Distinct patterns of cytokine secretion characterize new onset synovitis versus chronic rheumatoid arthritis

Journal of Rheumatology

Volumn 25, Issue 1, 1998, Pages 16-22

  Kanik, Keith S ^a,b,e   Hagiwara, Eri ^a,c   Yarboro, Cheryl H ^a,b   Schumacher, H Ralph ^a,b,d   Wilder, Ronald L ^a,b   Klinman, Dennis M ^a,c  

^a NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES   (United States)

^b NATIONAL INSTITUTES OF HEALTH   (United States)

^c CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

^d UNIVERSITY OF PENNSYLVANIA   (United States)

^e UNIVERSITY OF SOUTH FLORIDA   (United States)

Author keywords

Cytokines; Immunology; Interferon ; Interleukin 2; Rheumatoid arthritis; Tumor necrosis factor

Indexed keywords

CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 6; TUMOR NECROSIS FACTOR ALPHA;

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE RELEASE; DISEASE ACTIVITY; FEMALE; HUMAN; HUMAN CELL; INFLAMMATION; MALE; MONONUCLEAR CELL; PRIORITY JOURNAL; RHEUMATOID ARTHRITIS; SCORING SYSTEM; SYNOVIAL FLUID; SYNOVITIS;

ADULT; ARTHRITIS, RHEUMATOID; CHRONIC DISEASE; CYTOKINES; FEMALE; HUMANS; LEUKOCYTES, MONONUCLEAR; MALE; MIDDLE AGED; SYNOVITIS;

EID: 0031985926     PISSN: 0315162X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (28)

1. Fleming A, Crown JM, Corbett M. Early rheumatoid disease. 1. Onset. Ann Rheum Dis 1976;35:357-60.
2. Jacoby RK, Jayson MV, Cosh JA. Onset, early stages and prognosis of rheumatoid arthritis: A clinical study of 100 patients with 11 year follow-up. BMJ 1973;2:96-100.
3. Wilske KR, Healey LA. Remodeling the pyramid - a concept whose time has come. J Rheumatol 1989;16:565-7.
4. Mosmann TR, Cherwinski H, Bond MW, Giedlin MA, Coffman R. Two types of murine helper T cell clones. I. Definition according to profiles of lymphokine activities and secreted proteins. J Immunol 1986;136:2348-57.
5. Mosmann TR, Coffman RL. Two types of mouse helper T-cell clone. Immunol Today 1987;8:223-7.
6. Romagnani S. Induction of TH1 and TH2 responses: A key role in the "natural immune response"? Immunol Today 1992;13:379-81.
7. Fiorentino DF, Bond MW, Mosmann TR. Two type of mouse T helper cell: IV: TH2 clones secrete a factor that inhibits cytokine production by Th1 clones. J Exp Med 1989;170:2081-95.
8. Paliard X, De Waal Malefjit R, Yssel H, et al. Simultaneous production of IL-2, IL-4, IFN-gamma by activated human CD4+ and CD8+ T cell clones. J Immunol 1988;3:849-55.
9. Maggi E, Del Prete G, Marchia D, et al. Profiles of lymphokine activities and helper function for IgE in human T cell clones. Eur J Immunol 1988;18:1045-50.
10. Hagiwara E, Abbasi F, Mor C, Ishigatsubo Y, Klinman DM. Phenotype and frequency of cells secreting IL-2, IL-4, IL-6, IL-10, IFN-γ, and TNF-α in human peripheral blood. Cytokine 1995;7:815-22.
11. Al-Janadi M, Al-Balla S, Al-Dalaan A, Raziuddin S. Cytokine production by helper T cell populations from the synovial fluid and blood of patients with rheumatoid arthritis. J Rheumatol 1993;20:1647-53.
12. Al-Janadi M, Al-Balla S, Al-Dalaan A, Raziuddin S. Cytokine profile in systemic lupus erythematosus, rheumatoid arthritis, and other rheumatic diseases. J Clin Immunol 1993;13:58-67.
13. Brenna FM, Maini RN, Feldmann M. Cytokine expression in chronic inflammatory disease. Br Med Bull 1995;51:368-84.
14. Quayle AJ, Chomarat P, Miossex P, Kjelsen-Kragh J, Forre O, Natvig JB. Rheumatoid inflammatory T-cell clones express mostly TH1 but also TH2 and mixed (THO-like) cytokine patterns. Scand J Immunol 1993;38:75-82.
15. Schulze-Koops H, Lipsky PE, Kavanaugh AF, Davis LS. Elevated TH1-or TH0-like cytokine mRNA in peripheral circulation of patients with rheumatoid arthritis. J Immunol 1995;155:5029-37.
16. Simon AK, Seiplet E, Sieper J. Divergent T-cell cytokine patterns in inflammatory arthritis. Proc Natl Acad Sci USA 1994;91:8562-6.
17. Tanabe M, Ochi T, Tomita T, et al. Remarkable elevation of interleukin 6 and interleukin 8 levels in the bone marrow of patients with rheumatoid arthritis. J Rheumatol 1994;21:830-5.
18. Llorente L, Richaud-Patin Y, Renato F, et al. In vivo production of interleukin 10 by non-T cells in rheumatoid arthritis. Sjögren's syndrome and systemic lupus erythematosus. Arthritis Rheum 1994;37:1647-55.
19. Klinman DM, Nutman TB. ELIspot assay to detect cytokine secreting murine and human cells In: Coligen JE, Kruisbeek AM, Margulies DH, Shevach EM, Strober W, editors. Current protocols in immunology, 7th ed. Brooklyn, NY: Greene Publishing Associates, 1994.
20. Arnett FC, Edworthy SM, Bloch DA, et al. The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum 1988;31:315-24.
21. Boyum A. Separation of leukocytes from blood and bone marrow. Scand J Clin Lab Invest 1968;21:77-90.
22. Dolhain RE, Van Der Heiden AN, Ter Harr NT, Breedveld FC, Miltenberg AM. Shift towards T lymphocytes with a T Helper 1 cytokine-secretion profile in the joints of patients with rheumatoid arthritis. Arthritis Rheum 1996;39:1961-9.
23. Elliott MJ, Maini RN. New directions for biological therapy in rheumatoid arthritis. Int Arch Allergy Immunol 1994;104:112-25.
24. Elliott MJ, Maini RN, Feldmann M, et al. Randomised double-blind comparison of chimeric monoclonal antibody to tumor necrosis factor α versus placebo in rheumatoid arthritis. Lancet 1994;344:1105-10.
25. Hagiwara E, Gourley MF, Lee S, Klinman DM. Disease severity in patients with systemic lupus erythematosus correlates with an increased ratio of interleukin 10: Interferon-γ secreting cells in the peripheral blood. Arthritis Rheum 1995;39:379-85.
26. Hagiwara E, Adams E, Plotz P, Klinman DM. Abnormal cytokine production by peripheral blood mononuclear cells from patients with polymyositis and dermatomyositis. Clin Exp Rheum 1996;14:485-90.
27. Olanoff LS, Fundenberg HH. Familial autoimmunity: Twenty years later. J Clin Lab Immunol 1983;11:105-11.
28. Teitsson I, Thorsteinsson J, Arnason A, Valdimarsson H. Rheumatic diseases in an Icelandic family, clinical and immunologic survey. Scand J Rheumatol 1985;14:109-18.