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A gene-environment interaction between smoking and shared epitope genes in HLA-DR provides a high risk of seropositive rheumatoid arthritis
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Padyukov L, Silva C, Stolt P, et al. A gene-environment interaction between smoking and shared epitope genes in HLA-DR provides a high risk of seropositive rheumatoid arthritis. Arthritis Rheum 2004; 50:3085-3092. This is the first demonstration of an interaction between an environmental risk factor and a genetic risk factor in RA.
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(2004)
Arthritis Rheum
, vol.50
, pp. 3085-3092
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Padyukov, L.1
Silva, C.2
Stolt, P.3
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52
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3142769762
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Association between HLA class II genes and autoantibodies to cyclic citrullinated peptides (CCPs) influences the severity of rheumatoid arthritis
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Van Gaalen FA, van Aken J, Huizinga TW, et al. Association between HLA class II genes and autoantibodies to cyclic citrullinated peptides (CCPs) influences the severity of rheumatoid arthritis. Arthritis Rheum 2004; 50:2113-2121. This study demonstrated that the major genetic risk factor for RA specifically confers risk for the presence of anti-CCP antibodies.
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(2004)
Arthritis Rheum
, vol.50
, pp. 2113-2121
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Van Gaalen, F.A.1
Van Aken, J.2
Huizinga, T.W.3
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53
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0038107566
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Cutting edge: The conversion of arginine to citrulline allows for a high-affinity peptide interaction with the rheumatoid arthritis-associated HLA-DRB1*0401 MHC class II molecule
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Hill JA, Southwood S, Sette A, et al. Cutting edge: the conversion of arginine to citrulline allows for a high-affinity peptide interaction with the rheumatoid arthritis-associated HLA-DRB1*0401 MHC class II molecule. J Immunol 2003; 171:538-541.
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(2003)
J Immunol
, vol.171
, pp. 538-541
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Hill, J.A.1
Southwood, S.2
Sette, A.3
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