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Volumn 79, Issue , 2007, Pages 73-97

The CD8 T Cell in Multiple Sclerosis: Suppressor Cell Or Mediator of Neuropathology?

Author keywords

[No Author keywords available]

Indexed keywords

HLA A ANTIGEN; HLA A*0201 ANTIGEN; HLA-A*0201 ANTIGEN; UNCLASSIFIED DRUG;

EID: 34248659946     PISSN: 00747742     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S0074-7742(07)79004-9     Document Type: Review
Times cited : (50)

References (111)
  • 1
    • 0036319335 scopus 로고    scopus 로고
    • Astrocyte-endothelial interactions and blood-brain barrier permeability
    • Abbott N.J. Astrocyte-endothelial interactions and blood-brain barrier permeability. J. Anat. 200 (2002) 629-638
    • (2002) J. Anat. , vol.200 , pp. 629-638
    • Abbott, N.J.1
  • 2
    • 17644364388 scopus 로고    scopus 로고
    • Dynamics of CNS barriers: Evolution, differentiation, and modulation
    • Abbott N.J. Dynamics of CNS barriers: Evolution, differentiation, and modulation. Cell. Mol. Neurobiol. 25 (2005) 5-23
    • (2005) Cell. Mol. Neurobiol. , vol.25 , pp. 5-23
    • Abbott, N.J.1
  • 3
    • 0034618094 scopus 로고    scopus 로고
    • Clonal expansions of CD8(+) T cells dominate the T cell infiltrate in active multiple sclerosis lesions as shown by micromanipulation and single cell polymerase chain reaction
    • Babbe H., Roers A., Waisman A., Lassmann H., Goebels N., Hohlfeld R., Friese M., Schroder R., Deckert M., Schmidt S., Ravid R., and Rajewsky K. Clonal expansions of CD8(+) T cells dominate the T cell infiltrate in active multiple sclerosis lesions as shown by micromanipulation and single cell polymerase chain reaction. J. Exp. Med. 192 (2000) 393-404
    • (2000) J. Exp. Med. , vol.192 , pp. 393-404
    • Babbe, H.1    Roers, A.2    Waisman, A.3    Lassmann, H.4    Goebels, N.5    Hohlfeld, R.6    Friese, M.7    Schroder, R.8    Deckert, M.9    Schmidt, S.10    Ravid, R.11    Rajewsky, K.12
  • 4
    • 33746356813 scopus 로고    scopus 로고
    • Human regulatory T cells and their role in autoimmune disease
    • Baecher-Allan C., and Hafler D.A. Human regulatory T cells and their role in autoimmune disease. Immunol. Rev. 212 (2006) 203-216
    • (2006) Immunol. Rev. , vol.212 , pp. 203-216
    • Baecher-Allan, C.1    Hafler, D.A.2
  • 5
    • 2342471420 scopus 로고    scopus 로고
    • The blood-brain barrier: An overview: Structure, regulation, and clinical implications
    • Ballabh P., Braun A., and Nedergaard M. The blood-brain barrier: An overview: Structure, regulation, and clinical implications. Neurobiol. Dis. 16 (2004) 1-13
    • (2004) Neurobiol. Dis. , vol.16 , pp. 1-13
    • Ballabh, P.1    Braun, A.2    Nedergaard, M.3
  • 6
    • 6944255523 scopus 로고    scopus 로고
    • Delivery of therapeutic agents to the central nervous system: The problems and the possibilities
    • Begley D.J. Delivery of therapeutic agents to the central nervous system: The problems and the possibilities. Pharmacol. Ther. 104 (2004) 29-45
    • (2004) Pharmacol. Ther. , vol.104 , pp. 29-45
    • Begley, D.J.1
  • 7
    • 16844369607 scopus 로고    scopus 로고
    • Natural regulatory T cells in infectious disease
    • Belkaid Y., and Rouse B.T. Natural regulatory T cells in infectious disease. Nat. Immunol. 6 (2005) 353-360
    • (2005) Nat. Immunol. , vol.6 , pp. 353-360
    • Belkaid, Y.1    Rouse, B.T.2
  • 8
    • 33750628251 scopus 로고    scopus 로고
    • Glatiramer acetate (GA) therapy induces a focused, oligoclonal CD8+ T-cell repertoire in multiple sclerosis
    • Biegler B.W., Yan S.X., Ortega S.B., Tennakoon D.K., Racke M.K., and Karandikar N.J. Glatiramer acetate (GA) therapy induces a focused, oligoclonal CD8+ T-cell repertoire in multiple sclerosis. J. Neuroimmunol. 180 1-2 (2006) 159-171
    • (2006) J. Neuroimmunol. , vol.180 , Issue.1-2 , pp. 159-171
    • Biegler, B.W.1    Yan, S.X.2    Ortega, S.B.3    Tennakoon, D.K.4    Racke, M.K.5    Karandikar, N.J.6
  • 9
    • 0034026912 scopus 로고    scopus 로고
    • Acute axonal injury in multiple sclerosis. Correlation with demyelination and inflammation
    • Bitsch A., Schuchardt J., Bunkowski S., Kuhlmann T., and Bruck W. Acute axonal injury in multiple sclerosis. Correlation with demyelination and inflammation. Brain 123 Pt. 6 (2000) 1174-1183
    • (2000) Brain , vol.123 , Issue.PART 6 , pp. 1174-1183
    • Bitsch, A.1    Schuchardt, J.2    Bunkowski, S.3    Kuhlmann, T.4    Bruck, W.5
  • 10
    • 0034310720 scopus 로고    scopus 로고
    • Interleukin-1beta-induced changes in blood-brain barrier permeability, apparent diffusion coefficient, and cerebral blood volume in the rat brain: A magnetic resonance study
    • Blamire A.M., Anthony D.C., Rajagopalan B., Sibson N.R., Perry V.H., and Styles P. Interleukin-1beta-induced changes in blood-brain barrier permeability, apparent diffusion coefficient, and cerebral blood volume in the rat brain: A magnetic resonance study. J. Neurosci. 20 (2000) 8153-8159
    • (2000) J. Neurosci. , vol.20 , pp. 8153-8159
    • Blamire, A.M.1    Anthony, D.C.2    Rajagopalan, B.3    Sibson, N.R.4    Perry, V.H.5    Styles, P.6
  • 11
    • 0021079164 scopus 로고
    • Immunohistological analysis of T lymphocyte subsets in the central nervous system in chronic progressive multiple sclerosis
    • Booss J., Esiri M.M., Tourtellotte W.W., and Mason D.Y. Immunohistological analysis of T lymphocyte subsets in the central nervous system in chronic progressive multiple sclerosis. J. Neurol. Sci. 62 (1983) 219-232
    • (1983) J. Neurol. Sci. , vol.62 , pp. 219-232
    • Booss, J.1    Esiri, M.M.2    Tourtellotte, W.W.3    Mason, D.Y.4
  • 12
    • 23744445782 scopus 로고    scopus 로고
    • Chronic inflammatory pain leads to increased blood-brain barrier permeability and tight junction protein alterations
    • Brooks T.A., Hawkins B.T., Huber J.D., Egleton R.D., and Davis T.P. Chronic inflammatory pain leads to increased blood-brain barrier permeability and tight junction protein alterations. Am. J. Physiol. Heart Circ. Physiol. 289 (2005) H738-H743
    • (2005) Am. J. Physiol. Heart Circ. Physiol. , vol.289
    • Brooks, T.A.1    Hawkins, B.T.2    Huber, J.D.3    Egleton, R.D.4    Davis, T.P.5
  • 13
    • 17644444933 scopus 로고    scopus 로고
    • Inflammation and degeneration in multiple sclerosis
    • Bruck W., and Stadelmann C. Inflammation and degeneration in multiple sclerosis. Neurol. Sci. 24 Suppl. 5 (2003) S265-S267
    • (2003) Neurol. Sci. , vol.24 , Issue.SUPPL. 5
    • Bruck, W.1    Stadelmann, C.2
  • 14
    • 0032007065 scopus 로고    scopus 로고
    • Massive expansion of antigen-specific CD8+ T cells during an acute virus infection
    • Butz E.A., and Bevan M.J. Massive expansion of antigen-specific CD8+ T cells during an acute virus infection. Immunity 8 (1998) 167-175
    • (1998) Immunity , vol.8 , pp. 167-175
    • Butz, E.A.1    Bevan, M.J.2
  • 16
    • 3042731246 scopus 로고    scopus 로고
    • Is damage in central nervous system due to inflammation?
    • Chavarria A., and Alcocer-Varela J. Is damage in central nervous system due to inflammation?. Autoimmun. Rev. 3 (2004) 251-260
    • (2004) Autoimmun. Rev. , vol.3 , pp. 251-260
    • Chavarria, A.1    Alcocer-Varela, J.2
  • 19
    • 0037408259 scopus 로고    scopus 로고
    • Glatiramer acetate (Copaxone) therapy for multiple sclerosis
    • Dhib-Jalbut S. Glatiramer acetate (Copaxone) therapy for multiple sclerosis. Pharmacol. Ther. 98 (2003) 245-255
    • (2003) Pharmacol. Ther. , vol.98 , pp. 245-255
    • Dhib-Jalbut, S.1
  • 20
    • 0033061321 scopus 로고    scopus 로고
    • Transmembrane proteins in the tight junction barrier
    • Fanning A.S., Mitic L.L., and Anderson J.M. Transmembrane proteins in the tight junction barrier. J. Am. Soc. Nephrol. 10 (1999) 1337-1345
    • (1999) J. Am. Soc. Nephrol. , vol.10 , pp. 1337-1345
    • Fanning, A.S.1    Mitic, L.L.2    Anderson, J.M.3
  • 21
    • 0842321793 scopus 로고    scopus 로고
    • Cutting edge: In vitro-generated tolerogenic APC induce CD8+ T regulatory cells that can suppress ongoing experimental autoimmune encephalomyelitis
    • Faunce D.E., Terajewicz A., and Stein-Streilein J. Cutting edge: In vitro-generated tolerogenic APC induce CD8+ T regulatory cells that can suppress ongoing experimental autoimmune encephalomyelitis. J. Immunol. 172 (2004) 1991-1995
    • (2004) J. Immunol. , vol.172 , pp. 1991-1995
    • Faunce, D.E.1    Terajewicz, A.2    Stein-Streilein, J.3
  • 23
    • 0033975139 scopus 로고    scopus 로고
    • Multiple sclerosis: A modifying influence of HLA class I genes in an HLA class II associated autoimmune disease
    • Fogdell-Hahn A., Ligers A., Gronning M., Hillert J., and Olerup O. Multiple sclerosis: A modifying influence of HLA class I genes in an HLA class II associated autoimmune disease. Tissue Antigens 55 (2000) 140-148
    • (2000) Tissue Antigens , vol.55 , pp. 140-148
    • Fogdell-Hahn, A.1    Ligers, A.2    Gronning, M.3    Hillert, J.4    Olerup, O.5
  • 24
    • 12344280009 scopus 로고    scopus 로고
    • Specificity, magnitude, and kinetics of MOG-specific CD8+ T cell responses during experimental autoimmune encephalomyelitis
    • Ford M.L., and Evavold B.D. Specificity, magnitude, and kinetics of MOG-specific CD8+ T cell responses during experimental autoimmune encephalomyelitis. Eur. J. Immunol. 35 (2005) 76-85
    • (2005) Eur. J. Immunol. , vol.35 , pp. 76-85
    • Ford, M.L.1    Evavold, B.D.2
  • 26
    • 0037128654 scopus 로고    scopus 로고
    • Generation of human CD8 T regulatory cells by CD40 ligand-activated plasmacytoid dendritic cells
    • Gilliet M., and Liu Y.J. Generation of human CD8 T regulatory cells by CD40 ligand-activated plasmacytoid dendritic cells. J. Exp. Med. 195 (2002) 695-704
    • (2002) J. Exp. Med. , vol.195 , pp. 695-704
    • Gilliet, M.1    Liu, Y.J.2
  • 29
    • 2442653108 scopus 로고    scopus 로고
    • Sepsis associated encephalopathy (SAE): A review
    • Green R., Scott L.K., Minagar A., and Conrad S. Sepsis associated encephalopathy (SAE): A review. Front. Biosci. 9 (2004) 1637-1641
    • (2004) Front. Biosci. , vol.9 , pp. 1637-1641
    • Green, R.1    Scott, L.K.2    Minagar, A.3    Conrad, S.4
  • 31
    • 17644363679 scopus 로고    scopus 로고
    • In search of the astrocytic factor(s) modulating blood-brain barrier functions in brain capillary endothelial cells in vitro
    • Haseloff R.F., Blasig I.E., Bauer H.C., and Bauer H. In search of the astrocytic factor(s) modulating blood-brain barrier functions in brain capillary endothelial cells in vitro. Cell. Mol. Neurobiol. 25 (2005) 25-39
    • (2005) Cell. Mol. Neurobiol. , vol.25 , pp. 25-39
    • Haseloff, R.F.1    Blasig, I.E.2    Bauer, H.C.3    Bauer, H.4
  • 32
    • 22944483792 scopus 로고    scopus 로고
    • The blood-brain barrier/neurovascular unit in health and disease
    • Hawkins B.T., and Davis T.P. The blood-brain barrier/neurovascular unit in health and disease. Pharmacol. Rev. 57 (2005) 173-185
    • (2005) Pharmacol. Rev. , vol.57 , pp. 173-185
    • Hawkins, B.T.1    Davis, T.P.2
  • 35
    • 0035801332 scopus 로고    scopus 로고
    • A pathogenic role for myelin-specific CD8(+) T cells in a model for multiple sclerosis
    • Huseby E.S., Liggitt D., Brabb T., Schnabel B., Ohlen C., and Goverman J. A pathogenic role for myelin-specific CD8(+) T cells in a model for multiple sclerosis. J. Exp. Med. 194 (2001) 669-676
    • (2001) J. Exp. Med. , vol.194 , pp. 669-676
    • Huseby, E.S.1    Liggitt, D.2    Brabb, T.3    Schnabel, B.4    Ohlen, C.5    Goverman, J.6
  • 37
    • 0033552629 scopus 로고    scopus 로고
    • Direct binding of three tight junction-associated MAGUKs, ZO-1, ZO-2, and ZO-3, with the COOH termini of claudins
    • Itoh M., Furuse M., Morita K., Kubota K., Saitou M., and Tsukita S. Direct binding of three tight junction-associated MAGUKs, ZO-1, ZO-2, and ZO-3, with the COOH termini of claudins. J. Cell Biol. 147 (1999) 1351-1363
    • (1999) J. Cell Biol. , vol.147 , pp. 1351-1363
    • Itoh, M.1    Furuse, M.2    Morita, K.3    Kubota, K.4    Saitou, M.5    Tsukita, S.6
  • 38
    • 0026647293 scopus 로고
    • Role of CD8+ T cells in murine experimental allergic encephalomyelitis
    • Jiang H., Zhang S.I., and Pernis B. Role of CD8+ T cells in murine experimental allergic encephalomyelitis. Science 256 (1992) 1213-1215
    • (1992) Science , vol.256 , pp. 1213-1215
    • Jiang, H.1    Zhang, S.I.2    Pernis, B.3
  • 39
    • 0032899121 scopus 로고    scopus 로고
    • Prevalent class I-restricted T-cell response to the Theiler's virus epitope Db:VP2121-130 in the absence of endogenous CD4 help, tumor necrosis factor alpha, gamma interferon, perforin, or costimulation through CD28
    • Johnson A.J., Njenga M.K., Hansen M.J., Kuhns S.T., Chen L., Rodriguez M., and Pease L.R. Prevalent class I-restricted T-cell response to the Theiler's virus epitope Db:VP2121-130 in the absence of endogenous CD4 help, tumor necrosis factor alpha, gamma interferon, perforin, or costimulation through CD28. J. Virol. 73 (1999) 3702-3708
    • (1999) J. Virol. , vol.73 , pp. 3702-3708
    • Johnson, A.J.1    Njenga, M.K.2    Hansen, M.J.3    Kuhns, S.T.4    Chen, L.5    Rodriguez, M.6    Pease, L.R.7
  • 40
    • 0035656533 scopus 로고    scopus 로고
    • Preservation of motor function by inhibition of CD8+ virus peptide-specific T cells in Theiler's virus infection
    • Johnson A.J., Upshaw J., Pavelko K.D., Rodriguez M., and Pease L.R. Preservation of motor function by inhibition of CD8+ virus peptide-specific T cells in Theiler's virus infection. FASEB J. 15 (2001) 2760-2762
    • (2001) FASEB J. , vol.15 , pp. 2760-2762
    • Johnson, A.J.1    Upshaw, J.2    Pavelko, K.D.3    Rodriguez, M.4    Pease, L.R.5
  • 42
    • 0032521030 scopus 로고    scopus 로고
    • MHC class I-restricted lysis of human oligodendrocytes by myelin basic protein peptide-specific CD8 T lymphocytes
    • Jurewicz A., Biddison W.E., and Antel J.P. MHC class I-restricted lysis of human oligodendrocytes by myelin basic protein peptide-specific CD8 T lymphocytes. J. Immunol. 160 (1998) 3056-3059
    • (1998) J. Immunol. , vol.160 , pp. 3056-3059
    • Jurewicz, A.1    Biddison, W.E.2    Antel, J.P.3
  • 43
    • 12344279024 scopus 로고    scopus 로고
    • Natural history of multiple sclerosis
    • Kantarci O.H., and Weinshenker B.G. Natural history of multiple sclerosis. Neurol. Clin. 23 (2005) 17-38
    • (2005) Neurol. Clin. , vol.23 , pp. 17-38
    • Kantarci, O.H.1    Weinshenker, B.G.2
  • 45
    • 4043144986 scopus 로고    scopus 로고
    • Initiation of immune responses in brain is promoted by local dendritic cells
    • Karman J., Ling C., Sandor M., and Fabry Z. Initiation of immune responses in brain is promoted by local dendritic cells. J. Immunol. 173 (2004) 2353-2361
    • (2004) J. Immunol. , vol.173 , pp. 2353-2361
    • Karman, J.1    Ling, C.2    Sandor, M.3    Fabry, Z.4
  • 46
    • 0037728671 scopus 로고    scopus 로고
    • Herpes simplex virus-specific memory CD8+ T cells are selectively activated and retained in latently infected sensory ganglia
    • Khanna K.M., Bonneau R.H., Kinchington P.R., and Hendricks R.L. Herpes simplex virus-specific memory CD8+ T cells are selectively activated and retained in latently infected sensory ganglia. Immunity 18 (2003) 593-603
    • (2003) Immunity , vol.18 , pp. 593-603
    • Khanna, K.M.1    Bonneau, R.H.2    Kinchington, P.R.3    Hendricks, R.L.4
  • 47
    • 0034933540 scopus 로고    scopus 로고
    • Intracellular cytokine profile in T-cell subsets of multiple sclerosis patients: Different features in primary progressive disease
    • Killestein J., Den Drijver B.F., Van der Graaff W.L., Uitdehaag B.M., Polman C.H., and Van Lier R.A. Intracellular cytokine profile in T-cell subsets of multiple sclerosis patients: Different features in primary progressive disease. Mult. Scler. 7 (2001) 145-150
    • (2001) Mult. Scler. , vol.7 , pp. 145-150
    • Killestein, J.1    Den Drijver, B.F.2    Van der Graaff, W.L.3    Uitdehaag, B.M.4    Polman, C.H.5    Van Lier, R.A.6
  • 49
    • 1342323894 scopus 로고    scopus 로고
    • Role of specific CD8+ T cells in the severity of a fulminant zoonotic viral hemorrhagic fever, hantavirus pulmonary syndrome
    • Kilpatrick E.D., Terajima M., Koster F.T., Catalina M.D., Cruz J., and Ennis F.A. Role of specific CD8+ T cells in the severity of a fulminant zoonotic viral hemorrhagic fever, hantavirus pulmonary syndrome. J. Immunol. 172 (2004) 3297-3304
    • (2004) J. Immunol. , vol.172 , pp. 3297-3304
    • Kilpatrick, E.D.1    Terajima, M.2    Koster, F.T.3    Catalina, M.D.4    Cruz, J.5    Ennis, F.A.6
  • 50
    • 0141926694 scopus 로고    scopus 로고
    • Tight junctional abnormality in multiple sclerosis white matter affects all calibres of vessel and is associated with blood-brain barrier leakage and active demyelination
    • Kirk J., Plumb J., Mirakhur M., and McQuaid S. Tight junctional abnormality in multiple sclerosis white matter affects all calibres of vessel and is associated with blood-brain barrier leakage and active demyelination. J. Pathol. 201 (2003) 319-327
    • (2003) J. Pathol. , vol.201 , pp. 319-327
    • Kirk, J.1    Plumb, J.2    Mirakhur, M.3    McQuaid, S.4
  • 51
    • 0026694021 scopus 로고
    • Less mortality but more relapses in experimental allergic encephalomyelitis in CD8-/- mice
    • Koh D.R., Fung-Leung W.P., Ho A., Gray D., Acha-Orbea H., and Mak T.W. Less mortality but more relapses in experimental allergic encephalomyelitis in CD8-/- mice. Science 256 (1992) 1210-1213
    • (1992) Science , vol.256 , pp. 1210-1213
    • Koh, D.R.1    Fung-Leung, W.P.2    Ho, A.3    Gray, D.4    Acha-Orbea, H.5    Mak, T.W.6
  • 52
    • 0033598188 scopus 로고    scopus 로고
    • Ca(2+)-independent cell-adhesion activity of claudins, a family of integral membrane proteins localized at tight junctions
    • Kubota K., Furuse M., Sasaki H., Sonoda N., Fujita K., Nagafuchi A., and Tsukita S. Ca(2+)-independent cell-adhesion activity of claudins, a family of integral membrane proteins localized at tight junctions. Curr. Biol. 9 (1999) 1035-1038
    • (1999) Curr. Biol. , vol.9 , pp. 1035-1038
    • Kubota, K.1    Furuse, M.2    Sasaki, H.3    Sonoda, N.4    Fujita, K.5    Nagafuchi, A.6    Tsukita, S.7
  • 53
    • 0036788406 scopus 로고    scopus 로고
    • Acute axonal damage in multiple sclerosis is most extensive in early disease stages and decreases over time
    • Kuhlmann T., Lingfeld G., Bitsch A., Schuchardt J., and Bruck W. Acute axonal damage in multiple sclerosis is most extensive in early disease stages and decreases over time. Brain 125 (2002) 2202-2212
    • (2002) Brain , vol.125 , pp. 2202-2212
    • Kuhlmann, T.1    Lingfeld, G.2    Bitsch, A.3    Schuchardt, J.4    Bruck, W.5
  • 54
    • 0025719757 scopus 로고
    • Activation of T lymphocytes in dengue virus infections. High levels of soluble interleukin 2 receptor, soluble CD4, soluble CD8, interleukin 2, and interferon-gamma in sera of children with dengue
    • Kurane I., Innis B.L., Nimmannitya S., Nisalak A., Meager A., Janus J., and Ennis F.A. Activation of T lymphocytes in dengue virus infections. High levels of soluble interleukin 2 receptor, soluble CD4, soluble CD8, interleukin 2, and interferon-gamma in sera of children with dengue. J. Clin. Invest. 88 (1991) 1473-1480
    • (1991) J. Clin. Invest. , vol.88 , pp. 1473-1480
    • Kurane, I.1    Innis, B.L.2    Nimmannitya, S.3    Nisalak, A.4    Meager, A.5    Janus, J.6    Ennis, F.A.7
  • 55
    • 0035141553 scopus 로고    scopus 로고
    • Multiple sclerosis in the Faroe islands: An epitome
    • Kurtzke J.F., and Heltberg A. Multiple sclerosis in the Faroe islands: An epitome. J. Clin. Epidemiol. 54 (2001) 1-22
    • (2001) J. Clin. Epidemiol. , vol.54 , pp. 1-22
    • Kurtzke, J.F.1    Heltberg, A.2
  • 56
    • 1342345214 scopus 로고    scopus 로고
    • The CD4-Th1 model for multiple sclerosis: A critical [correction of crucial] re-appraisal
    • Lassmann H., and Ransohoff R.M. The CD4-Th1 model for multiple sclerosis: A critical [correction of crucial] re-appraisal. Trends Immunol. 25 (2004) 132-137
    • (2004) Trends Immunol. , vol.25 , pp. 132-137
    • Lassmann, H.1    Ransohoff, R.M.2
  • 58
    • 0034192426 scopus 로고    scopus 로고
    • CD8(+) T cells can block herpes simplex virus type 1 (HSV-1) reactivation from latency in sensory neurons
    • Liu T., Khanna K.M., Chen X., Fink D.J., and Hendricks R.L. CD8(+) T cells can block herpes simplex virus type 1 (HSV-1) reactivation from latency in sensory neurons. J. Exp. Med. 191 (2000) 1459-1466
    • (2000) J. Exp. Med. , vol.191 , pp. 1459-1466
    • Liu, T.1    Khanna, K.M.2    Chen, X.3    Fink, D.J.4    Hendricks, R.L.5
  • 60
    • 0342906187 scopus 로고    scopus 로고
    • Heterogeneity of multiple sclerosis lesions: Implications for the pathogenesis of demyelination
    • Lucchinetti C., Bruck W., Parisi J., Scheithauer B., Rodriguez M., and Lassmann H. Heterogeneity of multiple sclerosis lesions: Implications for the pathogenesis of demyelination. Ann. Neurol. 47 (2000) 707-717
    • (2000) Ann. Neurol. , vol.47 , pp. 707-717
    • Lucchinetti, C.1    Bruck, W.2    Parisi, J.3    Scheithauer, B.4    Rodriguez, M.5    Lassmann, H.6
  • 61
    • 3843127502 scopus 로고    scopus 로고
    • Evidence for pathogenic heterogeneity in multiple sclerosis
    • Lucchinetti C.F., Bruck W., and Lassmann H. Evidence for pathogenic heterogeneity in multiple sclerosis. Ann. Neurol. 56 (2004) 308
    • (2004) Ann. Neurol. , vol.56 , pp. 308
    • Lucchinetti, C.F.1    Bruck, W.2    Lassmann, H.3
  • 62
    • 0037443404 scopus 로고    scopus 로고
    • Regulatory T cells control autoimmunity in vivo by inducing apoptotic depletion of activated pathogenic lymphocytes
    • Madakamutil L.T., Maricic I., Sercarz E., and Kumar V. Regulatory T cells control autoimmunity in vivo by inducing apoptotic depletion of activated pathogenic lymphocytes. J. Immunol. 170 (2003) 2985-2992
    • (2003) J. Immunol. , vol.170 , pp. 2985-2992
    • Madakamutil, L.T.1    Maricic, I.2    Sercarz, E.3    Kumar, V.4
  • 64
    • 0034842960 scopus 로고    scopus 로고
    • Transection of major histocompatibility complex class I-induced neurites by cytotoxic T lymphocytes
    • Medana I., Martinic M.A., Wekerle H., and Neumann H. Transection of major histocompatibility complex class I-induced neurites by cytotoxic T lymphocytes. Am. J. Pathol. 159 (2001) 809-815
    • (2001) Am. J. Pathol. , vol.159 , pp. 809-815
    • Medana, I.1    Martinic, M.A.2    Wekerle, H.3    Neumann, H.4
  • 65
    • 33646337645 scopus 로고    scopus 로고
    • Human cerebral malaria and the blood-brain barrier
    • Medana I.M., and Turner G.D. Human cerebral malaria and the blood-brain barrier. Int. J. Parasitol. 36 (2006) 555-568
    • (2006) Int. J. Parasitol. , vol.36 , pp. 555-568
    • Medana, I.M.1    Turner, G.D.2
  • 66
    • 0034529401 scopus 로고    scopus 로고
    • MHC class I-restricted killing of neurons by virus-specific CD8+ T lymphocytes is effected through the Fas/FasL, but not the perforin pathway
    • Medana I.M., Gallimore A., Oxenius A., Martinic M.M., Wekerle H., and Neumann H. MHC class I-restricted killing of neurons by virus-specific CD8+ T lymphocytes is effected through the Fas/FasL, but not the perforin pathway. Eur. J. Immunol. 30 (2000) 3623-3633
    • (2000) Eur. J. Immunol. , vol.30 , pp. 3623-3633
    • Medana, I.M.1    Gallimore, A.2    Oxenius, A.3    Martinic, M.M.4    Wekerle, H.5    Neumann, H.6
  • 67
    • 0344961161 scopus 로고    scopus 로고
    • Blood-brain barrier disruption in multiple sclerosis
    • Minagar A., and Alexander J.S. Blood-brain barrier disruption in multiple sclerosis. Mult. Scler. 9 (2003) 540-549
    • (2003) Mult. Scler. , vol.9 , pp. 540-549
    • Minagar, A.1    Alexander, J.S.2
  • 70
    • 0035041728 scopus 로고    scopus 로고
    • An infectious basis for multiple sclerosis: Perspectives on the role of Chlamydia pneumoniae and other agents
    • Moses Jr. H., and Sriram S. An infectious basis for multiple sclerosis: Perspectives on the role of Chlamydia pneumoniae and other agents. BioDrugs 15 (2001) 199-206
    • (2001) BioDrugs , vol.15 , pp. 199-206
    • Moses Jr., H.1    Sriram, S.2
  • 75
    • 0029079852 scopus 로고
    • Induction of MHC class I genes in neurons
    • Neumann H., Cavalie A., Jenne D.E., and Wekerle H. Induction of MHC class I genes in neurons. Science 269 (1995) 549-552
    • (1995) Science , vol.269 , pp. 549-552
    • Neumann, H.1    Cavalie, A.2    Jenne, D.E.3    Wekerle, H.4
  • 76
    • 0036602982 scopus 로고    scopus 로고
    • Cytotoxic T lymphocytes in autoimmune and degenerative CNS diseases
    • Neumann H., Medana I.M., Bauer J., and Lassmann H. Cytotoxic T lymphocytes in autoimmune and degenerative CNS diseases. Trends Neurosci. 25 (2002) 313-319
    • (2002) Trends Neurosci. , vol.25 , pp. 313-319
    • Neumann, H.1    Medana, I.M.2    Bauer, J.3    Lassmann, H.4
  • 77
    • 0036187468 scopus 로고    scopus 로고
    • Myelin-specific tolerance attenuates the progression of a virus-induced demyelinating disease: Implications for the treatment of MS
    • Neville K.L., Padilla J., and Miller S.D. Myelin-specific tolerance attenuates the progression of a virus-induced demyelinating disease: Implications for the treatment of MS. J. Neuroimmunol. 123 (2002) 18-29
    • (2002) J. Neuroimmunol. , vol.123 , pp. 18-29
    • Neville, K.L.1    Padilla, J.2    Miller, S.D.3
  • 78
    • 29144504313 scopus 로고    scopus 로고
    • CD8+ T cell-mediated HLA-A*0201-restricted cytotoxicity to transaldolase peptide 168-176 in patients with multiple sclerosis
    • Niland B., Banki K., Biddison W.E., and Perl A. CD8+ T cell-mediated HLA-A*0201-restricted cytotoxicity to transaldolase peptide 168-176 in patients with multiple sclerosis. J. Immunol. 175 (2005) 8365-8378
    • (2005) J. Immunol. , vol.175 , pp. 8365-8378
    • Niland, B.1    Banki, K.2    Biddison, W.E.3    Perl, A.4
  • 83
    • 0036935830 scopus 로고    scopus 로고
    • Junctional complexes of the blood-brain barrier: Permeability changes in neuroinflammation
    • Petty M.A., and Lo E.H. Junctional complexes of the blood-brain barrier: Permeability changes in neuroinflammation. Prog. Neurobiol. 68 (2002) 311-323
    • (2002) Prog. Neurobiol. , vol.68 , pp. 311-323
    • Petty, M.A.1    Lo, E.H.2
  • 84
    • 0345432117 scopus 로고    scopus 로고
    • Absence of neurological deficits following extensive demyelination in a class I-deficient murine model of multiple sclerosis
    • Rivera-Quinones C., McGavern D., Schmelzer J.D., Hunter S.F., Low P.A., and Rodriguez M. Absence of neurological deficits following extensive demyelination in a class I-deficient murine model of multiple sclerosis. Nat. Med. 4 (1998) 187-193
    • (1998) Nat. Med. , vol.4 , pp. 187-193
    • Rivera-Quinones, C.1    McGavern, D.2    Schmelzer, J.D.3    Hunter, S.F.4    Low, P.A.5    Rodriguez, M.6
  • 85
    • 0037416178 scopus 로고    scopus 로고
    • Presentation of antigen by endothelial cells and chemoattraction are required for homing of insulin-specific CD8+ T cells
    • Savinov A.Y., Wong F.S., Stonebraker A.C., and Chervonsky A.V. Presentation of antigen by endothelial cells and chemoattraction are required for homing of insulin-specific CD8+ T cells. J. Exp. Med. 197 (2003) 643-656
    • (2003) J. Exp. Med. , vol.197 , pp. 643-656
    • Savinov, A.Y.1    Wong, F.S.2    Stonebraker, A.C.3    Chervonsky, A.V.4
  • 86
    • 27644518406 scopus 로고    scopus 로고
    • Association between peripheral IFN-gamma producing CD8+ T-cells and disability score in relapsing-remitting multiple sclerosis
    • Sepulcre J., Sanchez-Ibarrola A., Moreno C., and de Castro P. Association between peripheral IFN-gamma producing CD8+ T-cells and disability score in relapsing-remitting multiple sclerosis. Cytokine 32 (2005) 111-116
    • (2005) Cytokine , vol.32 , pp. 111-116
    • Sepulcre, J.1    Sanchez-Ibarrola, A.2    Moreno, C.3    de Castro, P.4
  • 87
    • 2942620592 scopus 로고    scopus 로고
    • Increased adhesion molecule and chemokine receptor expression on CD8+ T cells trafficking to cerebrospinal fluid in HIV-1 infection
    • Shacklett B.L., Cox C.A., Wilkens D.T., Karl Karlsson R., Nilsson A., Nixon D.F., and Price R.W. Increased adhesion molecule and chemokine receptor expression on CD8+ T cells trafficking to cerebrospinal fluid in HIV-1 infection. J. Infect. Dis. 189 (2004) 2202-2212
    • (2004) J. Infect. Dis. , vol.189 , pp. 2202-2212
    • Shacklett, B.L.1    Cox, C.A.2    Wilkens, D.T.3    Karl Karlsson, R.4    Nilsson, A.5    Nixon, D.F.6    Price, R.W.7
  • 89
    • 0033178617 scopus 로고    scopus 로고
    • Inhibition of autoimmune T cell responses in the DA rat by bone marrow-derived NK cells in vitro: Implications for autoimmunity
    • Smeltz R.B., Wolf N.A., and Swanborg R.H. Inhibition of autoimmune T cell responses in the DA rat by bone marrow-derived NK cells in vitro: Implications for autoimmunity. J. Immunol. 163 (1999) 1390-1397
    • (1999) J. Immunol. , vol.163 , pp. 1390-1397
    • Smeltz, R.B.1    Wolf, N.A.2    Swanborg, R.H.3
  • 91
    • 28444499085 scopus 로고    scopus 로고
    • Virtues and pitfalls of EAE for the development of therapies for multiple sclerosis
    • Steinman L., and Zamvil S.S. Virtues and pitfalls of EAE for the development of therapies for multiple sclerosis. Trends Immunol. 26 (2005) 565-571
    • (2005) Trends Immunol. , vol.26 , pp. 565-571
    • Steinman, L.1    Zamvil, S.S.2
  • 92
    • 33745728404 scopus 로고    scopus 로고
    • How to successfully apply animal studies in experimental allergic encephalomyelitis to research on multiple sclerosis
    • Steinman L., and Zamvil S.S. How to successfully apply animal studies in experimental allergic encephalomyelitis to research on multiple sclerosis. Ann. Neurol. 60 (2006) 12-21
    • (2006) Ann. Neurol. , vol.60 , pp. 12-21
    • Steinman, L.1    Zamvil, S.S.2
  • 94
    • 0033624408 scopus 로고    scopus 로고
    • Cytokines in CNS disorders: Neurotoxicity versus neuroprotection
    • Stoll G., Jander S., and Schroeter M. Cytokines in CNS disorders: Neurotoxicity versus neuroprotection. J. Neural. Transm. Suppl. 59 (2000) 81-89
    • (2000) J. Neural. Transm. Suppl. , vol.59 , pp. 81-89
    • Stoll, G.1    Jander, S.2    Schroeter, M.3
  • 95
    • 0035877190 scopus 로고    scopus 로고
    • Myelin antigen-specific CD8+ T cells are encephalitogenic and produce severe disease in C57BL/6 mice
    • Sun D., Whitaker J.N., Huang Z., Liu D., Coleclough C., Wekerle H., and Raine C.S. Myelin antigen-specific CD8+ T cells are encephalitogenic and produce severe disease in C57BL/6 mice. J. Immunol. 166 (2001) 7579-7587
    • (2001) J. Immunol. , vol.166 , pp. 7579-7587
    • Sun, D.1    Whitaker, J.N.2    Huang, Z.3    Liu, D.4    Coleclough, C.5    Wekerle, H.6    Raine, C.S.7
  • 96
    • 0029840391 scopus 로고    scopus 로고
    • A single T cell receptor recognizes structurally distinct MHC/peptide complexes with high specificity
    • Tallquist M.D., Yun T.J., and Pease L.R. A single T cell receptor recognizes structurally distinct MHC/peptide complexes with high specificity. J. Exp. Med. 184 (1996) 1017-1026
    • (1996) J. Exp. Med. , vol.184 , pp. 1017-1026
    • Tallquist, M.D.1    Yun, T.J.2    Pease, L.R.3
  • 97
    • 0034917817 scopus 로고    scopus 로고
    • Viruses can silently prime for and trigger central nervous system autoimmune disease
    • Theil D.J., Tsunoda I., Rodriguez F., Whitton J.L., and Fujinami R.S. Viruses can silently prime for and trigger central nervous system autoimmune disease. J. Neurovirol. 7 (2001) 220-227
    • (2001) J. Neurovirol. , vol.7 , pp. 220-227
    • Theil, D.J.1    Tsunoda, I.2    Rodriguez, F.3    Whitton, J.L.4    Fujinami, R.S.5
  • 99
    • 0032842426 scopus 로고    scopus 로고
    • Structural and signalling molecules come together at tight junctions
    • Tsukita S., Furuse M., and Itoh M. Structural and signalling molecules come together at tight junctions. Curr. Opin. Cell Biol. 11 (1999) 628-633
    • (1999) Curr. Opin. Cell Biol. , vol.11 , pp. 628-633
    • Tsukita, S.1    Furuse, M.2    Itoh, M.3
  • 100
    • 0037052704 scopus 로고    scopus 로고
    • Preservation of neurologic function during inflammatory demyelination correlates with axon sparing in a mouse model of multiple sclerosis
    • Ure D.R., and Rodriguez M. Preservation of neurologic function during inflammatory demyelination correlates with axon sparing in a mouse model of multiple sclerosis. Neuroscience 111 (2002) 399-411
    • (2002) Neuroscience , vol.111 , pp. 399-411
    • Ure, D.R.1    Rodriguez, M.2
  • 101
    • 5344228374 scopus 로고    scopus 로고
    • Multiple sclerosis is an inflammatory T-cell-mediated autoimmune disease
    • Weiner H.L. Multiple sclerosis is an inflammatory T-cell-mediated autoimmune disease. Arch. Neurol. 61 (2004) 1613-1615
    • (2004) Arch. Neurol. , vol.61 , pp. 1613-1615
    • Weiner, H.L.1
  • 102
    • 2542453748 scopus 로고    scopus 로고
    • Neuromyelitis optica: Current concepts
    • Wingerchuk D.M. Neuromyelitis optica: Current concepts. Front. Biosci. 9 (2004) 834-840
    • (2004) Front. Biosci. , vol.9 , pp. 834-840
    • Wingerchuk, D.M.1
  • 105
    • 0036627211 scopus 로고    scopus 로고
    • Tight junctions of the blood-brain barrier: Development, composition and regulation
    • Wolburg H., and Lippoldt A. Tight junctions of the blood-brain barrier: Development, composition and regulation. Vascul. Pharmacol. 38 (2002) 323-337
    • (2002) Vascul. Pharmacol. , vol.38 , pp. 323-337
    • Wolburg, H.1    Lippoldt, A.2
  • 106
    • 8644246082 scopus 로고    scopus 로고
    • Cytokines, nitric oxide, and cGMP modulate the permeability of an in vitro model of the human blood-brain barrier
    • Wong D., Dorovini-Zis K., and Vincent S.R. Cytokines, nitric oxide, and cGMP modulate the permeability of an in vitro model of the human blood-brain barrier. Exp. Neurol. 190 (2004) 446-455
    • (2004) Exp. Neurol. , vol.190 , pp. 446-455
    • Wong, D.1    Dorovini-Zis, K.2    Vincent, S.R.3
  • 108
    • 0025246367 scopus 로고
    • The T lymphocyte in experimental allergic encephalomyelitis
    • Zamvil S.S., and Steinman L. The T lymphocyte in experimental allergic encephalomyelitis. Annu. Rev. Immunol. 8 (1990) 579-621
    • (1990) Annu. Rev. Immunol. , vol.8 , pp. 579-621
    • Zamvil, S.S.1    Steinman, L.2
  • 110
    • 0035826778 scopus 로고    scopus 로고
    • Granzymes A and B directly cleave lamins and disrupt the nuclear lamina during granule-mediated cytolysis
    • Zhang D., Beresford P.J., Greenberg A.H., and Lieberman J. Granzymes A and B directly cleave lamins and disrupt the nuclear lamina during granule-mediated cytolysis. Proc. Natl. Acad. Sci. USA 98 (2001) 5746-5751
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 5746-5751
    • Zhang, D.1    Beresford, P.J.2    Greenberg, A.H.3    Lieberman, J.4


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