Predictive value of comparative molecular field analysis modelling of naphthalene inhibition of human CYP2A6 and mouse CYP2A5 enzymes

Toxicology in Vitro

Volumn 17, Issue 4, 2003, Pages 449-455

  Asikainen, Arja ^a   Tarhanen, Juhani ^a   Poso, Antti ^a   Pasanen, Markku ^b,c   Alhava, Esko ^a   Juvonen, Risto O ^a  

^a UNIVERSITY OF EASTERN FINLAND   (Finland)

^b UNIVERSITY OF OULU   (Finland)

^c NATIONAL AGENCY FOR MEDICINES   (Finland)

Author keywords

Coumarin 7 hydroxylation; CYP2A5; CYP2A6; Naphthalene

Indexed keywords

COUMARIN 7 HYDROXYLASE; CYTOCHROME P450 2A6; NAPHTHALENE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; COMPETITIVE INHIBITION; CONTROLLED STUDY; ENZYME INHIBITION; ENZYME SPECIFICITY; EXPERIMENTAL DESIGN; EXPERIMENTAL MODEL; FEMALE; HUMAN; HUMAN TISSUE; HUMAN VERSUS ANIMAL COMPARISON; IC 50; LIVER MICROSOME; MALE; MOUSE; NONHUMAN; OXIDATION; PREDICTION; STRUCTURE ACTIVITY RELATION; TOXICOKINETICS;

EID: 0038771110     PISSN: 08872333     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0887-2333(03)00065-1     Document Type: Article

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