Expression of Major Histocompatibility Complex Class I Molecules on the Different Cell Types in Multiple Sclerosis Lesions

Brain Pathology

Volumn 14, Issue 1, 2004, Pages 43-50

  Hoftberger R ^a   Aboul Enein, F ^a   Brueck, W ^b   Lucchinetti, C ^c   Rodriguez, M ^c   Schmidbauer, M ^d   Jellinger, K ^e   Lassmann, Hans ^a  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

^b UNIVERSITY OF GÖTTINGEN   (Germany)

^c MAYO CLINIC   (United States)

^d GENERAL HOSPITAL LINZ   (Austria)

^e INSTITUTE OF CLINICAL NEUROBIOLOGY   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

BETA 2 MICROGLOBULIN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2;

ADULT; AGED; ALPHA CHAIN; ANTIGEN EXPRESSION; ARTICLE; ASTROCYTE; AUTOPSY; CELL TYPE; CENTRAL NERVOUS SYSTEM; CHRONIC INFLAMMATION; CONFOCAL LASER MICROSCOPY; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; DEMYELINATION; DISEASE ACTIVITY; DISEASE SEVERITY; ENDOTHELIUM CELL; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOPATHOLOGY; MACROPHAGE; MAJOR CLINICAL STUDY; MALE; MICROGLIA; MULTIPLE SCLEROSIS; NERVE CELL; NERVE FIBER; NERVE FIBER DEGENERATION; OLIGODENDROGLIA;

EID: 1042299971     PISSN: 10156305     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1750-3639.2004.tb00496.x     Document Type: Article

References (47)

1. Achim CL, Morey MK, Wiley CA (1991) Expression of major histocompatibility complex and HIV antigens within the brains of AIDS patients. AIDS 5:535-541.
2. Achim CL, Wiley CA (1992) Expression of major histocompatibility complex antigens in the brains of patients with progressive multifocal leukoencephalopathy. J Neuropathol Exp Neurol 51:257-263.
3. Altintas A, Cai Z, Pease LR, Rodriguez M (1993) Differential expression of H-2K and H-2D in the central nervous system of mice infected with Theiler's virus. J Immunol 151:2803-2812.
4. Babbe H, Roers A, Waisman A, Lassmann H, Goebels N, Hohlfeld R, Friese M, Schroder R, Deckert M, Schmidt S, Ravid R, Rajewsky K (2000) Clonal expansions of CD8(+) T-cells dominate the T-cell infiltrate in active multiple sclerosis lesions as shown by micromanipulation and single cell polymerase chain reaction. J Exp Med 192:393-404.
5. Battistini L, Fischer FR, Raine CS, Brosnan CF (1996) CD1b is expressed in multiple sclerosis lesions. J Neuroimmunol 67:145-151.
6. Bitsch A, Schuchardt J, Bunkowski S, Kuhlmann T, Bruck W (2000) Acute axonal injury in multiple sclerosis. Correlation with demyelination and inflammation. Brain 123:1174-1183.
7. Bo L, Mork S, Kong PA, Nyland H, Pardo CA, Trapp BD (1994) Detection of MHC class II-antigens on macrophages and microglia, but not on astrocytes and endothelia in active multiple sclerosis lesions. J Neuroimmunol 51:135-146.
8. Booss J, Esiri MM, Tourtellotte WW, Mason DY (1983) Immunohistological analysis of T lymphocyte subsets in the central nervous system in chronic progressive multiple sclerosis. J Neurol Sci 62:219-232.
9. Bruck W, Porada P, Poser S, Rieckmann P, Hanefeld F, Kretzschmar HA, Lassmann H (1995) Monocyte/macrophage differentiation in early multiple sclerosis lesions. Ann Neurol 38:788-796.
10. Buttini M, Limonta S, Boddeke HW (1996) Peripheral administration of lipopolysaccharide induces activation of microglial cells in rat brain. Neurochem Int 29:25-35.
11. Cabarrocas J, Bauer J, Piaggio E, Liblau R, Lassmann H (2003) Effective and selective immune surveillance of the brain by MHC class I-restricted cytotoxic T lymphocytes. Eur J Immunol 33:1174-1182.
12. Doberson MJ, Hammer JA, Noronha AB, MacIntosh TD, Trapp BD, Brady RO, Quarles RH (1985) Generation and characterization of mouse monoclonal antibodies to the myelin-associated glycoprotein (MAG). Neurochem Res 10:499-513.
13. Ferguson B, Matyszak MK, Esiri MM, Perry VH (1997) Axonal damage in acute multiple sclerosis lesions. Brain 120:393-399.
14. Gay FW, Drye TJ, Dick GW, Esiri MM (1997) The application of multifactorial cluster analysis in the staging of plaques in early multiple sclerosis. Identification and characterization of the primary demyelinating lesion. Brain 120:1461-1483.
15. Gobin SJ, Montagne L, Van Zutphen M, Van Der Valk P, Van Den Elsen PJ, De Groot CJ (2001) Upregulation of transcription factors controlling MHC expression in multiple sclerosis lesions. Glia 36:68-77.
16. Hayashi T, Morimoto C, Burks JS, Kerr C, Hauser SL (1988) Dual-label immunocytochemistry of the active multiple sclerosis lesion: major histocompatibility complex and activation antigens. Ann Neurol 24:523-531.
17. Horwitz MS, Evans CF, Klier FG, Oldstone MB (1999) Detailed in vivo analysis of interferon-gamma induced major histocompatibility complex expression in the the central nervous system: astrocytes fail to express major histocompatibility complex class I and II molecules. Lab Invest 79:235-242.
18. Johnson AJ, Upshaw J, Pavelko KP, Rodriguez M, Pease LR (2001) Preservation of Motor Function by Inhibition of CD8+ Virus-peptide Specific T Cells in Theiler's Virus Infection. FASEB J 15:255-276.
19. Joly E, Mucke L, Oldstone MB (1991) Viral persistence in neurons explained by lack of major histocompatibility class I expression. Science 253: 1283-1285.
20. Kapoor R, Davies M, Smith KJ (1999) Temporary axonal conduction block and axonal loss in inflammatory neurological disease. A potential role for nitric oxide? Ann N Y Acad Sci 893:304-308.
21. Kornek B, Storch MK, Weissert R, Wallstroem E, Stefferl A, Olsson T, Linington C, Schmidbauer M, Lassmann H (2000) Multiple sclerosis and chronic autoimmune encephalomyelitis: a comparative quantitative study of axonal injury in active, inactive, and remyelinated lesions. Am J Pathol 157:267-276.
22. Lampson LA, Hickey WF (1986) Monoclonal antibody analysis of MHC expression in human brain biopsies: tissue ranging from "histologically normal" to that showing different levels of glial tumor involvement. J Immunol 136:4054-4062.
23. Larsson M, Fonteneau JF, Bhardwaj N (2001) Dendritic cells resurrect antigens from dead cells. Trends Immunol 22:141-148.
24. Lucchinetti C, Bruck W, Parisi J, Scheithauer B, Rodriguez M, Lassmann H (2000) Heterogeneity of multiple sclerosis lesions: implications for the pathogenesis of demyelination. Ann Neurol 47:707-717.
25. McRae A, Bona E, Hagberg H (1996) Microglia-astrocyte interactions after cortisone treatment in a neonatal hypoxia-ischemia model. Brain Res Dev Brain Res 94:44-51.
26. Medana IM, Gallimore A, Oxenius A, Martinic MM, Wekerle H, Neumann H (2000) MHC class I-restricted killing of neurons by virus-specific CD8+ T lymphocytes is effected through the Fas/ FasL, but not the perforin pathway. Eur J Immunol 30:3623-3633.
27. Neumann H, Cayalie A, Jenne DE, Wekerle H (1995) Induction of MHC class I genes in neurons. Science 269:549-552.
28. Neumann H, Misgeld T, Matsumuro K, Wekerle H (1998) Neurotrophins inhibit major histocompatibility class II inducibility of microglia: involvement of the p75 neurotrophin receptor. Proc Natl Acad Sci U S A 95:5779-5784.
29. Neumann H, Medana IM, Bauer J, Lassmann H (2002) Cytotoxic T lymphocytes in autoimmune and degenerative CNS diseases. Trends Neurosci 25:313-319.
30. Nyland H, Mork S, Matre R (1982) In-situ characterization of mononuclear cell infiltrates in lesions of multiple sclerosis. Neuropathol Appl Neurobiol 8:403-411.
31. Pender MP, Sears TA (1982) Conduction block in the peripheral nervous system in experimental allergic encephalomyelitis. Nature 296:860-862.
32. Piddlesden SJ, Lassmann H, Zimprich F, Morgan BP, Linington C (1993) The demyelinating potential of antibodies to myelin oligodendrocyte glycoprotein is related to their ability to fix complement. Am J Pathol 143:555-564.
33. Rall GF, Mucke L, Oldstone MB (1995) Consequences of cytotoxic T lymphocyte interaction with major histocompatibility complex class I-expressing neurons in vivo. J Exp Med 182: 1201-1212.
34. Ransohoff RM, Estes ML (1991) Astrocyte expression of major histocompatibility complex gene products in multiple sclerosis brain tissue obtained by stereotactic biopsy. Arch Neurol 48: 1244-1246.
35. Rivera-Quiñones C, McGavern D, Schmelzer JD, Hunter S, Low PA, Rodriguez M (1998) Absence of neurological deficits following extensive demyelination in a class I-deficient murine model of multiple sclerosis. Nature Med 4:187-193.
36. Rodriguez M, Leibowitz J, David CS (1986) Susceptibility to Theiler's virus-induced demyelination: mapping of the gene within the H-2D region. J Exp Med 163:620-631.
37. Rodriguez M, Sriram S (1988) Successful therapy of Theiler's virus-induced demyelination (DA Strain) with monoclonal anti-Lyt-2 antibody. J Immunol 140:2950-2955.
38. Smith KJ, Lassmann H (2002) The role of nitric oxide in multiple sclerosis. Lancet Neurol 1:232-241.
39. Sobel RA, Collins AB, Colvin RB, Bhan AK (1986) The in situ cellular immune response in acute herpes simplex encephalitis. Am J Pathol 125:332-338.
40. Stam NJ, Vroom TM, Peters PJ, Pastoors EB, Ploegh HL (1990) HLA-A- and HLA-B-specific monoclonal antibodies reactive with free heavy chains in western blots, in formalin-fixed, paraffin-embedded tissue sections and in cryo-immuno-electron microscopy. Int Immunol 2:113-125.
41. Trapp BD, Peterson J, Ransohoff RM, Rudick R, Mork S, Bo L (1998) Axonal transection in the lesions of multiple sclerosis. N Engl J Med 338: 278-285.
42. Traugott U, Scheinberg LC, Raine CS (1985) On the presence of Ia-positive endothelial cells and astrocytes in multiple sclerosis lesions and its relevance to antigen presentation. J Neuroimmunol 8:1-14.
43. Traugott U (1987) Multiple sclerosis: relevance of class I and class II MHC-expressing cells to lesion development. J Neuroimmunol 16:283-302.
44. Traugott U, Lebon P (1988) Multiple sclerosis: involvement of interferons in lesion pathogenesis. Ann Neurol 24:243-251.
45. van der Maesen K, Hinojoza JR, Sobel RA (1999) Endothelial cell class II major histocompatibility complex molecule expression in stereotactic brain biopsies of patients with acute inflammatory/demyelinating conditions. J Neuropathol Exp Neurol 58:346-358.
46. Vass K, Lassmann H (1990) Intrathecal application of interferon gamma. Progressive appearance of MHC antigens within the rat nervous system. Am J Pathol 137:789-800.
47. Woodroofe MN, Bellamy AS, Feldmann M, Davison AN, Cuzner ML (1986) Immunocytochemical characterisation of the immune reaction in the central nervous system in multiple sclerosis. Possible role for microglia in lesion growth. J Neurol Sci 74:135-152.