine 483 in cytochrome P450 2D6 is strongly substrate dependent. Biochem. Pharmacol. 70 (2005) 1253-1261
-
(2005)
Biochem. Pharmacol.
, vol.70
, pp. 1253-1261
-
-
Lussenburg, B.M.1
-
47
-
-
33745977430
-
5 by mass spectrometry and site-directed mutagenesis
-
5 by mass spectrometry and site-directed mutagenesis. J. Biol. Chem. 281 (2006) 20404-20417
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 20404-20417
-
-
Gao, Q.1
-
48
-
-
0027253615
-
Oxidation of acetaminophen to N-acetyl-p-aminobenzoquinone imine by human CYP3A4
-
Thummel K.E., et al. Oxidation of acetaminophen to N-acetyl-p-aminobenzoquinone imine by human CYP3A4. Biochem. Pharmacol. 45 (1993) 1563-1569
-
(1993)
Biochem. Pharmacol.
, vol.45
, pp. 1563-1569
-
-
Thummel, K.E.1
-
49
-
-
24944529052
-
Metabolic regio- and stereoselectivity of cytochrome P450 2D6 towards 3,4-methylenedioxy-N-alkylamphetamines: in silico predictions and experimental validation
-
Keizers P.H., et al. Metabolic regio- and stereoselectivity of cytochrome P450 2D6 towards 3,4-methylenedioxy-N-alkylamphetamines: in silico predictions and experimental validation. J. Med. Chem. 48 (2005) 6117-6127
-
(2005)
J. Med. Chem.
, vol.48
, pp. 6117-6127
-
-
Keizers, P.H.1
-
50
-
-
0038771110
-
Predictive value of comparative molecular field analysis modelling of naphthalene inhibition of human CYP2A6 and mouse CYP2A5 enzymes
-
Asikainen A., et al. Predictive value of comparative molecular field analysis modelling of naphthalene inhibition of human CYP2A6 and mouse CYP2A5 enzymes. Toxicol. In Vitro 17 (2003) 449-455
-
(2003)
Toxicol. In Vitro
, vol.17
, pp. 449-455
-
-
Asikainen, A.1
-
51
-
-
0038016455
-
Epoxidation of styrene by human cyt P450 1A2 by thin film electrolysis and peroxide activation compared to solution reactions
-
Estavillo C., et al. Epoxidation of styrene by human cyt P450 1A2 by thin film electrolysis and peroxide activation compared to solution reactions. Biophys. Chem. 104 (2003) 291-296
-
(2003)
Biophys. Chem.
, vol.104
, pp. 291-296
-
-
Estavillo, C.1
-
52
-
-
0027988797
-
Styrene metabolism by cDNA-expressed human hepatic and pulmonary cytochromes P450
-
Nakajima T., et al. Styrene metabolism by cDNA-expressed human hepatic and pulmonary cytochromes P450. Chem. Res. Toxicol. 7 (1994) 891-896
-
(1994)
Chem. Res. Toxicol.
, vol.7
, pp. 891-896
-
-
Nakajima, T.1
-
53
-
-
0032441633
-
Stereochemistry of the biotransformation of 1-hexene and 2-methyl-1-hexene with rat liver microsomes and purified P450s of rats and humans
-
Chiappe C., et al. Stereochemistry of the biotransformation of 1-hexene and 2-methyl-1-hexene with rat liver microsomes and purified P450s of rats and humans. Chem. Res. Toxicol. 11 (1998) 1487-1493
-
(1998)
Chem. Res. Toxicol.
, vol.11
, pp. 1487-1493
-
-
Chiappe, C.1
-
54
-
-
0033585107
-
Formation of indigo by recombinant mammalian cytochrome P450
-
Gillam E.M., et al. Formation of indigo by recombinant mammalian cytochrome P450. Biochem. Biophys. Res. Commun. 265 (1999) 469-472
-
(1999)
Biochem. Biophys. Res. Commun.
, vol.265
, pp. 469-472
-
-
Gillam, E.M.1
|